Reference of 36070-80-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 36070-80-1, name is 5-Chloropyrazine-2-carboxylic acid belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.
A mixture of 5-ch[oropyrazine-2-carboxy[ic acid [CAS RN: 36070-80-1] (1.00 g,6.31 mmo[, 1 .0 eq), tert-butyl. 4-aminopiperidine-1 -carboxylate [CAS-RN: 87120-72-7] (1.39 g, 6.94 mmo[, 1.1 eq), HATU (2.64 g, 6.94 mmo[, 1.1 eq) and DIPEA(2.33 mL, 12.6 mmo[, 2.0 eq) was dissolved in 38 mL DMF and stirred at rtovernight. The reaction mixture was partitioned between ethyl acetate andwater. The organic phase was washed with brine and filtered through a Whatman filter. The volatile components were removed in vacuo and the crude material obtained was purified via preparative MPLC (Biotage Isolera; 25 g SNAP cartridge: hexane-> hexane/ethyl acetate 2/3) to give 1 .01 g (43% yield oftheory) of the title compound.UPLC-MS (Method 2): R = 1.15 mm; MS (Elneg) m/z = 339 [M-H].
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Chloropyrazine-2-carboxylic acid, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; BAeRFACKER, Lars; SIEMEISTER, Gerhard; HEINRICH, Tobias; PRECHTL, Stefan; STOeCKIGT, Detlef; ROTTMANN, Antje; WO2015/113927; (2015); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem