Synthetic Route of 71257-38-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 71257-38-0, name is 1,2,3,4-Tetrahydropyrrolo[1,2-a]pyrazine belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.
EXAMPLE 2 2-Acetyl-1,2,3,4-Tetrahydropyrrolo-[1,2,-a]-pyrazine To a solution of 12.2 g 1,2,3,4-tetrahydropyrrolo-[1,2,-a]-pyrazine in 40 ml of anhydrous benzene was added 15.3 g of acetic anhydride in small portions. The reaction mixture was kept for 3 hours at room temperature. Then the reaction mass was poured into water, the organic phase was separated and washed with a 5% solution of sodium carbonate, and then water. The solvent was removed by distillation, the residue was distilled under vacuum, and the fraction with a boiling point of 146-147 C. at 2 mm Hg was collected. The yield of the title compound was 14 g (86%). Nmr (CDCl3): delta2.0 (s) (3H,CH3); 3.6-4.0 (m) (4H, 3,4-CH2); 4.6 (s) (2H, 1-CH2); 5.7-5.9 (m) (1H, 7-H); 5.9-6.06 (m) (1H, 8-H); 6.38-6.5 (m) (1H, 6-H). Anal. calculated for C9 H12 N2 O: C 65.38%; H 7.37%; N 17.01% and found: C 65.62%: H 7.32%; N 17.00%.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,2,3,4-Tetrahydropyrrolo[1,2-a]pyrazine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Russian-American Institute For New Drug Development; US5378846; (1995); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem