Related Products of 63744-22-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 63744-22-9, name is 6,8-Dibromoimidazo[1,2-a]pyrazine, This compound has unique chemical properties. The synthetic route is as follows.
11d (0.5 g, 2.8 mmol), 1a (0.8 g, 2.8 mmol), isopropanol (5.1 ml), and diisopropylethylamine (0.7 g, 5.6 mmol) were added to a 25 ml three-necked flask. The system was replaced with nitrogen for three times under stirring. The system was refluxed for 16 hours in 100 C oil bath. The system was cooled to 17 C, and concentrated to dryness under reduced pressure, purified by silica gel column chromatography (ethyl acetate / n-hexane = 1/10 to 1: 3) to give light yellow solid Compound 11e (0.7 g, 99.5% purity, yield 72.6%). MS m/z 374.0 [M+H]+.
The chemical industry reduces the impact on the environment during synthesis 6,8-Dibromoimidazo[1,2-a]pyrazine. I believe this compound will play a more active role in future production and life.
Reference:
Patent; Hangzhou Innogate Pharma Co., Ltd.; ZHANG, Hancheng; LIU, Shifeng; YE, Xiangyang; CHEN, Wenting; (53 pag.)EP3553065; (2019); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem