Category: Pyrazines

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 52197-12-3, name is 5-Methylpyrazine-2,3-dicarbonitrile, A new synthetic method of this compound is introduced below., Recommanded Product: 5-Methylpyrazine-2,3-dicarbonitrile

Magnesium shavings (0.337 g, 13.88 mmol) and a small iodinecrystal were refluxed in n-butanol (20 mL) for 5 h. After the mixturewas cooled to roomtemperature, 5-methylpyrazine-2,3-dicarbonitrile(1 g, 6.94 mmol) was added to the reaction mixture and heated underreflux for 20 h. After this time, the reaction mixture was cooled toroom temperature, filtered off through Celite and the solvent wasremoved using a rotary evaporator. Purification of the product wasaccomplished by washing the crude product with acetonitrile, nhexane,ethyl acetate, acetonitrile, toluene, tetrahydrofuran, chloroform,dichloromethane, ethanol,methanol and acetone for 12 h in theSoxhlet apparatus. The dark blue product was dried under vacuum at50 C. The MgPz is soluble in DMFand DMSO. Yield: 0.26 mg (39.06%).Mp > 300C. FT-IR (ATR) nu/cm-1: 712, 747, 766, 948 (=C-H bend),1071,1093,1137 (C-C str.),1205,1277,1321,1376 (C-N str.), 1475, 1515(C-H bend.),1573,1594 (C=C str.),1633 (C=N str.), 2869, 2962 (>CH2str.), 3096 (-C=H str.). UVeVis (DMSO, 1 x 10-5 M): lambdamax(nm), (log epsilon):344 (4.69), 581 (4.23), 636 (4.86). 1H NMR(600 MHz, DMSO-d6, ppm):delta = 8.76-8.12 (m, 4H aromatic-CH), 2.41 (bs,12H, -CH3). MS (MALDI-TOF)m/z: Calculated 600.84, found 601.98 [MH]. Calculated forC28H16N16Mg: C, 55.97%; H, 2.68%; N, 37.30%; found C, 56.15%; H,2.92%; N, 36.96%.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 128229-06-1, name is 2-(Chloromethyl)-5-methylpyrazine hydrochloride, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C6H8Cl2N2

2-(Chloromethyl)-5-methylpyrazine hydrochloride (19 mg) was added to a mixture of [5-(piperidin-4-yl)-1H-benzimidazol-2-yl]{4-[4-(trifluoromethyl)benzyl]piperazin-1-yl}methanone (48 mg), N,N-diisopropylethylamine (70 mul), acetonitrile (1 ml), and DMF (1 ml), followed by stirring at room temperature for 5 days. Water was added to the reaction mixture, and extraction was carried out using ethyl acetate. After the organic layer was dried over anhydrous sodium sulfate, the desiccant was removed, and then the solvent was evaporated under reduced pressure. The obtained residue was purified by silica gel column chromatography (chloroform-methanol), and then a 4 M hydrogen chloride/ethyl acetate solution (200 mul) was added to a solution of the obtained oily material in ethyl acetate (1 ml), followed by stirring at room temperature for 10 minutes. The solvent was evaporated under reduced pressure, and then ethyl acetate was added to the obtained residue. The resulting solid was collected by filtration, and then dried under reduced pressure, thereby obtaining (6-{1-[(5-methylpyrazin-2-yl)methyl]piperidin-4-yl}-1H-benzimidazol-2-yl){4-[4-(trifluoromethyl)benzyl]piperazin-1-yl}methanone trihydrochloride (55 mg) as a solid.

According to the analysis of related databases, 128229-06-1, the application of this compound in the production field has become more and more popular.

Related Products of 29094-61-9, A common heterocyclic compound, 29094-61-9, name is Glipizide, molecular formula is C21H27N5O4S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Glipizide (445.5 mg, 1.0 mmol) was dissolved in DMSO (anhydrous, 10ML). Sodium amide (76.03mg, 2. 0 mmol) was then added. The reaction mixture was stirred at room temperature for 10 min. DTPA-dianhydride (357.32 mg, 1.0 mmol) was dissolved in DMSO (anhydrous, 10ML). Sodium amide (76.03 mg, 2.0 mmol) was then added. The reaction mixture was stirred at room temperature for 10 min. DTPA-dianhydride (357.32 mg, 1.0 mmol) dissolved in 5 ml DMSO (anhydrous) was added and the mixture was stirred for 4 hours. The mixture was added with water (10 mL), followed by 1N-sodium hydroxide solution (3 mL) and stirred for 2 hours. The solid was filtered and washed with water. This recovered starting material was 142.6 mg (32%) after drying under vacuum. The aqueous phase was dialyzed with membrane (MW CO < 500) for 2 days. DTPA-GLP (506.6 MG, ; 61.7% yield) as a white solid was gathered after lyophilization. The synthetic scheme is shown in Figure 8. Figures 9-17 SHOWED LH-, L3C-NMR spectrum and assignment and mass spectrometry of DTPA-glipizide. The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Electric Literature of 2882-21-5, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 2882-21-5 as follows.

To a solution of 2-methoxy-6-methylpyrazine (21.3 g, 171.6 mmol) mAcOH (150 mL)was added NaBO2 H202 3H20 (31.7 g, 205.9 mmol). The mixture was stirred at 80C for 16 hours. The mixture was cocentrated in vacuo and diluted with 2 M aq. NaOH (300 mL). The mixture was extracted with EtOAc (200 mL x 4). The organic layer was washed with brine (100 mL), dried over Na2SO4 and concentrated in vacuo to give 3-methoxy-5-methylpyrazine1-oxide (14.4 g, 60% yield).

According to the analysis of related databases, 2882-21-5, the application of this compound in the production field has become more and more popular.

Adding a certain compound to certain chemical reactions, such as: 717847-03-5, name is 6-Morpholinopyrazin-2-amine, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 717847-03-5, Safety of 6-Morpholinopyrazin-2-amine

5,7-Difluoro-3-methyl-2-(4-methylpyridin-2-yl)-N-(6-morpholinopyrazin-2- yl)quinolin-4-amineThe Buchwald coupled product was prepared according to Procedure H using of dicyclohexyl(2′,4′,6′-triisopropylbiphenyl-2-yl)phosphine (0.025 g, 0.053 mmol), 6-morpholinopyrazin-2-amine (0.071 g, 0.39 mmol), 4-chloro-5,7-difluoro-3- methyl-2-(4-methylpyridin-2-yl)quinoline (0.1 g, 0.33 mmol) and Pd2dba3 (0.012 g, 0.013 mmol) and sodium tert-butoxide (0.079 g, 0.82 mmol) in toluene (3.3 mL) at 100 C for 48.5 h. The crude product was purified by columnchromatography on alumina (0 to 60% EtOAc in hexanes) to yield the desired product 5,7-difluoro-3-methyl-2-(4-methylpyridin-2-yl)-N-(6-morpholinopyrazin-2-yl)quinolin-4-amine. .H NMR (400 MHz, CD2C12) delta ppm 8.55 (1 H, d, J=5.1 Hz), 7.64 – 7.67 (1 H, m), 7.59 (1 H, s), 7.54 (1 H, ddd, J=9.6, 2.5, 1.4 Hz), 7.38 (1 H, s), 7.17 – 7.26 (2 H, m), 7.02 (1 H, ddd, J=13.3, 8.8, 2.5 Hz), 3.69 – 3.76 (4 H, m), 3.39 – 3.46 (4 H, m), 2.47 (3 H, s), 2.26 (3 H, s). Mass Spectrum (ESI) m/e = 449.1 (M + 1).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Adding a certain compound to certain chemical reactions, such as: 73627-18-6, name is 1,2,3,4-Tetrahydro-1-methylpyrrolo[1,2-a]pyrazine, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 73627-18-6, HPLC of Formula: C8H12N2

Synthesis of 4-(1-methyl-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)-4-oxobutanoic acid S4 A solution of (190 mg, 1.4 mmol) of 1-methyl-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine (A21) in THF (10 ml) was added dropwise in the course of 30 min to a suspension of (558 mg, 5.6 mmol) of succinic anhydride in THF (10 ml). The mixture was then stirred for 2 h at RT and concentrated in vacuo. The residue was taken up in chloroform, washed with water and brine, dried over MgSO4 and concentrated in vacuo. 257 mg (0.92 mmol, 54%) of 4-(1-methyl-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)-4-oxobutanoic acid (S4) were obtained.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1,2,3,4-Tetrahydro-1-methylpyrrolo[1,2-a]pyrazine, and friends who are interested can also refer to it.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 25773-40-4, name is 2-Isopropyl-3-methoxypyrazine, A new synthetic method of this compound is introduced below., COA of Formula: C8H12N2O

Photocatalytic experiments were carried out in a solar sim-ulator Atlas Suntest XLS+ (Germany). Illumination was providedwith a xenon lamp (2.2 kW) which was jacketed with special fil-ters restricting the transmission of wavelengths below 290 nm.Irradiation experiments were performed using a Pyrex glass UV-reactor containing 250 mL of aqueous solutions and the appropriateamount of TiO2(100 mg L-1) at natural pH. The suspension was keptin the dark for 30 min, prior to illumination to reach adsorptionequilibrium onto semiconductor surface. A relatively low amountof TiO2(100 mg L-1) and a higher initial concentration of IPMP(10 mg L-1) than the typical values found in drinking waters havebeen selected in the experiments in order to obtain slower kineticsand provide favorable conditions for the identification and struc-tural elucidation of transformation products and the mineralizationstudy.

The synthetic route of 25773-40-4 has been constantly updated, and we look forward to future research findings.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 213019-67-1, name is 3-(Trifluoromethyl)pyrazin-2-amine, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C5H4F3N3

A solution of bromine in dichloromethane (1 OmI) was added in portions to a stirred solution of 2-amino-3-trifluoromethylpyrazine (1 .5g, 9.2mmol) and pyridine (0.90m1, limmol) in chloroform. The resulting mixture was stirred at room temperature for 24hours. Volatiles were removed under reduced pressure and the residue was purified by chromatography on silica gel using a gradient of ethyl acetate in isohexane as eluent to give 2-am ino-3-trifluoromethyl-5-bromopyrazine (1 .7g, 77% yield) as an off-white solid.1H NMR (400 MHz, CDCI3)5 8.30 (s, 1H), 5.13 (br s, 2H).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 213019-67-1.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1220330-11-9, name is 5-Ethoxypyrazine-2-carboxylic acid, A new synthetic method of this compound is introduced below., Recommanded Product: 1220330-11-9

5-Ethoxypyrazine-2-carboxylic acid (53.9 mg, 320 muiotaetaomicron) was suspended in dichloromethane (5 mL), the suspension was cooled to 0-5C (ice bath) and oxalyl chloride (56.9 mg, 39.3 mu, 448 muiotaetaomicron) as well as dimethylformamide (0.308 M in toluene, 51.9 mu, 16 muiotaetaomicron) were added. The mixture was stirred for 1.5 h at room temperature. Then, it was concentrated in vacuo (40C, 5 mbar) and dried azeotropically by two cycles of addition of toluene (3 mL) followed by concentration in vacuo to afford 5-ethoxypyrazine-2-carbonyl chloride as yellow oil (59.7 mg, quant.). After that, tert-butyl ((3aS,4R,8R)-4-(5-amino-2-fluorophenyl)-4,7,7-trimethyl-8-oxido- 3,3a,4,7-tetrahydro-2H-isothiazolo[l,5-a] [l,4]thiazin-6-yl)carbamate (Int- 16ABp, 80 mg, 188 muiotaetaomicron) was dissolved in dichloromethane (5 mL), the solution cooled to 10C and N,N- diisopropylethylamine (36.5 mg, 49.4 mu, 283 muiotaetaomicron) was added, followed by a solution of 5- ethoxypyrazine-2-carbonyl chloride (vide supra, 47.7 mg, 256 muiotaetaomicron) in dichloromethane (4 mL). The reaction mixture was stirred for 15 min at 10C. Then, methanol (2 mL) was added, the mixture was stirred for 5 min at room temperature and concentrated in vacuo. The crude was purified by column chromatography (silica gel, 24 g, eluting with 2 M ammonia in methanol / dichloromethane, gradient 1 :99 to 3:97) to yield, after drying in vacuo (40C, 5 mbar), the title compound as a white solid (92 mg, 85% yield). HPLC (method LCMS_fglm) tR = 1.37 min. MS (ES+) m/z 575.4 [M+H] .

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

1057216-55-3, name is 2-Chloro-5-iodopyrazine, belongs to pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 2-Chloro-5-iodopyrazine

Intermediate 31 (350 mg, 1.05 mmol), 2-chloro-5-iodopyrazine (252 mg, 1.05 mmol), 2M aqueous sodium carbonate solution (1.58 mL, 3.16 mmol) and anhydrous DMSO (5 mL) were charged to a sealed tube. The mixture was degassed by bubbling with nitrogen for 5 minutes before the addition of tetrakis(triphenylphosphine)20 palladium(0) (61 mg, 0.05 mmol). The reaction mixture was sealed under nitrogen andstirred at 110C for 1 h. The mixture was diluted with water (40 mL) and extracted with EtOAc (3 x 20 mL). The organic phase was washed with saturated aqueous sodium bicarbonate solution (2 x 10 mL) followed by brine (10 mL), then dried over sodium sulfate and concentrated under vacuum. The residue was purified by FCC, eluting with17-80% EtOAc in heptane, to afford the title compound (285 mg, 54% at 80% purity) as an off white solid. oH (500 MHz, CDC13) 8.73-8.64 (m, 2H), 8.63-8.59 (m, 1H), 7.92 (s, 2H), 7.33-7.27 (m, 1H), 7.17 (d, J8.2 Hz, 1H), 7.15-7.07 (m, 1H), 7.00 (d, J6.6 Hz, 1H),6.67 (t, J73.5 Hz, 1H), 4.36 (s, 2H), 2.60 (s, 3H). Method C HPLC-MS: MH+ m/z 401,

The synthetic route of 1057216-55-3 has been constantly updated, and we look forward to future research findings.