Category: Pyrazines

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 446286-90-4, name is 2-Bromo-5-(piperazin-1-yl)pyrazine, A new synthetic method of this compound is introduced below., HPLC of Formula: C8H11BrN4

To a CH2Cl2 (150 mL) solution of Example 1, Part B (17 g, 50 mmol) in an ice bath was added trifluoroacetic acid (30 mL). The solution was stirred for 4 hr at room temperature, and then stripped in vacuo. The residue was partitioned between EtOAc (250 mL) and saturated NaHCO3 (200 mL). The organic layer was separated, and the aqueous layer extracted with EtOAc and CH2Cl2 (200 mL each). The combined organic extracts were washed with brine, dried over MgSO4, and evaporated to afford the crude piperazine in the form of a yellow solid (MS: m/z=243, 245 (M+H)). The resulting crude product was dissolved in CH2Cl2 (150 mL), and then cooled in an ice bath. To the resulting mixture was added Et3N (8.8 mL, 63 mmol) and methanesulfonyl chloride (4.2 mL, 55 mmol). The solution was stirred for 16 hr at room temperature. The mixture was then washed with water and brine, dried over MgSO4, and evaporated to produce 14.3 g (89% yield) of the desired sulfonamide in the form of a pale yellow oil. MS: m/z=321, 323 (M+H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Barta, Thomas E.; Becker, Daniel P.; Bedell, Louis J.; Boehm, Terri L.; Brown, David L.; Carroll, Jeffery N.; Chen, Yiyuan; Fobian, Yvette M.; Freskos, John N.; Gasiecki, Alan F.; Grapperhaus, Margaret L.; Heintz, Robert M.; Hockerman, Susan L.; Kassab, Darren J.; Khanna, Ish K.; Kolodziej, Stephen A.; Massa, Mark A.; McDonald, Joseph J.; Mischke, Brent V.; Mischke, Deborah A.; Mullins, Patrick B.; Nagy, Mark A.; Norton, Monica B.; Rico, Joseph G.; Schmidt, Michelle A.; Stehle, Nathan W.; Talley, John J.; Vernier, William F.; Villamil, Clara I.; Wang, Lijuan J.; Wynn, Thomas A.; US2005/9838; (2005); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 13924-99-7, name is 6-Oxo-1,6-dihydropyrazine-2-carboxylic acid, A new synthetic method of this compound is introduced below., HPLC of Formula: C5H4N2O3

Example 68. Formula II: R1 =CH3; R2 =R3 =H; R4 =OCH3 To 0.42 g (0.003 mol) of 6-hydroxy-pyrazinoic acid suspended in 10 mL of anhydrous methanol was added 4 mL of (0.030 mol) of chlorotrimethylsilane. The resultant mixture was allowed to stir for 48 hours at room temperature during which time the suspension became a solution. It is expected that this procedure may be used to convert 6-hydroxypyrazinoic acid to any 6-alkoxypyrazinoic ester by the use of the appropriate alcohol and, when the alcohol is not a liquid, the use of an inert solvent such as THF. The solvent and excess chlorotrimethylsilane were removed in vacuo by rotary evaporation. The crude product was purified by column chromatography on silica gel with a hexane-ethyl acetate gradient to yield 0.11 g (22%) of methyl 6-methoxypyrazinecarboxylate.

The synthetic route of 13924-99-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; The Research Foundation of State University of NY; US5643912; (1997); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Adding a certain compound to certain chemical reactions, such as: 33332-30-8, name is 2-Chloro-6-methoxypyrazine, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 33332-30-8, Recommanded Product: 2-Chloro-6-methoxypyrazine

To a solution of 0.49 g (0.0034 mol) of 2-chloro-6-methoxy-pyrazine (Example P7) in 9 mi of dichloromethane there are added, under an argon gas atmosphere, first, within a period of 45 minutes and at 20C, 0.19 g (0.002 mol) of hydrogen peroxide-urea adduct and then, dropwise, 0.3 ml (0.0021 mol) of trifluoroacetic anhydride in dichloromethane. Then there are again added, within a period of 45 minutes and at 20C, 0. 19 g (0.002 mol) of hydrogen peroxide-urea adduct and 0.3 ml (0.0021 mol) of trifluoroacetic anhydride in dichloro- methane, and the reaction mixture is stirred further at 20C for 30 minutes. The reaction is stopped by adding water, and the aqueous phase obtained is extracted with chloroform. The combined organic phases are washed with 5 % sodium hydrogen carbonate solution and saturated sodium chloride solution and dried over sodium sulfate. The desired title compound, having a melting point of 121-123C, is obtained in a yield of 0.53 g (98 % of theory). The compound can be used directly for the next reaction step. ‘H NMR (300 MHz, CDC13) : 7.802 ppm (d (J=1.2 Hz), 1 H) ; 7.691 ppm (d (J=1.2 Hz), 1 H) ; 4.012 ppm (s, 3H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Chloro-6-methoxypyrazine, other downstream synthetic routes, hurry up and to see.

Application of 476622-89-6,Some common heterocyclic compound, 476622-89-6, name is 5-Bromo-2-iodo-3-methoxypyrazine, molecular formula is C5H4BrIN2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: In a Schlenk flask, a solution containing the haloheterocycle (1mmol), the boronic acid (1.3mmol), methanol (5mL) and a 2M aqueous sodium carbonate solution (3.35mmol) in benzene (25mL) was deoxygenated by bubbling a stream of argon through it. Pd(PPh3)4 (0.14mmol) was then added and the flask was evacuated and purged with argon. The reaction mixture was heated for the time indicated and the reaction was quenched with water and extracted with CH2Cl2 (3×). The combined organic extracts were dried over Na2SO4, filtered and the solvent was evaporated in vacuo. The residue was purified by column chromatography on silica gel as indicated.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Bromo-2-iodo-3-methoxypyrazine, its application will become more common.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 84996-40-7, name is 2-Amino-3-(methylamino)pyrazine, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C5H8N4

To a mixture of 26 (3.99 g, 32.1 mmol) in THF (200 mL) was added carbonyldiimidazole (CDI; 10.4 g, 64.1 mmol), and the mixture was stirred at 70 C for 5 h. The reaction mixture was allowed to cool to room temperature and concentrated in vacuo. The residue was purified by flash column chromatography (silica gel, 0-5% MeOH in CHCl3). The residue was washed with EtOAc/n-hexane. To the residue in MeCN (100 mL) were added ethyl acrylate (7.00 mL, 64.4 mmol) and DBU (2.40 mL, 16.4 mmol), and the mixture was stirred at 50 C for 12 h under argon atmosphere. The mixture was concentrated in vacuo. The residue was purified by flash column chromatography (silica gel, 0-5% MeOH in CHCl3) to give 27 (6.11 g, 76%) as a colorless solid. 1H NMR (DMSO-d6) delta 1.10 (t, 3H, J = 7.1 Hz), 2.81 (t, 2H, J = 7.1 Hz), 3.34 (s, 3H), 4.00 (q, 2H, J = 7.1 Hz), 4.11 (t, 2H, J = 7.1 Hz), 7.95 (d, 1H, J = 3.3 Hz), 7.96 (d, 1H, J = 3.3 Hz); MS (ESI) m/z 251 [M+H]+.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 84996-40-7.

These common heterocyclic compound, 40155-47-3, name is 3-Methoxypyrazine-2-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 40155-47-3

4-(31) N-(3-((4aS,5S,7aS)-2-amino-5-(fluoromethyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-7a-yl)-4,5-difluorophenyl)-5-methoxypyrazine-2-carboxamide (also called 4-(17)) Methoxypyrazine-2-carboxylic acid (159 mg), PyBOP (898 mg), and diisopropylethylamine (754 mul) were added to a mixture of tert-butyl ((4aS,5S,7aS)-7a-(5-amino-2,3-difluorophenyl)-5-(fluoromethyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-2-yl)carbamate, obtained in Preparation Example 4-(30), (359 mg) in DCM (14 ml) at RT. The mixture was stirred for 3 h at the same temperature. The resultant mixture was purified directly by silica gel column chromatography (gradient from 15% to 70% EtOAc in heptane).

The synthetic route of 3-Methoxypyrazine-2-carboxylic acid has been constantly updated, and we look forward to future research findings.

Reference of 40155-47-3,Some common heterocyclic compound, 40155-47-3, name is 3-Methoxypyrazine-2-carboxylic acid, molecular formula is C6H6N2O3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of amine salt E1.1 (0.868g, 3.39 mmol) and carboxylic acid 1a (0.475g, 3.08 mmol) in DCE (50 mL) at room temperature was sequentially added bromotripyrrolidinophosphonium hexafluorophosphate (1.80 g, 3.85 mmol), and DIEA (1.59g, 112.33 mmol). The reaction was then stirred at room temperature for 72 hours. Then CH2CI2 (100 mL) and water (100 mL) were added to the reaction, layers separated, and the organic phase washed with water (2 x 100 mL), dried over Na2S04, and concentrated in vacuoto afford a residue. The residue was purified by column chromatography using silica gel, eluting with 100% EtOAc, to afford the desired compound as an off white solid (0.690g, 69% yield). LC-MS: mass calc’d. for C17H15CI2N5O2 [M+H]+ 356.1 , found 356.0; tR= 0.688 min.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Methoxypyrazine-2-carboxylic acid, its application will become more common.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 61442-38-4, name is 6-Aminopyrazine-2-carboxylic acid, A new synthetic method of this compound is introduced below., COA of Formula: C5H5N3O2

A mixture of l-(3-((5-aminopyridin-3-yl)amino)-5-methyl-5H-chromeno[4,3- c]pyridin-8-yl)pyrrobdin-2-one (60 mg, 0.14 mmol, HC1 salt), 6-aminopyrazine-2-carboxybc acid (24 mg, 0.17 mmol) and EDCI.HC1 (30 mg, 0.16 mmol) in pyridine (2 mL) was heated at 50 C for 2 h. A black solution was formed. LCMS (Rt = 0.687 min; MS Calcd: 508.2; MS Found: 509.1 [M+H]+). The mixture was concentrated and the residue was poured into water (20 mL) and stirred for 2 minutes. The aqueous layer was extracted with ethyl acetate (20 mL x3). The combined organic layer was washed with water (20 mL x2) and brine (20 mL), dried over anhydrous Na2S04, filtered and concentrated. The residue was purified by prep-HPLC (0.225% FA as an additive) and lyophilized to give 6-amino-N-(5-((5-methyl-8-(2- oxopyrrolidin-l-yl)-5H-chromeno[4,3-c]pyridin-3-yl)amino)pyridin-3-yl)pyrazine-2- carboxamide (23.5 mg, yield: 32%) as a yellow solid. (1570) NMR (400 MHz DMSO-rie) d 1.55 (3H, d, J= 6.5 Hz), 2.01-2.10 (2H, m), 2.52-2.54 (2H, m, overlapped with the peak of DMSO), 3.84 (2H, t, J= 7.7 Hz), 5.30 (1H, q , J= 6.4 Hz), 6.80 (1H, s), 6.82 (2H, brs), 7.33 (1H, dd, J= 8.7, 2.1 Hz), 7.41 (1H, d, J= 2.3 Hz), 7.90 (1H, d, J= 8.8 Hz), 8.15 (1H, s), 8.36 (1H, s), 8.55 (1H, s), 8.70 (1H, s), 8.76-8.83 (2H, m), 9.71 (1H, brs), 10.46 (1H, brs).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 25680-54-0, name is 3-Ethylpyrazin-2(1H)-one, This compound has unique chemical properties. The synthetic route is as follows., Formula: C6H8N2O

(iii) 3-Ethyl-2-hydroxypyrazine (5 g) was heated with phosphorus oxychloride (15 ml) at reflux for 3 hours. The reaction was allowed to cool to ambient temperature and then poured onto 200 g of crushed ice. The mixture was extracted with dichloromethane (3*150 ml) and the combined extracts were dried (MgSO4). Volatile material was removed by evaporation to give a brown oil. The oil was purified by chromatography on silica gel, eluding with dichloromethane, to give 2-chloro-3-ethylpyrazine as a colourless oil (5.64 g, 98%); 1 H NMR (d6 -DMSO, 200 MHz): 1.25 (t,3H), 2.93 (q,2H), 8.36 (d,1H), 8.59 (d,1H); mass spectrum (+ve CI): 143 (M+H)+.

According to the analysis of related databases, 25680-54-0, the application of this compound in the production field has become more and more popular.

Some common heterocyclic compound, 723286-67-7, name is Ethyl 1,2,4-Triazolo[4,3-a]pyrazine-3-carboxylate, molecular formula is C8H8N4O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 723286-67-7

A mixture of 170 mg of ethyl [1, 2,4] triazolo [4, 3-a] pyrazine-3-carboxylate from Example 8, Step B and 3 mL of tert-butylamine was heated in a sealed tube at reflux for 8 h. Concentration followed by flash chromatography (silica gel, eluting sequentially with 100% ethyl acetate and 10% methanol/dichloromethane) gave the title compound as a viscous oil. LC/MS 219.9 (M+1).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 723286-67-7, its application will become more common.