Category: 71257-38-0

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 71257-38-0, name is 1,2,3,4-Tetrahydropyrrolo[1,2-a]pyrazine, A new synthetic method of this compound is introduced below., category: Pyrazines

Diisopropylethylamine (12.15 mmole) and di-tert-butyl dicarbonate (8.9 mmole) were added to a solution of the correspondingly 1-substituted 1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine (8.1 mmole) in DCM. The reaction mixture was stirred for 16 hours at 25 C. The organic phase was then washed with sodium carbonate solution, water and satd. NaCl solution, dried over Na2SO4 and concentrated by evaporation. The crude product was purified by column chromatography (silica gel, ethyl acetate/DCM, 99:1); 1,2,3,4-Tetrahydro-pyrrolo[1,2-a]pyrazine was dissolved in dichloromethane (90 ml) at to it DIPEA (12.15 mmol) and boc anhydride (8.9 mmol) were added at 0 C. The resulting reaction mixture was allowed to stir for 16 hrs at 25 C. Organic layer was washed with sodium carbonate, water and brine and finally dried over sodium sulfate. Evaporation of the organic layer gave the crude product which was purified by column chromatography (1% ethyl acetate in dichloromethane) or (10% ethyl acetate in hexane); 1,2,3,4-Tetrahydro-pyrrolo[1,2-a]pyrazine which was dissolved in dichloromethane (90 ml) at to it DIPEA (12.15 mmol) and boc anhydride (8.9 mmol) were added at 0 C. The resulting reaction mixture was allowed to stir for 16 hrs at 25 C. Organic layer was washed with sodium carbonate, water and brine and finally dried over sodium sulfate. Evaporation of the organic layer gave the crude product which was purified by column chromatography (1% ethyl acetate in dichloromethane) or (10% ethyl acetate in hexane).

The synthetic route of 71257-38-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GRUENENTHAL GmbH; US2009/186899; (2009); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Related Products of 71257-38-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 71257-38-0 name is 1,2,3,4-Tetrahydropyrrolo[1,2-a]pyrazine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Example 1112,2-Dimethyl-1 -(7-(phenylethynyl)-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)- yl)propan-1-one[00350] Pivaloyl chloride (3.27 g, 3.34 mL, 27.2 mmol) is added dropwise at 0 C to a solution of 1 ,2,3,4-tetrahydropyrrolo[1 ,2-a]pyrazine (3.01 g, 24.7 mmol) (WO2009/90055) and TEA (4.60 mL, 32.6 mmol) in DCM (40 mL). The resulting mixture is stirred at 0 C for 15 min and washed with an aqueous citric acid solution (10%). The organic phase is dried over MgSO and concentrated at reduced pressure. The obtained residue is purified by column chromatography (silica gel, DCM/acetone, 10:1 ) to give 1 -(3,4-dihydropyrrolo[1 ,2-a]pyrazin-2(1 H)-yl)-2,2-dimethylpropan-1 -one (3.10 g, 61 %) as a yellowish crystalline intermediate product.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1,2,3,4-Tetrahydropyrrolo[1,2-a]pyrazine, and friends who are interested can also refer to it.

Reference:
Patent; MERZ PHARMA GmbH & CO. KGaA; ZEMRIBO, Ronalds; FOTINS, Juris; ABEL, Ulrich; KUBAS, Holger; MEYER, Udo; WOLTER, Falko Ernst; HECHENBERGER, Mirko; WO2012/172093; (2012); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 71257-38-0, name is 1,2,3,4-Tetrahydropyrrolo[1,2-a]pyrazine, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 1,2,3,4-Tetrahydropyrrolo[1,2-a]pyrazine

Step 3 4-[[3-(3,4-dihydro-1H-pyrrolo[1,2-c]pyrazine-2-carbonyl)-4-fluoro-phenyl]methyl]-2H-phthalazin-1-one 2-Fluoro-5-[(4-oxo-3H-phthalazin-1-yl)methyl]benzoic acid 1a (300 mg, 1 mmol) was dissolved in 3 mL of N,N-dimethylformamide, followed by addition of O-(1-benzotriazolyl)-N,N,N’,N’-tetramethyluronium hexafluorophosphate (568 mg, 1.50 mmol), 1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine 2c (210 mg, 1.50 mmol) and N, N-diisopropylethylamine (350 muL, 2 mmol). After stirring for 12 hours, the reaction mixture was concentrated under reduced pressure and the resulting residue was purified by thin layer chromatography with elution system A to obtain 4-[[3-(3,4-dihydro-1H-pyrrolo[1,2-c]pyrazine-2-carbonyl)-4-fluoro-phenyl]methyl]-2H-phthalazin-1-one 2 (15 mg, yield 3.7%) as a white solid. MS m/z (ESI): 403.1 [M+1] 1H NMR (400 MHz, CDCl3): delta 10.19 (br. s, 1H), 8.51 (d, 1H), 7.82 (m, 3H), 7.41 (m, 2H), 7.13 (m, 1H), 6.65 (m, 1H), 6.24 (m, 1H), 5.81 (m, 1H), 4.97 (s, 1H), 4.59 (s, 1H), 4.33 (s, 2H), 4.13 (m, 1H), 4.00 (m, 1H), 3.71 (m, 1H), 2.85 (m, 1H)

According to the analysis of related databases, 71257-38-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; JIANGSU HANSOH PHARMACEUTICAL CO., LTD.; Tang, Peng Cho; Li, Xin; Li, Xiangqin; Chen, Yang; Wang, Bin; Zhu, Zhe; US2013/131068; (2013); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 71257-38-0, name is 1,2,3,4-Tetrahydropyrrolo[1,2-a]pyrazine, This compound has unique chemical properties. The synthetic route is as follows., name: 1,2,3,4-Tetrahydropyrrolo[1,2-a]pyrazine

EXAMPLE 6 2-Benzoyl-1,2,3,4-Tetrahydropyrrolo-[1,2-a]-Pyrazine To a solution of 12.2 g of 1,2,3,4-tetrahydropyrrolo-[1,2-a]-pyrazine and 22.2 g of triethylamine in 50 ml of anhydrous benzene, 15.4 g of benzoyl chloride was added in small portions at 10-15 C. The reaction mass was stirred for 3 hours at room temperature and then poured into water. The organic phase was separated, and washed with a 5% solution of sodium carbonate and then water. The solvent was removed by distillation, the residue was distilled under vacuum, and the fraction with a boiling point of 189-191 C. at 1 mm Hg was collected. The yield of the title compound was 15 g (66.5%). Nmr (CDCl3): delta3.7-3.9 (m) (4H, 3,4-CH2); 4.58 (s) (2H, 1-CH2); 5.6-5.8 (m) (1H, 7-H); 5.8-6.0 (m) (1H, 8-H); 6.2-6.4 (m) (1H, 6 -H); 7.2-7.4 (m) (5H-C6 H5). Anal. calculated for C14 H14 N2 O: C 74.31%; H 6.24%; N 12.38% and found: C 74.21%; H 6.24%; N 12.45%.

According to the analysis of related databases, 71257-38-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Russian-American Institute For New Drug Development; US5378846; (1995); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Synthetic Route of 71257-38-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 71257-38-0, name is 1,2,3,4-Tetrahydropyrrolo[1,2-a]pyrazine belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.

EXAMPLE 2 2-Acetyl-1,2,3,4-Tetrahydropyrrolo-[1,2,-a]-pyrazine To a solution of 12.2 g 1,2,3,4-tetrahydropyrrolo-[1,2,-a]-pyrazine in 40 ml of anhydrous benzene was added 15.3 g of acetic anhydride in small portions. The reaction mixture was kept for 3 hours at room temperature. Then the reaction mass was poured into water, the organic phase was separated and washed with a 5% solution of sodium carbonate, and then water. The solvent was removed by distillation, the residue was distilled under vacuum, and the fraction with a boiling point of 146-147 C. at 2 mm Hg was collected. The yield of the title compound was 14 g (86%). Nmr (CDCl3): delta2.0 (s) (3H,CH3); 3.6-4.0 (m) (4H, 3,4-CH2); 4.6 (s) (2H, 1-CH2); 5.7-5.9 (m) (1H, 7-H); 5.9-6.06 (m) (1H, 8-H); 6.38-6.5 (m) (1H, 6-H). Anal. calculated for C9 H12 N2 O: C 65.38%; H 7.37%; N 17.01% and found: C 65.62%: H 7.32%; N 17.00%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,2,3,4-Tetrahydropyrrolo[1,2-a]pyrazine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Russian-American Institute For New Drug Development; US5378846; (1995); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 71257-38-0, name is 1,2,3,4-Tetrahydropyrrolo[1,2-a]pyrazine, A new synthetic method of this compound is introduced below., name: 1,2,3,4-Tetrahydropyrrolo[1,2-a]pyrazine

Diisopropylethylamine (12.15 mmole) and di-tert-butyl dicarbonate (8.9 mmole) were added to a solution of the correspondingly 1-substituted 1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine (8.1 mmole) in DCM. The reaction mixture was stirred for 16 hours at 25 C. The organic phase was then washed with sodium carbonate solution, water and satd. NaCl solution, dried over Na2SO4 and concentrated by evaporation. The crude product was purified by column chromatography (silica gel, ethyl acetate/DCM, 99:1); 1,2,3,4-Tetrahydro-pyrrolo[1,2-a]pyrazine was dissolved in dichloromethane (90 ml) at to it DIPEA (12.15 mmol) and boc anhydride (8.9 mmol) were added at 0 C. The resulting reaction mixture was allowed to stir for 16 hrs at 25 C. Organic layer was washed with sodium carbonate, water and brine and finally dried over sodium sulfate. Evaporation of the organic layer gave the crude product which was purified by column chromatography (1% ethyl acetate in dichloromethane) or (10% ethyl acetate in hexane); 1,2,3,4-Tetrahydro-pyrrolo[1,2-a]pyrazine which was dissolved in dichloromethane (90 ml) at to it DIPEA (12.15 mmol) and boc anhydride (8.9 mmol) were added at 0 C. The resulting reaction mixture was allowed to stir for 16 hrs at 25 C. Organic layer was washed with sodium carbonate, water and brine and finally dried over sodium sulfate. Evaporation of the organic layer gave the crude product which was purified by column chromatography (1% ethyl acetate in dichloromethane) or (10% ethyl acetate in hexane).

The synthetic route of 71257-38-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GRUENENTHAL GmbH; US2009/186899; (2009); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Application of 71257-38-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 71257-38-0 name is 1,2,3,4-Tetrahydropyrrolo[1,2-a]pyrazine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of 4-oxo-piperidine-1-carboxylic acid tert-butyl ester (4.68 mmol) and 1,2,3,4-tetrahydro-pyrrolo[1,2-a]pyrazine (3.9 mmol) in methanol (15 ml) there was added, under nitrogen, at 25 C., a catalytic amount of acetic acid, followed by sodium cyanoborohydride (2.5 eq.). The resulting solution was stirred for 16 h at that temperature until the reaction was complete (TLC monitoring). Ice was added to the reaction mixture, and then concentration in vacuo was carried out. The residue was taken up in dichloromethane (100 ml) and washed with saturated sodium bicarbonate solution and with saturated sodium chloride solution. The organic phase was dried (Na2SO4), filtered, and concentrated in vacuo. The crude product so obtained was used directly in the following synthesis step. Yield: 40%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1,2,3,4-Tetrahydropyrrolo[1,2-a]pyrazine, and friends who are interested can also refer to it.

Reference:
Patent; Gruenenthal GmbH; US2008/153843; (2008); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 71257-38-0 as follows. category: Pyrazines

Stage 1, Method B. Diisopropylethylamine (12.15 mmole) and di-tert-butyl dicarbonate (8.9 mmole) were added to a solution of the correspondingly 1-substituted 1,2,3,4- tetrahydropyrrolo [1, 2-a] pyrazine (8.1 mmole) in DCM. The reaction mixture was stirred for 16 hours at 25C. The organic phase was then washed with sodium carbonate solution, water and saturated NaCl solution, dried over sodium sulfate and concentrated by evaporation. The crude product was purified by column chromatography (silica gel, ethyl acetate/DCM, 99:1)

According to the analysis of related databases, 71257-38-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; GRUeNENTHAL GMBH; WO2009/90055; (2009); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem