Park, Hae-Ryung published the artcileElectronic cigarette smoke reduces ribosomal protein gene expression to impair protein synthesis in primary human airway epithelial cells, Safety of 2,3,5-Trimethylpyrazine, the main research area is electronic cigarette smoke ribosomal protein gene expression epithelial cell.
The widespread use of electronic cigarettes (e-cig) is a serious public health concern; however, mechanisms by which e-cig impair the function of airway epithelial cells-the direct target of e-cig smoke-are not fully understood. Here we report transcriptomic changes, including decreased expression of many ribosomal genes, in airway epithelial cells in response to e-cig exposure. Using RNA-seq we identify over 200 differentially expressed genes in air-liquid interface cultured primary normal human bronchial epithelial (NHBE) exposed to e-cig smoke solution from com. e-cig cartridges. In particular, exposure to e-cig smoke solution inhibits biol. pathways involving ribosomes and protein biogenesis in NHBE cells. Consistent with this effect, expression of corresponding ribosomal proteins and subsequent protein biogenesis are reduced in the cells exposed to e-cig. Gas chromatog./mass spectrometry (GC/MS) anal. identified the presence of five flavoring chems. designated as ′high priority′ in regard to respiratory health, and methylglyoxal in e-cig smoke solution Together, our findings reveal the potential detrimental effect of e-cig smoke on ribosomes and the associated protein biogenesis in airway epithelium. Our study calls for further investigation into how these changes in the airway epithelium contribute to the current epidemic of lung injuries in e-cig users.
Scientific Reports published new progress about Animal gene, RPS14 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 14667-55-1 belongs to class pyrazines, name is 2,3,5-Trimethylpyrazine, and the molecular formula is C7H10N2, Safety of 2,3,5-Trimethylpyrazine.