Related Products of 54608-52-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 54608-52-5, name is 2-Hydrazinopyrazine belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.
Step B: Preparation of (la/?,5a/?)-2-(Pyrazin-2-yl)-la,2,5,5a-tetrahydro-li/-2,3- diaza-cyclopropa[a]pentalene-4-carboxylic Acid Ethyl Ester. [Method ClTo a stirred suspension of 2-ethoxy-2-oxo-l-((lLambda,5i?)-2-oxobicyclo[3.1.0]hexan-3- ylidene)ethanolate (300 mg, 1.28 mmol) in ethanol (5 mL) was added 2-hydrazinylpyrazine (141 mg, 1.28 mmol) followed by 6 N HCl (0.5 mL, 3.0 mmol). The reaction was stirred overnight at room temperature. The reaction was diluted with H2O and extracted with DCM. The combined organic phases were washed with H2O, dried over MgSO4, and concentrated. Purification by silica gel flash chromatography gave the title compound (150 mg). LCMS mlz = 271.2 [M+H]+; 1H NMR (400 MHz, CDCl3) delta ppm 0.47 (td, J= 4.7 and 3.4 Hz, IH), 1.22-1.28 (m, IH), 1.39 (t, J= 7.1 Hz, 3H), 2.26-2.30 (m, IH), 2.77-2.82 (m, IH), 2.87 (d, J= 16.6 Hz, IH), 2.98 (dd, J = 16.6 and 6.3 Hz, IH), 4.40 (q, J = 7.1 Hz, 2H), 8.40 (dd, J= 2.6 and 1.5 Hz, IH), 8.51 (d, 7= 2.5 Hz, IH), 9.39 (d, J = 1.3 Hz, IH).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Hydrazinopyrazine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; ARENA PHARMACEUTICALS, INC.; JONES, Robert M.; HAN, Sangdon; THORESEN, Lars; JUNG, Jae-Kyu; STRAH-PLEYNET, Sonja; ZHU, Xiuwen; XIONG, Yifeng; YUE, Dawei; WO2011/25541; (2011); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem