Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 91476-80-1, name is 5,6,7,8-Tetrahydroimidazo[1,2-a]pyrazine, A new synthetic method of this compound is introduced below., Safety of 5,6,7,8-Tetrahydroimidazo[1,2-a]pyrazine
Compound ii-26a (2.38 g, 19.33 mmol) (see US 2008/153843 A1 and others) was dissolved in tetrahydrofuran (95 mL), and thereto was added compound ii-2b (9.50 g, 17.39 mmol). The resultant solution was stirred at room temperature. After the end of the reaction, purified water was added to the reaction liquid. From the water phase, the resultant reaction product was extracted with ethyl acetate. The resultant organic phase was washed with a 5% aqueous sodium hydrogencarbonate solution, purified water, and a saturated salt solution in turn. The organic phase was dried over anhydrous magnesium sulfate, and magnesium sulfate was then removed therefrom by filtration. The solvent was distilled off therefrom under reduced pressure. The resultant residue was subjected to silica gel chromatography to yield compound ii-2 6b (yielded amount: 8.3 g, yield: 80%).1H-NMR (CDCl3) delta: 7.40-7.30 (4H, m), 7.08-6.81 (8H, m), 5.09-4.98 (4H, m), 4.54-4.51 (1H, m), 4.48-4.33 (1H, m), 4.17-3.94 (2H, m), 3.84 (3H, s), 3.80 (3H, s), 3.63-3.45 (1H, m), 1.88-1.60 (1H, m).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Shionogi & Co., Ltd.; HISAKAWA, Shinya; HASEGAWA, Yasushi; AOKI, Toshiaki; KUSANO, Hiroki; SANO, Masayuki; SATO, Jun; YAMAWAKI, Kenji; EP2557082; (2013); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem