Tag: M.W=300-400

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 723286-80-4, name is tert-Butyl 3-bromo-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylate, A new synthetic method of this compound is introduced below., Safety of tert-Butyl 3-bromo-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylate

A mixture of pyrazole (33.7 mg, 0.495 mmol) and sodium hydride (19.79 mg, 0.495 mmol) in Lambda/,Lambda/-dimethylformamide (DMF) (1 ml) was cooled to 0 0C and 1 ,1- dimethylethyl 3-bromo-5,6-dihydro[1 ,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylate (50 mg, 0.165 mmol, commercially available from e.g. Allichem, Ark Pharm or Bepharm) was added. After completion of the addition, the mixture was stirred at room temp for 30 mins and then at 1 10 0C. After 3 h, the DMF was evaporated and a few drops of NH4CI solution were added followed by ethyl acetate (50 ml). The solution was dried (Na2SO4), filtered and concentrated. The product was purified by MDAP to give desired product in 24.1 mg. LCMS MH+ = 291 (at) 0.79 min (2 min run)

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; GLAXO GROUP LIMITED; DEAN, David Kenneth; MUNOZ-MURIEDAS, Jorge; SIME, Mairi; STEADMAN, Jon Graham Anthony; THEWLIS, Rachel Elizabeth Anne; TRANI, Giancarlo; WALTER, Daryl Simon; WO2010/125102; (2010); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 87597-21-5, name is Ethyl 6,8-dibromoimidazo[1,2-a]pyrazine-2-carboxylate, A new synthetic method of this compound is introduced below., Application In Synthesis of Ethyl 6,8-dibromoimidazo[1,2-a]pyrazine-2-carboxylate

Intermediate 1-07 (1.00 g, 2.87 mmol) was dissolved in DCM (28 mE) and N-bromosuccinimide (0.61 g, 3.44 mmol) and trifluoroacetic acid (0.25 mE) were added. The reaction mixture was stirring at rt for 16 h and then heated at 60 C. for 2 h more. The reaction mixture was cooled, andwashed with watet The organic phase was dried (Na2SO4), filtered and the solvent removed in vacuum. The residue was purified by biotage with a gradient cyclohexane/EtOAc:from 100% to 50:50 The desired fractions were collected to obtained 1.15 g of a white solid as intermediate 1-09 (Y:94%).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS (CNIO); Serrano Marugan, Manuel; Pastor Fernandez, Joaquin; Martinez Gonzalez, Sonia; Ortega Molina, Ana; Bischoff, James R.; Oyarzabal Santamarina, Julen; (220 pag.)US9993554; (2018); B2;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Application of 476622-89-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 476622-89-6, name is 5-Bromo-2-iodo-3-methoxypyrazine belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.

Step 1 . Synthesis of 5-bromo-3-methoxy-2-(4-methyl-1 /-/-imidazol-1 – yl)pyrazine (C11 ). A solution of 5-bromo-2-iodo-3-methoxypyrazine (which may be prepared according to Garg, N . K. et al., J. Am. Chem. Soc. 2002, 124, 13179- 13184) (92 g, 0.29 mol), 4-methyl-1 H-imidazole (38.5 g, 0.47 mol), K3P04 (157 g, 0.74 mol) and trans- ,2-diaminocyclohexane (15 mL, 0.12 mol) in dioxane (300 mL) was heated at reflux under a stream of argon for 15 minutes. Copper(l) iodide (5.5 g, 29 mmol) was added, and the reaction mixture was heated at reflux for an additional 30 minutes. After cooling to room temperature, the reaction mixture was diluted with ethyl acetate (1 .0 L) and chromatographed on silica (Gradient: 0% to 16% methanol in ethyl acetate) to provide the title compound. Yield: 21.7 g, 0.081 mol, 28%. 1 H N MR (400 MHz, CDCI3) delta 2.28 (s, 3H), 4.15 (s, 3H), 7.53 (s, 1 H), 8.08 (s, 1 H), 8.38 (s, 1 H).

The synthetic route of 5-Bromo-2-iodo-3-methoxypyrazine has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PFIZER INC.; AM ENDE, Christopher William; JOHNSON, Douglas Scott; O’DONNELL, Christopher John; PETTERSSON, Martin Youngjin; SUBRAMANYAM, Chakrapani; WO2011/48525; (2011); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

These common heterocyclic compound, 476622-89-6, name is 5-Bromo-2-iodo-3-methoxypyrazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 476622-89-6

General procedure: In a Schlenk flask, a solution containing the haloheterocycle (1mmol), the boronic acid (1.3mmol), methanol (5mL) and a 2M aqueous sodium carbonate solution (3.35mmol) in benzene (25mL) was deoxygenated by bubbling a stream of argon through it. Pd(PPh3)4 (0.14mmol) was then added and the flask was evacuated and purged with argon. The reaction mixture was heated for the time indicated and the reaction was quenched with water and extracted with CH2Cl2 (3¡Á). The combined organic extracts were dried over Na2SO4, filtered and the solvent was evaporated in vacuo. The residue was purified by column chromatography on silica gel as indicated.

The synthetic route of 5-Bromo-2-iodo-3-methoxypyrazine has been constantly updated, and we look forward to future research findings.

Reference:
Article; Garcia-Rodriguez, Jose; Perez-Rodriguez, Santiago; Ortiz, Maria A.; Pereira, Raquel; De Lera, Angel R.; Piedrafita, F. Javier; Bioorganic and Medicinal Chemistry; vol. 22; 4; (2014); p. 1285 – 1302;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 66490-61-7, name is 3,5,6-Tribromopyrazin-2-amine, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C4H2Br3N3

EXAMPLE 2 Preparation of 3-Amino-5,6-dibromopyrazinethiol Aminotribromopyrazine was prepared, by the same procedure reported for the trichloro analog, from tetrabromopyrazine. Using the same procedure as above, 30 g. of aminotribromopyrazine, and 24 g. of sodium sulfide nonohydrate in 500 IPA gave 13.5 g. (53% yield) of the desired compound. Anal. Calcd. for C4 H3 Br2 N3 S: C, 16.86; H, 1.06; N, 14.74. Found: C, 17.55; H, 1.21; N, 14.89.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 66490-61-7.

Reference:
Patent; The Dow Chemical Company; US4075207; (1978); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Application of 476622-89-6,Some common heterocyclic compound, 476622-89-6, name is 5-Bromo-2-iodo-3-methoxypyrazine, molecular formula is C5H4BrIN2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: In a Schlenk flask, a solution containing the haloheterocycle (1mmol), the boronic acid (1.3mmol), methanol (5mL) and a 2M aqueous sodium carbonate solution (3.35mmol) in benzene (25mL) was deoxygenated by bubbling a stream of argon through it. Pd(PPh3)4 (0.14mmol) was then added and the flask was evacuated and purged with argon. The reaction mixture was heated for the time indicated and the reaction was quenched with water and extracted with CH2Cl2 (3×). The combined organic extracts were dried over Na2SO4, filtered and the solvent was evaporated in vacuo. The residue was purified by column chromatography on silica gel as indicated.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Bromo-2-iodo-3-methoxypyrazine, its application will become more common.

Related Products of 66490-61-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 66490-61-7, name is 3,5,6-Tribromopyrazin-2-amine belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.

General procedure: [0268] In a mixture of 3,5,6-tribromopyrazin-2-amine (146 mg, 0.5 mmol), triethylamine (202 mg, 2 mmol), and catalytic amount of DMAP (5 mol %) in dry CH2CI2 (5 mL) was added 3- fluorobenzoylchloride (176 mg, 1 mmol) at room temperature. The mixture was stirred at room temperature overnight, and concentrated under reduced pressure. The residue was then dissolved in MeOH (5 mL) and K2CO3 (100 mg) was added. The mixture was stirred at 60 C for 1 h. The mixture was then reduced down and the product purified via silica chromatography (ethyl acetate:hexanes).

The synthetic route of 3,5,6-Tribromopyrazin-2-amine has been constantly updated, and we look forward to future research findings.

623565-14-0, name is 2-Ethyl 5-(4-nitrobenzyl) 6,7-dihydropyrazolo[1,5-a]pyrazine-2,5(4H)-dicarboxylate, belongs to pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. COA of Formula: C17H18N4O6

Step 4: 2-Hydroxymethyl-6. 7-dihvdro-4H-pyrazolo1, 5-alpyrazine-5-carboxylic acid 4-nitrobenzvl ester; LiBH4 (640 mg) and MeOH (1.2mL) was added to the THF (267 mL) solution of 6, 7-dihydro-4H-pyrazolo [1,5-a] pyrazine-2, 5-dicarboxylic acid 2-ethyl ester 5- (4- nitrobenzyl) ester (10 g) under a nitrogen atmosphere at room temperature and stirred for 3 h at 40 C. Additional LiBH4 (523 mg) and MeOH (1.0 mL) was added to the solution and stirred for 1 h at 40 C and 1 h at 50 C. The mixture was acidified with 3 mol/L HCI to pH 2 and stirred for 1 h at room temperature, then solid K2CO3 was added to the solution to adjust pH to 8. The insoluble material was filtered off and the filtrate was extracted with AcOEt. The organic layer was dried (K2CO3), and concentrated under reduced pressure. The residue was purified with silica gel column chromatography (CHCI3/MeOH =49/1-19/1) to afford titled compound as pale yellow crystals (8.44 g, 95%). 1H NMR (CDCI3) 8 1. 69 (br, 1 H), 3.98 (t, 2H, J = 5.5 Hz), 4.19 (t, 2H, J = 5.5 Hz), 4.65 (s, 2H), 4.75 (s, 2H), 5.28 (s, 2H), 6.08 (s, 1H), 7.53 (d, 2H, J = 8.7 Hz), 8.24 (d, 2H, J=8. 7Hz).

The synthetic route of 623565-14-0 has been constantly updated, and we look forward to future research findings.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1320266-92-9, name is 8-Chloro-1-iodo-3-isopropylimidazo[1,5-a]pyrazine, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of 8-Chloro-1-iodo-3-isopropylimidazo[1,5-a]pyrazine

Intermediate K (33 mg, 0.10 mmol) and NH4OH were heated to 80 C for 6 h in a microwave. The reaction mixture was concentrated in vacuo and purified using silica gel chromatography with a hexane/EtOAc gradient to yield Intermediate L (33 mg, 66% yield). ¾-NMR (300 MHz, CDC13) delta 1.4 (d, 6H, / = 5.4 Hz), 3.17-3.26 (m, 1H), 5.88 (br s, 2H), 7.02 (d, 1H, J= 5.1 Hz), 7.23 (d, 1H, J= 5.1 Hz). MS (ESI) (M+H)+ 303.2

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1320266-92-9.

Related Products of 949922-61-6,Some common heterocyclic compound, 949922-61-6, name is tert-Butyl 3-bromo-5,6-dihydroimidazo[1,2-a]pyrazine-7(8H)-carboxylate, molecular formula is C11H16BrN3O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A mixture of tert-butyl 3-bromo-5,6-dihydroimidazo[l,2-a]pyrazine-7(8H)- carboxylate (109mg, 0.361mmol), (S)-3-methyl-6-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2- yl)isochroman-l-one (208mg, 0.721mmol), Pd(PPH3)2Cl2 (25.3mg, 0.0036 mmol), Na2C03 (2M, 361ul ) in dioxane (3.6ml) was heated at 90°C 16 h. The reaction mixture was diluted with H20 and extracted with EtOAc(3x). Combined organic layer was washed with brine, dried over MgS04, filtered, concentrated and purified by flash chromatography (snap 25g) using (7-60- 100)percentEtOAc/Hexanes as mobile phase to give the title product as white foam. LC/MS:[M+H]+ 384.2

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route tert-Butyl 3-bromo-5,6-dihydroimidazo[1,2-a]pyrazine-7(8H)-carboxylate, its application will become more common.