Tag: M.W=200-300

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 6966-01-4, name is Methyl 3-amino-6-bromopyrazine-2-carboxylate, This compound has unique chemical properties. The synthetic route is as follows., Formula: C6H6BrN3O2

Methyl 3-amino-6-bromopyrazine-2-carboxylate (10 g,1 eq) was suspended in concentrated H2SO4 (40 mL), andthen, NaNO2 (5.96 g, 2 eq) was added in batches at -5 to0 C, after which the reaction was stirred at 25 C for 2 huntil the solid was all dissolved. Then, the reaction solutionwas poured into ice water (400 mL) and vigorously stirredfor 1.5 h. Afterward, the solution was extracted with ethylacetate (3 9 50 mL). The organic layer was combined andwashed with water (3 9 30 mL). Then, it was dried withanhydrous Na2SO4 for 5 h and filtered to remove the dryingagent. The ethyl acetate was removed by distillation under reduced pressure to obtain methyl 3-hydroxy-6-bromopyrazine-2-carboxylate (9.3 g, 92.7%) (TLC,EA:MeOH = 1:1, v/v, Rf = 0.77).Methyl 3-hydroxy-6-bromopyrazine-2-carboxylate(4)Yield: 92.7%, gray solid, m.p.: 120-122 C (Lit.120.5-121.5 C) (Caldwell et al. 2012). 1H-NMR(400 MHz, DMSO-d6): d 8.40 (s, 1H), 3.85 (s, 3H). 13CNMR(101 MHz, DMSO-d6): d 163.20, 157.11, 143.89,134.81, 122.06, 52.43. MS (EI): m/z = 233.0 (M?, Br79,40), 235.0 (M?, Br81, 40), 202.0 (M?, -OCH3, Br79, 45),204.0 (M?, -OCH3, Br81, 25), 174.0 (M?, -COOCH3,Br79, 100), 176.0 (M?, -COOCH3, Br79, 60).

According to the analysis of related databases, 6966-01-4, the application of this compound in the production field has become more and more popular.

Reference:
Article; Liu, Feng-Liang; Li, Cui-Qin; Xiang, Hao-Yue; Feng, Si; Chemical Papers; vol. 71; 11; (2017); p. 2153 – 2158;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Application of 63744-22-9, A common heterocyclic compound, 63744-22-9, name is 6,8-Dibromoimidazo[1,2-a]pyrazine, molecular formula is C6H3Br2N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 10-1 :Preparation of 6,8-dibromo-3-iodo-imidazo[1 ,2-a]pyrazine To a stirred solution of intermediate example 1-1 (8.7 g g, 31.4 mmol) in DMF (210 mL) was added NIS (7.42 g, 33 mmol, 1.05 eq) in one portion at rt. After 18 h stirring at 60 C, the solvent was removed in vaccuo and the residue was taken up in DCM and washed with water and saturated sodium thiosulfate solution. The organic phase was dried over sodium sulphate, filtered and the solvent was evaporated to yield 9.46 g (74.8 %) 6,8-dibromo-3-iodo-imidazo[1,2-a]pyrazine: 1H-NMR (300 MHz, CDCb): delta = 8.22 (1H, s), 7.91 (1H, s) ppm.

The synthetic route of 63744-22-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; KOPPITZ, Marcus; KLAR, Ulrich; JAUTELAT, Rolf; KOSEMUND, Dirk; BOHLMANN, Rolf; BADER, Benjamin; LIENAU, Philip; SIEMEISTER, Gerhard; WO2012/80230; (2012); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 24241-18-7, name is 2-Amino-3,5-dibromopyrazine belongs to Pyrazines compound, it is a common compound, a new synthetic route is introduced below. HPLC of Formula: C4H3Br2N3

Step 1: 5-Bromo-3-trimethylsilanylethynyl-pyrazin-2-ylamine To a 150 mL round-bottomed flask was added 3,5-dibromopyrazin-2-amine (3 g, 11.86mmol) and triethylamine (16.53 ml, 119 mmol) in THF (60 ml) to give a yellow suspension.To the stirring solution was added bis(triphenylphosphine)palladium(ll) chloride (833mg, 1.l86mmol) and copper(l) iodide (452mg, 2.373mmo1). Whilst maintaining the temperature below 10C, ethynyltrimethylsilane (1.844m1, 13.OSmmol) was added slowly and the reaction stirred at below 10C for 30mins before warming to room temperature and stirring for afurther 30mins.The reaction was concentrated under reduced pressure. After dilution with ethyl acetate the organics were washed with brine, the organic layer separated, dried over Mg504, filtered and the solvent removed under reduced pressure. The residue was loaded onto silica and purified by flash column chromatography, elution with iso hexane:ethyl acetate (0-30%) onan 80g silica column. The required fractions were combined and the solvent removed under reduced pressure to yield the product as a light brown solid (2.5g).

The synthetic route of 24241-18-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; NOVARTIS AG; BELLENIE, Benjamin Richard; BLOOMFIELD, Graham Charles; BRUCE, Ian; CULSHAW, Andrew James; HALL, Edward Charles; HOLLINGWORTH, Gregory; NEEF, James; SPENDIFF, Matthew; WATSON, Simon James; (395 pag.)WO2015/162459; (2015); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1196152-38-1, name is 2-Bromo-5-(trifluoromethyl)pyrazine, A new synthetic method of this compound is introduced below., HPLC of Formula: C5H2BrF3N2

Example 44k (300 mg, 0.8 mmol), 2-Chloro-5-(trifluoromethyl)pyrimidine (199 mg, 1.09 mmol) and N,N-diisopropylethylamine (287 mul, 1.67 mmol) are dissolved in 4 ml of anhydrous DMSO and heated in a microwave reactor during 30 minutes at 150C. The crude is partitioned between EtOAc and water, the organic layer is dried over anhydrous Na2S04 then concentrated under reduced pressure to obtain 360 mg of the title product. HPLC-MS (Method 10): Rt = 3. MS (ES+): m/z = 505 [M+H]+ . The enantiomers are obtained by HPLC using a chiral stationary phase. Method for separation: HPLC apparatus type: Waters 600 Pump; column: Daicel Chiralpack AD-H, 5.0 muiotaeta, 250 mm x 20 mm; method: eluent hexane/ IPA 70:30; flow rate: 15 mL/min, Temperature: 25 C; UV Detection: 254 nm Example of separation by chiral HPLC: Submitted to separation: 665 mg of Example 1 prepared as described above; Obtained: 157 mg of enantiomer 1 (Exp. 2) and 40 mg of enantiomer 2 (Exp. 3). Example 109 is synthesized as described for example 1 starting from example 44g (80 mg, 0.24 mmol) instead of example 44k, 2-Bromo-5-(trifluoromethyl)pyrazine (70 mg, 0.31 mmol) instead of 2-Chloro-5-(trifluoromethyl)pyrimidine, N,N-diisopropylethylamine (80 mu, 0.48 mmol) and 1 ml of anhydrous DMSO; the reaction mixture is heated during 30 minutes at 100C in a microwave reactor. After the work-up the crude is purified by Silica gel flash chromatography using EtOAc/hexane/MeOH 80:20: 1 as eluent to obtain the title compound (80 mg, 70% yield). HPLC-MS (Method 5): Rt = 2.95 min. MS (APCI+): m/z = 487 [M+H]+

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; HOENKE, Christoph; GIOVANNINI, Riccardo; LESSEL, Uta; ROSENBROCK, Holger; SCHMID, Bernhard; WO2015/55698; (2015); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Related Products of 143591-61-1, The chemical industry reduces the impact on the environment during synthesis 143591-61-1, name is 3-Bromo-8-chloroimidazo[1,2-a]pyrazine, I believe this compound will play a more active role in future production and life.

Method B 3-Bromo-?/-(3′-(trifluoromethyl)phenyl)imidazori,2-alpyrazin-8-amine [00247] Sodium hydride (84 mg, 2.10 mmol – 60% in mineral oil) was dissolved in DMSO (2mL). 3-(Trifluoromethyl)aniline (340 mg, 0.263 mL, 2.11 mmol) was then added and the resulting mixture was stirred at room temperature under a nitrogen gas atmosphere for 10 minutes. A solution of 3-bromo-8-bromo/chloroimidazo[l,2-a]pyrazine (245 mg, 1.05 mmol) in DMSO (2 mL) was then added and stirring at room temperature under a nitrogen gas atmosphere continued for another 2 hours. The reaction was quenched by the addition of saturated ammonium chloride solution (aq.) followed by extraction into EtOAc. The organic extracts were washed with brine, dried and concentrated in vacuo. Purification by flash column chromatography (gradient 7:1 to 6:1 40-60 petrol :EtO Ac) followed by trituration with 40-60 petrol gave the title compound (98 mg, 26%) as a white powder. 1H NMR (d6- DMSO): 10.12 (IH, s), 8.58 (IH, br s), 8.32 (IH, d, J 8.5 Hz), 7.88 (IH, d, J4.6), 7.85 (IH, s), 7.63 (IH, d, J4.7), 7.56 (IH, t, J7.9), 7.35 (IH, d, J7.8).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Bromo-8-chloroimidazo[1,2-a]pyrazine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; BioMarin IGA, Ltd.; WREN, Stephen Paul; WYNNE, Graham Michael; LECCI, Cristina; WILSON, Francis Xavier; PRICE, Paul Damien; MIDDLETON, Penny; WO2010/69684; (2010); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Related Products of 486424-37-7,Some common heterocyclic compound, 486424-37-7, name is 3-Amino-6-bromopyrazine-2-carboxylic acid, molecular formula is C5H4BrN3O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

CDI (2.23 g, 13.8 mmol) was added to a suspension of commercial 3-amino-6- bromopyrazine-2-carboxylic acid (2.00 g, 9.17 mmol) in DMF (20 ml). The reaction was stirred at RT for 16 h. The reaction mixture was cooled (0 C) then diluted with water (20 ml). The solid was collected by filtration then washed with the minimum volume of water and cooled (0 C) MeCN then dried under vacuum to afford the product as a yellow solid (2.23 g, 86%). 1H NMR (250 MHz, DMSO-cfe) delta 8.55 (s, 2H), 7.96 – 7.82 (m, 3H), 7.15 – 7.07 (dm, 1 H). LC/MS (System A, MeOH quench): m/z (ESI+) = 232 [Methyl ester M(79Br)H+], 234 [Methyl ester M(81Br)H+]), Rt = 0.87 min, UV purity = 95%.

The synthetic route of 486424-37-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ENTERPRISE THERAPEUTICS LIMITED; MCCARTHY, Clive; HARGRAVE, Jonathan David; HAY, Duncan Alexander; SCHOFIELD, Thomas Beauregard; WENT, Naomi; (111 pag.)WO2017/221008; (2017); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 144692-85-3, name is 2,3-Dichlorofuro[3,4-b]pyrazine-5,7-dione, A new synthetic method of this compound is introduced below., Application In Synthesis of 2,3-Dichlorofuro[3,4-b]pyrazine-5,7-dione

Under air, a test tube was charged with 2,3-dichlorodiazaphthalic anhydride (410mg, 1.872mmol) and 2-chloroethylamine hydrochloride (223mg, 1.919mmol). Acetic anhydride (400muL) was added and the reaction sealed and heated to 120C for 30min. The reaction was cooled to ambient temperature and diluted with H2O (2mL). The crude solid was filtered and washed with H2O (2¡Á5mL) and then purified by eluting through a plug (SiO2; CH2Cl2) to afford analytically pure 5a as a white solid. Yield=391mg (75%). (0022) 1H NMR (500MHz, CDCl3): delta 4.18 (t, 3JHH=6.1, 2H, CH2), 3.83 (t, 3JHH=6.1, 2H, CH2). 13C{1H} NMR (126MHz, CDCl3): delta 161.9, 154.1, 143.4, 40.5, 40.4. HR ESI-MS positive ion: 333.9521m/z [M+Na+MeOH]+ (calc. 333.9523). Anal. Calcd for C8H4Cl3N3O2 (280.49gmol-1): C, 34.26; H, 1.44; N, 14.98. Found: C, 34.33; H, 1.38; N, 14.96.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Knighton, Richard C.; Chaplin, Adrian B.; Tetrahedron; vol. 73; 31; (2017); p. 4591 – 4596;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

These common heterocyclic compound, 5900-13-0, name is 5-Bromo-3-methoxypyrazin-2-amine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. HPLC of Formula: C5H6BrN3O

(+/-)-l-(3,5-dichlorophenyl)-2,2,2-trifiuoroethane-l-sulfonyl chloride (165 mg, 0.48 mmol) was added to a solution of 5-bromo-3-methoxypyrazin-2-amine (107 mg, 0.53 mmol) in anhydrous pyridine (5 mL) The reaction was sealed under nitrogen and stirred at room temperature for 60 min then at 60 C for 45 min. The reaction was allowed to cool to room temperature then concentrated in vacuo. The residue was purified over silica (Biotage 10 g SNAP cartridge) eluted with Heptane:EtOAc 1 :0 to 8:2 to 6:4 to 4:6 to afford the title compound (20 mg, 7%) as a light brown solid. H NMR (500 MHz, CDCls) delta 4.06 (s, 3H), 5.71 (q, 1H), 7.36 (br.s, 1H), 7.46 (d, 2H), 7.49 (m,lH), 8.03 (s, 1H).

The synthetic route of 5-Bromo-3-methoxypyrazin-2-amine has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ACTIVE BIOTECH AB; FRITZSON, Ingela; LIBERG, David; EAST, Stephen; MACKINNON, Colin; PREVOST, Natacha; WO2014/184234; (2014); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 1049026-49-4, Name is 2-Bromo-5-(methylthio)pyrazine, SMILES is CSC1=CN=C(Br)C=N1, belongs to Pyrazines compound. In a document, author is Gao, Ruichang, introduce the new discover, HPLC of Formula: C5H5BrN2S.

Screening of a Planococcus bacterium producing a cold-adapted protease and its application in low-salt fish sauce fermentation

A strain of bacteria isolated from a traditional fermented shrimp paste showed high protease activity at low-temperature (15 degrees C). The strain was identified asPlanococcus maritimusand namedPlanococcus maritimusXJ2.P. maritimusXJ2 grows well in a low-temperature, low-salt, and alkaline environment. The protease produced byP. maritimusXJ2 exhibited the highest enzyme activity at 40 degrees C, pH 9.0 and showed salt tolerance. The amino acid nitrogen content of low-salt fish sauce inoculated withP. maritimusXJ2 was 1.28 +/- 0.04 g/100 ml, which was significantly higher than that of the control withoutP. maritimusXJ2 (0.89 +/- 0.02 g/100 ml,p < .01). The amounts of key desirable volatiles, such as alcohols, ketones, acids, esters, and pyrazine were higher inP. maritimusXJ2 than in the control (p < .05).P. maritimusXJ2 could be used as a starter culture for low-salt fish sauce incubated at 21 degrees C. Practical applications The bacteria identified in this study has a good capacity to ferment the fish for good quality of fish sauce. A new method for the rapid fermentation of low-salt fish sauce and the improvement of its flavor by usingPlanococcus maritimusXJ2 is established. The procedure can help people to produce fish sauce in a shorter time, which will promote the development of fish sauce industry. Therefore, the starter and the method have good practical application in fish sauce produce. The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 1049026-49-4 is helpful to your research. HPLC of Formula: C5H5BrN2S.

1049026-49-4, Name is 2-Bromo-5-(methylthio)pyrazine, molecular formula is C5H5BrN2S, belongs to Pyrazines compound, is a common compound. In a patnet, author is Wu, Haozhong, once mentioned the new application about 1049026-49-4, Recommanded Product: 1049026-49-4.

Each phenyl group performs its own functions on luminescence: phenyl substituted effect in tetraphenylpyrazine

Aggregation-induced emission (AIE) has drawn considerable attention owing to its interesting phenomenon, and the AIE mechanisms of different molecule systems have been gradually revealed. Here, we investigated the difference in 3-carbazole-pyrazine-based isomers and explored the effects of three substituted phenyl groups (ortho, meta and para) on the tetraphenylpyrazine derivatives (TPPs). The meta- and para-phenyl groups could slightly and significantly adjust their emission properties, respectively. The ortho-phenyl group could distort the pyrazine plane owing to the large steric hinderance of the two moieties; this triggered many molecular motions and led to the wastage of excited state energy, stimulating the AIE characteristics of TPPs. This result is demonstrated for other pyrazine derivatives and can serve as a design strategy of AIE molecules.

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