Tag: M.W=200-300

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 944709-42-6 as follows. Recommanded Product: 944709-42-6

Into a flask under an. inert atmosphere of N2, were placed 6,8-dibromo-[1,2,4]triazolo[1,5-a]pyrazine (6.0 g, 21.6mmol) and bis(triphenylphosphine)palladium(II) dichloride (1.5 g, 2.2 mmol). To this was added the zinc reagent from Step A, and the mixture was stirred at RT for 16 h. The mixture was quenched by the addition of sat. aq. NH4C1 (200 mL), and extracted with EtOAc (3 x 100 mL). The combined organic layer was dried over anhydr. Na2SO4, filtered and the filtrate was concentrated in vacuo to dryness. The residue was purified by column chromatography withEtOAc/petroleum ether (1/5) to afford the title compound.

According to the analysis of related databases, 944709-42-6, the application of this compound in the production field has become more and more popular.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 30818-40-7 as follows. Safety of 3,5,6-Trichloropyrazine-2-carbonitrile

101881 To a solution of 3,5,6-trichloropyrazine-2-carbonitrile (5 g, 23.99 mmol) in dioxane (20 mL) at 0 C under nitrogen was added propan-2-amine (4.09 mL, 48.0 mmol). The reaction solution was stirred at 23 oC for 4 h, then quenched with brine (300 mL) and extracted with ethyl acetate (2 x 200 mL). The organic layers were combined, dried over anhydrous MgSO4, filtered and concentrated. The residue was purified via flash column chromatography (5-30% EtOAc in heptane) to afford the title compound (5 g, 90%). 1H NMR (500 MHz, DMSO-d6) oe ppm 1.23 (d, J=6.83 Hz, 6 H) 4.22 (dt, J=8.05, 6.47 Hz, 1 H) 8.27 (d, J=7.81 Hz, 1 H); ESI-MS mlz [M+H]+ 231.0.

According to the analysis of related databases, 30818-40-7, the application of this compound in the production field has become more and more popular.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 486424-37-7, name is 3-Amino-6-bromopyrazine-2-carboxylic acid belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below. COA of Formula: C5H4BrN3O2

Block B can be prepared according to scheme 2 in FIG. 2. Referring to FIG. 2, the synthesis of Block B can be performed as described below. (0164) Intermediate 6 Block B [0029] To a solution of Intermediate 6 (6.0 g, 27.4 mmol) in DMSO (30 mL) was added CDI (8.9 g, 54.8 mmol), DIPEA (3.8 g, 30.1 mmol) and DMAP (0.17 g, 1.37 mmol). The solution was stirred at rt for 4 hours. Aniline (2.5 g, 27.4 mmol) was added and the mixture was stirred at rt overnight. Water was added and the formed solid was collected by filtration. The crude product was purified by silica-gel column to afford 2.5 g of Block B (31 %) as yellow solid. (0165) [0030] LC-MS (M+l): 293.2; 1H MR (400 MHz, DMSO-d6) 510.28 (s, 1H), 8.42 (s, 1H), 7.78 (d, J = 8.0 Hz, 2H), 7.74 (s, 2H), 7.36 (t, J = 8.0 Hz, 2H), 7.13 (t, J = 7.6 Hz, 1H) .

The synthetic route of 486424-37-7 has been constantly updated, and we look forward to future research findings.

Synthetic Route of 61655-77-4, These common heterocyclic compound, 61655-77-4, name is 2-Chloro-6-(4-methylpiperazin-1-yl)pyrazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Reaction Scheme 12EXAMPLE 43 : 1 -(4-methoxybenzyl)-3 -methyl-5 -(6-(4-methylpiperazin- 1 -yl)pyrazin-2- yP- 1 H-pyrazolo [3 ,4-b”|pyridineTo a stirred solution of 8 and 63 in 1,4 dioxane and water was added CS2CO3, the solution degassed, purged with nitrogen for 15 min, Pd(PPh3)4 was added and the reaction mass was again purged with nitrogen for another 15 min. The reaction mass was heated at 100C in a sealed tube overnight. After completion of the reaction the reaction mass was partitioned between ethyl acetate and water and the organic layer was separated and again extracted with ethyl acetate. The combined organic layer was dried over sodium sulphate and the solvent completely distilled off to get the crude. The crude was passed through 100-200 mesh silica gel eluting the pure compound at 70-80% ethyl acetate in hexane as off white coloured solid compound 64 (25 mg).

The synthetic route of 61655-77-4 has been constantly updated, and we look forward to future research findings.

Related Products of 63744-22-9, A common heterocyclic compound, 63744-22-9, name is 6,8-Dibromoimidazo[1,2-a]pyrazine, molecular formula is C6H3Br2N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

In a 250 mL round bottom flask equipped with a condenser was placed 6,8-dibromoimidazo[l,2-a]pyrazine (2000 mg, 7.22 mmol) and added 30 mL isopropanol followed by N,N-diisopropylethylamine (2.52 ml, 14.44 mmol) and (R)-(4-(4- aminophenyl)morpholin-2-yl)methanol (1504.12 mg, 7.22 mmol). The reaction was heated to reflux (oil bath 95 C) overnight. The reaction was cooled and precipitates were collected by filtration and washed with isopropanol followed by hexanes to give the desired compound XVII.

The synthetic route of 63744-22-9 has been constantly updated, and we look forward to future research findings.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 762240-92-6, name is 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 762240-92-6

General procedure: A solution of 3-(trifluoromethyl)-5,6,7,8-tetrahydro [1,2,4]triazolo[4,3-a]pyrazine hydrochloride salt 9 (1.0 eq.) in dimethylformamide (DMF, 2e3 mL) was added potassium carbonate (2.5eq.) at 5 C and stirred for 15 min at room temperature. To this,various chloride derivatives (1.0 eq.) in DMF was added to reaction mixture at same temperature. The resultant reaction mixture was allowed to stir at room temperature for 24 h. The completion of the reaction was monitored on TLC (using 10% MeOH: DCM and ammonia as a modifier as mobile phase). The reaction mixture was poured into ice-cold water and extracted with ethyl acetate(2 x 15 mL). Organic layers were combined and the combined organic layer was dried over sodium sulfate and concentrated under reduced pressure to afford crude material and crystallized it from methanol to get 3-(trifluoromethyl)-5,6,7,8-tetrahydro [1,2,4]triazolo [4,3-a]pyrazine derivatives (12f-12j) in good practical yield.

According to the analysis of related databases, 762240-92-6, the application of this compound in the production field has become more and more popular.

Application of 51171-02-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 51171-02-9, name is Methyl 3-Bromo-2-pyrazinecarboxylate belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.

Example 97 (3-Methyl-pyrazin-2-yl)-[1-(2-phenyl-ethanesulfonyl)-piperidin-4-ylmethyl]-amine EXAMPLE 97 was prepared from C-[1-(2-phenyl-ethanesulfonyl)-piperidin-4-yl]-methylamine and 3-bromo-pyrazine-2-carboxylic acid methyl ester followed by reduction with lithium tri-sec-butylborohydride at 0 C. in THF: MS (m+1)=375.5.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 3-Bromo-2-pyrazinecarboxylate, other downstream synthetic routes, hurry up and to see.

Application of 1082843-72-8, A common heterocyclic compound, 1082843-72-8, name is 6-Bromo-3-chloropyrazin-2-amine, molecular formula is C4H3BrClN3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

[0957] Into a 2 L 4-necked round-bottom flask, purged andmaintained with an inert atmosphere ofnitrogen, was placeda solution of compound 90e (42.8 g, 206 mmol) in 1,4-dioxane (1 L), compound 90b (80.0 g, 206 mmol), Pd(dppf)Cl2 (7.53 g, 10.3 mmol) andCs 2C0 3 (167 g, 514 mmol). Thereaction mixture was stirred overnight at 90 C. Upon cooling, the reaction was quenched with water (100 mL). Theresulting mixture was extracted with DCM. The combinedorganic layers were dried over Na2S04 , filtered and concentrated underreduced pressure. The resultant residue was purified by flash column chromatography on silica gel (DCM/MeOH (1 00:3 v/v)) to obtain compound 90fas a yellow solid(23.0 g, 29% yield). Mass Spectrum (LCMS, ESI pos.):Calcd. for C18H23ClN60 2 : 391.2 (M+H). found 391.1.

The synthetic route of 1082843-72-8 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1256921-67-1, name is Methyl 6-bromo-3-chloropyrazine-2-carboxylate, A new synthetic method of this compound is introduced below., category: Pyrazines

Step 11-1, Preparation of methyl 6-bromo-3-[(2R)-4-[(tert-butoxy)carbonyl]-2-ethylpiperazin-1-yl]pyrazine-2-carboxylate To a 15-mL pressure tube vessel, was placed 6-bromo-3-chloropyrazine-2-carboxylic acid methyl ester (300 mg, 1.19 mmol), tert-butyl (3R)-3-ethylpiperazine-1-carboxylate (370 mg, 1.72 mmol, 1.4 equiv), DIEA (0.3 mL, 1.78 mmol, 1.5 equiv), and DMSO (6 mL). The resulting solution was stirred at 140 C. for 1 h, cooled to rt, and diluted with EtOAc (?15 mL). The organic layer was washed with 1N HCl (2*) and brine (1*), dried with anhydrous Na2SO4, and concentrated. The residue was purified from C18 reversed phase column chromatography eluting with 0.1% TFA-ACN/0.1% TFA-H2O. 140 mg (27%) of methyl 6-bromo-3-[(2R)-4-[(tert-butoxy)carbonyl]-2-ethylpiperazin-1-yl]pyrazine-2-carboxylate was isolated. LCMS (M+H)+: 429.3.

The synthetic route of 1256921-67-1 has been constantly updated, and we look forward to future research findings.

These common heterocyclic compound, 1458-18-0, name is Methyl 3-amino-5,6-dichloropyrazine-2-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 1458-18-0

To a stirred mixture of methyl 3-amino-5, 6-dichloropyrazine-2-carboxylate (1.5 g, 6.756 nMol, 1 equiv) and (3-fluorophenyl) boronic acid (0.95 g, 6.790 nMol, 1.00 equiv) in 1, 4-dioxane (100 mL) and H 2O (5mL) were added Cs 2CO 3 (6.60 g, 0.020 nMol, 3 equiv) and Pd (dppf) Cl 2 (0.74 g, 0.001 nMol, 0.15 equiv) in portions at room temperature under nitrogen atmosphere. The resulting mixture was stirred for 3 h at 70 C under nitrogen atmosphere. The resulting mixture was filtered, the filter cake was washed with CH 2Cl 2 (1×30 mL) . The filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH 2Cl 2 /EtOAc (4: 1) to afford methyl 3-amino-6-chloro-5- (3-fluorophenyl) pyrazine-2-carboxylate (900 mg, 47.30%) as a yellow solid. LCMS: m/z (ESI) , [M+H] + = 282.0. 1H-NMR (300 MHz, Chloroform-d) delta 4.03 (3H, s) , 7.22 (1H , m) , 7.41-7.59 (2H , m) , 7.65 (1H , ddd) .

The synthetic route of Methyl 3-amino-5,6-dichloropyrazine-2-carboxylate has been constantly updated, and we look forward to future research findings.