Tag: M.W=200-300

Adding a certain compound to certain chemical reactions, such as: 1082843-70-6, name is 3,5-Dibromo-2-chloropyrazine, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1082843-70-6, Recommanded Product: 3,5-Dibromo-2-chloropyrazine

Step 2: Synthesis of Intermediate 1b as described in the general reaction scheme; 3-chloro-6-bromopyrazin-2-yl amine Compound A” described in the previous step (9.5 g, 37.55 mmol) is suspended in concentrated NH4OH (60 mL) and the resulting mixture is heated in a pressure autoclave to 80 C., typically overnight. The vessel is then allowed to cool down to room temperature slowly, and is then further cooled in an ice bath, causing the precipitation of the desired material. The solid is separated by filtration, washed with cyclohexane, to afford after drying, the title Intermediate 1b (5 g) as a 83/17 mixture of regiosiomers. The mixture is then purified by column chromatography. M+H+, m/z=209

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3,5-Dibromo-2-chloropyrazine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; WIGERINCK, Piet Tom Bert Paul; ANDREWS, Martin James Inglis; De WEER, Marc Maurice Germain; SABOURAULT, Nicholas Luc; KLUGE, Stefan Christian; US2011/118269; (2011); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Adding a certain compound to certain chemical reactions, such as: 723286-79-1, name is tert-Butyl 5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylate, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 723286-79-1, SDS of cas: 723286-79-1

The compound obtained in Step 3 (1 g) was dissolved in chloroform (20 mL), sodium bicarbonate (688 mg) and N- bromosuccinimide (873 mg) was added at 0 C., the-reaction solution was stirred for 2 hours at room temperature and extracted 3 times with chloroform after addition of water, the organic layer gave the title compound by the residue obtained, which was concentrated after drying over sodium sulfate and purified by silica gel column chromatography (693mg, 51%). LRMS (ESI) m / z 303 [M + H] +.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, tert-Butyl 5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; TAIHO PHARMACEUTICAL COMPANY LIMITED; MINAMIGUCHI, KAZUHISA; OKAJIMA, SHIGEO; AOKI, SHINICHI; ASAI, MASANORI; ASAI, TAKAHIRO; YAMANAKA, HIROYOSHI; DOHI, SUGURU; (149 pag.)JP5851663; (2016); B1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Some common heterocyclic compound, 63744-22-9, name is 6,8-Dibromoimidazo[1,2-a]pyrazine, molecular formula is C6H3Br2N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 6,8-Dibromoimidazo[1,2-a]pyrazine

In a 250 mL round bottom flask equipped with a condenser was placed 6,8-dibromoimidazo[l,2-a]pyrazine (2000 mg, 7.22 mmol) and added 30 mL isopropanol followed by Nu,Nu-diisopropylethylamine (2.52 ml, 14.44 mmol) and (R)-(4-(4- aminophenyl)mo holin-2-yl)methanol (1504.12 mg, 7.22 mmol). The reaction was heated to reflux (oil bath 95 C) overnight. The reaction was cooled and precipitates were collected by filtration and washed with isopropanol followed by hexanes to give the desired compound XVII.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 63744-22-9, its application will become more common.

Reference:
Patent; GILEAD SCIENCES, INC.; DI PAOLO, Julie, A.; LIN, Joseph, Haw-Ling; LIN, Shao-Lee; (86 pag.)WO2016/172117; (2016); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Synthetic Route of 143591-61-1, A common heterocyclic compound, 143591-61-1, name is 3-Bromo-8-chloroimidazo[1,2-a]pyrazine, molecular formula is C6H3BrClN3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

This solid was suspended in 1 : 1 dichloromethane/methanol (150 ml) and treated with solid sodium methoxide (9.8 g, 0.18 mol). The resulting mixture was then stirred at 40C for 2 h. The reaction was cooled, diluted with water (750 ml) then extracted with dichloromethane (600 ml). The organics were dried over anhydrous magnesium sulphate, filtered and concentrated to give 3-BROMO-8- METHOXYIMIDAZO [L, 2-A] PYRAZINE as a white solid (24.5 g, 89% over 2 steps):

The synthetic route of 143591-61-1 has been constantly updated, and we look forward to future research findings.

1458-01-1, name is Methyl 3,5-diamino-6-chloropyrazine-2-carboxylate, belongs to pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: Methyl 3,5-diamino-6-chloropyrazine-2-carboxylate

Step 1 A stirred suspension of 3,5-diamino-6-chloro-pyrazine-2-carboxylic acid methyl ester (110 g, 542.9 mmol) in MeOH (500 ml) at 5-10° C. (ice-bath) is treated dropwise with a suspension of lithium hydroxide (46.6 g, 1111 mmol) in water (500 ml). The reaction mixture is heated to 50° C. for 5 hours then cooled to room temperature and stirred overnight. The resulting precipitate is collected by filtration and dried in a vacuum oven to afford Lithium 3,5-diamino-6-chloro-pyrazine-2-carboxylic acid as the lithium salt (di-hydrate); [M-Li]- 187

The synthetic route of 1458-01-1 has been constantly updated, and we look forward to future research findings.

These common heterocyclic compound, 58139-03-0, name is 2-Iodo-6-methoxypyrazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C5H5IN2O

1. 3-[2-(6-Methoxypyrazin)yl]-3-hydroxy-1-azabicyclo-[2.2.1]heptane t-Butyllithium (24 ml of a 1.7M solution in pentane, 40.8 mmol) was added dropwise to a rapidly stirred solution of 2-iodo-6-methoxypyrazine (4.7 g, 19.9 mmol) in ether (125 ml), at -50° C. The reaction mixture was stirred for 0.25 h and a solution of 1-azabicyclo[2.2.1]heptan-3-one (2.86 g, 25.8 mmol) in ether (20 ml) (predried over MgSO4), then added and warmed to room temperature. Aqueous workup and extraction into dichloromethane gave the crude product which was chromatographed on alumina using dichloromethane/methanol (96:4) as eluant to give the title alcohol (2.91 g) as a yellow oil; (Found: M+ =221.1166; C11 H15 N3 O2 requires M+ =21.1164); m/e 221 (M+); delta(250 MHz, CDCl3) 1.46-1.62 (1H, m, CH of CH2); 2.26-2.40 (1H, m, CH of CH2); 2.50 (1H, dd, J=3.5 and 12 Hz, CH of CH2 –N); 2.60 (1H, dd, J=4.5 and 14 Hz, CH of CH2 –N); 2.72 (1H, d, J=4.5 Hz, CH-bridgehead); 2.74-3.06 (2H, m, CH2 –N); 3.07-3.14 (1H, m, CH of CH2 –N); 3.42 (1H, dd, J=1.5 and 14 Hz, CH of CH2 –N); 3.96 (3H, s, OMe); 8.13 (1H, s, pyrazine-H); 8.37 (1H, s, pyrazine-H).

The synthetic route of 2-Iodo-6-methoxypyrazine has been constantly updated, and we look forward to future research findings.

Application of 762240-92-6,Some common heterocyclic compound, 762240-92-6, name is 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride, molecular formula is C6H8ClF3N4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Into a 50 mL round-bottom flask was added 20 mL dichloromethane, followed by the addition of phenyl-butyric acid derivative (3.37 g, 0.01 mol) and triazolopyrazine hydrochloride (228 g, 0.01 mol). The temperature of the reaction mixture was cooled down to 0 C. in an ice-salt bath. 1-Hydroxylbenzotriazole (1.62 g, 0.012 mol) and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (2.29 g, 0.012 mol) were further added. 3 g Triethylamine was then added dropwise and the mixture was stirred at room temperature for 24 h. The reaction solution was washed with 3×20 mL distilled water. The obtained organic layers were collected and dried over anhydrous magnesium sulfate for 1 h. Then, the desiccant was filtered off and the resulting reactant was concentrated to 4.7 g. The yield was 92%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride, its application will become more common.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 51171-02-9, name is Methyl 3-Bromo-2-pyrazinecarboxylate, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: Methyl 3-Bromo-2-pyrazinecarboxylate

A solution of 3-bromopyrazine-2-carboxylic acid methyl ester (0.10 g, 0.45 mmol), 2- tritylsulfanylethylamine (0.29 g, 0.90 mmol) and triethylamine (0.06 mL, 0.44 mmol) in acetonitrile (5 mL) was heated to reflux for 18 h under argon. The mixture was concentrated under reduced pressure and purified by column chromatography (3:1 Hex:EtOAc), yielding 0.058 g (28%) of the desired product.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 51171-02-9.

Related Products of 1082843-70-6,Some common heterocyclic compound, 1082843-70-6, name is 3,5-Dibromo-2-chloropyrazine, molecular formula is C4HBr2ClN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A solution containing 3,5-dibromo-2-chloropyrazine (1.03 g, 3.60 mmol) and tert-butyl N-[(3S)-3-piperidyl]carbamate (600 mg, 3.00 mmol) in methyl sulfoxide 5.0 mL was heated 85C. The reaction was quenched with water then extract with EtOAc. The organic layers wasdried with sodium sulfate, filtered, and concentrated in vacuum. The crude product was purified by flash chromatography (EtOAc/Heptane eluted at 35%EtOAc) to give the desired product 350 mg 30% yield. MS (ESI) m/z: 393.2.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3,5-Dibromo-2-chloropyrazine, its application will become more common.

Related Products of 951626-95-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 951626-95-2, name is Ethyl 4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxylate belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.

General procedure: To the stirring solution of compound 6a (45 mg,0.18 mmol) in THF (5 mL) was added sodium hydride (9 mg, 0.21 mmol) in portions at 0C and allowed to stir at room temperature for 15 minutes. Reaction mixture was again re-cooled to 0C and thereto was added 3,4-dichlorobenzyl chloride (56 mg,0.22 mmol drop wise and reaction mixture was allowed to stir at room temperature for 15 h. Reaction mixture was poured in ice-chilled water (50 mL) and extracted with ethyl acetate (2 x 50 mL). The combined organic layer was washed with water (40 mL) followed by brine (10 mL), dried over anhydrous sodium sulphate, filtered and the filtrate was evaporated to dryness. The purification using flash column chromatography on silica gel (100-200 mesh) using MeOH in DCM afforded off white colored solid compound 1(65 mg, 89%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxylate, other downstream synthetic routes, hurry up and to see.