Tag: M.W=200-300

Electric Literature of 6966-01-4, These common heterocyclic compound, 6966-01-4, name is Methyl 3-amino-6-bromopyrazine-2-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a 250 ml reaction flask add 43g III, 43 ml 98.3% concentrated sulfuric acid, stirring. – 20 – 0 C lower, adding 25.6g sodium nitrite, canada finishes rose to 55 – 60 C, thermal insulation stirring for about 30min to the raw basic reaction end. The reaction liquid dropping 430g ice water, canada finishes insulation stirring for about 1.5h to the reaction is complete. Filtering, the filter cake 50 C drying by blowing 6h, get 37.6g orange solid IV, yield 87%.

The synthetic route of 6966-01-4 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 762240-92-6, name is 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride, A new synthetic method of this compound is introduced below., COA of Formula: C6H8ClF3N4

Into a 50 mL round-bottom flask was added 20 mL acetonitrile, followed by the addition of the phenyl-butyric acid derivative obtained in Example 46 (3.32 g, 0.01 mol) and triazolopyrazine hydrochloride (228 g, 0.01 mol). The temperature of the reaction mixture was cooled down to 0 C. in an ice-salt bath. 1-Hydroxylbenzotriazole (1.62 g, 0.012 mol) and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (2.29 g, 0.012 mol) were further added. 3 g Triethylamine was then added dropwise and the mixture was stirred at room temperature for 24 h. The reaction solution was washed with 3 X 20 mL distilled water. The obtained organic layers were collected and dried over anhydrous magnesium sulfate for 1 h. Then, the desiccant was filtered off and the resulting reactant was concentrated to 4.81 g. The yield was 95%. [alpha] D20=+22.2 (c 1.0, CHCl3). M.p. 188-191 C. IR (cm-1): 3374, 2897, 1686, 1635, 1519, 1368, 1164, 1128, 1016. 1H NMR (400 MHz, CDCl3) delta 7.187.05 (m, 1H), 7.02-6.85 (m, 1H), 5.31 (s, 1H), 5.154.76 (m, 2H), 4.433.78 (m, 5H), 2.982.92 (m, 2H), 2.712.61 (m, 2H), 1.36 (s, 9H). ESI-MS: 508.0 (M++1). HRMS Calcd. for: C21H23F6N5O3Na (M+Na)+ requires 530.1598, found 530.1604.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Related Products of 345311-03-7, A common heterocyclic compound, 345311-03-7, name is tert-Butyl 5,6-dihydroimidazo[1,2-a]pyrazine-7(8H)-carboxylate, molecular formula is C11H17N3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

1,1-Dimethylethyl 5,6,7,8-tetrahydroimidazo[1,2-a]pyrazin-7-carboxylate (Description 163, 505 mg, 2.26 mmol) in dichloromethane (2.5 mL) was added to stirred, cooled (0 C.) trifluoroacetic acid (5 mL) and the mixture was stirred at 0 C. for 15 minutes, then at room temperature for 45 minutes. The solvent was evaporated under reduced pressure to give the title compound. m/z (ES+) 124 (M+1).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 32111-21-0, name is 2-Iodopyrazine, A new synthetic method of this compound is introduced below., HPLC of Formula: C4H3IN2

To a solution of 3-nitrophenol (0.151 g, 0.733 mmol) in DMSO (5 mL) was added NaH (35 mg of a 60% dispersion, 0.88 mmol) at 0 C under Ar atmosphere. After stirring for 30 min, 2-iodopyrazine (0.133 mg, 0.953 mmol) was added and mixture heated to 85 C for 4h. To the mixture was added satd. NH4Cl solution (25 mL) and the product extracted with EtOAc (2×25 mL). The combined organic extracts were washed with brine, dried (Na2SO4) and concentrated to yield a crude residue which was purified by column chromatography to afford (97 mg, 61% yield) 2-(3-nitrophenoxy)pyrazine as a white solid.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Synthetic Route of 5900-13-0,Some common heterocyclic compound, 5900-13-0, name is 5-Bromo-3-methoxypyrazin-2-amine, molecular formula is C5H6BrN3O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example B-79: Preparation of 3-{4-[3-(5-Amino-6-methoxy-pyrazin-2-yl)-1-(2,2-difluoro-ethyl)-1H- pyrazol-4-yl]-pyrimidin-2-ylamino}-propionitrilePreparation of B-79-2:To a solution of 5-bromo-3-methoxypyrazin-2-amine (4.50 g, 19.8 mmol) and 4-(dimethylamino)pyridine (1.24g, 10.1 mmol) in 70ml THF was added di-terf-butyldicarbonate (10.4 g, 47.6 mmol) and the reaction mixture was stirred at room temperature for 5.5 hour. The solvents were removed under reduced pressure and the residue was flash chromed on silica gel eluting 3:1 Hexanes/EtOAc to give B-79-2 as a white solid (5.403g, 67%). Example 1-1 : Preparation of (2S)-1-({4-[3-(5-amino-6-methoxypyrazin-2-yl)-1-(2,2-difluoroethyl)-1H- pyrazol-4-yl]pyrimidin-2-yl}amino)propan-2-olPreparation of 1-1-11-1-1 To a solution of 5-bromo-3-methoxypyrazin-2-amine (4.05g, 19.8mmol) in 70 mL dry THF was added DMAP (1.24g, 10,1 mmol) followed by boc anhydride (10.4g, 47.6mmol) in one portion at room temperature. The resulting mixture was allowed to stir at room temperature. When the starting material was gone by TLC, the reaction mixture was concentrated under reduced pressure to an amber oil. A precipitate developed when the oil residue was slurried in 3:1 Hexanes/EtOAc which was collected. The precipitate was dissolved in EtOAc and washed with saturated aqueous NaCI with some 0.5N HCI so pH was -5. The organic layer was dried over MgSO4 and cone. The crude product was purified by silica gel chromatography (eluting 3:1 Hexanes/EtOAc) to give 5.4Og of compound 1-1-1 as a white solid. 1 H NMR (400 MHz, DMSO-d6) delta ppm 1.36 (s, 18 H) 3.99 (s, 3 H) 8.37 (s, 1 H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Bromo-3-methoxypyrazin-2-amine, its application will become more common.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1379338-74-5, name is 5,7-Dichloropyrido[3,4-b]pyrazine, A new synthetic method of this compound is introduced below., category: Pyrazines

Intermediate 37: 1,1-dimethylethyl 3-{[(7-chloropyrido[3,4-b]pyrazin-5-yl)amino]methyl}-4,4-difluoro-1-piperidinecarboxylate (Isomer 2) 5,7-Dichloropyrido[3,4-b]pyrazine (620 mg, 3.10 mmol) was dissolved in N-methyl-2-pyrrolidinone (NMP) (5 mL) and to this was added DIPEA (0.601 mL, 4.65 mmol) and 1,1-dimethylethyl 3-(aminomethyl)-4,4-difluoro-1-piperidinecarboxylate (776 mg, 3.10 mmol). This was heated in a microwave at 130 C. for 30 min. The reaction mixture was partitioned between ethyl acetate and water. The aqueous was re-extracted twice with ethyl acetate and the combined organic layers washed with brine, dried over a hydrophobic frit and concentrated in vacuo to yield a brown oil. It was dissolved in DCM and passed through silica (100 g) eluting with a 10-50% ethyl acetate in cyclohexane gradient. Appropriate fractions were combined and concentrated in vacuo to yield the title compound as a yellow solid, 1.0 g. Chiral separation was achieved (Sample preparation: Sample dissolved in ethanol (30 ml) sonicating and heating with air gun as required. 4-5 ml injections were then pumped onto a preparative scale Whelk-O(S,S) column (2 inch). Details as follows: Column-Whelk-O(S,S) (50×250 mm, 10 micron); Detection-UV DAD-300 nm (bandwidth 180 nm, reference 550 nm (bandwidth 100 nm)); Flow Rate-70 ml/min; Mobile Phase A: Heptane; Mobile Phase B: IPA; Isocratic method (premixed) 5% B; Runtime-60 min; Number of runs-8) to yield the title compound (second eluting peak from the chiral column) as a yellow solid (441 mg). LCMS (Method B): Rt=1.27 min, MH+=414 The following intermediate was obtained as the first eluting peak from the chiral separation above: Intermediate 38: 1,1-dimethylethyl 3-{[(7-chloropyrido[3,4-b]pyrazin-5-yl)amino]methyl}-4,4-difluoro-1-piperidinecarboxylate (Isomer 1) LCMS (Method B): Rt=1.27 min, MH+=414

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5900-13-0, name is 5-Bromo-3-methoxypyrazin-2-amine, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C5H6BrN3O

Intermediate Example lnt-3: ferf-Butyl {1-[4-(6-bromo-8-methoxy-3-phenylimidazo[1,2-a]pyrazin-2 l)phenyl]cyclobutyl}carbamate A mixture of crude fert-butyl (1-{4-[bromo(phenyl)acetyl]phenyl}cyclobutyl)- carbamate [lnt-1-A] (203 mg, 0.38 mmol, 1.0 eq), 5-bromo-3-methoxypyrazin-2- amine (74.6 mg, 0.38 mmol, 1 eq.; Jiang, B. et al. Bioorg. Med. Chem (2001), 9, 1 149-1154.) and diisopropylethylamine (0.064 ml_, 0.38 mmol, 1.0 eq) in 2.3 ml_ butyronitril was heated to 120 for 17 hours and t o 125 *C for 6h. The reaction mixture was concentrated in vacuo. The crude mixture was purified via preparative HPLC under basic conditions (column: Waters X-Bridge, eluent: ACN/water (15/85) -> ACN/water 55/45) to deliver 9 mg (4%) of the title compound. UPLC-MS (Method 2): RT = 1.62 min; m/z = 549 (M) +.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 5900-13-0.

Related Products of 1458-18-0,Some common heterocyclic compound, 1458-18-0, name is Methyl 3-amino-5,6-dichloropyrazine-2-carboxylate, molecular formula is C6H5Cl2N3O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Sodium metal (0.31 g, 13.5 mmol, 1 equiv) was carefully added to anhydrous MeOH (300 mL) at 0 C and stirred at room temperature until full dissolution was observed. Methyl 3- amino-5,6-dichloropyrazine-2-carboxylate (3.00 g, 13.5 mmol, 1 equiv) was added and the mixture was stirred at reflux for 3 hours. The mixture was cooled to room temperature and product filtered to obtain methyl 3-amino-6-chloro-5-methoxypyrazine-2-carboxylate (2.45 g, 83%) used without further purification. 1H MR (400 MHz, DMSO-i) delta 7.63 (s 2H), 3.97 (s 3H), 3.80 (s 3H).

The synthetic route of 1458-18-0 has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 117719-17-2, name is 5-Bromo-3-morpholinopyrazin-2-amine, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 117719-17-2, Recommanded Product: 117719-17-2

Compound 10 (6.5 g, 25.086 mmol, 1.0 equiv) and ethyl bromopyruvate (3.462 mL, 27.595 mmol, 1.1 equiv) were mixed in the minimum amount of dimethoxyethane (DME). The mixture was refluxed for 20 h. The solvent was evaporated and the residue was purified by automated chromatography (Biotage, EtOAc in cyclohexane, 5-10%) to yield 3.086 g of compound 11 (35% yield).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5-Bromo-3-morpholinopyrazin-2-amine, and friends who are interested can also refer to it.

Related Products of 369638-68-6, These common heterocyclic compound, 369638-68-6, name is tert-Butyl (5-methylpyrazin-2-yl)carbamate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a flask fitted with overhead stirrer, condenser, thermometer and nitrogen line was added tert-butyl (5-methylpyrazin-2-yl)carbamate (1.0 eq), and water (6.85 vols). The mixture was heated to 70 C. and trifluoroacetic acid (TFA) (1.2 eq) was added slowly drop-wise over 90-120 minutes. Water (0.22 vols) was added to wash the TFA into the flask. The reaction mixture was heated at 65-75 C. for at least 30 minutes, and then cooled to 15-25 C. Then 32% w/w sodium hydroxide (1.30 eq) was added drop-wise over 30-60 minutes maintaining the reaction temperature between 15-40 C. Water (0.22 vols) was added to wash the sodium hydroxide into the flask. N-Propylacetate (7.0 vols) was added and the mixture agitated for 45 minutes at 20 C. The layers were separated, the organic layer was retained and the aqueous layer was returned to the flask. N-Propylacetate (7.0 vols) was added and the mixture agitated for 45 minutes at 20 C. The layers were separated, the organic layer was retained and the aqueous layer was returned to the flask. This process was repeated twice. The combined organic layers were filtered through a filter containing silica (20% w/w) into a clean dry flask. The mixture was heated to 40 C. and then vacuum distilled to a final volume of 1.0-1.33 vols. Toluene (3.0 vols) was added, and the vacuum distillation continued at 40 C. to a final volume of 1.0-1.33 vols. This process was repeated twice. The resulting mixture was cooled to 5 C., and agitated for 1 hour at this temperature then filtered, washed with toluene (0.3 vols) at 0-5 C. The batch is slurry washed with toluene (1.0 vol) at 0-5 C. After drying at 45 C. overnight, the desired product was obtained as a solid (corrected yield typically 75%). 1H NMR delta (400 MHz CDCl3): 7.92 (s, 1H), 7.87 (s, 1H), 4.6 (bs, 2H), 2.40 (s, 3H)

The synthetic route of 369638-68-6 has been constantly updated, and we look forward to future research findings.