Tag: M.W=200-300

Some common heterocyclic compound, 1379338-74-5, name is 5,7-Dichloropyrido[3,4-b]pyrazine, molecular formula is C7H3Cl2N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 1379338-74-5

(C) (9/-/-fluoren-9-yl)methyl 5-(7-chloropyrido[4,3-£>]pyrazi n-5- yl)hexahyd ropy rrolo[3,4-£>] pyrrole- 1 (2H)-carboxylate[0129] The mixture of (9/-/-fluoren-9-yl)methyl hexahydropyrrolo[3,4-£>]pyrrole-1 (2/-/)- carboxylate (100 mg, 0.5 mmol) and 5,7-dichloropyrido[4,3-£>]pyrazine (600 mg, 1 .8 mmol) in dioxane was stirred at 0 C for 30 minutes and then at room temperature for 4 hours. The mixture was concentrated, and the residue was purified by chromatography to give the title compound. MS (m/z): 498 (M+H)+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1379338-74-5, its application will become more common.

These common heterocyclic compound, 6966-01-4, name is Methyl 3-amino-6-bromopyrazine-2-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 6966-01-4

To 3-aminopyridine (10 g, 106 mmol) at 70 C were added methyl 3-amino-6-bromo-2- pyrazinecarboxylate (1.0 g, 4.3 mmol) and 1, 8-DIAZABICYCLO [5.4. 0] undec-7-ene (645 UL, 4.3 mmol). The reaction solution was stirred for 4 h, diluted with water (75 mL) and extracted with methylene chloride. The combined organic layers were washed with a saturated ammonium chloride solution, dried (MGS04), filtered and evaporated in vacuo. The crude product was purified on a silica gel column using methylene CHLORIDE/ETHANOL, (9: 1), as the eluent to give 750 mg (59% yield) of the title compound as a yellow solid: 1 H NMR (CDC13, 400 MHz) 8 9.50 (br s, 1 H), 8.82 (d, J = 3 Hz, 1 H), 8.43 (dd, J = 5 and 1 Hz, 1 H), 8.31 (s, 1 H), 8.23 (ddd, J = 8,3 and 2 Hz, 1 H), 7.34 (dd, J = 8,5 Hz, 1 H); MS (TSP) M/Z 294 (M++1).

The synthetic route of Methyl 3-amino-6-bromopyrazine-2-carboxylate has been constantly updated, and we look forward to future research findings.

Application of 24241-18-7, A common heterocyclic compound, 24241-18-7, name is 2-Amino-3,5-dibromopyrazine, molecular formula is C4H3Br2N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

18b (3.0 g, 12 mmol) was added into acetic acid (20 mL) and concentrated sulfuric acid (4 mL) under ice bath. To this mixture was added a pre-prepared solution of NaNO2 (1.65 g, 24 mmol) in water (10 mL). The reaction mixturewas stirred at room temperature for 3 h, and then poured into ice water (100 g). The precipitate was collected by filtrated, washed with water and dried to give an off-white solid (1.8 g, yield 61%). 3,5-Dibromo-2-hydroxylpyrazine (21b)Yield: 61%, off-white solid, M.p.: 182-184 C. 1H NMR(400 MHz, CDCl3):delta 11.23 (br, 1H), 7.53 (s, 1H). 1HNMR (400 MHz, DMSO-d6): delta 13.16 (s, 1H), 7.94 (s, 1H).13C NMR (125 MHz, CD3OD): delta 154.19, 136.73, 131.57, 114.62. ESI-MS m/z: 250.9 [M – H]-.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1082843-70-6, name is 3,5-Dibromo-2-chloropyrazine, A new synthetic method of this compound is introduced below., COA of Formula: C4HBr2ClN2

To a scintillation vial containing 3,5-dibromo-2-chloropyrazine (1 g, 3.67 mmol) and TEA (1 .024 ml, 7.34 mmol) was added MeCN (5 ml) and (tetrahydro-2H-pyran-4- yl)methanamine (0.557 g, 3.67 mmol). The homogenous reaction mixture was capped, and heated to 80 C in a oil bath for 4 hr. The reaction mixture was concentrated to dryness, diluted with EtOAc and sequentially washed with sat NaHC03, and sat NaCI. The organic layer was dried Na2S04, filtered and concentrated. The crude was purified by column chromatography on silica gel ( 20%EtOAc/Hexane) to yield 6-bromo-3-chloro- N-((tetrahydro-2H-pyran-4-yl)methyl)pyrazin-2-amine (688 mg, 2.244 mmol, 61 .1 % yield), yield), LCMS (m/z): 308.0 (MH+), retention time = 0.94 min, and 6-bromo-5- chloro-N-((tetrahydro-2H-pyran-4-yl)methyl)pyrazin-2-amine (55 mg, 0.179 mmol, 4.89 % yield), LCMS (m/z): 308.0 (MH+), retention time = 0.91 min

The synthetic route of 1082843-70-6 has been constantly updated, and we look forward to future research findings.

Electric Literature of 6966-01-4,Some common heterocyclic compound, 6966-01-4, name is Methyl 3-amino-6-bromopyrazine-2-carboxylate, molecular formula is C6H6BrN3O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

(Step 8-iv) Methyl 3-amino-6-bromopyrazine-2-carboxylate (700 mg, 3 mmol) was dissolved in dioxane (4 mL) with 3-furan boronic acid (0.36 g, 3.2 mmol), potassium acetate (980 mg 10 mmol) and tetrakispalladium triphenylphosphine (200 mg, 0.17 mmol) in a microwave vessel. Nitrogen was bubbled through for 5 minutes, followed by sealing the vessel and microirradiating the mixture for 20 minutes at 170 0C. The reaction mixture was diluted with ethyl acetate/saturated sodium bicarbonate, dried over sodium sulfate, and concentrated to give a solid, which was purified by silica gel column chromatography (0 to 70 % EtOAc/hexanes) to give methyl 3-amino-6-(furan-3- yl)pyrazine-2-carboxylate as a solid. This methyl ester was dissolved in THF/MeOH and an aqueous solution of LiOH hydrate (150 mg, 3.6 mmol) was added. The reaction mixture was stirred for 1 hour at room temperature, concentrated to half the volume, and diluted with ethyl acetate/10% aqueous citric acid solution. The organic layer was washed with brine, dried, and concentrated in vacuo to yield 3-amino-6-(furan-3-yl)pyrazine-2- carboxylic acid as a solid (0.46 g, 2.3 mmol, 77 % overall yield).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl 3-amino-6-bromopyrazine-2-carboxylate, its application will become more common.

87486-34-8, name is 3,5-Dibromo-1-methylpyrazin-2(1H)-one, belongs to pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 3,5-Dibromo-1-methylpyrazin-2(1H)-one

Example 123c 5-Bromo-3-(1-ethyl-1H-pyrazol-4-ylamino)-1-methylpyrazin-2(1H)-one 123c A 100-mL single-neck round-bottomed flask equipped with a magnetic stirrer and reflux condenser was charged with 123b (500 mg, 4.5 mmol), 3,5-dibromo-1-methylpyrazin-2(1H)-one (2.40 g, 9.0 mmol), DIPethyl acetate (3 mL), and isopropanol (50 mL). The mixture was heated at 100° C. for 2 h. It was then cooled to room temperature and filtered. The filtrate was concentrated under reduced pressure to afford 123c (802 mg, 60percent) as a white solid. MS-ESI: [M+H]+ 298.0

The synthetic route of 87486-34-8 has been constantly updated, and we look forward to future research findings.

Related Products of 1458-01-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1458-01-1, name is Methyl 3,5-diamino-6-chloropyrazine-2-carboxylate, This compound has unique chemical properties. The synthetic route is as follows.

Preparation 14 3-Chloro-pyrazine-2,6-diamineLithium hydroxide (12.4g, 0.30 mol) was added to a stirred suspension of 3,5-diamino- 6-chloro-pyrazine-2-carboxylic acid methyl ester (20 g, 99 mmol) in methanol (300 ml) and water (120 ml) and the reaction heated at 9O0C for 1.5 hours before allowing to cool to room temperature. The reaction was concentrated in vacuo to afford a yellow slurry and this was suspended in 1 ,4-dioxane (350 ml) and 2M aqueous HCI solution (200 ml,) was added. The mixture was heated at 100 0C for 2 hours and then allowed to cool before removing the 1 ,4-dioxane in vacuo. The resulting aqueous solution was taken to pH 8 using sodium carbonate (saturated aqueous) and extracted into ethyl acetate (3 x 300 ml). The combined organic layers were washed with brine (300 ml), dried (Na2SO4) and concentrated in vacuo to afford a yellow solid (11.7g, 82percent).1HNMR(d6-DMSO): 5.95(br s, 2H), 6.02(br s, 2H), 6.82(s, 1 H).

The chemical industry reduces the impact on the environment during synthesis Methyl 3,5-diamino-6-chloropyrazine-2-carboxylate. I believe this compound will play a more active role in future production and life.

Reference of 6966-01-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 6966-01-4, name is Methyl 3-amino-6-bromopyrazine-2-carboxylate belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.

To a solution of methyl 3-amino-6-bromopyrazine-2-carboxylate (4.6 g, 20.0 mmol) and 4-(2-(benzyloxycarbonylamino)ethyl)phenylboronic acid (6.58 g, 22.0 mmol) in 50 mL of dioxane was added 2M Na2C03 solution (20 ml, 40.0 mmol). The reaction mixture was purged with a nitrogen before the addition of PdCl2(dppf) (1.5 g, 2.0 mmol). The reaction mixture was heated at 90 C for 1.5 h under a balloon of nitrogen. The reaction mixture was cooled and diluted with ethyl acetate and saturated NaHCO-, solution. The organic layer was separated and dried over magnesium sulfate. The filtrate was concentrated and the residue was purified by silica gel chromatography (ISCO; 80g cartridge: ethyl acetate/dichloromethane, 0-50%) to give the title compound as a light yellow solid which was dissolved in 60 mL of EtOH and 10 mL of THF. 30 mL (60 mmol) of 2N LiOH was added and the mixture was stirred at room temperature overnight. The reaction mixture was concentrated then treated with 2N HC1 solution to pH=5 to effect a light yellow precipitate that was filtered and air dried for use without further purification. [M+H]+ = 392.2.

The synthetic route of Methyl 3-amino-6-bromopyrazine-2-carboxylate has been constantly updated, and we look forward to future research findings.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1458-01-1, name is Methyl 3,5-diamino-6-chloropyrazine-2-carboxylate belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below. Formula: C6H7ClN4O2

General procedure: Methyl 3,5-diamino-6-chloropyrazine-2-carboxylate 2 (1 eq.) was combined with K2CO3 (10 eq.), the appropriate (het)aryl boronic acid (1.5 eq.) and Pd(PPh3)4 (5 mol%) in a two-neck round bottom flask. The flask was connected to a condenser and purged with nitrogen. A 4:1 mixture of anhydrous toluene: MeOH (60 mL) was added via syringe and the reaction mixture was heated at reflux for 0.5-18 h. The mixture was allowed to cool to room temperature and filtered through Celite (10 x 3 cm, eluting with 3 x 20 mL EtOAc). The filtrate was evaporated to dryness and the residue purified by silica gel flash column chromatography using EtOAc/pet spirit.

The synthetic route of 1458-01-1 has been constantly updated, and we look forward to future research findings.

Synthetic Route of 143591-61-1,Some common heterocyclic compound, 143591-61-1, name is 3-Bromo-8-chloroimidazo[1,2-a]pyrazine, molecular formula is C6H3BrClN3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Intermediate Example 3-1 : Preparation of 3-bromo-8-methylsulfanyl- imidazo[1 ,2-a]pyrazine To a stirred solution of 3-bromo-8-chloro-imidazo[1 ,2-a]pyrazine ( 1 1 .63 g, 50 mmol) in 120 mL NMP is added at -15C under stirring sodium thiomethylate (3.52 g, 50 mmol) After stirring for 4 h the mixture is left to come to rt and stirred overnight. 500 mL of water are added and the light brown solid is filtered off, washed and dried in vaccuo to yield 8.81 (72 %) of the title compound. UPLC-MS: RT = 0.93 min; m/z 245.1 [MH+]; required MW = 244.1.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Bromo-8-chloroimidazo[1,2-a]pyrazine, its application will become more common.