Tag: M.W=200-300

Synthetic Route of 762240-92-6, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 762240-92-6 as follows.

7-[(3R)-3-[N-(tert-butoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoyl]-3-(trifluoro-methyl)-5,6,7,8-tetrahydro-1,2,4-triazolo[4,3-a]pyrazine (12)To a solution of 3-trifluoromethyl-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazine hydrochloride (11) (1.0 eq, 28.0 gm), diisopropylethylamine (2.0 eq, 31.0 gm), 1-hydroxybenzotriazole (1.2 eq, 22.0 gm), and EDC-HCl (1.2 eq, 28.0 gm) in N,N-dimethylformamide (4.0 vol, 160.0 ml), a solution of (3R)-3-[N-(tert-butoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid (07) (40.0 gm, 0.12 mol) in N,N-dimethylformamide (4.0 vol, 160.0 ml) was charged at 0-5 C. within 1 hour. The clear pale yellow solution was further stirred for 12 hours at 25-30 C. After stirring for 12 hours, the N,N-dimethylformamide was distilled out completely at 55-65 C. under reduced pressure to give a brown coloured residue. The brown coloured residue was further basified with 10% Na2CO3 solution (1.0 vol, 40.0 ml) and the product was extracted in ethyl acetate (3×10.0 vol, 3×400.0 ml). The combined ethyl acetate layers were washed with water, charcoalized and filtered, and the ethyl acetate was distilled out completely to give a white coloured product. The product was triturated with hexane (10.0 vol, 400.0 ml) and filtered at 25-30 C. The crude Boc-protected sitagliptin free base (12) was further purified by crystallising it from a mixture of isopropanol (20.0 vol) and water (2.0 vol).Molar Yield: 75-81% (56 gm)Chemical Purity: 95-97% (as measured by HPLC)

According to the analysis of related databases, 762240-92-6, the application of this compound in the production field has become more and more popular.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 41270-66-0, name is 5-Chloro-2,3-diphenylpyrazine, A new synthetic method of this compound is introduced below., HPLC of Formula: C16H11ClN2

[131] Step 1. 2-(4-((5,6-Diphenylpyrazin-2-yl)(perdeutero-propan-2-yl)amino)butan-l-ol(12c). To a solution of commercially available 5-chloro-2,3-diphenylpyrazine (10) (0.70 g, 2.62 mmol) in NMP (2 mL), was added d7-aminoalcohol lie (0.54 g, 3.93 mmol, 1.5 equiv, prepared as described in Example 7). The reaction vessel was sealed and heated to 190 0C for 15 hours, then cooled to ambient temperature. The mixture was diluted with ice water and extracted with Et2O (3 x 20 rnL). The combined organic layers were washed successively with water and brine. The resulting organic layer was dried (MgSO4), filtered and concentrated in vacuo. The resulting residue was purified by column chromatography (SiO2, 30-50% EtOAc/heptane) to afford 12c (0.20 g, 21%). MS (M+H): 369.2.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

63744-22-9, name is 6,8-Dibromoimidazo[1,2-a]pyrazine, belongs to pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 6,8-Dibromoimidazo[1,2-a]pyrazine

Example 8-1 :Preparation of 6,8-dibromo-3-iodo-imidazo[1 , 2-a]pyrazineTo a stirred solution of intermediate example 1 -1 (8.7 g g, 31 .4 mmol) in DMF (210 mL) was added NiS (7.42 g, 33 mmoi, 1 .05 eq) in one portion at rt. After 18 h stirring at 60 C, the solvent was removed in vaccuo and the residue was taken up in DCM and washed with water and saturated sodium thiosulfate solution. The organic phase was dried over sodium sulphate, filtered and the solvent was evaporated to yield 9.46 g (74.8 %) 6,8-Dibromo-3-iodo-imidazo[1 ,2-a]pyrazine: 1H-NMR (300 MHz, CDCl3): delta = 8.22 (1 H, s), 7.91 (1 H, s) ppm.

The synthetic route of 63744-22-9 has been constantly updated, and we look forward to future research findings.

Reference of 87486-34-8, A common heterocyclic compound, 87486-34-8, name is 3,5-Dibromo-1-methylpyrazin-2(1H)-one, molecular formula is C5H4Br2N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a solution of 2a-j (10 mmol, 1.0 eq) , 3,5-dibromo-1-methylpyrazin-2(1H)-one (2.95 g, 11 mmol, 1.1 eq) and DIEA (3.3 mL,20 mmol, 2.0 eq) in MeCN (20mL) was stirred at 80 °C for 5 hours. After cooling to room temperature, thesolvent was removed in vacuo, and the residue was purified using silica gelchromatography to give the title compounds, yield 72-85percent.

The synthetic route of 87486-34-8 has been constantly updated, and we look forward to future research findings.

Electric Literature of 143591-61-1,Some common heterocyclic compound, 143591-61-1, name is 3-Bromo-8-chloroimidazo[1,2-a]pyrazine, molecular formula is C6H3BrClN3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example A26 3-Bromo-8-morpholin-4-yl-imidazo[1,2-a]pyrazine Morpholine (2.0 ml, 23.2 mmol) was added to a stirred solution of a mixture 72/28 of 3-bromo-8-chloro-imidazo[1,2-c]pyrazine and 3,8-dibromo-imidazo[1,2-c]pyrazine (intermediate 15) (5.9 g, 11.6 mmol) and DIPEA (1.93 ml, 13.9 mmol) in ACN (54 ml). The mixture was stirred at 80 C. for 7 h. and then the solvent was evaporated in vacuo. The crude product was dissolved in DCM and washed with a saturated solution of sodium carbonate. The organic layer was separated, dried (Na2SO4), filtered and the solvents evaporated in vacuo. The crude product was purified by flash column chromatography (silica; EtOAc in DCM 10/90). The desired fractions were collected and evaporated in vacuo and the crude product precipitated from Et2O to yield intermediate 26 (2.79 g, 85%) as a white solid.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Bromo-8-chloroimidazo[1,2-a]pyrazine, its application will become more common.

Adding a certain compound to certain chemical reactions, such as: 6966-01-4, name is Methyl 3-amino-6-bromopyrazine-2-carboxylate, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6966-01-4, Product Details of 6966-01-4

Step 1. tert-butyl 3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]sulfonylpiperidine-1-carboxylate (2 g, 4.431 mmol), methyl 3-amino-6-bromo-pyrazine-2-carboxylate (934.6 mg, 4.028 mmol) and K3PO4 (1.710 g, 8.056 mmol) with MeCN (14.09 mL)/water (3.133 mL). Degassed with vacuum/nitrogen over 5 cycles, treated with Pd[P(tBu)3]2 (114.9 mg, 0.2248 mmol), degassed further 5 cycles and stirred under nitrogen for 2 hours at 60 C. The reaction mixture was cooled to ambient temperature and poured onto icewater/ethylacetate. The organic layer was washed with aq NaHCO3, brine, dried over MgSO4, and concentrated in vacuo. The residue was purified by chromatography on silica gel eluting with 50-70% EtAc/petrol. The relevant fractions were concentrated in vacuo to a solid. Trituration with ether/petroleumether gave methyl 3-amino-6-[4-[(1-tert-butoxycarbonyl-3-piperidyl)sulfonyl]phenyl]pyrazine-2-carboxylate as a colourless solid (1.728 g, 3.626 mmol, 90.02%). H NMR (400.0 MHz, DMSO-d6) delta 9.05 (s, 1H), 8.3 (d, 2H), 8.0 (d, 2H), 7.7 (br s, 2H), 4.0-4.1 (m, 1H), 3.9 (s, 3H), 3.7-3.8 (m, 1H), 3.3-3.4 (m, 1H), 2.77-2.95 (m, 2H), 1.95-2.05 (m, 1H), 1.7-1.75 (m, 1H), 1.6-1.65 (m, 1H) and 1.20-1.40 (m, 10H) ppm; LC/MS m/z 421.1 [M-56+1]+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 3-amino-6-bromopyrazine-2-carboxylate, other downstream synthetic routes, hurry up and to see.

Electric Literature of 1458-18-0, The chemical industry reduces the impact on the environment during synthesis 1458-18-0, name is Methyl 3-amino-5,6-dichloropyrazine-2-carboxylate, I believe this compound will play a more active role in future production and life.

A mixture of methyl 3-amino-5, 6-dichloropyrazine-2-carboxylate (1 g, 4.5 nMol, 1 equiv) and (5-methylfuran-2-yl) boronic acid (0.6 g, 4.8 nMol) and Pd (dppf) Cl 2 (0.3 g, 0.5 nMol) and Na 2CO 3 (1.0 g, 9.0 nMol) in dioxane/H 2O (40 mL) was stirred for 4 hours at 90 under nitrogen atmosphere. The resulted mixture was filtered, the filter cake was washed with DCM: MeOH (1: 1) (3 x 10 mL) . The filtrate was extracted with CH 2Cl 2 (3 x 10 mL) . Then the organic layer was dried by Na 2SO 4, and the solution concentrated under reduced pressure. The crude product was purified by Prep-HPLC with the following conditions (CH 2Cl 2: EtOAc (1: 1) ) to afford methyl 6-chloro-3-methyl-5- (5-methylfuran-3-yl) pyrazine-2-carboxylate (125 mg, 7.1%) as a yellow solid. LCMS: m/z (ESI) , [M+H] + = 268.2.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 3-amino-5,6-dichloropyrazine-2-carboxylate, other downstream synthetic routes, hurry up and to see.

These common heterocyclic compound, 1196152-38-1, name is 2-Bromo-5-(trifluoromethyl)pyrazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 1196152-38-1

Description 121: 1,1-dimethylethyl (lS,4S,6S)-4-({[5-(trifluoromethyl)-2- pyrazinylJoxyJmethylJ-S-azabicyclo^.l.OJheptane-S-carboxylate (D121); To a solution of 1,1-dimethylethyl (lR,4S,6R)-4-(hydroxymethyl)-3- azabicyclo[4.1.0]heptane-3-carboxylate D104 (120 mg) and 2-bromo-5-(trifluoromethyl)pyrazine D66 (120 mg) in DMF (2 ml) at 00C (ice bath) was added NaH (31.7 mg, 0.792 mmol) (gas evolution). The reaction mixture was slowly warmed to room temperature and stirred at room temperature for 1 hour. The reaction was quenched by a slow and careful addition of saturated aqueous solution of NaHCCb (40 ml). The organic phase was extracted with DCM (3×20 ml), the combined organic phases were washed with water and brine, dried over Na2SO4, filtered and concentrated to give the title compound D121 (150 mg) which was used in the next step without any purification.UPLC (Acid Final QC): rt = 0.89 minutes, peak observed: 274 (M+l – Boc), 374 (M+l) C17H22F3NsOs requires 373.

The synthetic route of 2-Bromo-5-(trifluoromethyl)pyrazine has been constantly updated, and we look forward to future research findings.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 951626-95-2, name is Ethyl 4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxylate, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C9H11N3O3

Compound P (1.50 g, 7.17 mmol, 1.00 eq.) was dissolved in DMF (36.0 mL), cooled to 0 C. and treated with 60% sodium hydride in mineral oil (345 mg, 1.20 mmol, 1.20 eq.) in five portions. The reaction mixture was stirred for 15 min and 4-methoxybenzyl chloride (1.17 mL, 1.20 mmol, 1.20 eq.) was added. After 2 h, the reaction mixture was diluted with water (50 mL) and extracted with EtOAc (3*). The combined extracts were washed with water, brine, dried over Na2SO4, filtered, and concentrated in vacuo. The crude material was purified by flash chromatography on silica gel (hexanes/EtOAc) to provide the title compound (2.25 g, 95% yield) as a pale yellow solid. 1H NMR (400 MHz, CDCl3) delta 7.28-7.25 (m, 3H), 6.91-6.89 (m, 2H), 4.71 (s, 2H), 4.43 (q, J=7.1 Hz, 2H), 4.41-4.38 (m, 2H), 3.82 (s, 3H), 3.69-3.66 (m, 2H), 1.42 (t, J=7.1 Hz, 3H). ES-MS [M+1]+: 329.9.

According to the analysis of related databases, 951626-95-2, the application of this compound in the production field has become more and more popular.

Synthetic Route of 87486-34-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 87486-34-8, name is 3,5-Dibromo-1-methylpyrazin-2(1H)-one belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.

General procedure: To a solution of 2a-j (10 mmol, 1.0 eq) , 3,5-dibromo-1-methylpyrazin-2(1H)-one (2.95 g, 11 mmol, 1.1 eq) and DIEA (3.3 mL,20 mmol, 2.0 eq) in MeCN (20mL) was stirred at 80 °C for 5 hours. After cooling to room temperature, thesolvent was removed in vacuo, and the residue was purified using silica gelchromatography to give the title compounds, yield 72-85percent.

The synthetic route of 3,5-Dibromo-1-methylpyrazin-2(1H)-one has been constantly updated, and we look forward to future research findings.