Tag: M.W=200-300

Application of 110223-15-9,Some common heterocyclic compound, 110223-15-9, name is 2-Amino-3-benzyloxypyrazine, molecular formula is C11H11N3O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

3-(benzyloxy)pyridin-2-amine (100 mg, 0.50 mmol) and sodium hydride (60% in mineral oil, 22 mg, 0.55 mmol) was dissolved in tetrahydrofuran (0.25M) and then 1-adamantyl isocyanate (106 mg, 0.6 mmol) was added dropwise and heating at reflux for 20 hours. After the reaction was cooled to room temperature, water was added to terminate the reaction, and extracted with ethyl acetate, drying the extracted solution over sodium sulfate, it was filtered and concentrated under reduced pressure. By separation and purification of the residue by column chromatography (ethyl acetate / n-hexane = 1/2) to give the title compound 50 mg at a yield of 26.6%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Amino-3-benzyloxypyrazine, its application will become more common.

762240-92-6, name is 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride, belongs to pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. HPLC of Formula: C6H8ClF3N4

2,4,5-Trifluorophenylacetic acid (2-1) (available from several commercial suppliers) (0.25 g, 1.32 mol), Meldrum’s acid (0.21 kg, 1.45 mol), and DMAP (12.9 g, 0.11 mol) were charged into a 5 L three-neck flask. Acetonitrile (750 mL) was added in one portion at room temperature. N,N-diisopropylethylamine (492 mL, 2.83 mol) was added in one portion at room temperature while maintaining the temperature below 40 C. Pivaloyl chloride (178 mL, 1.45 mol) was added dropwise over 1 to 2 h while maintaining the temperature below 50 C. The reaction was aged at 45-50 C for 2-3 h. Triazole hydrochliride 1-4 (0.30 kg, 1.32 mol) was added in one portion at 45-50 C. Trifluoroacetic acid (30.3 mL, 0.39 mol) was added dropwise, and the reaction solution aged at 50-55 C for 6 h. Without further work-up, the crude reaction mixture containing 2-3 can be used directly for conversion inrto DP-IV inhibitors. The isolated solution yield was 88-90%.

The synthetic route of 762240-92-6 has been constantly updated, and we look forward to future research findings.

Reference of 369638-68-6,Some common heterocyclic compound, 369638-68-6, name is tert-Butyl (5-methylpyrazin-2-yl)carbamate, molecular formula is C10H15N3O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

tert-butyl 5-methylpyrazin-2-yl carbamate (6.27 g, 30.0 mmol) was weighed and dissolved in 30 mL dichloromethane, and in an ice water bath, 20 mL trifluoroacetic acid was added slowly. It was moved to react at room temperature for 1 hour, rotate evaporated to dryness to remove the solvent, and was used for the next step directly.

The synthetic route of 369638-68-6 has been constantly updated, and we look forward to future research findings.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 330786-09-9, name is Methyl 3,5-dichloropyrazine-2-carboxylate belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below. HPLC of Formula: C6H4Cl2N2O2

Step 1: [0443] Dichloropyrazine S1.1 (synthesized as described in Yamada, K.; Mastuki, K.; Omori, K.; Kikkawa, K. US Patent Application 2004/0142930A1) (0.46 g, 2.7 mmol) was diluted with 10 mL of acetonitrile. To this was then added DIPEA (0.52 mL, 3.0 mmol) and cyclopropylamine (0.19 mL, 2.7 mmol) and the reactions stirred at rt overnight. The following day the reaction was concentrated by rotary evaporation and the resulting syrup diluted with water and stirred until a filterable precipitate formed. The solid was isolated by filtration and washed with water affording the desired product as a bright yellow solid containing regioisomers S1.2 and S1.3. Step 2: [0444] The mixture of regioisomers S1.2 and S1.3 (0.42 g, 1.9 mmol) were diluted with 20 mL of dioxane and 2.0 mL of 1M LiOH. The reaction was stirred at rt until all starting material had been consumed. The reaction was then acidified to pH=2 with 1M HCl and diluted with water to a total volume of 70 mL. The resulting solid was isolated by filtration affording the major isomer, S1.4, as a yellow solid (107 mg, 26%). Upon sitting, a precipitate formed in the filtrate which was then isolated and identified as regioisomer S1.5 (0.17 g, 42%).

The synthetic route of 330786-09-9 has been constantly updated, and we look forward to future research findings.

Some common heterocyclic compound, 1458-01-1, name is Methyl 3,5-diamino-6-chloropyrazine-2-carboxylate, molecular formula is C6H7ClN4O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of Methyl 3,5-diamino-6-chloropyrazine-2-carboxylate

Intermediate 1: 3,5-Diamino-6-chloropyrazine-2-carboxylic acid A mixture of methyl 3,5-diamino-6-chloropyrazine-2-carboxylate (100 g; 494 mmol), methanol (1 L) and NaOH (6 mol/L in water; 240 mL; 1.44 mol) is refluxed for 3 h. The mixture is allowed to cool to room temperature and then neutralised by addition of hydrochloric acid (6 M in water; ca. 120 mL). Water (200 mL) is added. The precipitate formed is collected by filtration while applying suction, washed with water and dried at 60° C. Yield: 99.6 g (107percent of theory). ESI Mass spectrum: m/z=189 [M+H]+; m/z=187 [M-H]-

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1458-01-1, its application will become more common.

13301-04-7, name is Methyl 3,6-dibromopyrazine-2-carboxylate, belongs to pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 13301-04-7

A mixture of 3,6-dibromopyrazine-2-carboxylic acid methyl ester (5.00 g, 17 mm), THF (1 0 0 m 1), cooled to -7 8 C. A solution of Diisobutylaluminium hydride (34 ml, 34 mmol) was slowly added dropwise at -78 C for 2 h. The reaction was quenched at -78 C by addition of glacial acetic acid and the solvent was removed by distillation under reduced pressure. The residue was dissolved in 3 N hydrochloric acid, the dichloromethane was added and the water was extracted and washed with saturated NaC1 The solution was washed, dried over anhydrous Na2S04, and the solvent was removed by distillation under reduced pressure. The residue was purified on a silica gel column to afford the title compound as an off-white solid

The synthetic route of 13301-04-7 has been constantly updated, and we look forward to future research findings.

Related Products of 907597-26-6,Some common heterocyclic compound, 907597-26-6, name is 3-Bromoisothiazolo[4,5-b]pyrazine, molecular formula is C5H2BrN3S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A mixture of 3-bromoisothiazolo[4,5-b]pyrazine (Ark Pharm, catAK-30773: 17 mg, 0.080 mmol), 2-methylbiphenyl-3-amine (Example 11, Step 1: 14.7 mg, 0.080 mmol), [(2-di-cyclohexylphosphino-3,6-dimethoxy-2?,4?,6?-triisopropyl-1,1?-biphenyl)-2-(2?-amino-1,1?-biphenyl)]palladium(II) methanesulfonate (BrettPhos Pd G3, 11 mg, 0.012 mmol), and cesium carbonate (130 mg, 0.40 mmol) in tert-butyl alcohol was purged with nitrogen, and then stirred at 100 C. for 2 h. After being cooled to room temperature, the crude reaction mixture was diluted with methanol and purified by prep HPLC (pH=2, acetonitrile/water+TFA) to provide the desired compound as the TFA salt. LC-MS calculated for C18H15N4S (M+H)+: m/z=319.1; found 319.2.

The synthetic route of 907597-26-6 has been constantly updated, and we look forward to future research findings.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 24241-18-7 as follows. Computed Properties of C4H3Br2N3

Intermediate Example 9-1 : Preparation of 6,8-dibromo-imidazo[1 ,2-a]pyrazine To a stirred suspension of 2-amino-3,5-dibrompyrazine (427 g, 1688mmol) in water (6.4 L) / THF (482 ml_), at rt was added bromacetaldehyde-diethylacetal (998 g, 5065 mmol) in one portion. After stirring under reflux for 4 h, the clear orange solution was stirred for an additional 15 h at rt. The suspension was filtered, and the remaining solid was washed with MeOH (2 L) and dried in vaccuo at 60 C to yield 6,8-dibromo-imidazo[1 ,2-a]pyrazine as an off-white solid (500 g, 107% with residual MeOH): 1H-NMR (300 MHz, d6-DMSO): delta =9.02 (s, 1 H), 8.23 (d, 1 H), 7.89 (d, 1 H) ppm. UPLC-MS: RT = 0.80 min; m/z 277.9 [MH+]; required MW = 276.9.

According to the analysis of related databases, 24241-18-7, the application of this compound in the production field has become more and more popular.

Synthetic Route of 762240-92-6, The chemical industry reduces the impact on the environment during synthesis 762240-92-6, name is 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride, I believe this compound will play a more active role in future production and life.

2,4,5-Trifluorophenylacetic acid (2-1) (150 g, 0.789 mol), Meldrum’s acid (125 g, 0.868 mol), and 4-(dimethylamino)pyridine (DMAP) (7.7 g, 0063 mol) were charged into a 5 L three-neck flask. N,N-Dimethylacetamide (DMAc) (525 mL) was added in one portion at room temperature to dissolve the solids. N,N-diisopropylethylamine (282 mL, 1.62 mol) was added in one portion at room temperature while maintaining the temperature below 40 C. Pivaloyl chloride (107 mL, 0.868 mol) was added dropwise over 1 to 2 h while maintaining the temperature between 0 and 5 C. The reaction mixture was aged at 5 C. for 1 h. Triazole hydrochloride 14 (180 g, 0.789 mol) was added in one portion at 40-50 C. The reaction solution was aged at 70 C. for several h. 5% Aqueous sodium hydrogencarbonate solution (625 mL) was then added dropwise at 20 -45 C. The batch was seeded and aged at 20-30 C. for 1-2 h. Then an additional 525 mL of 5% aqueous sodium hydrogencarbonate solution was added dropwise over 2-3 h. After aging several h at room temperature, the slurry was cooled to 0-5 C. and aged 1 h before filtering the solid. The wet cake was displacement-washed with 20% aqueous DMAc (300 mL), followed by an additional two batches of 20% aqueous DMAc (400 mL), and finally water (400 mL). The cake was suction-dried at room temperature.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride, other downstream synthetic routes, hurry up and to see.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 87486-34-8, name is 3,5-Dibromo-1-methylpyrazin-2(1H)-one, A new synthetic method of this compound is introduced below., Recommanded Product: 87486-34-8

General procedure: To a solution of 2a-j (10 mmol, 1.0 eq) , 3,5-dibromo-1-methylpyrazin-2(1H)-one (2.95 g, 11 mmol, 1.1 eq) and DIEA (3.3 mL,20 mmol, 2.0 eq) in MeCN (20mL) was stirred at 80 °C for 5 hours. After cooling to room temperature, thesolvent was removed in vacuo, and the residue was purified using silica gelchromatography to give the title compounds, yield 72-85percent. methyl3-((6-bromo-4-methyl-3-oxo-3,4-dihydropyrazin-2-yl)amino)-4-methylpe ntanoate(4a): 1H NMR (400 MHz, DMSO-d6) delta 7.35 (d, 1H), 7.03 (s, 1H), 4.18? 4.07 (m, 1H), 3.54 (s, 3H), 3.36 (s, 3H), 2.69 ? 2.55 (m, 2H), 1.94 ? 1.80(m, 1H), 0.92 ? 0.76 (m, 6H). ESI-ms (m/z): 332.0 [M+H]+

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.