Tag: M.W=200-300

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 762240-92-6 as follows. Computed Properties of C6H8ClF3N4

General procedure: A solution of 3-(trifluoromethyl)-5,6,7,8-tetrahydro [1,2,4]triazolo[4,3-a]pyrazine hydrochloride salt 9 (1.0 eq.) in dimethylformamide (DMF, 2e3 mL) was added potassium carbonate (2.5eq.) at 5 C and stirred for 15 min at room temperature. To this,various chloride derivatives (1.0 eq.) in DMF was added to reaction mixture at same temperature. The resultant reaction mixture was allowed to stir at room temperature for 24 h. The completion of the reaction was monitored on TLC (using 10% MeOH: DCM and ammonia as a modifier as mobile phase). The reaction mixture was poured into ice-cold water and extracted with ethyl acetate(2 x 15 mL). Organic layers were combined and the combined organic layer was dried over sodium sulfate and concentrated under reduced pressure to afford crude material and crystallized it from methanol to get 3-(trifluoromethyl)-5,6,7,8-tetrahydro [1,2,4]triazolo [4,3-a]pyrazine derivatives (12f-12j) in good practical yield.2.1.7.1. (4-fluorophenyl) (3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanone (12f). Solid, m. p.179-185 C; Anal. Calcd for C13H10F4N4O: C, 49.69; H, 3.21; F, 24.18;N, 17.83; O, 5.09%; found C, 49.82; H, 3.28; N, 17.92%; IR (KBr) (numax,cm-1): 3023 (=C-Hstr), 2964 (C-Hstr), 1642 (C=Ostr), 1574 (C=Cstr),1321 (C-Nstr), 1245 (C-Fstr); 1H NMR (400 MHz, DMSO) delta 7.89-7.78(m, 2H, -Ar), 7.17 (t, J = 7.8 Hz, 2H, -Ar), 4.53 (s, 1H, C6), 4.35 (s, 1H,C6), 4.30e4.20 (m, 2H, C10), 3.81 (t, J = 5.4 Hz, 1H, C9), 3.71 (t,J = 5.4 Hz, 1H, C9); ESI-MS (m/z): 315.2 [M+1].

According to the analysis of related databases, 762240-92-6, the application of this compound in the production field has become more and more popular.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1458-18-0, name is Methyl 3-amino-5,6-dichloropyrazine-2-carboxylate, A new synthetic method of this compound is introduced below., category: Pyrazines

To a stirring solution of methyl 3-amino-5, 6-dichloropyrazine-2-carboxylate (3.6 g, 16.29 nMol) in MeOH (20 mL) was added NaOH (1.3 g, 32.58 nMol) at 25 . Then the mixture was stirred at this temperature for 16 h. LCMS showed the reaction was complete. Then the mixture was concentrated and residue was poured to water and then extracted with EA (2 x 25 mL) . The organic solution was then concentrated to give the crude product 3-amino-5, 6-dichloropyrazine-2-carboxylic acid (2.6 g, yield: 77.1%) as a yellow solid. LCMS: m/z (ESI) , [M+H] + = 208.1.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Adding a certain compound to certain chemical reactions, such as: 762240-92-6, name is 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 762240-92-6, Application In Synthesis of 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride

General procedure: A solution of 3-(trifluoromethyl)-5,6,7,8-tetrahydro [1,2,4]triazolo[4,3-a]pyrazine hydrochloride salt (1.0 eq.) in dimethylformamide(DMF, 2-3 mL)was added potassium carbonate (2.5eq.) at and stirred for 15 min at room temperature. To this, N-(benzo[d]thiazol-2-yl)-2-chloroacetamide derivatives (1.0 eq.) in DMF was added to the reaction mixture at room temperature. The resulting reaction mixturewas heated at 70 C for 18 h. The completion of the reaction was monitored on TLC (using 10% MeOH: DCM and ammonia as a modifier as mobile phase) which confirmed that the reaction got completed after 18 h. The reaction mixture was pouredinto ice-cold water and extracted with ethyl acetate (2 x 30 mL).Organic layers were combined and the combined organic layer was dried over sodium sulfate and concentrated under reduced pressure to afford crude desired product and crystallized it from methanol to get N-(benzo[d]thiazol-2-yl)-2-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo [4,3-a]pyrazin-7 (8H)-yl)acetamide derivatives(12a-12e) in good practical yield.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride, other downstream synthetic routes, hurry up and to see.

Electric Literature of 951626-95-2, The chemical industry reduces the impact on the environment during synthesis 951626-95-2, name is Ethyl 4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxylate, I believe this compound will play a more active role in future production and life.

A 60%) dispersion of sodium hydride in mineral oils (0.16 g, 4.0 mmol) was added to a stirred solution of 4,5,6, 7-tetrahydro-4-oxo-pyrazolo[l,5-a]pyrazine-2-carboxylic acid ethyl ester (0.7 g, 3.35 mmol) in DMF (14 mL) at 0 C. The mixture was stirred at room temperature for 1 hour and then benzyl bromide (0.48 mL, 4.0 mmol) was added. The mixture was stirred at room temperature for 16 hours, diluted with H20 and extracted with DCM. The organic layer was separated, washed with brine, dried (NaS04), filtered and the solvents evaporated in vacuo. The crude product was purified by flash columnchromatography (silica; AcOEt in DCM 0/100 to 50/50). The desired fractions were collected and the solvents evaporated in vacuo to yield 4,5,6,7-tetrahydro-4-oxo-5-(phenylmethyl)- pyrazolo[l,5-a]pyrazine-2-carboxylic acid ethyl ester (0.83 g, 83% yield) as a white oil. C16H17N3O3 LCMS: Rt 1.79, m/z 300 [M+H]+ (see LCMS Method 1).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxylate, other downstream synthetic routes, hurry up and to see.

Synthetic Route of 87486-34-8, These common heterocyclic compound, 87486-34-8, name is 3,5-Dibromo-1-methylpyrazin-2(1H)-one, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 197c tert-Butyl 4-(5-(6-Bromo-4-methyl-3-oxo-3,4-dihydropyrazin-2-ylamino)pyridin-2-yl)piperazine-1-carboxylate 197c A mixture of 197b (500 mg, 1.8 mmol), 3,5-dibromo-1-methylpyrazin-2(1H)-one (530 mg, 2.0 mmol), N-ethyl-N-isopropylpropan-2-amine (1.5 mL, 0.90 mmol), and propan-2-ol (20 mL) was stirred at 100°C for 15 h. After the reaction was completed, the solvent was removed under reduced pressure to afford 197c as a brown solid (375 mg, 45percent). MS-ESI: [M+H]+ 465.

Statistics shows that 3,5-Dibromo-1-methylpyrazin-2(1H)-one is playing an increasingly important role. we look forward to future research findings about 87486-34-8.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1458-18-0, name is Methyl 3-amino-5,6-dichloropyrazine-2-carboxylate, A new synthetic method of this compound is introduced below., Recommanded Product: 1458-18-0

Example 68[0291] A suspension of methyl 3-amino-5,6-dichloro-2-pyrazinecarboxylate (5.0 gm, 2.25 X 10~2 moles) in 2-propanol (50 mL) was stirred asN-methylpiperazine (2.48 gm, 2.48 X 10~2 moles) was added. To this mixture was added diisopropyethylamine (3.2 gm, 2.48 X 10″2 moles) after which the reaction was heated to reflux. At reflux, a brown solution resulted. After 2 hours at reflux, TLC (silica, 10% methanol in methylene chloride) showed all of the starting material had been consumed with the formation of a single product. The reaction was cooled to room temperature overnight which caused the product to crystallize. The solid product was isolated by filtration and was washed with 2-propanol and then with diethyl ether. After drying there was obtained 5.8 gm (90.2%>) of the product as a pink solid.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 24241-18-7, name is 2-Amino-3,5-dibromopyrazine, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of 2-Amino-3,5-dibromopyrazine

To a 1000 mL single-necked round bottom flask was added 2-amino-3,5-dibromopyrazine (43.18 g, 220 mmol), chloroacetaldehyde (77.72 g, 396 mmol) and DMF 550 mL. The mixture in the reaction flask was stirred at 80 C for 8.5 hours. TLC and GC confirmed the reaction was complete. After the reaction was completed, the solvent was removed by rotary evaporation to give a crude product, which was purified by silica gel column chromatography to obtain the pure product 6,8-dibromoimidazo [1,2a] pyrazine. After drying, the yield was 83.71% and the purity was 99.00% (HPLC

According to the analysis of related databases, 24241-18-7, the application of this compound in the production field has become more and more popular.

Synthetic Route of 63744-22-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 63744-22-9, name is 6,8-Dibromoimidazo[1,2-a]pyrazine belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.

To 4-(4-(oxetan-3-yl)piperazin-l-yl)aniline II (2.00 g, 8.57 mmoles), hunig’s base (3.29 mL) and 6,8-dibromoimidazo[l,2-a]pyrazine (2.37 g, 8.57 mmoles) was added in DMF (43 mL). The reaction was stirred at 85 C in a pressure tube for overnight. The material was quenched with saturated sodium bicarbonate, extracted with DCM (120 mL x 3) and the organic layers were combined and washed with water (120 mL x 3), dried over anhydrous sodium carbonate and concentrated. The crude material was purified using a 120 g Isco column and eluted off using a stepwise gradient of 0-60% (10% MeOH/DCM). The desired fractions were combined and concentrated to provide the title compound III.

The synthetic route of 6,8-Dibromoimidazo[1,2-a]pyrazine has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 25710-18-3, name is 2,3-Dichloropyrido[2,3-b]pyrazine, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 25710-18-3, Recommanded Product: 2,3-Dichloropyrido[2,3-b]pyrazine

2,3-Dichloropyrido[2,3-b]pyrazine (step 2) (500 mg, 2.5 mmol) in dry dioxane (10ml), under nitrogen was treated with phenylboronic acid (305 mg, 2.5 mmol), potassium carbonate (691 mg, 5 mmol) in water (0.5 ml) and tetrakis(triphenylphosphine)palladium(0) (144 mg, 0.125 mmol). The resulting mixture was heated using microwave radiation at 100°C for 1 hour.After cooling to RT, the mixture was diluted with water (100 ml) and extracted with DCM (x3). The combined organic extracts were washed with brine, dried over MgS04 and filtered. The solvent was removed in vacuo and the crude product was purified by chromatography on silica eluting with 0-30percent EtOAc/iso-hexane to afford the title compound as a solid;LCMS: Rt 1 .03 mins MS m/z 242/244 [M+H]+; Method 2minl_C_v0031 H NMR (400MHz, DMSO-d6) delta 9.2 (1 H, m), 8.6 (1 H, dd), 8.0 (1 H, m), 7.9 (2H, m), 7.6 (3H, m)

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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 91775-62-1, name is 3-Bromo-8-methoxyimidazo[1,2-a]pyrazine, A new synthetic method of this compound is introduced below., Recommanded Product: 3-Bromo-8-methoxyimidazo[1,2-a]pyrazine

A suspension OF 3-BROMO-8-METHOXYIMIDAZO [1, 2-A] PYRAZINE (1. 6 g, 7 mmol) in hydrogen bromide (30 wt % in acetic acid, 15 ml) was heated at 80C for 90 min. The reaction was cooled, diluted with water (75 ml) then neutralised with solid sodium hydrogencarbonate. The resulting solid was collected by filtration, washed with water then dried under vacuum to afford 3-BROMO-7H-IMIDAZO [1, 2- A] PYRAZIN-8-ONE as a white powder:

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.