Tag: M.W=200-300

Adding a certain compound to certain chemical reactions, such as: 168123-82-8, name is 7-Bromopyrido[2,3-b]pyrazine-2,3(1H,4H)-dione, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 168123-82-8, COA of Formula: C7H4BrN3O2

General procedure: A mixture of substituted pyridine-2,3-diamine 1 (20 mmol) anddiethyl oxalate(10 mL) was stirred at 100 C for 12 h and cooled toroom temperature subsequently. Ethoxyethane was added toobtain solid. The formed solid was then centrifuged and dried toobtain brown solid compound of pyrido[2,3-b]pyrazine-2,3(1H,4H)-dione 2. The mixture of pyrido[2,3-b]pyrazine-2,3(1H, 4H)-dione and POCl3(20 ml) was stirred at 130 C and then cooled toroom temperature. The mixture was poured into the ice water. Theformed solid was filter and then evaporated solvent in vacuo toobtain unpurified 2,3-dichloropyrido[2,3-b]pyrazine 3. Then theunpurified was mixture with LiOH (10 mmol) in THF/H2O (5:2,35 mL). The mixture was stirred at 65 C for 12 h. The resultingmixture was cooled to room temperature, and then brine (10 mL)was added to mixture. After extraction with THF (3 50 ml), thecombined organic layers were washed with brine (30 mL), dried over anhydrous MgSO4, and filtered, followed by evaporation of thesolvent in vacuo to obtain the unpurified 2-chloropyrido[2,3-b]pyrazin-3(4H)-one 4a-c. The crude products were purified by columnchromatography on silica gel using petroleum ether/EtOAc(3:1) as eluent to provide the desired product 2-chloropyrido[2,3-b]pyrazin-3(4H)-one derivatives4a-c.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 7-Bromopyrido[2,3-b]pyrazine-2,3(1H,4H)-dione, and friends who are interested can also refer to it.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1250996-70-3, name is tert-Butyl 2-(hydroxymethyl)-5,6-dihydroimidazo[1,2-a]pyrazine-7(8H)-carboxylate, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C12H19N3O3

[0090] Method B-Step g: Preparation of tert-butyl 2-(morpholinomethyl)-5,6- dihydroimidazo[l,2-a]pyrazine-7(8H)-carboxylate [0091] To a solution of tert-butyl 2-(hydroxymethyl)-5,6-dihydro imidazo[l,2-a]pyrazine- 7(8H)-carboxylate (400 mg, 1.579 mmol) and triethylamine (320 mg, 3.158 mmol) in CH2C12 (4 mL) was added methanesulfonyl chloride (199 mg, 1.737 mmol) dropwise at 0 C. The mixture was stirred at room temperature for 30 minutes. TLC showed the reaction was complete. The reaction mixture was poured into 10 mL of ethyl acetate and washed with water (3 mL) twice. The organic layer was dried over Na2S04 and concentrated in vacuo, then dissolved in DMF (8 mL) with K2CC>3 (395 mg, 3.98 mmol), then morpholine (347 mg, 3.98 mmol) was added. The mixture was stirred at 100 C for 2 hours. TLC showed that the reaction was complete. The reaction mixture was portioned between ethyl acetate (20 mL) and water (5 mL), washed with brine (5 mLx3). The organic layer was concentrated under reduced pressure, purified by silica gel column chromatography (CH2Cl2:MeOH = 50:1 ) to give a brown oil (220 mg, 51.43%). *H NMR (400 MHz, CDC13) delta 6.75 (s, 1H), 4.67 (s, 2H), 3.94 (d, / = 2.6 Hz, 2H), 3.83 (s, 2H), 3.74 (m, 7=4.4 Hz, 4H), 3.45 (s, 2H), 2.53 (s, 4H), 1.48 (s, 9H).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1250996-70-3.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 5900-13-0, name is 5-Bromo-3-methoxypyrazin-2-amine, A new synthetic method of this compound is introduced below., Quality Control of 5-Bromo-3-methoxypyrazin-2-amine

To compound i-176 (20 g, 98 mmol, 1.00 eq.),2-isopropenyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(17.3 g, 103 mmol, 1.05 equivalent) and Na2CO3 (20.8 g, 196 mmol, 2.00 eq.) in 1,4-dioxane (160 mL)Add Pd(dppf)Cl2 to the solution in H2O (40 mL)(1.43 g, 1.96 mmol, 0.02 eq.).The resulting reaction mixture was degassed twice, each time refilled with N2,Then heat to 90 C for 15 hours. The reaction mixture was cooled to EtOAc (EtOAc)EtOAc. Water (200 mL) was added to the filtrate.The two layers were separated and aqueous was extracted with EtOAc (2 The combined organic layers were washed with brine (200 mL)Dry over anhydrous Na2SO4, filter and concentrate under reduced pressure.The residue was purified by silica gel column chromatography to give a solid compoundI-170 (16g).

The synthetic route of 5900-13-0 has been constantly updated, and we look forward to future research findings.

Related Products of 51171-02-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 51171-02-9, name is Methyl 3-Bromo-2-pyrazinecarboxylate, This compound has unique chemical properties. The synthetic route is as follows.

A mixture of methyl 2-bromopyrazine-3-carboxylate (J. Med. Chem. , 1969, 12, 285) (2.2 g, 10.1 mmol) and 4-AMINO-1-BENZYLPIPERIDINE (2.0 g, 10.5 mmol) was refluxed in 2- propanol overnight. Thin layer chromatography (10% methanol in ethyl acetate) showed the reaction was complete. The solvent was evaporated, and the crude product dissolved in chloroform (100 mL), which was washed with saturated sodium carbonate solution (20 ML), and dried over magnesium sulfate. The title compound was obtained as a gum (3.8 g). MS 327 (M+1).

The chemical industry reduces the impact on the environment during synthesis Methyl 3-Bromo-2-pyrazinecarboxylate. I believe this compound will play a more active role in future production and life.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 762240-92-6, name is 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride, A new synthetic method of this compound is introduced below., HPLC of Formula: C6H8ClF3N4

EXAMPLE 7B Example 7 is repeated with a different carbamate as starting compound, producing (R)-Benzyl-4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-yl-carbamate, compound (X) with R = benzyl (amide formation with carbonyl diimidazole and triazolopyrazine hydrochloride-triethylamine) Carbonyl diimidazole (510 mg, 3.15 mmol) is added in one portion at 0 C under nitrogen to a solution of (R)-3-(benzyloxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoic acid (1.00 g, 2.62 mmol) in dry THF (5.0 mL). After 10 minutes a white precipitate appears, triethylamine (369 muL, 2.62 mmol) is added followed by 3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride (599 mg, 2.62 mmol) and the mixture is heated to reflux overnight. The mixture is then cooled to room temperature and water (10 mL) and toluene (10 mL) are added, the phases are separated and the organic phase is washed with water (3 x 5 mL), dried over sodium sulphate and concentrated under reduced pressure to a residue, pure enough by HPLC to carry out the debenzylation step. 1H NMR (300 MHz, d6-dmso, 100 C) delta 7.4-7.2 (m, 7H), 6.90 (bs, 1H) 4.97 & 4.90 (AB system, J= 12.9 Hz, 2 x 1 H), 4.92 (s, 2H) 4.26-4.14 (m, 3H), 3.97 (t, J=5.5 Hz, 2H), 2.92 & 2.67 (2 x dd, J=14.1, 4.9 Hz, 2 x 1 H), 2.83-2.72 (m, 2H)

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Synthetic Route of 24241-18-7, These common heterocyclic compound, 24241-18-7, name is 2-Amino-3,5-dibromopyrazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a stirred suspension of 2-amino-3,5-dibrompyrazine (427 g, 1688 mmol) in water (6.4 L)/THF (482 mL), at rt was added bromacetaldehyde-diethylacetal (998 g, 5065 mmol) in one portion. After stirring under reflux for 4 h, the clear orange solution was stirred for an additional 15 h at rt. The suspension was filtered, and the remaining solid was washed with MeOH (2 L) and dried in vaccuo at 60 C. to yield 6,8-dibromo-imidazo[1,2-a]pyrazine as an off-white solid (500 g, 107% with residual MeOH): 1H-NMR (300 MHz, d6-DMSO): delta=9.02 (s, 1H), 8.23 (d, 1H), 7.89 (d, 1H) ppm. UPLC-MS: RT=0.80 min; m/z 277.9 [MH+]; required MW=276.9.

Statistics shows that 2-Amino-3,5-dibromopyrazine is playing an increasingly important role. we look forward to future research findings about 24241-18-7.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 87486-34-8, name is 3,5-Dibromo-1-methylpyrazin-2(1H)-one, This compound has unique chemical properties. The synthetic route is as follows., category: Pyrazines

Example 331a 5-Bromo-1-methyl-3-(3-methylisothiazol-5-ylamino)pyrazin-2(1H)-one 331a A sealed tube equipped with a magnetic stirrer was charged with 3-methylisothiazol-5-amine (170 mg, 1.5 mmol), 3,5-dibromo-1-methylpyrazin-2(1H)-one (400 mg, 1.5 mmol), Pd(OAc)2 (84 mg, 0.375 mmol), BINAP (116 mg, 0.188 mmol), K2CO3 (450 mg, 4.5 mmol), and 1,4-dioxane (4 mL). After three cycles of vacuum/nitrogen flush, the mixture was heated at 120°C in a sealed tube for 18 h. It was then cooled to room temperature and filtered. The filtrate was evaporated under reduced pressure. The residue was purified by silica-gel column chromatography eluting with dichloromethane/methanol (100:1 to 25:1) to afford 331a (220 mg, 50percent) as a yellow solid. MS-ESI: [M+H]+ 301.0.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 87486-34-8.

Application of 87486-34-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 87486-34-8 name is 3,5-Dibromo-1-methylpyrazin-2(1H)-one, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Example lOld 5 -Bromo- 1 -methyl- 3 – [4- (morpholine-4-carbonyl)phenylamino] – 1H- pyrazin-2-one lOld CGIPHARM60WOlOldA 250-mL single-neck round-bottomed flask equipped with a magnetic stirrer and reflux condenser was charged with 3,5-dibromo-l-methylpyrazin-2(lH)-one (J. Heterocycl. Chem. 1983, 20, 919) (21.8 g, 81.4 mmol), 4-aminobenzmorpholide (23.6 g, 114 mmol) and dimethyl- acetamide (130 mL). The reaction mixture was then heated under nitrogen at 105 °C for 14 h (Note: A spatula was used to break up the solids formed after 4 h of heating). After this time the suspension was cooled to room temperature, poured into stirring water (1.5 L) and filtered. The resulting precipitate was washed with water (2 x 250 mL) and allowed to partially dry on the filter paper for 10-15 minutes. After this time the filter cake was washed with hot ethyl acetate (2 x 250 mL), followed by hot ethanol (250 mL) and dried under reduced pressure to afford a 63percent yield (24.3 g) of lOld as a light orange solid: mp 276-277 °C; ]H NMR (500 MHz, CDC13) delta 8.39 (bs, 1H), 7.81 (dd, 2H, / = 9.0, 2.0 Hz), 7.45 (dd, 2H, J = 9.0, 2.0 Hz), 6.81 (s, 1H), 3.71 (m, 8H), 3.55 (s, 3H); MS (ESI+) m/z 393 (M+H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3,5-Dibromo-1-methylpyrazin-2(1H)-one, and friends who are interested can also refer to it.

Reference of 1458-18-0, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1458-18-0 as follows.

The mixture of methyl 3-amino-5, 6-dichloropyrazine-2-carboxylate (0.5 g, 2.26 nMol) , 4, 4, 5, 5-tetramethyl-2- (5-methylfuran-2-yl) -1, 3, 2-dioxaborolane (0.71 g, 3.39 nMol) in dioxane (20 mL) was added Na 2CO 3 (0.94 g, 4.53 nMol) and Pd (dppf) Cl 2 (0.83 g, 1.13 nMol) at 100 . Then the mixture was stirred at this temperature for 2 h. LCMS showed the reaction was completed and purified with silica gel chromatography to give a desired product methyl 3-amino-6-chloro-5- (5-methylfuran-3-yl) pyrazine-2-carboxylate. LCMS: m/z (ESI) , [M+H] + = 268.4.

According to the analysis of related databases, 1458-18-0, the application of this compound in the production field has become more and more popular.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 110223-15-9, name is 2-Amino-3-benzyloxypyrazine belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below. name: 2-Amino-3-benzyloxypyrazine

2-Bromo-4′-methoxyacetophenone (1.64 g, 7.14 mmol) was added to a solution of 2- amino-3-benzyloxypyrazine (Compound m in scheme 1,1. 5 g, 6.80 mmol) in ethanol (10 mL). The reaction mixture was refluxed for 5 h. The reaction mixture was allowed to cool to r. t. and an off- white coloured solid precipitated out. The solid was collected and washed with ice-cold ethanol to give a white solid (1. 08 g, 66%). lH-NMR (CDC13) 6 11.4 (d, J4. 2 Hz, 1H), 8.23 (s, 1H), 7. 86 (t, J 2.9 Hz, 1H), 7. 83 (t, J2. 1 Hz, 1H), 7.52 (dd, J0. 7 & 5.5 Hz, 1H), 7.04 (t, J2. 9 Hz, 1H), 7.02 (t, J2. 0 Hz, 1H), 6.94 (t, J3.0 Hz, 1H), 3.79 (s, 3H) ; MS (ESI) 242.0 ([M+H]

The synthetic route of 110223-15-9 has been constantly updated, and we look forward to future research findings.