Tag: M.W=200-300

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1007128-70-2, name is 5,8-Dibromopyrido[3,4-b]pyrazine belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below. Computed Properties of C7H3Br2N3

[0383] XII-3 (5.0 g, 17.3 mmol) and NaOMe (1.4 g, 26 mmol) were dissolved in MeOH(60 mL), and then the mixture was stirred at 60C for 0.5 h. Removed the solvent, diluted withEtOAc (100 mL), washed with brine, dried over Na2SO4 and concentrated to give XII-4 (3.7 g, 89%yield) as a light yellow solid, which was used in next step without further purification. ?H NMR(CDC13, 300 MHz) (59.05 (d, J= 1.8 Hz, 1H), 8.88 (d, J= 1.8 Hz, 1H), 8.46 (s, 1H), 4.17 (s, 3H).

The synthetic route of 1007128-70-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; INTERMUNE, INC.; RAMPHAL, Johnnie, Y.; BUCKMAN, Brad, Owen; EMAYAN, Kumaraswamy; NICHOLAS, John, Beamond; SEIWERT, Scott, D.; WO2015/153683; (2015); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 59021-15-7, name is 3-Iodo-2,5-dimethylpyrazine, A new synthetic method of this compound is introduced below., Application In Synthesis of 3-Iodo-2,5-dimethylpyrazine

To a solution of 3,6-dimethyl2-iodopyrazine (see J. Org. Chem. 1961, 26, 1907; 1.00 g, 4.27 mmol), in diethyl ether (13 mL) was added n-butyllithium (2.6 M in hexane, 1.64 mL, 4.27 mmol) dropwise at -35 C. After being stirred at same temperature for 10 min, the reaction mixture was poured into dry ice. The mixture was extracted with 4N aqueous sodium hydroxide, and then the aqueous layer was acidified with cone. Hydrochloric acid. The mixture was extracted with chloroform, and the organic layer was dried over sodium sulfate, filtrated and concentrated in vacuo The crude was triturated with diethyl ether to give 3,6-dimethylpyrazine-2-carboxylate. MS (ESI): w/z l51 (M-H).

The synthetic route of 59021-15-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MITSUBISHI TANABE PHARMA CORPORATION; KAWANISHI, Eiji; HONGU, Mitsuya; TANAKA, Yoshihito; WO2011/105628; (2011); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Adding a certain compound to certain chemical reactions, such as: 13457-28-8, name is Methyl 3-bromo-6-chloropyrazine-2-carboxylate, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 13457-28-8, Quality Control of Methyl 3-bromo-6-chloropyrazine-2-carboxylate

To a 250 ml three-neck flask was added 50 ml of tetrahydrofuran, 50 ml of water, and Compound 3 (20 g, 0.08 mol). Lithium hydroxide monohydrate (5 g, 0.12 mol) in water/70 ml of water was added dropwise. The reaction was completed at 0C for 1 hour. The reaction is complete. Methyl tert-butyl ether extraction (30 ml x 2). The aqueous phase was adjusted to pH=1 with 4N hydrochloric acid and extracted with dichloromethane (50 ml¡Á3). Dry 10 g of anhydrous sodium sulfate and spin-dry to obtain white solid compound 4 (18 g, yield 96%).

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Reference:
Patent; Shaoyuan Science And Technology (Shanghai) Co., Ltd.; Shanghai Shaoyuan Reagent Co., Ltd.; Wei Yuanbo; Guo Tao; Wu Yong; (8 pag.)CN108101857; (2018); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 356783-14-7 as follows. COA of Formula: C6H4Cl2N2O2

(a) In 20 mL of acetonitrile was dissolved 2.0 g of methyl 3,6-dichloro-2-pyrazinecarboxylate. After adding 2.8 g of potassium fluoride and 0.51 g of 18-crown-6-ether, the mixture thus obtained was heated under reflux for 9.5 hours in an atmosphere of nitrogen gas. After cooling, the solvent was removed under reduced pressure, and the residue was purified by silica gel chromatography [eluent: n-hexane:ethyl acetate=15:1] to obtain 1.1 g of methyl 3,6-difluoro-2-pyrazinecarboxylate as a colorless oily product. R (neat) cm-1: 1743 H-NMR (CDCl3) delta: 4.05(3H,s), 8.28(1H,dd,J=1.6 Hz, 8.4 Hz)

According to the analysis of related databases, 356783-14-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Toyama Chemical Co., Ltd.; US2003/130213; (2003); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Reference of 1250996-70-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1250996-70-3, name is tert-Butyl 2-(hydroxymethyl)-5,6-dihydroimidazo[1,2-a]pyrazine-7(8H)-carboxylate belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.

[0083] Method A-Step d: Preparation of (5,6,7,8-tetrahydroimidazo[l,2-a]pyrazin2- yl)methanol [0084] Tert-butyl 2-(hydroxymethyl)-5,6-dihydroimidazo[l,2-a]pyrazine-7(8H)- carboxylate (200 mg, 0.79 mmol) was dissolved in 3M HCl/ethyl acetate (3 mL). The mixture was stirred at room temperature for 4 hours, then the solvent was removed under vacuum. The residue was applied to silica gel column chromatography (CH2Cl2:MeOH:NH3-H20 = 100:10: 1) to give a yellow oil (100 mg, 82.6%). *H NMR (400 MHz, CDC13) delta 6.77 (s, 1H), 4.57 (s, 2H), 4.09 (s, 2H), 3.94 (t, J = 5.4 Hz, 2H), 3.24 (t, J = 5.2 Hz, 2H).

The synthetic route of tert-Butyl 2-(hydroxymethyl)-5,6-dihydroimidazo[1,2-a]pyrazine-7(8H)-carboxylate has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ZHANG, Xiaohu; WO2014/113191; (2014); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 21943-15-7, name is 3,5-Dibromo-2-hydroxypyrazine, A new synthetic method of this compound is introduced below., Product Details of 21943-15-7

Preparation of compound 36b: 3,5-dibromo-2-methoxypyrazine To a stirred solution of 36a (8 g, 0.031 mol) in dry THF (100 mL) was added dropwise a solution of CH2N2 in Et2O (0.7 N, 134 mL, 0.093 mol) at 0 0C. After the addition, the resulting mixture was stirred at r.t. for 0.3 h. The reaction mixture was concentrated in vacuo and the residue was purified by column chromatography (petroleum ether/EtOAc 10:1 ) which gave the title compound 36b as a yellow solid (5.5 g, 32.6%). 1H NMR (400 MHz, CDCI3) 3.963 (s, 3H), 8.060 (s, 1 H).

The synthetic route of 21943-15-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PFIZER INC.; NINKOVIC, Sacha; BRAGANZA, John Frederick; COLLINS, Michael Raymond; KATH, John Charles; LI, Hui; RICHTER, Daniel Tyler; WO2010/16005; (2010); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Related Products of 1007128-70-2,Some common heterocyclic compound, 1007128-70-2, name is 5,8-Dibromopyrido[3,4-b]pyrazine, molecular formula is C7H3Br2N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

In a 50 mL round bottom flask, fitted with a condenser and under nitrogen, 5,8-Dibromo-pyrido[3,4-b]pyrazine (750.0 mg; 2.518 mmol), sodium iodide (1.1 g; 7.554 mmol) and chlorotrimethylsilane (319.6 m; 2.518 mmol) were added to anhydrous MeCN (5.0 ml). The brown suspension was heated to reflux and the tan suspension was stirred at reflux for 2h. The tan suspension was let cool to room temperature, poured into water (70 mL) and the brown suspension was stirred at room temperature for 30 min. The beige solid was filtered and the solid was dissolved in DCM and MeOH, adsorbed on a PuriFlash lOg celite column and purified by chromatography on a PuriFlash 40g 30u column (DCM for 20 column volumes). The major product eluted between 0.9 to 3.9 column volumes. The pure fractions were concentrated under reduced pressure and the brown solid was dried under vacuo to give 492 mg of a brown solid as the title compound (492.0 mg; 56.1 %). MS:336 [M+H]+.

The synthetic route of 1007128-70-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MERCK PATENT GMBH; SHERER, Brian; LAN, Ruoxi; BRUGGER, Nadia; CHEN, Xiaoling; TOURE, Momar; CLEARY, Esther; DESELM, Lizbeth Celeste; WANG, Yanping; (397 pag.)WO2020/25517; (2020); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 446286-90-4, name is 2-Bromo-5-(piperazin-1-yl)pyrazine, A new synthetic method of this compound is introduced below., HPLC of Formula: C8H11BrN4

To a CH2Cl2 (150 mL) solution of Example 1, Part B (17 g, 50 mmol) in an ice bath was added trifluoroacetic acid (30 mL). The solution was stirred for 4 hr at room temperature, and then stripped in vacuo. The residue was partitioned between EtOAc (250 mL) and saturated NaHCO3 (200 mL). The organic layer was separated, and the aqueous layer extracted with EtOAc and CH2Cl2 (200 mL each). The combined organic extracts were washed with brine, dried over MgSO4, and evaporated to afford the crude piperazine in the form of a yellow solid (MS: m/z=243, 245 (M+H)). The resulting crude product was dissolved in CH2Cl2 (150 mL), and then cooled in an ice bath. To the resulting mixture was added Et3N (8.8 mL, 63 mmol) and methanesulfonyl chloride (4.2 mL, 55 mmol). The solution was stirred for 16 hr at room temperature. The mixture was then washed with water and brine, dried over MgSO4, and evaporated to produce 14.3 g (89% yield) of the desired sulfonamide in the form of a pale yellow oil. MS: m/z=321, 323 (M+H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Barta, Thomas E.; Becker, Daniel P.; Bedell, Louis J.; Boehm, Terri L.; Brown, David L.; Carroll, Jeffery N.; Chen, Yiyuan; Fobian, Yvette M.; Freskos, John N.; Gasiecki, Alan F.; Grapperhaus, Margaret L.; Heintz, Robert M.; Hockerman, Susan L.; Kassab, Darren J.; Khanna, Ish K.; Kolodziej, Stephen A.; Massa, Mark A.; McDonald, Joseph J.; Mischke, Brent V.; Mischke, Deborah A.; Mullins, Patrick B.; Nagy, Mark A.; Norton, Monica B.; Rico, Joseph G.; Schmidt, Michelle A.; Stehle, Nathan W.; Talley, John J.; Vernier, William F.; Villamil, Clara I.; Wang, Lijuan J.; Wynn, Thomas A.; US2005/9838; (2005); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

1057216-55-3, name is 2-Chloro-5-iodopyrazine, belongs to pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 2-Chloro-5-iodopyrazine

Intermediate 31 (350 mg, 1.05 mmol), 2-chloro-5-iodopyrazine (252 mg, 1.05 mmol), 2M aqueous sodium carbonate solution (1.58 mL, 3.16 mmol) and anhydrous DMSO (5 mL) were charged to a sealed tube. The mixture was degassed by bubbling with nitrogen for 5 minutes before the addition of tetrakis(triphenylphosphine)20 palladium(0) (61 mg, 0.05 mmol). The reaction mixture was sealed under nitrogen andstirred at 110C for 1 h. The mixture was diluted with water (40 mL) and extracted with EtOAc (3 x 20 mL). The organic phase was washed with saturated aqueous sodium bicarbonate solution (2 x 10 mL) followed by brine (10 mL), then dried over sodium sulfate and concentrated under vacuum. The residue was purified by FCC, eluting with17-80% EtOAc in heptane, to afford the title compound (285 mg, 54% at 80% purity) as an off white solid. oH (500 MHz, CDC13) 8.73-8.64 (m, 2H), 8.63-8.59 (m, 1H), 7.92 (s, 2H), 7.33-7.27 (m, 1H), 7.17 (d, J8.2 Hz, 1H), 7.15-7.07 (m, 1H), 7.00 (d, J6.6 Hz, 1H),6.67 (t, J73.5 Hz, 1H), 4.36 (s, 2H), 2.60 (s, 3H). Method C HPLC-MS: MH+ m/z 401,

The synthetic route of 1057216-55-3 has been constantly updated, and we look forward to future research findings.

1250996-70-3, name is tert-Butyl 2-(hydroxymethyl)-5,6-dihydroimidazo[1,2-a]pyrazine-7(8H)-carboxylate, belongs to pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Quality Control of tert-Butyl 2-(hydroxymethyl)-5,6-dihydroimidazo[1,2-a]pyrazine-7(8H)-carboxylate

To a solution of 2-hydroxymethyl-5,6-dihydro-8H-imidazo[1,2-a]pyrazine-7-carboxylic acid tert-butyl ester (IV, 0.34 g, 1.34 mmol) in dry methanol (12 mL) was added 20% HQ in dioxane (18 mL) at 0 C and the resulting mixture was stirred at room temperature for 16 h. The solvent was evaporated under reduced pressure to get the crude product which was triturated with diethylether to afford the titled product as a pale-yellow solid (V, 0.25 g, 95 %). LC-MS m/z calcd for C7HuN30, 153.1 ; found 154.2 [M+H]+.

The synthetic route of 1250996-70-3 has been constantly updated, and we look forward to future research findings.