Tag: M.W=200-300

Related Products of 957344-74-0,Some common heterocyclic compound, 957344-74-0, name is 5,8-Dibromoimidazo[1,2-a]pyrazine, molecular formula is C6H3Br2N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 2 (5-Bromo-imidazo[l,2-a]pyrazin-8-yl)-[4-(l-methyl-piperidin-4-ylmethoxy)-phenyl] -amine[00319] To a solution of 5,8-dibromo-imidazo[l,2-a]pyrazme (0.100g, 0.36mmol) in isopropanol (5mL) are added l,4-diazabicyclo[2,2,2]octane (DABCO) (0.036mL, 0 36mmol) and 4-(l- methyl-pipe?dm-4-ylmethoxy)-phenylamme (79 6mg, 0 36mmol) The reaction mixture is stirred at9O0C overnight The solvent is evaporated and the residue chromatographed on silica gel column elutmg with 97 3 followed by 94 6 and 90 10 DCM MeOH The title compound is obtained as a solid(20mg, 13%) LCMS Rt 2 30mm (94%), m/z (APCI) 417

The synthetic route of 957344-74-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GALAPAGOS N.V.; WO2007/131991; (2007); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Synthetic Route of 622392-04-5, A common heterocyclic compound, 622392-04-5, name is 2-Bromo-5-iodopyrazine, molecular formula is C4H2BrIN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a slurry of [1-BENZYL-4- [4- (4,] 4,5, [5-TETRAMETHYL- [1,] 3,2] dioxaborolan-2-yl) – benzenesulfonyl]-piperidine-4-carboxylic acid tert-butyl ester (1) (12.0 g, 22.2 mmol) in toluene (40 mL) was added solid 2-bromo-5-iodo-pyrazine (2) (6.98 g, 24.5 mmol, prepared in accordance with Example 21, Part B), 2 N [NA2C03] (25 mL), ethanol (2.5 mL), and Pd (dppf) Cl2 (0.90 [G,] 1.1 mmol). The resulting mixture was heated at [60C] for 16 hr. Afterward, the mixture was partitioned between EtOAc and water, and then filtered to remove insolubles. The organic layer was separated, washed with brine, dried over [MGS04,] and evaporated to a brown solid. The crude material was purified by flash column chromatography on silica gel (eluting with 5-80% ethyl acetate in hexane) to . afford 6.60 g (52% yield) of the desired product (3) as an off-white solid. LCMS: m/z =572.3, 574.3.

The synthetic route of 622392-04-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PHARMACIA CORPORATION; WO2004/811; (2003); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Adding a certain compound to certain chemical reactions, such as: 762240-92-6, name is 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 762240-92-6, Formula: C6H8ClF3N4

100 g of 3-tert-butoxycarbonylamino-4-(2,4,5-trif- luorophenyl)butyric acid of formula (II) was charged with 800 ml of toluene into a 2 litre 4 necked round bottom flask attached with dean stark apparatus followed by 70 ml of triethyl amine at room temperature. Then 100 g of 3-(trifluo- romethyl)-5,6,7,8-tetrahydro-[ 1 ,2,4]triazolo[4,3-a]pyrazine HC1 was charged and stirred for 5 minutes. 7.5 g of phenyl boronic acid was charged to the reaction mass. Afier 48 hours of stirring at reflux temperature, the reaction was complete. The reaction mass was cooled to room temperature and 1000 ml of water was added to it. The organic layer was separated and washed twice with 500 ml of iN HC1. The organic layer was separated and washed with 500 ml of water followed by 6% NaHCO3 and finally by 500 ml ofwater. The organic layer was then separated, treated with sodium sulfate and then with charcoal and filtered. The solvent was distilled out under vacuum. The solid obtained was stirred with 500 ml of diisopropyl ether for 2 hours, filtered, washed with diisopropyl ether and then dried under vacuum at 50 C. for 12-15 hours. 10078] HPLC was used to obtain the chromatographic purity and chiral purity.Weight: 140 g (140.0% w/w, 91.95%) Chromatographic purity: >98.0%Chiral purity (calculated as [desired enantiomer]/[desired enantiomer+undesired enantiomer]x 100): >99.5%

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Rao, Dharmaraj Ramachandra; Kankan, Rajendra Narayanrao; Ghagare, Maruti; Kadam, Swati Atul; US2015/197523; (2015); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 313340-08-8, name is 3,5-Dichloro-6-ethylpyrazine-2-carboxamide belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below. category: Pyrazines

A mixture of 3,5-dichloro-6-ethylpyrazine-2-carboxamide (600 mg), 3-(methylsulfonyl)aniline (467 mg), N,N-diisopropylethylamine (0.48 mL) and dioxane (18 mL) was stirred in a sealed tube at 170 C. for 17 hours. After cooling, the mixture was partitioned using ethyl acetate and water, and the organic layer was washed with saturated aqueous sodium chloride and then dried over anhydrous magnesium sulfate. After the solvent was distilled off, the residue was washed with chloroform, and the solid was collected by filtration and dried to give 5-chloro-6-ethyl-3-{[3-(methylsulfonyl)phenyl]amino}pyrazine-2-carboxamide (412 mg) as a yellow solid.

The synthetic route of 313340-08-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Waters Technologies Corporation; US2012/40968; (2012); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 143591-61-1, name is 3-Bromo-8-chloroimidazo[1,2-a]pyrazine, A new synthetic method of this compound is introduced below., Recommanded Product: 143591-61-1

This solid was suspended in 1 : 1 dichloromethane/methanol (150 ml) and treated with solid sodium methoxide (9.8 g, 0.18 mol). The resulting mixture was then stirred at 40C for 2 h. The reaction was cooled, diluted with water (750 ml) then extracted with dichloromethane (600 ml). The organics were dried over anhydrous magnesium sulphate, filtered and concentrated to give 3-BROMO-8- METHOXYIMIDAZO [L, 2-A] PYRAZINE as a white solid (24.5 g, 89% over 2 steps):

The synthetic route of 143591-61-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MERCK SHARP & DOHME LIMITED; WO2004/41826; (2004); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Related Products of 25710-18-3, These common heterocyclic compound, 25710-18-3, name is 2,3-Dichloropyrido[2,3-b]pyrazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a stirred solution of 2,3-dichloropyrido[3,2-b]pyrazine (3) (4.76 g, 18.5 mmol) in dimethylsulfoxide (DMSO, 2 ml) solution was added phenylacetylene (2.3 ml, 21.3 mmol), triethylamine (18.0 ml, 129.6 mmol), palladium(II) acetate (290 mg, 1.3 mmol), copper(I) iodide (437 mg, 1.7 mmol) and triphenylphosphine (388 mg, 2.0 mmol) at 80 °C for 2 h. The resulting mixture was concentrated in vacuum to remove the solvent and then water was added. The mixture was extracted with ethyl acetate and the organic layer was washed with water and dried over MgSO4. After removal of solvent in vacuum, the residue was purified by SiO2 column chromatography (CH2Cl2/n-hexane = 3:2) to yield the desired compound 4, 2-chloro-3-(phenylethynyl)pyrido[3,2-b]pyrazine (83percent, 4.6 g). 1H NMR (500 MHz, CDCl3) delta 7.46 (m, 6H), 7.73 (m, 6H), 8.34 (d, J = 8.3 Hz, 2H), 9.19 (dd, J = 2.31, 1.8 Hz, 2H); MS (ESI) m/z 266 ([M+H]+).

The synthetic route of 25710-18-3 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Gong, Young-Dae; Dong, Mi-Sook; Lee, Sang-Bum; Kim, Nayeon; Bae, Mi-Seon; Kang, Nam-Sook; Bioorganic and Medicinal Chemistry; vol. 19; 18; (2011); p. 5639 – 5647;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Related Products of 313340-08-8, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 313340-08-8, name is 3,5-Dichloro-6-ethylpyrazine-2-carboxamide, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: To a solution of compound6(0.4 mmol) and anappropriateaniline derivatives(0.2 mmol) in 1,4-dioxane, was added DIPEA (0.4 mmol). The mixture was stirred at 100oC for 12 h. The solution was diluted withwater, andfiltered. The residue was washed with water twice and dried to give the crude product as yellow solid in 42-74% yield.

The chemical industry reduces the impact on the environment during synthesis 3,5-Dichloro-6-ethylpyrazine-2-carboxamide. I believe this compound will play a more active role in future production and life.

Reference:
Article; Wang, Yueliang; Xing, Li; Ji, Yinchun; Ye, Jiqing; Dai, Yang; Gu, Wangting; Ai, Jing; Song, Zilan; Bioorganic and Medicinal Chemistry Letters; vol. 29; 6; (2019); p. 836 – 838;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Reference of 173253-42-4, These common heterocyclic compound, 173253-42-4, name is 2-Amino-5-bromo-6-chloropyrazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 1. 5,6-Bis(4-fluorophenyl)pyrazin-2-amine A mixture of 5-bromo-6-chloropyrazin-2-amine (2 g, 9.66 mmol, 1.00 equiv), 4-fluorophenylboronic acid (3.38 g, 24.14 mmol, 2.50 equiv), Pd(PPh3)4 (1.11 g, 0.96 mmol, 0.10 equiv), K3PO4 (8.19 g, 38.66 mmol, 4.00 equiv), and 1,4-dioxane (10 mL) was stirred overnight at 100 C. in an oil bath. The resulting mixture was concentrated in vacuo, and the residue was purified via silica gel column chromatography (ethyl acetate: petroleum ether (1:20)), resulting in 1.7 g (62%) of 5,6-bis(4-fluorophenyl)pyrazin-2-amine as a brown solid.LC-MS (ES, m/z): 284 [M+H]+ 1H-NMR (300 MHz, CDCl3, ppm) delta 8.059 (s, 1H), 7.505-7.233 (m, 4H), 7.037-6.930 (m, 4H), 4.763 (s, 1H)

The synthetic route of 173253-42-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BIOENERGENIX; US2012/225846; (2012); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1057216-55-3, name is 2-Chloro-5-iodopyrazine belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below. Product Details of 1057216-55-3

Step-a: Synthesis of 2-((5-iodopyrazin-2-yl)oxy)ethan-1-ol Into a 40-mL vial was placed 2-chloro-5-iodopyrazine (5.0 g, 20.80 mmol, 1.00 equiv), ethane-1,2-diol (3.36 g, 54.13 mmol, 2.60 equiv), sodium hydroxide (1.65 g, 41.25 mmol, 1.98 equiv), and NMP (5 mL). The resulting solution was stirred at 100 C. in an oil bath until completion. The reaction was then quenched by the addition of 200 mL water/ice. The solid was collected by filtration to deliver the title compound in 5.1 g (92%) as a light yellow solid. LCMS: 267 [M+H]+.

The synthetic route of 1057216-55-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; EISAI R & D MANAGEMENT CO., LTD.; BOCK, Mark; HAO, Ming-Hong; KORPAL, Manav; NYAVANANDI, Vijay Kumar; PUYANG, Xiaoling; SAMAJDAR, Susanta; SMITH, Peter Gerard; WANG, John; ZHENG, Guo Zhu; ZHU, Ping; MITCHELL, Lorna Helen; LARSEN, Nicholas; RIOUX, Nathalie; PRAJAPATI, Sudeep; REYNOLDS, Dominic; O’SHEA, Morgan; SAMARAKOON, Thiwanka; (134 pag.)US2018/141913; (2018); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Reference of 21943-15-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 21943-15-7, name is 3,5-Dibromo-2-hydroxypyrazine belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.

General procedure: The suspension of 18b (2.51 g, 10.0 mmol), NaCN (0.59 g,12.0 mmol), CuI (0.95 g, 5.0 mmol) and Pd(PPh3)4 (0.14 g,0.1 mmol) were stirred in DMF (20 mL) at 120 C for 10 h under nitrogen protection. After cooling to room temperature, 10% aqueous solution of Na2S2O3(10 mL) and water(50 mL) were added. The mixture was extracted with ethyl acetate (50 mL × 3), washed with water (3 × 50 mL), dried over anhydrous Na2SO4 and concentrated. The residue was purified by chromatography on silica gel eluting with PE/EA (10:1-2:1) to give an off-white solid (1.1 g, yield 55%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3,5-Dibromo-2-hydroxypyrazine, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Guo, Qi; Xu, Mingshuo; Guo, Shuang; Zhu, Fuqiang; Xie, Yuanchao; Shen, Jingshan; Chemical Papers; vol. 73; 5; (2019); p. 1043 – 1051;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem