Tag: M.W=200-250

Cao, Duc Danh; Trinh, Thi Thanh Van; Mai, Huong Doan Thi; Vu, Van Nam; Le, Hong Minh; Thi, Quyen Vu; Nguyen, Mai Anh; Duong, Thu Trang; Tran, Dang Thach; Chau, Van Minh; Ma, Rui; Shetye, Gauri; Cho, Sanghyun; Murphy, Brian T.; Pham, Van Cuong published the artcile< Antimicrobial lavandulylated flavonoids from a sponge-derived Streptomyces sp. G248 in East Vietnam Sea>, Quality Control of 2873-36-1, the main research area is Streptomyces antimicrobial lavandulylate flavonoid; Streptomyces; actinomycete; anti-microbial; anti-tuberculosis; cytotoxicity; flavonoid.

Three new lavandulylated flavonoids, (2S,2S)-6-lavandulyl-7,4-dimethoxy-5,2-dihydroxylflavanone (1), (2S,2-S)-6-lavandulyl-5,7,2,4-tetrahydroxylflavanone (2), and (2S)-5-lavandulyl-2-methoxy-2,4,4,6-tetrahydroxylchalcone (3), along with seven known compounds 4-10 were isolated from culture broth of Streptomyces sp. G248. Their structures were established by spectroscopic data anal., including 1D and 2D NMR (NMR), and high-resolution electrospray ionization mass spectrometry (HR-ESI-MS). The absolute configurations of 1-3 were resolved by comparison of their exptl. and calculated electronic CD spectra. Compounds 1-3 exhibited remarkable antimicrobial activity. Whereas, two known compounds 4 and 5 exhibited inhibitory activity against Mycobacterium tuberculosis H37Rv with min. inhibitory concentration (MIC) values of 6.0 μg/mL and 11.1 μg/mL, resp.

Marine Drugs published new progress about Antimicrobial agents. 2873-36-1 belongs to class pyrazines, and the molecular formula is C11H18N2O2, Quality Control of 2873-36-1.

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Shen, Shuo; Li, Wei published the artcile< The inhibitory effects of metabolites from Bacillus pumilus on potato virus Y and the induction of early response genes in Nicotiana tabacum>, SDS of cas: 2873-36-1, the main research area is Bacillus Nicotiana metabolites potato virus Y; Active compounds; Early response genes; Halophilic bacterium Bacillus pumilus; Inhibitory activity; Potato Virus Y genes encoding viral proteins.

To develop a new antiviral preparation from a microbial source, the halophilic bacterium Bacillus pumilus E303035 was isolated from a soil sample collected at Qarhan Salt Lake in Qinghai, China. The inhibitory activity of an Et acetate extract of its fermentation broth was higher than that of an n-butanol extract After isolation and purification, 9 compounds were obtained: cyclo(L-Leu-L-Pro) (1), cyclo(L-Pro-L-Tyr) (2), Brevianamide F (3), 2-(3-Indolyl) ethanol (4), N-[2-(1H-indol-3-yl) ethyl] acetamide (5), 3, 3-di(1H-indol-3-yl)propane-1,2-diol (6), Lincomycin B (7), dibutylphthalate (8), and p-hydroxyphenethyl alc. (9). Compounds 1, 5, and 9 showed inhibitory activities against potato virus Y (PVY). Compounds 1, 4, and 9 had significant inhibitory activity against genes HC-pro, P3, and Nib, compound 5 against gene P3, and compounds 1 and 4 against NIa. Compounds 1, 4, 5, and 9 had significant inhibitory activity against genes VPg and 6K1. Active compounds 1, 5, and 9 had various effects on the expression of viral genes related to pathogenesis. Expression of genes cullin and XTH was up-regulated and CP was down-regulated, compared to the pos. control.

AMB Express published new progress about Cullins Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 2873-36-1 belongs to class pyrazines, and the molecular formula is C11H18N2O2, SDS of cas: 2873-36-1.

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Salman, Mahwish; Tariq, Anam; Mustafa, Ghulam; Javed, Muhammad Rizwan; Naheed, Shazia; Qamar, Sarmad Ahmad published the artcile< Cyclo(L-Leucyl-L-Prolyl) from Lactobacillus coryniformis BCH-4 inhibits the proliferation of Aspergillus flavus: an in vitro to in silico approach>, Reference of 2873-36-1, the main research area is Lactobacillus Aspergillus proliferation Cyclo L Leucyl Prolyl antifungal bioprotectant; Antifungal potential; Aspergillus flavus; Bioprotectant; Cyclo(L-Leu-L-Pro); Lactobacillus coryniformis; Molecular docking.

Fungal spoilage led to a considerable economic loss of foodstuff which ultimately affects public health due to mycotoxins production Moreover, the consumption of com. antifungal drugs creates side effects and develops antifungal resistance. To overcome these challenges, the current work was aimed to investigate novel antifungal cyclic dipeptide (CDP) from Lactobacillus coryniformis (Loigolactobacillus coryniformis) BCH-4. CDPs have flexible, cyclic, and stable conformation. The proline-based CDPs provide addnl. structural compatibility and bio-functional values. Keeping in view, high-performance liquid chromatog. (HPLC) was performed to explore cyclo(L-Leu-L-Pro) from L. coryniformis BCH-4. The HPLC detected concentration (135 ± 7.07 mg/mL) exhibited in vitro antifungal activity of 5.66 ± 0.57 mm (inhibitory zone) against Aspergillus flavus. Based on these results, cyclo(L-Leu-L-Pro) was used as a bioprotectant for selected food samples (grapes, lemon, cashew nuts, and almonds). A significant impact of cyclo(L-Leu-L-Pro) was observed in contrast with MRS broth (control) and cell-free supernatant. In silico mol. docking anal. of this CDP was carried out against FAD glucose dehydrogenase, dihydrofolate reductase, and urate oxidase of A. flavus as target proteins. Among these proteins, FAD glucose dehydrogenase exerted strong interactions with cyclo(L-Leu-L-Pro) having S-score of – 8.21. The results evaluated that the detected CDP has strong interactions with selected proteins, causing excellent growth inhibition of A. flavus. Therefore, cyclo(L-Leu-L-Pro) could be used as a potent bioprotectant against food-borne pathogenic fungi.

Archives of Microbiology published new progress about Almond. 2873-36-1 belongs to class pyrazines, and the molecular formula is C11H18N2O2, Reference of 2873-36-1.

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Zhu, Junli; Zhang, Yuwei; Deng, Jingmin; Jiang, Hanyun; Zhuang, Liumin; Ye, Wei; Ma, Jiayu; Jiang, Jingyang; Feng, Lifang published the artcile< Diketopiperazines Synthesis Gene in Shewanella baltica and Roles of Diketopiperazines and Resveratrol in Quorum Sensing>, HPLC of Formula: 2873-36-1, the main research area is diketopiperazine resveratrol quorum sensing Shewanella; Shewanella baltica; cyclodipeptide synthase (CDPS); diketopiperazines; quorum sensing; resveratrol.

The synthesis pathways of quorum sensing (QS) signal mols. and the mechanism of action of quorum sensing inhibitors (QSIs) have gained considerable attention as research topics in the field of food preservation. Here, Shewanella baltica was detected as the specific spoilage organism in large yellow croaker during 4° storage, and it produced the QS signal mols. autoinducer-2 (AI-2) and diketopiperazines (DKPs). Then, a cyclodipeptide synthase (CDPS) homologous gene, sb1370, was screened, and knockout and rescue results revealed that this gene was involved in DKP synthesis but not in AI-2 synthesis, and it also played an important role in QS. Furthermore, fish fillets and mutant strains were treated with resveratrol, and the results suggested that resveratrol was an ideal QSI for inhibition of DKPs production via the sb1370 gene and reduced QS in S. baltica, thus delaying the process of fish spoilage during chilling storage.

Journal of Agricultural and Food Chemistry published new progress about Diketopiperazines Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 2873-36-1 belongs to class pyrazines, and the molecular formula is C11H18N2O2, HPLC of Formula: 2873-36-1.

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Wang, Yanbo; Wang, Feifei; Bao, Xingyue; Feng, Jie; Fu, Linglin published the artcile< Inhibition of biogenic amines in Shewanella baltica by anthocyanins involving a quorum sensing system>, Product Details of C11H18N2O2, the main research area is anthocyanin antibacterial agent biogenic amine quorum sensing Shewanalla; Anthocyanins; Biogenic amines; Diketopiperazines; Quorum sensing inhibitor.

Quorum sensing (QS) is a cell d.-dependent signaling system responsible for various physiol. activities in bacteria. We initially investigated the relation between a QS system and biogenic amine (BA) production in Shewanella baltica, the specific spoilage organism of refrigerated large yellow croaker (Pseudosciaene crocea). In addition, the inhibition effects of anthocyanins from blueberry and purple sweet potato against QS signals and putrescine production were explored. Two kinds of diketopiperazines, cyclo-(l-Pro-l-Leu) and cyclo-(l-Pro-l-Pro), and two kinds of BAs, putrescine and cadaverine, were detected in the culture extract of S. baltica cultivated in sterile large yellow croaker juice, wherein putrescine presented significantly pos. correlations with cyclo-(l-Pro-l-Leu) and cyclo-(l-Pro-l-Pro). In addition, anthocyanins at subminimum inhibitory concentration inhibited the production of diketopiperazines and putrescine in S. baltica 23, a strain with strong putrescine production Furthermore, a transcriptional anal. showed that anthocyanins suppressed the expression of the odc gene in S. baltica, the gene responsible for the production of putrescine from decarboxylation of ornithine. These results established a correlation of the main BA putrescine with the QS system in S. baltica and revealed that anthocyanins could be developed as new QS inhibitors and seafood preservative candidates.

Journal of Food Protection published new progress about Anthocyanins Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 2873-36-1 belongs to class pyrazines, and the molecular formula is C11H18N2O2, Product Details of C11H18N2O2.

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Khan, Mohammad Sayyar; Gao, Junlian; Munir, Iqbal; Zhang, Mingfang; Liu, Yixin; Moe, The Su; Xue, Jing; Zhang, Xiuhai published the artcile< Characterization of endophytic fungi, Acremonium sp., from Lilium davidii and analysis of its antifungal and plant growth-promoting effects>, Product Details of C11H18N2O2, the main research area is Acremonium Botrytis Lilium plant growth antifungal agent.

The present study was aimed at isolating endophytic fungi from the Asian culinary and medicinal plant Lilium davidii and analyzing its antifungal and plant growth-promoting effects. In this study, the fungal endophyte Acremonium sp. Ld-03 was isolated from the bulbs of L. davidii and identified through morphol. and mol. anal. The mol. and morphol. anal. confirmed the endophytic fungal strain as Acremonium sp. Ld-03. Antifungal effects of Ld-03 were observed against Fusarium oxysporum, Botrytis cinerea, Botryosphaeria dothidea, and Fusarium fujikuroi. The highest growth inhibition, i.e., 78.39 ± 4.21%, was observed for B. dothidea followed by 56.68 ± 4.38%, 43.62 ± 3.81%, and 20.12 ± 2.45% for B. cinerea, F. fujikuroi, and F. oxysporum, resp. Anal. of the Et acetate fraction through UHPLC-LTQ-IT-MS/MS revealed putative secondary metabolites which included xanthurenic acid, valyl aspartic acid, gancidin W, peptides, and cyclic dipeptides such as valylarginine, cyclo-[L-(4-hydroxy-Pro)-L-leu], cyclo(Pro-Phe), and (3S,6S)-3-benzyl-6-(4-hydroxybenzyl)piperazine-2,5-dione. Other metabolites included (S)-3-(4-hydroxyphenyl)-2-((S)-pyrrolidine-2-carboxamido)propanoic acid, di-Bu phthalate (DBP), 9-octadecenamide, D-erythro-C18-Sphingosine, N-palmitoyl sphinganine, and hydroxypalmitoyl sphinganine. The strain Ld-03 showed indole acetic acid (IAA) production with or without the application of exogenous tryptophan. The IAA ranged from 53.12 ± 3.20 μg ml-1 to 167.71 ± 7.12 μg ml-1 under different tryptophan concentrations The strain was able to produce siderophore, and its production was significantly decreased with increasing Fe(III) citrate concentrations in the medium. The endophytic fungal strain also showed production of organic acids and phosphate solubilization activity. Plant growth-promoting effects of the strain were evaluated on in vitro seedling growth of Allium tuberosum. Application of 40% culture dilution resulted in a significant increase in root and shoot length, i.e., 24.03 ± 2.71 mm and 37.27 ± 1.86 mm, resp., compared to nontreated control plants. The fungal endophyte Ld-03 demonstrated the potential of conferring disease resistance and plant growth promotion. Therefore, we conclude that the isolated Acremonium sp. Ld-03 should be further investigated before utilization as a biocontrol agent and plant growth stimulator.

BioMed Research International published new progress about Aconitum tuberosum. 2873-36-1 belongs to class pyrazines, and the molecular formula is C11H18N2O2, Product Details of C11H18N2O2.

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Sun, Xiaowen; Zhang, Run; Ding, Meijuan; Liu, Yongxuan; Li, Lin published the artcile< Biocontrol of the root-knot nematode Meloidogyne incognita by a nematicidal bacterium Pseudomonas simiae MB751 with cyclic dipeptide>, SDS of cas: 2873-36-1, the main research area is cyclic dipeptide biocontrol root Pseudomonas Meloidogyne infection; Meloidogyne incognita; Pseudomonas simiae; cyclic dipeptide; nematicidal activity; root-knot nematode.

Root-knot nematodes (RKNs) are harmful plant-parasitic nematodes that cause serious damage to plant hosts. In the long-term practice of RKN management, bacterial nematicides have attracted increasing attention as an effective biocontrol means. Here we determined the active substances against Meloidogyne incognita from a nematicidal bacterium, developed a biocontrol agent (BCA) based on optimized culture processes. The effects of the BCA on RKN control and plant growth-promotion were evaluated in tomato pot trials. Pseudomonas simiae strain MB751 exhibiting significant nematicidal activity against M. incognita second-stage juveniles (J2) with approx. 80% mortality (with culture supernatant, 96% volume percentage) was isolated from a vineyard. A set of purification and identification experiments was performed to determine the main nematicidal component in MB751. A cyclic dipeptide Cyclo(L-Pro-L-Leu) was identified with a lethal concentration necessary to kill 50% of the population (LC50) of 65.3μg mL-1 against M. incognita J2. Following optimization trials on culture medium/fermentation conditions, such as the single factor test, Plackett-Burman test, steepest ascent, and response surface methodol. experiments, the MB751 fermentation broth was then prepared as a BCA via a cold-air drying process. The BCA and was evaluated in tomato pot experiments for effectiveness in suppressing M. incognita. Significant effects on M. incognita suppression and plant-growth promotion as well as induced systemic resistance to M. incognita of tomato, were observed The cyclic dipeptide-producing bacterium P. simiae MB751 exhibited high nematicidal activity and performance. Further development of this BCA should be pursued for the management of M. incognita in agriculture.

Pest Management Science published new progress about Biological pest control. 2873-36-1 belongs to class pyrazines, and the molecular formula is C11H18N2O2, SDS of cas: 2873-36-1.

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Zhao, Lijun; Duan, Feixia; Gong, Meng; Tian, Xue; Guo, Yan; Jia, Lirong; Deng, Sha published the artcile< (+)-Terpinen-4-ol Inhibits Bacillus cereus Biofilm Formation by Upregulating the Interspecies Quorum Sensing Signals Diketopiperazines and Diffusing Signaling Factors>, Related Products of 2873-36-1, the main research area is Bacillus biofilm formation terpinenol quorum sensing diketopiperazine; Bacillus cereus; EPS synthesis; biofilm inhibition; diffusing signaling factor; diketopiperazine; monocyclic monoterpenoids; quorum sensing; rpfB.

Bacillus cereus is a Gram-pos. endospore-forming foodborne pathogen that causes lethal food poisoning and significant economic losses, usually through biofilm- and endospore-induced recurrent cross- and postprocessing contamination. Due to the lack of critical inhibitory targets and control strategies, B. cereus biofilm contamination is a problem that urgently needs a solution In this study, the antibacterial and antibiofilm activities of several natural potential bacterial quorum sensing (QS) interferers, a group of spice-originated monoterpenoids, were screened, and terpinen-4-ol effectively inhibited B. cereus growth and biofilm and spore germination with min. growth inhibition and 50% biofilm inhibitory concentrations of 8 and 2μmol/mL, resp. FESEM/CLSM and phenotypic research illustrated that in addition to a decrease in the number of attached B. cereus cells, (+)-terpinen-4-ol also obviously reduced extracellular matrix synthesis, especially exopolysaccharides, and inhibited the swarming motility and protease activity of B. cereus. (+)-Terpinen-4-ol did not exert a significant effect on AI-2 signals in B. cereus. Accordingly, the B. cereus-produced interspecies QS signals diffusing signal factors (DSFs, C8-C15) and diketopiperazines (DKPs) were detected and identified here, which suppressed B. cereus biofilm formation in a concentration-dependent manner. (+)-Terpinen-4-ol significantly increased the levels of specific DSF and DKP signals in B. cereus and down-regulated the gene expression of some rpfB homologues in transcription level. Moreover, both DKPs and DSFs inhibited swarming motility and protease activity in B. cereus, while just the DSF signals 2-dodecenoic acid and 11-methyl-2-dodecenoic acid inhibited exopolysaccharide synthesis like (+)-terpinen-4-ol. In summary, B. cereus strains were found to produce nine DSF- and six DKP-type QS signaling mols., which repressed B. cereus biofilm formation. (+)-Terpinen-4-ol was confirmed to be a promising antibacterial and antibiofilm agent against B. cereus upregulating DSFs and DKPs levels, and it could target the critical genes rpfB for DSFs turnover.

Journal of Agricultural and Food Chemistry published new progress about Antibacterial agents. 2873-36-1 belongs to class pyrazines, and the molecular formula is C11H18N2O2, Related Products of 2873-36-1.

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Ma, Haoran; Wang, Fuqian; Jin, Xiaoqi; Jiang, Jie; Hu, Song; Cheng, Lu; Zhang, Geng published the artcile< A new diketopiperazine from an endophytic fungus Aspergillus aculeatus F027>, Computed Properties of 2873-36-1, the main research area is diketopiperazine isolation structure Aspergillus; Aspergillus aculeatus ; diketopiperazine; endophytic fungus.

A new diketopiperazine cyclo-(L-Phe-N-ethyl-L-Glu), along with 2 known diketopiperazines cyclo-(L-Pro-L-Leu) and cyclo-(L-Pro-L-Phe) were isolated from the cultures of an endophytic fungus Aspergillus aculeatus F027. The structures of these compounds were elucidated based on spectroscopic data. The configurations of these compounds were determined by advanced Marfey’s anal. Antibacterial activity of the diketopiperazines against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa were also evaluated.

Natural Product Research published new progress about Aspergillus aculeatus. 2873-36-1 belongs to class pyrazines, and the molecular formula is C11H18N2O2, Computed Properties of 2873-36-1.

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Yeoh, Chiann Ying; Rosandy, Andi Rifki; Khalid, Rozida Mohd; Cheah, Yoke Kqueen published the artcile< Barrientosiimonas humi ethyl acetate extract exerts cytotoxicity against MCF-7 and MDA-MB-231 cells via induction of apoptosis and cell cycle arrest>, Formula: C11H18N2O2, the main research area is Barrientosiimonas ethyl acetate extract anticancer apoptosis cell cycle arrest.

To elucidate the cytotoxic effect of the secondary metabolites of Barrientosiimonas humi (B. humi) on MCF-7 and MDA-MB-231 human breast cancer cells and its underlying mechanisms of action. The extract was obtained from the fermentation of B. humi and fractionation of the crude extract was conducted via column chromatog. Cytotoxicity of the B. humi extract was determined by using MTT assay and real-time cellular anal. Morphol. changes, cell cycle profiles, mode of cell death, and caspase expressions of control and treated breast cancer cells were determined The Et acetate extract isolated from B. humi was cytotoxic against MCF-7 and MDA-MB-231 cell lines. One of the dichloromethane (DCM) fractions, designated as DCM-F2, exhibited the strongest activity among all the fractions and thereby was selected for further studies. DCM-F2 had selective cytotoxicity on target cells by inducing apoptosis, particularly in the early stage, and cell cycle arrest. Treated cells caused inhibition of cell cycle progression at 72 h leading to a significant increase (P < 0.05) in the G0/G1 population. DCM-F2 treated MDA-MB-231 cells showed caspase-dependent apoptosis, whereas DCM-F2 treated MCF-7 cells showed a caspase-independent apoptosis pathway. Five compounds were successfully isolated from B. humi. Cyclo (Pro-Tyr) was the most cytotoxic and selective compound against MCF-7 cells. B. humi Et acetate extract exhibits significant cytotoxicity against MCF-7 and MDA-MB-231 cells via induction of apoptosis and cell cycle arrest. Asian Pacific Journal of Tropical Biomedicine published new progress about Antitumor agents. 2873-36-1 belongs to class pyrazines, and the molecular formula is C11H18N2O2, Formula: C11H18N2O2.

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem