Tag: M.W=100-200

Let’s face it, organic chemistry can seem difficult to learn. Especially from a beginner’s point of view. Like 19847-12-2, Name is Pyrazinecarbonitrile. In a document, author is Elkamhawy, Ahmed, introducing its new discovery. Category: Pyrazines.

Herein, two new series ofN-substituted indole-based analogues were rationally designed, synthesizedviamicrowave heating technology, and evaluated as noteworthy MAO-B potential inhibitors. Compared to the reported indazole-based hitsVIandVII, compounds4band4eexhibited higher inhibitory activities over MAO-B with IC(50)values of 1.65 and 0.78 mu M, respectively. When compared to the modest selectivity index of rasagiline (II, a well-known MAO-B inhibitor, SI > 50), both4band4ealso showed better selectivity indices (SI > 60 and 120, respectively). A further kinetic evaluation of the most potent derivative (4e) displayed a competitive mode of inhibition (inhibition constant (K-i)/MAO-B = 94.52 nM). Reasonable explanations of the elicited biological activities were presentedviaSAR study and molecular docking simulation. Accordingly, the remarkable MAO-B inhibitory activity of4e(N-(1-(3-fluorobenzoyl)-1H-indol-5-yl)pyrazine-2-carboxamide), with its selectivity and competitive inhibition, advocates its potential role as a promising lead worthy of further optimization.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 19847-12-2 help many people in the next few years. Category: Pyrazines.

Reference:
Pyrazine – Wikipedia,
,Pyrazine | C4H4N2 – PubChem

Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Moghzi, Faezeh, once mentioned the application of 14508-49-7, Name is 2-Chloropyrazine, molecular formula is C4H3ClN2, molecular weight is 114.53, MDL number is MFCD00006124, category is pyrazines. Now introduce a scientific discovery about this category, COA of Formula: C4H3ClN2.

Four new praseodymium(III) metal-organic compounds varying in dimensionality from 0D to 3D have been designed and synthesized based on N-heterocyclic polycarboxylic acids, including pyridine-2,6-dicarboxylic acid (H(2)pydc) and pyrazine-2,3-dicarboxylic acid (H(2)pzdc). Altering the concentration of piperazine (pip, ancillary ligand) enables control over the dimensionality of the compound by switching between the 0D [H(2)pip][Hpip][Pr(pydc)(3)]center dot 4H(2)O (I) and the 1D {[Pr(pydc)( Hpydc)(H2O)(2)]center dot 4H(2)O}(n) (II) coordination polymer (CP). Upon replacing H(2)pydc with H2pzdc, CP II is converted to the 2D CP [Pr(pzdc)(Hpzdc)(H2O)(3)](n) (III) and using the metalloligand [Zn(Hpzdc)(2)(H2O)(2)](2-) the 3D heterometallic CP {[Pr2Zn(pzdc)(4)(H2O)(6)]center dot 2H(2)O}(n) (IV) is formed. Compound IV shows high stability in the absence of uncoordinated solvent molecules and is stable up to 400 degrees C, even in the presence of humidity. Therefore, IV was utilized for iodine adsorption in the vapour phase and in the presence of humidity. The results confirm the remarkable potential of IV for reversible adsorption of iodine vapour.

Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 14508-49-7, COA of Formula: C4H3ClN2.

Reference:
Pyrazine – Wikipedia,
,Pyrazine | C4H4N2 – PubChem

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 2847-30-5, Name is 2-Methoxy-3-methylpyrazine, molecular formula is C6H8N2O. In an article, author is Yu, You-Jun,once mentioned of 2847-30-5, Application In Synthesis of 2-Methoxy-3-methylpyrazine.

Derivatives based on anthryleno[1,2-b]pyrazine-2,3-dicarbonitrile (DCPA) are used as luminescent materials, to realize near-infrared (NIR) electroluminescence. By functionalizing DCPA with aromatic amine donors, two emitters named DCPA-TPA and DCPA-BBPA are designed and synthesized. Both molecules have large dipole moments owing to the strong intramolecular charge transfer interactions between the amine donors and the DCPA acceptor. Thus, compared with doped films, the emission of neat films of DCPA-TPA and DCPA-BBPA can fully fall into the NIR region (>700 nm) with increasing surrounding polarity by increasing doping ratio. Moreover, the non-doped devices based on DCPA-TPA and DCPA-BBPA provide NIR emission with peaks at 838 and 916 nm, respectively. A maximum radiance of 20707 mW Sr-1 m(-2) was realized for the further optimized device based on DCPA-TPA. This work provides a simple and efficient strategy of molecular design for developing NIR emitting materials.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 2847-30-5, you can contact me at any time and look forward to more communication. Application In Synthesis of 2-Methoxy-3-methylpyrazine.

Reference:
Pyrazine – Wikipedia,
,Pyrazine | C4H4N2 – PubChem

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 14508-49-7, Name is 2-Chloropyrazine, molecular formula is , belongs to pyrazines compound. In a document, author is Wu, Kun, Computed Properties of C4H3ClN2.

Herein, we report the synthesis of three pairs of isostructural zirconium- and hafnium-based homometallic metal-organic frameworks (MOFs, termed Zr-MOF-1 and Hf-MOF-1, Zr-MOF-2 and Hf-MOF-2, and Zr-MOF-3 and Hf-MOF-3) with respective scu, sqc, and flu topologies by using the aggregation-induced-emission (AIE) ligand H4BTTB (4,4 ‘,4 ”,4 ”’-(pyrazine-2,3,5,6-tetrayl)tetrabenzoic acid). As expected, all of them display excellent luminescence properties, and their potential application in the detection of Cr2O72- has been extensively studied. Among them, Zr/Hf-MOF-2 exhibits the high adsorption capacity for Cr2O72- (153 mg g(-1) and 149 mg g(-1), respectively), while Zr/Hf-MOF-3 demonstrates exceptional sensitivity in the detection of Cr2O72-, and the limits of detection are calculated to be 0.013 mu M and 0.019 mu M, respectively. The values are comparable to those of the best-performing MOF materials reported so far. Significantly, single-crystal X-ray diffraction studies revealed the exact location and configuration of Cr2O72- inside Zr/Hf-MOF-2. To the best of our knowledge, this is the first example of Zr/Hf-MOFs with direct evidence showing that Cr2O72- is linked to the Zr/Hf oxide cluster by replacing its terminal H2O/OH- groups within the single crystal.

If you are hungry for even more, make sure to check my other article about 14508-49-7, Computed Properties of C4H3ClN2.

Reference:
Pyrazine – Wikipedia,
,Pyrazine | C4H4N2 – PubChem

Reference of 89-01-0, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 89-01-0, Name is Pyrazine-2,3-dicarboxylic acid, SMILES is O=C(C1=NC=CN=C1C(O)=O)O, belongs to Pyrazines compound. In a article, author is Tan, Yee Seng, introduce new discover of the category.

C20H38CdN4O4P2S4, triclinic, P (1) over bar (no. 2), a = 9.6352(2) angstrom, b = 11.3986(2) angstrom, c = 14.8017(3) angstrom, alpha = 85.713(2)degrees, beta = 89.877(2)degrees, gamma = 86.048(2)degrees, V = 1617.23(6) angstrom(3), Z = 2, R-gt(F) = 0.0285, wR(ref)(F-2) = 0.0829, T = 100 K.

Reference of 89-01-0, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 89-01-0.

Reference:
Pyrazine – Wikipedia,
,Pyrazine | C4H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 89283-32-9, name is (3-Chloropyrazin-2-yl)methanol, A new synthetic method of this compound is introduced below., Recommanded Product: 89283-32-9

1.44 g of 3-chloro-2-pyrazine methanol, 2 mol% of vanadium nitrate (relative to the substrate 3-chloro-2-pyrazine methanol),Add to the 50mL reaction tube, Add 5mL of acetonitrile,Fill the air ball, close the reaction tube, and raise the temperature to 40 C with stirring.And kept for 10 h, until the reaction is over, and cooled to room temperature.Sampling was analyzed using gas chromatography.The conversion rate of 3-chloro-2-pyrazine methanol is 96.1%.The selectivity of 3-chloro-2-pyrazinecarboxaldehyde is greater than 99%.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Dalian University of Technology; Du Zhongtian; Tang Yangyang; Sun Xiaowan; Yue Jiajia; (6 pag.)CN106866508; (2019); B;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Related Products of 54013-07-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 54013-07-9, name is 5-Methoxypyrazin-2-amine, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: Isoquinolin-3-amine (3.23 g, 22.4 mmol) was added to a solution of 1,1′-thiocarbonyldipyridin-2(1H)-one (5.20 g, 22.4 mmol) in dichloromethane (50 mL) at room temperature. The reaction was stirred for 2 h, then purified by flash chromatography on silica gel (0-10% ethyl acetate in hexanes). Product fractions were combined and concentrated in vacuo to give 3-isothiocyanatoisoquinoline(3.9 g, 93 %) as a white solid.

The chemical industry reduces the impact on the environment during synthesis 5-Methoxypyrazin-2-amine. I believe this compound will play a more active role in future production and life.

Reference:
Article; Iwuagwu, Christiana; King, Dalton; McDonald, Ivar M.; Cook, James; Zusi, F. Christopher; Hill, Matthew D.; Mate, Robert A.; Fang, Haiquan; Knox, Ronald; Gallagher, Lizbeth; Post-Munson Amy Easton, Debra; Miller, Regina; Benitex, Yulia; Siuciak, Judy; Lodge, Nicholas; Zaczek, Robert; Morgan, Daniel; Bristow, Linda; Macor, John E.; Olson, Richard E.; Bioorganic and Medicinal Chemistry Letters; vol. 27; 5; (2017); p. 1261 – 1266;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

15707-23-0, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 15707-23-0 as follows.

Ag2O (23.2 mg, 0.1 mmol), 3-nitro-1,2-benzenedicarboxylicacid (H2npt) (42.2 mg, 0.2 mmol) and epyz (24.4 mg, 0.2 mmol) were dissolved in methanol-H2O-DMF mixed solvent (6 mL,v/v/v = 1/1/1) in the presence of ammonia (0.5 mL, 14 M) underultrasonic treatment (160 W, 40 kHz, 30 min) under 40 C. Theresultant colorless solution was allowed slowly to evaporate atroom temperature in the dark. After several days, colorless platecrystals of 1 were isolated in about a 43% yield. They were washedwith a small volume of cold ethanol. Anal. Calc. for Ag2C15H13N3O6:C, 32.94; H, 2.40; N, 7.68. Found: C, 32.98; H, 2.38; N, 7.72%. IR(KBr): m (cm1) = 3440 (m), 3088 (w),3046 (w), 2976 (m),2932(w), 2876 (w), 1590 (s), 1520 (s), 1457(s), 1408 (s), 1344 (s),1288 (m), 1162 (m), 1027 (w), 929 (m), 859 (m), 824 (m), 782(w), 747 (w), 704 (m), 683 (m), 586 (w).

According to the analysis of related databases, 2-Ethyl-3-methylpyrazine, the application of this compound in the production field has become more and more popular.

Reference:
Article; Zhang, Ting; Wang, Dan-Feng; Huang, Rong-Bin; Zheng, Lan-Sun; Inorganica Chimica Acta; vol. 427; (2015); p. 299 – 304;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Electric Literature of 109838-85-9, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 109838-85-9 as follows.

Preparation 34: ((lS,2RV3-amino-l-(3,5-difluorotenzyl)-2-hydroxy-propyl)carbamic acid t-butyl esterStepA: (2S,5R)-2-(3,5-difluorobenzyl)-5-isopropyl-3,6-dimethoxy-2,5-dihvdropyrazine(R)-2,5-dihydro-3,6-dimethoxy-2-isopropylpyrazine was dissolved THF and n-BuLi was added thereto at -78 °C, followed by addition of difluorobenzyl chloride. After the reaction was complete, NH4Cl was added to the reaction mixture, followed by extraction with EtOAc. The organic extract was dried over MgSO4 and concentrated under reduced pressure. The residue was purified by column chromatography (eluent: EtOAc: n-Hex = 1/1) to afford the title compound (339 mg, 80percent).MSbetaVI+l] = 313 (M+l)

According to the analysis of related databases, 109838-85-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; LG LIFE SCIENCES, LTD.; WO2009/38412; (2009); A2;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Application of 1286754-14-0,Some common heterocyclic compound, 1286754-14-0, name is Ethyl imidazo[1,2-a]pyrazine-3-carboxylate, molecular formula is C9H9N3O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

The imidazo [1,2 – the a] pyrazine -3 – carboxylic acid ethyl ester (780 mg, 4 . 08 mmol) is dissolved under stirring 20 ml in tetrahydrofuran, then add 10% palladium carbon 400 mg, hydrogen under the protection of the 35 C stirring 12 hours, the reaction to remove the catalyst, concentrated under reduced pressure, column chromatography purification to obtain 5, 6, 7, 8 – tetrahydro imidazo [1,2 – the a] pyrazine -3 – carboxylic acid ethyl ester (600 mg, yield: 75.3%, white solid).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Ethyl imidazo[1,2-a]pyrazine-3-carboxylate, its application will become more common.

Reference:
Patent; Sichuan Kelun Pharmaceutical Institute Co., Ltd.; Xie Yinong; You Zejin; Song Zhanbo; Su Ruifei; Deng Zhiwen; Wang Yajun; Chen Xing; Zeng Hong; Song Hongmei; Qi Wei; Wang Lichun; Wang Jingyi; (57 pag.)CN106478631; (2017); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem