Tag: M.W=100-200

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 2-Amino-4,5-dihydrothiazole-4-carboxylic acid(SMILESS: O=C(C1N=C(N)SC1)O,cas:2150-55-2) is researched.Category: isothiazole. The article 《Molecularly imprinted polymer stir bar sorption extraction and electrospray ionization tandem mass spectrometry for determination of 2-aminothiazoline-4-carboxylic acid as a marker for cyanide exposure in forensic urine analysis》 in relation to this compound, is published in Analytical Methods. Let’s take a look at the latest research on this compound (cas:2150-55-2).

In forensic casework, a stable and quantifiable marker is desirable for the determination of cyanide poisoning in biol. fluids. 2-Aminothiazoline-4-carboxylic acid (ATCA) is a chem. stable urinary metabolite of cyanide that has been considered to be a reliable biol. marker for cyanide exposure. However, endogenous ATCA is always present in low quantity originating from either dietary intake of cyanide or from normal metabolism of amino acids. A selective and sensitive anal. method is needed to determine the endogenous level of ATCA in order to identify cyanide poisoning. The objective of this research was to prepare molecularly imprinted polymers (MIPs) on the surface of a silica stir bar for molecularly imprinted stir bar sorption extraction (MISBSE). Under optimal extraction conditions, the MISBSE could selectively preconc. ATCA from urine samples. The binding capacity of one MISBSE stir bar for ATCA was determined to be 35 ± 3 ng (n = 3). Combining MISBSE with electrospray ionization tandem mass spectrometry (ESI/MS/MS), ATCA was detected without derivatization at the 400 ng/mL concentration level. This new strategy of MISBSE-ESI/MS/MS enhanced the selectivity and sensitivity for the detection of ACTA in urine samples.

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Reference:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Related Products of 118994-89-1. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: Ethyl oxazole-5-carboxylate, is researched, Molecular C6H7NO3, CAS is 118994-89-1, about Nickel-Catalyzed Decarboxylative Arylation of Heteroarenes through sp2 C-H Functionalization.

The direct decarboxylative arylation of hetereoarenes with benzoic acids through a nickel-catalyzed sp2 C-H functionalization process was developed. This process provides the first examples of decarboxylative cross-coupling reactions with aromatic acids through nickel catalysis and tolerates a variety of functional groups. Moreover, this method provides efficient access to 2-aryl-substituted azoles, an important structural unit in natural products, medicinal compounds, and functional materials.

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Reference:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Synthetic Communications called One-pot synthesis of DL-2-amino-2-thiazoline-4-carboxylic acid, Author is Xuan, Richeng; Hu, Weixiao; Yang, Zhongyu, which mentions a compound: 2150-55-2, SMILESS is O=C(C1N=C(N)SC1)O, Molecular C4H6N2O2S, Recommanded Product: 2-Amino-4,5-dihydrothiazole-4-carboxylic acid.

DL-2-Amino-2-thiazoline-4-carboxylic acid was prepared in one-pot reaction from 2,3-dichloropropionic acid. Not only the procedure was simplified, but also the yield was increased from less than 63% recorded to 93%.

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Reference:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Category: pyrazines. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: Ethyl oxazole-5-carboxylate, is researched, Molecular C6H7NO3, CAS is 118994-89-1, about The Kondrat’eva Reaction in Flow: Direct Access to Annulated Pyridines. Author is Lehmann, Johannes; Alzieu, Thibaut; Martin, Rainer E.; Britton, Robert.

A continuous flow inverse-electron-demand Kondrat’eva reaction has been developed that provides direct access to cycloalka[c]pyridines from unactivated oxazoles and cycloalkenes. The cycloadditions of both unactivated alkenes and deactivated oxazoles are promoted in continuous flow at elevated temperatures and pressures (230 °C, 750psi). E.g., reaction of 5-phenyloxazole and cyclopentene in presence of TFA gave 55% 4-phenyl-6,7-dihydro-5H-cyclopenta[c]pyridine (I). Annulated pyridines obtained by this one-step process are valuable scaffolds for medicinal chem.

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Reference:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Reference of 2-Amino-4,5-dihydrothiazole-4-carboxylic acid. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 2-Amino-4,5-dihydrothiazole-4-carboxylic acid, is researched, Molecular C4H6N2O2S, CAS is 2150-55-2, about Theoretical and experimental approach to hydrophilic interaction dispersive solid-phase extraction of 2-aminothiazoline-4-carboxylic acid from human post-mortem blood. Author is Giebultowicz, Joanna; Sobiech, Monika; Ruzycka, Monika; Lulinski, Piotr.

The authors proposed an innovative hydrophilic interaction dispersive solid-phase extraction (HI-d-SPE) protocol suitable for the isolation of the potential cyanide intoxication marker, 2-aminothiazoline-4-carboxylic acid (ATCA), from such complicated matrix as post-mortem blood. To create an optimal HI-d-SPE protocol, two sorbents were used: a molecularly imprinted polymer (MIP) and com. available Oasis-MCX. The latter sorbent was identified as more recovery-efficient with higher clean-up abilities in a carefully optimized process. Computational anal. was employed to provide insight into the adsorption mechanism of the two selected sorbents. The theor. results were in agreement with the experiment regarding the efficiency of the sorbent. HI-d-SPE was successfully applied to the anal. of ATCA in 20 post-mortem blood samples using LC-MS/MS. The anal. performance of the method was finally compared to prior existing methods, in turn revealing its superiority.

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Pyrazine – Wikipedia,
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Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 118994-89-1, is researched, SMILESS is O=C(C1=CN=CO1)OCC, Molecular C6H7NO3Journal, Tetrahedron Letters called A general route to the Streptomyces-derived inthomycin family: the first synthesis of (+)-inthomycin B, Author is Webb, Michael R.; Donald, Craig; Taylor, Richard J. K., the main research direction is asym synthesis inthomycin B Stille coupling palladium catalyst; Stille coupling stannyl diene oxazole vinyl iodide; Kiyooka ketene acetal amino acid derived oxazaborolidinone directed aldol.SDS of cas: 118994-89-1.

A concise, convergent and stereocontrolled synthesis of (+)-inthomycin B (I), based on the Stille coupling of a stannyl-diene with an oxazole vinyl iodide unit, is described. The asym. center was introduced using the Kiyooka ketene acetal/amino acid-derived oxazaborolidinone procedure.

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Reference:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Zanaletti, Riccardo; Bettinetti, Laura; Castaldo, Cristiana; Cocconcelli, Giuseppe; Comery, Thomas; Dunlop, John; Gaviraghi, Giovanni; Ghiron, Chiara; Haydar, Simon N.; Jow, Flora; Maccari, Laura; Micco, Iolanda; Nencini, Arianna; Scali, Carla; Turlizzi, Elisa; Valacchi, Michela researched the compound: 3-(Pyridin-4-yl)-1H-pyrazol-5-amine( cas:91912-53-7 ).Application In Synthesis of 3-(Pyridin-4-yl)-1H-pyrazol-5-amine.They published the article 《Discovery of a novel alpha-7 nicotinic acetylcholine receptor agonist series and characterization of the potent, selective, and orally efficacious agonist 5-(4-Acetyl[1,4]diazepan-1-yl)pentanoic acid [5-(4-Methoxyphenyl)-1H-pyrazol-3-yl] amide (SEN15924, WAY-361789)》 about this compound( cas:91912-53-7 ) in Journal of Medicinal Chemistry. Keywords: acetyldiazepanyl pentanoic acid methoxyphenyl pyrazolyl amide synthesis cholinergic agonist; nicotinic acetylcholine receptor agonist discovery structure activity mol docking. We’ll tell you more about this compound (cas:91912-53-7).

Alpha-7 nicotinic acetylcholine receptors (α7 nAChR) are implicated in the modulation of many cognitive functions such as attention, working memory, and episodic memory. For this reason, α7 nAChR agonists represent promising therapeutic candidates for the treatment of cognitive impairment associated with Alzheimer’s disease (AD) and schizophrenia. A medicinal chem. effort, around our previously reported chem. series, permitted the discovery of a novel class of α7 nAChR agonists with improved selectivity, in particular against the α3 receptor subtype and better ADME profile. The exploration of this series led to the identification of 5-(4-acetyl[1,4]diazepan-1-yl)pentanoic acid [5-(4-methoxyphenyl)-1H-pyrazol-3-yl] amide [(I), SEN15924, WAY-361789], a novel, full agonist of the α7 nAChR that was evaluated in vitro and in vivo. Compound I proved to be potent and selective, and it demonstrated a fair pharmacokinetic profile accompanied by efficacy in rodent behavioral cognition models (novel object recognition and auditory sensory gating).

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Reference:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Formula: C5H5FN2. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 5-Amino-2-fluoropyridine, is researched, Molecular C5H5FN2, CAS is 1827-27-6, about Synthesis and in vitro evaluation of [18F]BMS-754807: A potential PET ligand for IGF-1R. Author is Majo, Vattoly J.; Arango, Victoria; Simpson, Norman R.; Prabhakaran, Jaya; Kassir, Suham A.; Underwood, Mark D.; Bakalian, Mihran; Canoll, Peter; John Mann, J.; Dileep Kumar, J. S..

Radiosynthesis and in vitro evaluation of [18F](S)-1-(4-((5-cyclopropyl-1H-pyrazol-3-yl)amino)pyrrolo[2,1-f][1,2,4]triazin-2-yl)-N-(6-fluoropyridin-3-yl)-2-methylpyrrolidine-2-carboxamide ([18F]BMS-754807 or [18F] I) a specific IGF-1R inhibitor was performed. [18F]I demonstrated specific binding in vitro to human cancer tissues. Synthesis of reference standard II(X= F) and corresponding bromo derivative II(X = X = Br), the precursor for radiolabeling were achieved from 2,4-dichloropyrrolo[2,1-f][1,2,4]triazine in three steps with 50% overall yield. The radioproduct was obtained in 8% yield by reacting 1a with [18F]TBAF in DMSO at 170 °C at high radiochem. purity and specific activity (1-2 Ci/μmol, N = 10). The proof of concept of IGF-IR imaging with [18F]I was demonstrated by in vitro autoradiog. studies using pathol. identified surgically removed grade IV glioblastoma, breast cancer and pancreatic tumor tissues. These studies indicate that [18F]I can be a potential PET tracer for monitoring IGF-1R.

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Pyrazine – Wikipedia,
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Yang, Ke; Zhang, Cheng; Wang, Peng; Zhang, Yan; Ge, Haibo published an article about the compound: Ethyl oxazole-5-carboxylate( cas:118994-89-1,SMILESS:O=C(C1=CN=CO1)OCC ).Formula: C6H7NO3. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:118994-89-1) through the article.

Nickel-catalyzed ligand-free decarboxylative cross-coupling of azole derivatives with α-oxoglyoxylic acids was developed. This work represents the first example of decarboxylative cross-coupling reactions, in a C-H bond functionalization manner, through nickel catalysis, and tolerates various functional groups. Addnl., this approach provides an efficient access to (ox)azole ketones, an important structural motif in many medicinal compounds with a broad range of biol. activities. © 2014 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Reference:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Osano, Mana; Jhaveri, Dishit P.; Wipf, Peter researched the compound: Ethyl oxazole-5-carboxylate( cas:118994-89-1 ).Category: pyrazines.They published the article 《Formation of 6-Azaindoles by Intramolecular Diels-Alder Reaction of Oxazoles and Total Synthesis of Marinoquinoline A》 about this compound( cas:118994-89-1 ) in Organic Letters. Keywords: marinoquinoline total synthesis. We’ll tell you more about this compound (cas:118994-89-1).

A new variant of the intramol. Diels-Alder oxazole (IMDAO) cycloaddition that provides direct access to 6-azaindoles was developed. The IMDAO reaction was applied in a total synthesis of the aminophenylpyrrole-derived alkaloid marinoquinoline A, also featuring the use of a Curtius reaction for preparation of a 5-aminooxazole, a propargylic C,H-bond insertion, an in situ alkyne-allene isomerization, and a ruthenium-catalyzed cycloisomerization for benzene ring annulation to the 6-azaindole.

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Reference:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem