Tag: M.W=100-200

Computed Properties of C4H6N2O2S. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 2-Amino-4,5-dihydrothiazole-4-carboxylic acid, is researched, Molecular C4H6N2O2S, CAS is 2150-55-2, about Microbial enzyme conversion of L-cysteine and L-cystine. Author is Liu, Zhong; Yang, Wenbo; Bai, Gang; Tian, Wang; Jin, Yongjie.

Pseudomonas sp. TS1138 isolated from soil samples was able to form L-cysteine from DL-2-Amiuo-δ2-Thiazoline-4-Carboxylic Acid (DL-ATC) after cultured 16 h. The optimum carbon and nitrogen sources of strain growth and enzyme formation are glucose and urea. This enzyme was induced by DL-ATC. The product was identified to be L-Cysteine based on thin layer chromatog., optical rotation and HPLC studies.

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Pyrazine – Wikipedia,
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Ohmachi, Tetsuo; Nishino, Mizuka; Kawata, Maki; Edo, Namiko; Funaki, Hiroko; Narita, Megumi; Mori, Kazuyuki; Tamura, Yoshiharu; Asada, Yoshihiro published an article about the compound: 2-Amino-4,5-dihydrothiazole-4-carboxylic acid( cas:2150-55-2,SMILESS:O=C(C1N=C(N)SC1)O ).Product Details of 2150-55-2. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:2150-55-2) through the article.

The newly isolated strain Pseudomonas sp. ON-4a converts D,L-2-amino-Δ2-thiazoline-4-carboxylic acid (D,L-ATC) to L-cysteine via N-carbamoyl-L-cysteine. A genomic DNA fragment from this strain containing the gene(s) encoding enzymes that convert D,L-ATC into L-cysteine was cloned in Escherichia coli. Transformants expressing cysteine-forming activity were selected by growth of an E. coli mutant defective in the cysB gene. A pos. clone, denoted CM1, carrying the plasmid pCM1 with an insert DNA of approx. 3.4 kb was obtained, and the nucleotide sequence of a complementing region was analyzed. Anal. of the sequence found two open reading frames, ORF1 and ORF2, which encoded proteins of 183 and 435 amino acid residues, resp. E. coli DH5α harboring pTrCM1, which was constructed by inserting the subcloned sequence into an expression vector, expressed two proteins of 25 kDa and 45 kDa. From the analyses of crude extracts of E. coli DH5α carrying deletion derivatives of pTrCM1 by sodium dodecyl sulfatepolyacrylamide gel electrophoresis and by enzymic activity, it was found that the 25-kDa protein encoded by ORF1 was the enzyme L-2-amino-Δ2-thiazoline-4-carboxylic acid hydrolase, which catalyzes the conversion of D,L-ATC to N-carbamoyl-L-cysteine, and that the 45-kDa protein encoded by ORF2 was the enzyme N-carbamoyl-L-cysteine amidohydrolase, which catalyzes the conversion of N-carbamoyl-L-cysteine to L-cysteine.

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So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Huai, Lihua; Chen, Ning researched the compound: 2-Amino-4,5-dihydrothiazole-4-carboxylic acid( cas:2150-55-2 ).Name: 2-Amino-4,5-dihydrothiazole-4-carboxylic acid.They published the article 《Effect of dissolved oxygen on production of L-cysteine synthetase by Pseudomonas sp. TS1138》 about this compound( cas:2150-55-2 ) in Shipin Kexue (Beijing, China). Keywords: dissolved oxygen cysteine synthetase Pseudomonas fermentation. We’ll tell you more about this compound (cas:2150-55-2).

Pseudomonas sp. TS1138 has potential to produce L-cysteine synthetase through asym. hydrolysis of DL-2-amino-Δ2-thiazoline-4-carboxylic acid (DL-ATC). The effect of dissolved oxygen level on the production of L-cysteine synthetase was investigated in shake flasks or 7 L bioreactor. The results indicated that the cell growth and the production of L-cysteine synthetase were inhibited at low dissolved oxygen level. Although cell growth was improved at the high dissolved oxygen level, the inhibition against production of L-cysteine synthetase was still observed in shake flasks. In 7 L bioreactor, dissolved oxygen concentration controlled at more than 30% was helpful for improving the cell growth and the production of L-cysteine synthetase through regulating agitation rate and air flow rate during the middle and late stage.

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Pyrazine – Wikipedia,
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The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Novel pyrazolopyrimidines as highly potent B-Raf inhibitors》. Authors are Di Grandi, Martin J.; Berger, Dan M.; Hopper, Darrin W.; Zhang, Chunchun; Dutia, Minu; Dunnick, Alejandro L.; Torres, Nancy; Levin, Jeremy I.; Diamantidis, George; Zapf, Christoph W.; Bloom, Jonathan D.; Hu, YongBo; Powell, Dennis; Wojciechowicz, Donald; Collins, Karen; Frommer, Eileen.The article about the compound:3-(Pyridin-4-yl)-1H-pyrazol-5-aminecas:91912-53-7,SMILESS:NC1=CC(C2=CC=NC=C2)=NN1).Product Details of 91912-53-7. Through the article, more information about this compound (cas:91912-53-7) is conveyed.

A novel series of pyrazolo[1,5-a]pyrimidines bearing a 3-hydroxyphenyl group at C(3) and substituted tropanes at C(7) have been identified as potent B-Raf inhibitors. Exploration of alternative functional groups as a replacement for the C(3) phenol demonstrated indazole to be an effective isostere. Several compounds possessing substituted indazole residues, such as 4e, 4p, and 4r, potently inhibited cell proliferation at submicromolar concentrations in the A375 and WM266 cell lines, and the latter two compounds also exhibited good therapeutic indexes in cells.

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Category: pyrazines. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 2-Amino-4,5-dihydrothiazole-4-carboxylic acid, is researched, Molecular C4H6N2O2S, CAS is 2150-55-2, about The stability of L-ATC hydrolase participating in L-cysteine production.

In the production of L-cysteine from DL-2-amino-Δ2-thiazoline-4-carboxylic acid (DL-ATC), the stability of the relevant enzymes produced by Pseudomonas sp. was tested, and strategies to improve the stability of L-ATC hydrolase were investigated with respect to water activity and ionic strength. Among the 3 enzymes which participate in L-cysteine production, i.e., ATC racemase, L-ATC hydrolase, and S-carbamyl-L-cysteine hydrolase, L-ATC hydrolase is the least stable. Various mixtures of salts and sorbitol were added to adjust the water activities of the tested solutions As the water activity decreased from 0.93 to 0.80, the stability of L-ATC hydrolase was sharply enhanced. In the absence of sorbitol, the stability of L-ATC hydrolase increased in proportion to ionic strength. Even though enzyme stability was not good at a low ionic strength, it was enhanced by lowering the water activity with the addition of sorbitol. The half-life of L-ATC hydrolase in sorbitol-salt mixtures increased by 10- to 20-fold compared to that of a control.

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Application of 118994-89-1. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: Ethyl oxazole-5-carboxylate, is researched, Molecular C6H7NO3, CAS is 118994-89-1, about Copper-catalyzed diarylation of Se with aryl iodides and heterocycles. Author is Hu, Dehua; Liu, Miaochang; Wu, Huayue; Gao, Wenxia; Wu, Ge.

The regioselective copper-catalyzed three-component coupling reaction of electron-deficient heterocycles, like aryl-oxadiazoles/aryloxazoles/dimethyl-purine-diones, etc. with aryl iodides in presence of Se powder so as to yield corresponding diaryl-selenated heterocycles such as arylselanyl-aryl-oxadiazoles I [R = Ph, 4-MeC6H4, 2-thienyl, etc.; R1 = Ph, 2-naphthyl, 3-thienyl, etc.] and arylselanyl-aryl-oxazoles II [R2 = Ph, 2,4,6-triMeC6H2; R3 = CO2Et, Ph, 4-MeSC6H4, etc.] was disclosed. The established methodol. provided an efficient and practical pathway to access arylselenated heterocycles via copper-catalyzed double C-Se bond formation. This transformation featured the use of elemental Se as the selenating reagent, a cost-effective catalytic system and the late-stage selenation of bioactive compounds

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The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 2-Amino-4,5-dihydrothiazole-4-carboxylic acid( cas:2150-55-2 ) is researched.Computed Properties of C4H6N2O2S.Lulinski, Piotr; Giebultowicz, Joanna; Wroczynski, Piotr; Maciejewska, Dorota published the article 《A highly selective molecularly imprinted sorbent for extraction of 2-aminothiazoline-4-carboxylic acid – Synthesis, characterization and application in post-mortem whole blood analysis》 about this compound( cas:2150-55-2 ) in Journal of Chromatography A. Keywords: molecularly imprinted sorbent extraction aminothiazolinecarboxylate synthesis characterization blood analysis; 2-Aminothiazoline-4-carboxylic acid; Dispersive solid phase extraction; Molecularly imprinted polymers; Post-mortem whole blood. Let’s learn more about this compound (cas:2150-55-2).

In this paper, the optimized synthesis and detailed characterization of novel imprinted material for selective extraction of 2-aminothiazoline-4-carboxylic acid (ATCA) were described. The prepolymeric system contained 1-allyl-2-thiourea and ethylene glycol dimethacrylate in methanol, THF and DMSO porogenic mixture and 2-aminothiazole-4-carboxylic acid which was used as the template for ATCA. This structural analog of the target analyte was found to provide the imprinted polymer with sufficient binding capacity (60.7 ± 0.9 μg g-1) and high selectivity (imprinting factor equal to 18.4) toward ATCA. The adsorption of ATCA was analyzed by the Langmuir model. The heterogeneous population of binding sites on the imprinted polymer was characterized by dissociation constants equal to 3.72 μg L-1 and 435 μg L-1 for high and low affinity binding sites, resp. The morphol. of the polymer was studied employing SEM and BET analyses and the composition was confirmed by EDS and 13C CP/MAS NMR analyses. Adsorption of amino acids on the imprinted material was tested to analyze the impact of the sample components. The superiority of the imprinted sorbent was proved in a novel dispersive solid phase extraction procedure of ATCA from post-mortem whole blood with respect to the extraction efficacy on the com. ion-exchange sorbents. The limit of quantification and limit of detection of ATCA in the new anal. method were 12 μg L-1 and 3.5 μg L-1, resp. The recovery of ATCA was in the range of 81-89% and the precision of the method ranged from 1.5 to 2.7%.

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So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Youn, Sung Hun; Park, Hae Woong; Choe, Deokyeong; Shin, Chul Soo researched the compound: 2-Amino-4,5-dihydrothiazole-4-carboxylic acid( cas:2150-55-2 ).Quality Control of 2-Amino-4,5-dihydrothiazole-4-carboxylic acid.They published the article 《Preparation of eutectic substrate mixtures for enzymatic conversion of ATC to L-cysteine at high concentration levels》 about this compound( cas:2150-55-2 ) in Bioprocess and Biosystems Engineering. Keywords: enzymic conversion eutectic mixture cysteine production. We’ll tell you more about this compound (cas:2150-55-2).

High concentration eutectic substrate solutions for the enzymic production of L-cysteine were prepared Eutectic melting of binary mixtures consisting of D,L-2-amino-Δ2-thiazoline-4-carboxylic acid (ATC) as a substrate and malonic acid occurred at 39 °C with an ATC mole fraction of 0.5. Formation of eutectic mixtures was confirmed using SEM, SEM-EDS, and XPS surface analyses. Sorbitol, MnSO4, and NaOH were used as supplements for the enzymic reactions. Strategies for sequential addition of five compounds, including a binary ATC mixture and supplements, during preparation of eutectic substrate solutions were established. Eutectic substrate solutions were stable for 24 h. After 6 h of enzymic reactions, a 550 mM L-cysteine yield was obtained from a 670 mM eutectic ATC solution

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So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Xing, Qi; Lv, Hui; Xia, Chungu; Li, Fuwei researched the compound: Ethyl oxazole-5-carboxylate( cas:118994-89-1 ).Reference of Ethyl oxazole-5-carboxylate.They published the article 《Palladium-catalyzed intermolecular carbonylative cross-coupling of heteroaryl C(sp2)-H bonds with amines: an efficient strategy for oxidative aminocarbonylation of azoles》 about this compound( cas:118994-89-1 ) in Chemical Communications (Cambridge, United Kingdom). Keywords: heteroarylamide preparation green chem; azole amine intermol oxidative aminocarbonylation palladium catalyst. We’ll tell you more about this compound (cas:118994-89-1).

An efficient palladium-catalyzed oxidative aminocarbonylation of azoles such as benzothiazole, 5-chloro benzoxazole, 4,5-dimethyl-1,3-thiazole, etc. has been developed. This system allows for intermol. carbonylative cross-coupling of aromatic C(sp2)-H bonds with simple amines RR1NH [R = H, CH2CH3, c-C6H11, etc.; R1 = C(H3)3, (CH2)2CH3, CH2C6H5, etc.; RR1 = -(CH2)2O(CH2)2-, -(CH2)5-], which has often been asked for, but has not been realized so far. It provides a straightforward approach to a variety of azol-2-amides RR1NC(O)R2 (R2 = 1,3-benzothiazol-2-yl, 5-chloro-1,3-benzoxazol-2-yl, dimethyl-1,3-thiazol-2-yl, etc.).

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The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 5-Amino-2-fluoropyridine(SMILESS: NC1=CN=C(C=C1)F,cas:1827-27-6) is researched.Quality Control of Nickel(II) bromide ethylene glycol dimethyl ether complex. The article 《Pyridyl-urea catalysts for the solvent-free ring-opening polymerization of lactones and trimethylene carbonate》 in relation to this compound, is published in European Polymer Journal. Let’s take a look at the latest research on this compound (cas:1827-27-6).

The ring-opening polymerization (ROP) of lactones is an effective method for the preparation of biocompatible and biodegradable aliphatic polyesters, for which the development of efficient organocatalysts with high activity and good controllability is highly desirable. A series of novel pyridyl-urea catalysts was synthesized and applied in the solvent-free ROP of lactones and trimethylene carbonate. Combined with 7-methyl-1,5,7-triazabicyclo[4.4.0]dec-5-ene (MTBD), the pyridyl-urea/MTBD systems showed a fast and living/controlled behavior in the ROP, generating polymers with narrow mol. weight distributions. The influences of catalyst structure, type of base, pyridyl-urea/base ratio, feed ratio of monomer/initiator and reaction temperature on the catalytic properties were investigated. A possible mechanism was proposed on the basis of NMR titration and dilution experiments

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