Tag: M.W=100-200

Category: pyrazines. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 5-Amino-2-fluoropyridine, is researched, Molecular C5H5FN2, CAS is 1827-27-6, about Synthesis of 6-substituted pyrido[3,4-d]pyrimidin-4(3H)-ones via directed lithiation of 2-substituted 5-aminopyridine derivatives. Author is Rewcastle, Gordon W.; Denny, William A.; Winters, R. Thomas; Colbry, Norman L.; Showalter, H. D. Hollis.

Directed lithiation of Boc or pivaloyl derivatives of 2-substituted 5-aminopyridines I (R = Cl, F, OMe, R1 = COnCMe3, X = H, n = 1, 2) with BuLi-TMEDA in di-Et ether at -10°C gave 4-lithio derivatives which were quenched with CO2 to give the analogous C-4 carboxylic acids I (X = CO2H). Hydrolysis of the protecting groups with either TFA or aqueous KOH gave 2-substituted 5-aminopyridine-4-carboxylic acids I (R1 = H, X = CO2H) which were converted to 6-substituted pyrido[3,4-d]pyrimidin-4(3H)-ones II by reaction with formamide or, more optionally, formamidine acetate. Boc protected aminopyridines provided the best overall results, with synthesis of these derivatives best achieved by direct reaction of the aminopyridine with di-tert-Bu dicarbonate in the absence of added base.

Compound(1827-27-6)Category: pyrazines received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(5-Amino-2-fluoropyridine), if you are interested, you can check out my other related articles.

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Computed Properties of C4H6N2O2S. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 2-Amino-4,5-dihydrothiazole-4-carboxylic acid, is researched, Molecular C4H6N2O2S, CAS is 2150-55-2, about Asymmetric synthesis of S-carboxymethyl-L-cysteine by a chemicoenzymic method.

A chemienzymic method is developed for production of S-carboxymethyl-L-cysteine (I) from DL-2-aminothiazoline-4-carboxylic acid (II) in the presence of ClCH2CO2H using a hydrolyzing system. The carboxymethylation of L-cysteine with ClCH2CO2H to I proceeded effectively at 26° and pH ≥8.0, the yield reaching nearly 100%. The carboxymethylation of II with ClCH2CO2H was not observed Next, the production of I from II in the presence of ClCH2CO2H was examined using rinsed cells of Pseudomonas desmolytica AJ-11898. About 10 g I/L was produced from 18 g II/L in 8 h, the molar yield being 45%. This finding shows that the aminothiazolinecarboxylate racemase in P. desmolytica AJ-11898 may be inhibited by the ClCH2CO2H added to the reaction mixture In fact, the II remaining in the reaction mixture was in the D-form. Moreover, the yield of L-cysteine from DL-II in the absence of ClCH2CO2H was ∼50% when cells of AJ-11898 pretreated with SH reagents were used as the enzyme source.

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SDS of cas: 118994-89-1. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: Ethyl oxazole-5-carboxylate, is researched, Molecular C6H7NO3, CAS is 118994-89-1, about Construction of 2-(2-Arylphenyl)azoles via Cobalt-Catalyzed C-H/C-H Cross-Coupling Reactions and Evaluation of Their Antifungal Activity.

Although compounds with a 2-(2-arylphenyl) benzoxazole motif are biol. important, there are only a few methods for synthesizing them. Herein, authors report an efficient method for synthesis of such compounds by means of cobalt-catalyzed C-H/C-H cross-coupling reactions. This method has a broad substrate scope and good tolerance for sensitive functional groups. In addition, authors demonstrate that introducing a heteroarene moiety to biphenyl compounds enhanced their antifungal activity.

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Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Journal of Medicinal Chemistry called Design and Synthesis of the Potent, Orally Available, Brain-Penetrable Arylpyrazole Class of Neuropeptide Y5 Receptor Antagonists, Author is Sato, Nagaaki; Takahashi, Toshiyuki; Shibata, Takunobu; Haga, Yuji; Sakuraba, Aya; Hirose, Masaaki; Sato, Miki; Nonoshita, Katsumasa; Koike, Yuko; Kitazawa, Hidefumi; Fujino, Naoko; Ishii, Yasuyuki; Ishihara, Akane; Kanatani, Akio; Fukami, Takehiro, which mentions a compound: 91912-53-7, SMILESS is NC1=CC(C2=CC=NC=C2)=NN1, Molecular C8H8N4, COA of Formula: C8H8N4.

Novel arylpyrazole derivatives were synthesized and evaluated as neuropeptide Y5 receptor antagonists. The 2,3-dihydro-1H-cyclopenta[a]naphthalene derivative I showed good binding affinity and antagonistic activity for the Y5 receptor. After intracerebroventricular administration in SD rats, (-)-I significantly inhibited food intake that was induced by the centrally administered Y5-preferring agonist, bovine pancreatic polypeptide, but had only a negligible effect on NPY-induced feeding.

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Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 91912-53-7, is researched, Molecular C8H8N4, about Pyrazolo[1,5-a]pyrido[3,4-e]pyrimidin-6-ones. II. Synthesis and in vitro antimicrobial evaluation, the main research direction is pyrazolopyridopyrimidinone preparation bactericide fungicide; pyridopyrimidinone pyrazolo preparation bactericide fungicide; pyrimidinone pyrazolopyrido preparation bactericide fungicide.Product Details of 91912-53-7.

A series of pyrazolo[1,5-a]pyrido[3,4-e]pyrimidin-6-ones, I (R1 = H, Me, Ph, 2-furyl, etc., R2 = cyano, CO2Et, H, Ph, NO2, Cl, R3, R4 = H, Me), was prepared by a simple synthetic procedure based on the reaction of hydroxylamine or methoxyamine with 2,3-substituted Et 7-dimethylaminovinyl pyrazolo[1,5-a]pyrimidin-6-carboxylates II. The antimicrobial activity of the obtained compounds was evaluated on a series of standard strains of Gram pos., Gram neg. bacteria and fungi. None of the tested compounds showed significant activity.

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Recommanded Product: 2-Amino-4,5-dihydrothiazole-4-carboxylic acid. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 2-Amino-4,5-dihydrothiazole-4-carboxylic acid, is researched, Molecular C4H6N2O2S, CAS is 2150-55-2, about Metabolic pathway of L-cysteine formation from DL-2-amino-Δ2-thiazoline-4-carboxylic acid by Pseudomonas. Author is Sano, Konosuke; Eguchi, Chikahiko; Yasuda, Naohiko; Mitsugi, Koji.

DL-2-Amino-Δ2-thiazoline-4-carboxylic acid (DL-ATC) was completely converted to L-cysteine by intact cells or homogenates of P. thiazolinophilum. S-Carbamylcysteine was the actual intermediate of ATC hydrolysis. P. desmolytica Hydrolyzed only 50% of DL-ATC, but completely converted L-ATC into L-cysteine, suggesting that the organism had no ATC-racemizing enzyme and that ATC is racemized by an enzyme in P. thiazolinophilum. A proposed pathway from D-ATC to L-cysteine in P.thiazolinophilum is presented.

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Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Organic & Biomolecular Chemistry called Continuous flow as an enabling technology: a fast and versatile entry to functionalized glyoxal derivatives, Author is Lima, Fabio; Meisenbach, Mark; Schenkel, Berthold; Sedelmeier, Joerg, which mentions a compound: 118994-89-1, SMILESS is O=C(C1=CN=CO1)OCC, Molecular C6H7NO3, Quality Control of Ethyl oxazole-5-carboxylate.

Two complementary strategies employing organolithium chem. for the synthesis of glyoxal derivatives RC(O)R1R2 (R = methoxymethyl, 3,5-difluorophenyl, pyridin-2-yl, quinolin-6-yl, etc.; R1 = Cl, OEt, H; R2 = Cl, OEt, 3-chlorophenyl) were reported. Micro-mixer technol. allows for the generation of unstable organometallic intermediates and their instantaneous in-line quenching with esters as electrophiles RC(O)OEt. Selective mono-addition was observed via putative stabilized tetrahedral intermediates. Advantages offered by flow chem. technologies facilitate direct and efficient access to masked 1,2-dicarbonyl compounds while mitigating undesired byproduct formation. These two approaches enable the production of advanced and valuable synthetic building blocks for heterocyclic chem. with throughputs of grams per min.

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Recommanded Product: 3-(Pyridin-4-yl)-1H-pyrazol-5-amine. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 3-(Pyridin-4-yl)-1H-pyrazol-5-amine, is researched, Molecular C8H8N4, CAS is 91912-53-7, about Design and Synthesis of the Potent, Orally Available, Brain-Penetrable Arylpyrazole Class of Neuropeptide Y5 Receptor Antagonists. Author is Sato, Nagaaki; Takahashi, Toshiyuki; Shibata, Takunobu; Haga, Yuji; Sakuraba, Aya; Hirose, Masaaki; Sato, Miki; Nonoshita, Katsumasa; Koike, Yuko; Kitazawa, Hidefumi; Fujino, Naoko; Ishii, Yasuyuki; Ishihara, Akane; Kanatani, Akio; Fukami, Takehiro.

Novel arylpyrazole derivatives were synthesized and evaluated as neuropeptide Y5 receptor antagonists. The 2,3-dihydro-1H-cyclopenta[a]naphthalene derivative I showed good binding affinity and antagonistic activity for the Y5 receptor. After intracerebroventricular administration in SD rats, (-)-I significantly inhibited food intake that was induced by the centrally administered Y5-preferring agonist, bovine pancreatic polypeptide, but had only a negligible effect on NPY-induced feeding.

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Pyrazine – Wikipedia,
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The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 2-Amino-4,5-dihydrothiazole-4-carboxylic acid( cas:2150-55-2 ) is researched.Safety of 2-Amino-4,5-dihydrothiazole-4-carboxylic acid.Ryu, Ok Hee; Shin, Chul Soo published the article 《Analysis of the reaction steps in the bioconversion of D,L-ATC to L-cysteine》 about this compound( cas:2150-55-2 ) in Journal of Microbiology and Biotechnology. Keywords: cysteine preparation aminothiazolinecarboxylate enzyme Pseudomonas. Let’s learn more about this compound (cas:2150-55-2).

The reaction steps involved in the bioconversion of a chem. synthesized precursor, D,L-2-amino-Δ2-thiazoline-4-carboxylic acid (D,L-ATC), to L-cysteine and the properties of the involved enzymes were investigated. It was found that the conversion consisted of two steps, i.e., D,L-ATC to S-carbamyl-L-cysteine (S-C-L-cysteine) and S-C-L-cysteine to L-cysteine, and the S-C-L-cysteine was an intermediate between them. While the enzymes involved in the reactions were induced by the addition of D,L-ATC as an inducer, S-C-L-cysteine induced only the enzyme involved in the latter step. The conversion of S-C-L-cysteine to L-cysteine could be also carried out in the presence of hydroxylamine and its rate was much faster than that by the corresponding enzyme. On the other hand, L-cysteine (or L-cystine) was decomposed to evolve H2S by the enzyme considered to be a kind of desulfhydrase. However, hydroxylamine was a perfect inhibitor for this enzyme.

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Application of 91912-53-7. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 3-(Pyridin-4-yl)-1H-pyrazol-5-amine, is researched, Molecular C8H8N4, CAS is 91912-53-7, about Organocatalytic Stereoconvergent Synthesis of α-CF3 Amides: Triketopiperazines and Their Heterocyclic Metamorphosis. Author is Foster, Robert W.; Lenz, Eva N.; Simpkins, Nigel S.; Stead, Darren.

The highly enantioselective alkylation of α-CF3 enolates, generated from triketopiperazines, has been accomplished through use of a bifunctional thiourea organocatalyst to facilitate 1,4-addition to varied enone acceptors. On treatment with appropriate nitrogen nucleophiles, the chiral triketopiperazine products underwent metamorphosis, to provide novel fused heterocyclic lactams such as extended pyrazolopyrimidines.

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Pyrazine – Wikipedia,
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