Tag: M.W=100-200

Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Moghzi, Faezeh, once mentioned the application of 14508-49-7, Name is 2-Chloropyrazine, molecular formula is C4H3ClN2, molecular weight is 114.53, MDL number is MFCD00006124, category is Pyrazines. Now introduce a scientific discovery about this category, Safety of 2-Chloropyrazine.

0D to 3D Pr-III metal-organic networks crystal engineered for optimal iodine adsorption

Four new praseodymium(III) metal-organic compounds varying in dimensionality from 0D to 3D have been designed and synthesized based on N-heterocyclic polycarboxylic acids, including pyridine-2,6-dicarboxylic acid (H(2)pydc) and pyrazine-2,3-dicarboxylic acid (H(2)pzdc). Altering the concentration of piperazine (pip, ancillary ligand) enables control over the dimensionality of the compound by switching between the 0D [H(2)pip][Hpip][Pr(pydc)(3)]center dot 4H(2)O (I) and the 1D {[Pr(pydc)( Hpydc)(H2O)(2)]center dot 4H(2)O}(n) (II) coordination polymer (CP). Upon replacing H(2)pydc with H2pzdc, CP II is converted to the 2D CP [Pr(pzdc)(Hpzdc)(H2O)(3)](n) (III) and using the metalloligand [Zn(Hpzdc)(2)(H2O)(2)](2-) the 3D heterometallic CP {[Pr2Zn(pzdc)(4)(H2O)(6)]center dot 2H(2)O}(n) (IV) is formed. Compound IV shows high stability in the absence of uncoordinated solvent molecules and is stable up to 400 degrees C, even in the presence of humidity. Therefore, IV was utilized for iodine adsorption in the vapour phase and in the presence of humidity. The results confirm the remarkable potential of IV for reversible adsorption of iodine vapour.

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A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, Formula: C6H8N2, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 123-32-0, Name is 2,5-Dimethylpyrazine, molecular formula is C6H8N2. In an article, author is Zhu, Meiqing,once mentioned of 123-32-0.

A novel pyrene-based fluorescent probe for the rapid and efficient detection of Co2+ in HeLa cells and natural water samples

Excessive levels of Co2+ in the environment can cause serious diseases to humans and affect the growth of crops. Therefore, it is necessary to develop effective methods for monitoring Co2+. In the present work, a novel, low-toxic fluorescent probe, PEPA, for the rapid and efficient detection of Co2+ is synthesized. PEPA shows high sensitivity, with a limit of detection of 0.104 mu M and a fast response to Co2+ (<4 min). The detection mechanism was confirmed by FT-IR. HRMS and DFT calculations. Co2+ can restrict the free rotation of the C=N group and the pyrazine ring of PEPA, resulting in the enhancement of fluorescence. In addition, the recognition process of Co2+ can be realized with the naked eye (i.e., a color change from colorless to blue fluorescence). The successful detection of Co2+ in test strips and environmental water samples provides strong support for its application potential. Interestingly, the recovery rate of Co2+ detected by PEPA can reach 93% after being recovered four times. Importantly, PEPA was suitable for the fluorescence imaging of exogenous Co2+ in HeLa cells. (C) 2020 Elsevier B.V. All rights reserved. If you¡¯re interested in learning more about 123-32-0. The above is the message from the blog manager. Formula: C6H8N2.

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 14508-49-7, Name is 2-Chloropyrazine, molecular formula is , belongs to Pyrazines compound. In a document, author is Wu, Kun, Category: Pyrazines.

Cr2O72- inside Zr/Hf-based metal-organic frameworks: highly sensitive and selective detection and crystallographic evidence

Herein, we report the synthesis of three pairs of isostructural zirconium- and hafnium-based homometallic metal-organic frameworks (MOFs, termed Zr-MOF-1 and Hf-MOF-1, Zr-MOF-2 and Hf-MOF-2, and Zr-MOF-3 and Hf-MOF-3) with respective scu, sqc, and flu topologies by using the aggregation-induced-emission (AIE) ligand H4BTTB (4,4 ‘,4 ”,4 ”’-(pyrazine-2,3,5,6-tetrayl)tetrabenzoic acid). As expected, all of them display excellent luminescence properties, and their potential application in the detection of Cr2O72- has been extensively studied. Among them, Zr/Hf-MOF-2 exhibits the high adsorption capacity for Cr2O72- (153 mg g(-1) and 149 mg g(-1), respectively), while Zr/Hf-MOF-3 demonstrates exceptional sensitivity in the detection of Cr2O72-, and the limits of detection are calculated to be 0.013 mu M and 0.019 mu M, respectively. The values are comparable to those of the best-performing MOF materials reported so far. Significantly, single-crystal X-ray diffraction studies revealed the exact location and configuration of Cr2O72- inside Zr/Hf-MOF-2. To the best of our knowledge, this is the first example of Zr/Hf-MOFs with direct evidence showing that Cr2O72- is linked to the Zr/Hf oxide cluster by replacing its terminal H2O/OH- groups within the single crystal.

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Application of 20737-42-2, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 20737-42-2, Name is 3-Oxo-3,4-dihydropyrazine-2-carboxylic acid, SMILES is O=C(C1=NC=CNC1=O)O, belongs to Pyrazines compound. In a article, author is Seo, Yohan, introduce new discover of the category.

Expansion of chemical space based on a pyrrolo[1,2-a]pyrazine core: Synthesis and its anticancer activity in prostate cancer and breast cancer cells

In connection with our continued research to generate new aza-fused heteroaromatic chemical scaffolds, we developed a highly atom-economical three-component route to novel 3,4-dihydropyrrolo[1,2-a] pyrazine ring skeleton multi-functionalized on the pyrazine unit. This [4+1+1] annulation approach led us to gain access to a new N-fused bicyclic chemical space having two distinctive functional groups (heteroaryl and aroyl) in a trans manner. Investigation of anticancer activity of the synthesized compounds and their derivatives revealed that (3R*,4S*)-3-(4-bromophenyl)-4-(4-fluorobenzoyl)-2-(2-oxo-2-phenylethyl)-3,4-dihydropyrrolo[1,2-a]pyrazin-2-ium bromide (3h) has potent anticancer activity. 3h significantly inhibited cell viability in prostate cancer cells (PC-3) and breast cancer cells (MCF-7) with IC50 value of 1.18 +/- 0.05 mu M and 1.95 +/- 0.04 mu M, respectively. In addition, 3h strongly reduced cell migration in a dose dependent manner, and induced apoptosis via caspase-3 activation and cleavage of PARP in PC-3 and MCF-7 cells. Our results in this study imply that 3h can be a potential anticancer agent against prostate cancer and breast cancer. (C) 2019 Elsevier Masson SAS. All rights reserved.

Application of 20737-42-2, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 20737-42-2.

Let¡¯s face it, organic chemistry can seem difficult to learn. Especially from a beginner¡¯s point of view. Like 19847-12-2, Name is Pyrazinecarbonitrile. In a document, author is Elkamhawy, Ahmed, introducing its new discovery. Quality Control of Pyrazinecarbonitrile.

Discovery ofN-(1-(3-fluorobenzoyl)-1H-indol-5-yl)pyrazine-2-carboxamide: a novel, selective, and competitive indole-based lead inhibitor for human monoamine oxidase B

Herein, two new series ofN-substituted indole-based analogues were rationally designed, synthesizedviamicrowave heating technology, and evaluated as noteworthy MAO-B potential inhibitors. Compared to the reported indazole-based hitsVIandVII, compounds4band4eexhibited higher inhibitory activities over MAO-B with IC(50)values of 1.65 and 0.78 mu M, respectively. When compared to the modest selectivity index of rasagiline (II, a well-known MAO-B inhibitor, SI > 50), both4band4ealso showed better selectivity indices (SI > 60 and 120, respectively). A further kinetic evaluation of the most potent derivative (4e) displayed a competitive mode of inhibition (inhibition constant (K-i)/MAO-B = 94.52 nM). Reasonable explanations of the elicited biological activities were presentedviaSAR study and molecular docking simulation. Accordingly, the remarkable MAO-B inhibitory activity of4e(N-(1-(3-fluorobenzoyl)-1H-indol-5-yl)pyrazine-2-carboxamide), with its selectivity and competitive inhibition, advocates its potential role as a promising lead worthy of further optimization.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 19847-12-2 help many people in the next few years. Quality Control of Pyrazinecarbonitrile.

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 2847-30-5, Name is 2-Methoxy-3-methylpyrazine, molecular formula is C6H8N2O, belongs to Pyrazines compound. In a document, author is Aljohani, Marwah, introduce the new discover, COA of Formula: C6H8N2O.

Influence of Excipients on Cocrystal Stability and Formation

Cocrystal formation is widely used to modify and optimize the physicochemical properties of an active pharmaceutical ingredient (API). However, the stability of cocrystals toward formulation with excipients is little investigated. In this work, the effect of grinding in the presence of the common excipients polyvinylpyrrolidone (PVP) and microcrystalline cellulose (MCC) on 11 cocrystals and a salt of the sulfonamide diuretic chlorothiazide (ctz) was studied (ctz-bipy, ctz-ebipy, ctz-pbipy, ctz-pyr, ctzhyp, ctz-hma, ctz-bza, ctz-nia, ctz-ina, ctz-cbz, ctz-aca, ctz-ppa, (bzamH(+))(ctz(-)); bipy = 4,4′-bipyridine, ebipy = 1,2-di(4-pyridyl)ethylene, pbipy = 1,3-di(4-pyridyl)propane, pyr = pyrazine, hyp = 2-hydroxypyridine, hma = hexamethylenetetramine, bza = benzamide, nia = nicotinamide, ina = isonicotinamide, cbz = carbamazepine, aca = acetamide, ppa = propionamide, bzamH+ = benzamidinium). Except for ctz-ppa and ctz-aca, all cocrystals were stable toward milling with 1 weight equiv PVP or MCC. It was also shown that the cocrystals ctz-bipy, ctz-ebipy, ctz-pbipy, ctz-pyr, ctz-hma, ctz-bza, ctz-ina, ctz-cbz, and the salt (bzamH+)(ctz-) formed in situ, when ctz was milled with the respective coformer in the presence of PVP or MCC. The stability and formation of ctz-cbz, ctz-nia, and htz-nia (htz = hydrochlorothiazide) toward grinding with a wider range of excipients (HPC, alpha-lactose, deoxycholic acid, and sodium taurocholate) was also investigated, and the results are discussed with regard to the heterosynthons of the ctz cocrystals and competing H bonding with the excipients.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 2847-30-5. COA of Formula: C6H8N2O.

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 19847-12-2, Name is Pyrazinecarbonitrile, molecular formula is C5H3N3. In an article, author is Shi, Fu,once mentioned of 19847-12-2, SDS of cas: 19847-12-2.

A high selective fluorescent sensor for Cu2+ in solution and test paper strips

A novel and efficient fluorescent sensor with a pyrazine triphenylamine unit was developed. The sensor exhibits large Stokes shift (216 nm) due to the excited-state intramolecular proton transfer (ESIPT) process. After complexing with Cu2+, the ESIPT process was blocked and the fluorescence of the sensor was quenched. Job’s plot and ESI-MS results indicated that the stoichiometric ratio between the sensor and Cu2+ was 1:1. The detection limit was determined to be 2.47 x 10(-8) mol L-1. The sensor could be used to detect Cu2+ in practical samples with high accuracy. Furthermore, the sensor also could be made into test paper strips for the qualitative and quantitative detection of Cu2+.

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Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 2847-30-5, Name is 2-Methoxy-3-methylpyrazine, molecular formula is C6H8N2O. In an article, author is Tan, Yee Seng,once mentioned of 2847-30-5, Name: 2-Methoxy-3-methylpyrazine.

Crystal structure of catena-[(mu(2)-pyrazine-kappa N-2:N ‘)-bis(O,O ‘-di-ethyldithiophosphato-kappa S-2,S ‘)cadmium(II)], {C12H24CdN2O4P2S4}(n)

C12H24CdN2O4P2S4, monoclinic, P2/n (no. 13), a = 11.7844(2) angstrom, b = 7.6063(1) angstrom, c = 13.1965(2) angstrom, beta = 111.594(2)degrees, V = 1099.86(3) angstrom(3), Z = 2, R-gt(F) = 0.0171, wR(ref)(F-2) = 0.0467, T = 100 K.

If you¡¯re interested in learning more about 2847-30-5. The above is the message from the blog manager. Name: 2-Methoxy-3-methylpyrazine.

Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 19847-12-2, Name is Pyrazinecarbonitrile, SMILES is N#CC1=NC=CN=C1, in an article , author is Tomer, Nisha, once mentioned of 19847-12-2, HPLC of Formula: C5H3N3.

A chromone based Schiff base: An efficient colorimetric sensor for specific detection of Cu (II) ion in real water samples

A new chromone based Schiff base ligand L was synthesized by the condensation of 3-formyl chromone and pyrazine-2-carbohydrazide as a colorimetric probe to detect Cu (II) ions selectively. An instant visual colour change from colourless to yellow was obtained on addition of Cu2+ ions to the probe L solution, while other metal ions found ineffective. The ligand L was characterized by H-1 NMR, FTIR and HRMS spectral techniques. UV-Visible spectroscopic technique was used to study the sensing ability of probe L for copper ions above other metal ions. The Job’s plot obtained from absorption studies and HRMS data confirmed that the Cu2+ ions bind with ligand L in 1:1 stoichiometric ratio. DFT computations were also supported the binding framework between L and Cu (II) ions. The LOD value and the association constant were obtained 3.9 x 10(-7) M and 2.3 x 10(5) M-1 respectively, via Benesi-Hildebrand equation. Selectivity of L towards Cu2+ ions was also studied and it was found that the probe L worked specifically for copper ions without any considerable influence of other intruding metal ions. In addition, in real water samples, the ligand L was fully implemented for identification and quantification of Cu2+ ions. (C) 2020 Elsevier B.V. All rights reserved.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 19847-12-2, you can contact me at any time and look forward to more communication. HPLC of Formula: C5H3N3.

Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , Product Details of 14508-49-7, 14508-49-7, Name is 2-Chloropyrazine, molecular formula is C4H3ClN2, belongs to Pyrazines compound. In a document, author is Parisi, Emmanuele, introduce the new discover.

Tautomeric and conformational switching in a new versatile N-rich heterocyclic ligand

A new N-rich triazolo-triazole derivative, 4-methyl-7-(pyrazin-2-yl)-2H-[1,2,4]triazolo[3,2-c][1,2,4]triazole (C8H7N7), bearing a pyrazine residue at 7-position of the triazolo-triazole bicycle, was synthesized, and its acid-base and metal coordination properties were evaluated in solution. The results showed amphoteric behavior and the formation of stable complexes with Cu(II) and Zn(II) in pH intervals in which the ligand is neutral or deprotonated. Computational studies were performed in order to evaluate the stability of the different tautomers/conformers of the ligand, and the proton position in the neutral and acidic forms. Single crystal X-ray analysis of the free neutral ligand (2H/s-trans tautomer/conformer), and of its singly protonated (2H-3H/s-trans), doubly protonated (2H-3H-7H/s-trans) and deprotonated forms showed that the influence of the pyrazine ring on the triazolo-triazole system is mainly as electron withdrawing and chelating group, and proton acceptor. Different coordination modes have been evidenced for the neutral and deprotonated ligand. Upon metal coordination, the neutral ligand switches from 2H/strans to 3H/s-cis tautomer/conformer forming five-membered chelate rings, while the anionic deprotonated ligand forms six-membered chelate rings in the s-trans conformation. Altogether, five different tautomers/conformers of the ligand were isolated and characterized. In vitro tests confirmed the general antiproliferative activity of triazolo-triazole compounds and the importance of substitution in position 7 for their selectivity.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 14508-49-7. Product Details of 14508-49-7.