Tag: M.W=100-200

Reference of 2847-30-5, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 2847-30-5, Name is 2-Methoxy-3-methylpyrazine, SMILES is COC1=C(C)N=CC=N1, belongs to Pyrazines compound. In a article, author is Wang, Xu De, introduce new discover of the category.

2-Pyrazine-PPD, a novel dammarane derivative, showed anticancer activity by reactive oxygen species-mediate apoptosis and endoplasmic reticulum stress in gastric cancer cells

20 (R)-Dammarane-3 beta, 12 beta, 20, 25-tetrol (25-OH-PPD), a ginsenoside, was derived from Panax ginseng (C. A. Meyer) and inhibited growth of several cancer cell lines. To improve the anti-cancer activity, we introduced the pyrazine ring to 25-OH-PPD and obtained the compound 20(R)-[2,3-beta]-Pyrazine-dammarane-12 beta,20,25-triol (2-Pyrazine-PPD). we evaluated the anti-cancer activity of 2-Pyrazine-PPD and investigated the main anti-cancer mechanisms of 2-Pyrazine-PPD in gastric cancer cells. We found that 2-Pyrazine-PPD remarkably suppressed the proliferation of gastric cancer cells in a concentration-dependent, and showed little toxicity to the normal cell (human gastric epithelial cell line-GES-1). Further study indicated that 2-Pyrazine-PPD induced apoptosis by mitochondria pathway in BGC-803 cancer cells, and activated unfolded protein response and the protein kinase RNA-activated (PKR)-like ER kinase (PERK)/Eukaryotic translation initiation factor-2 alpha (eIF-2 alpha)/Activating transcription factor 4 (ATF4) axis, the expression level of the protein C/EBP homologous protein (CHOP), the marker of endoplasmic reticulum stress, and the apoptosis inducing by 2-Pyrazine-PPD can partly be inhibited by siRNA-mediated knockdown of CHOP. Moreover, the production of reactive oxygen species was remarkably up-regulated in BGC-803 cancer cells treated with 2-Pyrazine-PPD. N-acetylcysteine (NAC, a reactive oxygen species scavenger) can attenuate 2-Pyrazine-PPD-induced apoptosis and endoplasmic reticulum stress. Taken together, we suggested that 2-Pyrazine-PPD exhibited remarkable anti-cancer activity by reactive oxygen species-mediate cell apoptosis and endoplasmic reticulum stress in gastric cancer cells. Our results uncovered the mechanism of 2-Pyrazine-PPD as a promising anti-tumor candidate for gastric cancer therapy.

Reference of 2847-30-5, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 2847-30-5.

Synthetic Route of 20737-42-2, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 20737-42-2, Name is 3-Oxo-3,4-dihydropyrazine-2-carboxylic acid, SMILES is O=C(C1=NC=CNC1=O)O, belongs to Pyrazines compound. In a article, author is Romero, Angel H., introduce new discover of the category.

Anticancer potential of new 3-nitroaryl-6-(N-methyl)piperazin-1,2,4-triazolo[3,4-a]phthalazines targeting voltage-gated K+ channel: Copper-catalyzed one-pot synthesis from 4-chloro-1-phthalazinyl-arylhydrazones

A series of six 3-aryl-6-(N-methylpiperazin)-1,2,4-triazolo[3,4-a]phthalazines were prepared through a facile and efficient one-pot copper-catalyzed procedure from 4-chloro-1-phthalazinyl-arylhydrazones with relatively good yields (62-83%). The one-pot copper-catalytic procedure consists of two simultaneous reactions: (i) a direct intramolecular dehydrogentaive cyclization between ylidenic carbon and adjacent pyrazine nitrogen to form 1,2,4-triazolo ring and, (ii) a direct N-amination on carbon-chlorine bond. Then, an in vitro anticancer evaluation was performed for the synthesized compounds against five selected human cancer cells (A549, MCF-7, SKBr3, PC-3 and HeLa). The nitro-derivatives were significantly more active against cancer strains than against the rest of tested compounds. Specifically, compound 8d was identified as the most promising anticancer agent with significant biological responses and low relative toxicities on human dermis fibroblast. The cytotoxic effect of compound 8d was more significant on PC3, MCF-7 and SKBr3 cancer cells with low-micromolar IC50 value ranging from 0.11 to 0.59 mu M, superior to Adriamycin drug. Mechanistic experimental and theoretical studies demonstrated that compounds 8d act as a K+ channel inhibitor in cancer models. Further molecular docking studies suggest that the EGFR Tyrosine Kinase enzyme may be a potential target for the most active 3-aryl-6-(N-methylpiperazin)-1,2,4-triazolo[3,4-a]phthalazines.

Synthetic Route of 20737-42-2, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 20737-42-2 is helpful to your research.

Chemistry is an experimental science, Computed Properties of C6H8N2, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 123-32-0, Name is 2,5-Dimethylpyrazine, molecular formula is C6H8N2, belongs to Pyrazines compound. In a document, author is Chen, Li.

Development of A-DA’D-A Small-Molecular Acceptors Based on a 6,12-Dihydro-diindolo[1,2-b:10,20-e]pyrazine Unit for Efficient As-Cast Polymer Solar Cells

Development of high-performance small-molecular acceptors (SMAs) and an eco-friendly and simple device fabrication procedure is very crucial for scalable production of polymer solar cells (PSCs) in the future. Here, we designed and synthesized two new nonacyclic SMAs (IPYT-IC and IPYT-ICF) featuring an A-DA’D-A-type molecular configuration, in which an electron- deficient 6,12-dihydro-diindolo[1,2-b:10,20-e]pyrazine (IPY) moiety was used as the additional acceptor unit (A’) and fused with the electron-rich diarylcyclopentadienylthiophene segment (D) to form a DA’D-type central core (IPYT), and 3-(dicyanomethylidene)indol-1-one (IC) or 5,6-difluoro-3-(dicyanomethylene)indol-1-one (ICF) acted as the terminal acceptor group (A). The rigid coplanar DA’D-type core containing a weakly electron-deficient IPY unit is beneficial to broaden the absorption range, improve light-harvesting ability, reduce the band gap, upshift the lowest unoccupied molecular orbital (LUMO) energy level, and enhance the charge transport of the resultant SMAs. Meanwhile, with respect to IPYT-IC, fluorinated IPYT-ICF exhibits a stronger absorption with a narrower band gap, higher electron mobility, and lower-lying highest occupied molecular orbital/LUMO energy levels. The as-cast PSCs based on IPYT-ICF using the polymer PTB7-Th as an electron donor achieve a power conversion efficiency of up to 7.00% with eco-friendly o-xylene (XY) as the processing solvent without any additive and post-treatment, which is higher than that of devices based on IPYT-IC (4.50%) mainly originating from the larger J(sc) and FF because of the higher carrier mobilities, better charge transport and collection properties, weaker charge recombination, and superior film morphology. However, IPYT-IC-based devices present an outstanding V-oc of up to 0.98 V because the weakly electron-deficient A’ unit (IPY) upshifts LUMO levels of these SMAs. Our results illustrate that the weakly electron-deficient IPY can be a promising A’ unit to develop efficient A-DA’D-A-type SMAs for additive-free and eco-friendly as-cast PSCs.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 123-32-0. Computed Properties of C6H8N2.

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 20737-42-2, Name is 3-Oxo-3,4-dihydropyrazine-2-carboxylic acid, SMILES is O=C(C1=NC=CNC1=O)O, belongs to Pyrazines compound. In a document, author is Liu, Jian, introduce the new discover, Quality Control of 3-Oxo-3,4-dihydropyrazine-2-carboxylic acid.

Potent, non-covalent reversible BTK inhibitors with 8-amino-imidazo[1,5-a] pyrazine core featuring 3-position bicyclic ring substitutes

Bruton’s tyrosine kinase (BTK) is a Tec family kinase with a well-defined role in the B cell receptor (BCR) pathway. It has become an attractive kinase target for selective B cell inhibition, and for the treatment of B cell related diseases. Many BTK inhibitors have been discovered for the treatment of cancer and rheumatoid arthritis, including a series of BTK inhibitors based on 8-amino-imidazo[1,5-a]pyrazine we recently reported. The X-ray crystal structures of BTK with inhibitors were also published, which provided great help for the SAR design. Here we report our SAR work introducing ring constraints for the 3-position piperidine amides on the BTK inhibitors based on 8-amino-imidazo[1,5-a]pyrazine. This modification improved the potency in BTK inhibitions, as well as the PK profile and the off-target selectivity. The dose-dependent efficacy of two BTK inhibitors was observed in the rat collagen induced arthritis (CIA) model.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 20737-42-2 is helpful to your research. Quality Control of 3-Oxo-3,4-dihydropyrazine-2-carboxylic acid.

Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 33332-25-1, Name is Methyl 5-chloropyrazine-2-carboxylate, molecular formula is , belongs to Pyrazines compound. In a document, author is Dehury, Niranjan, HPLC of Formula: C6H5ClN2O2.

Tandem alpha/beta-alkylation and transfer hydrogenation by heterodimetallic ruthenium-iridium complex

Herein, we present a new and air-stable polypyridyl based heterodimetallic complex [cp*Ir-III(mu-L)Ru-II(p-cym)] (PF6)(2) (5) exhibiting facile tandem alpha/beta-alkylation/transfer hydrogenation of ketones/alcohol under mild re-action conditions. The heterodimetallic 5 is found to show better reactivity and selectivity as compared to their homodimetallic analogues (3 and 4), monometallic (1 and 2) and dimeric precursors [cp*IrCl(mu-Cl)](2) and [(p-cym)RuCl(mu-Cl)](2). In addition, the present catalytic system 5 demonstrates a good flexibility and selective formation of alpha-alkylated ketones (C) or beta-alkylated alcohol (D) by simple variation of reagents and reaction condition which may be envisioned to play a pivotal role in organic and organometallic chemistry as it lead to the development of pharmaceutically relevant intermediates for the synthesis of different types of heterocycles.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 33332-25-1, in my other articles. HPLC of Formula: C6H5ClN2O2.

Synthetic Route of 14508-49-7, Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 14508-49-7, Name is 2-Chloropyrazine, SMILES is ClC1=CN=CC=N1, belongs to Pyrazines compound. In a article, author is Loos, Pierre-Francois, introduce new discover of the category.

A Mountaineering Strategy to Excited States: Highly Accurate Energies and Benchmarks for Medium Sized Molecules

Following our previous work focusing on compounds containing up to 3 non-hydrogen atoms [J. Chem. Theory Comput. 2018, 14, 4360-4379], we present here highly accurate vertical transition energies obtained for 27 molecules encompassing 4, 5, and 6 non-hydrogen atoms: acetone, acrolein, benzene, butadiene, cyanoacetylene, cyanoformaldehyde, cyanogen, cyclopentadiene, cyclopropenone, cyclopropenethione, diacetylene, furan, glyoxal, imidazole, isobutene, methylenecyclopropene, propynal, pyrazine, pyridazine, pyridine, pyrimidine, pyrrole, tetrazine, thioacetone, thiophene, thiopropynal, and triazine. To obtain these energies, we use equation-of-motion/linear-response coupled cluster theory up to the highest technically possible excitation order for these systems (CC3, EOM-CCSDT, and EOM-CCSDTQ) and selected configuration interaction (SCI) calculations (with tens of millions of determinants in the reference space), as well as the multiconfigurational n-electron valence state perturbation theory (NEVPT2) method. All these approaches are applied in combination with diffuse-containing atomic basis sets. For all transitions, we report at least CC3/aug-cc-pVQZ vertical excitation energies as well as CC3/aug-cc-pVTZ oscillator strengths for each dipole-allowed transition. We show that CC3 almost systematically delivers transition energies in agreement with higher-level methods with a typical deviation of +/- 0.04 eV, except for transitions with a dominant double excitation character where the error is much larger. The present contribution gathers a large, diverse, and accurate set of more than 200 highly accurate transition energies for states of various natures (valence, Rydberg, singlet, triplet, n -> pi*, pi -> pi*, …). We use this series of theoretical best estimates to benchmark a series of popular methods for excited state calculations: CIS(D), ADC(2), CC2, STEOM-CCSD, EOM-CCSD, CCSDR(3), CCSDT-3, CC3, and NEVPT2. The results of these benchmarks are compared to the available literature data.

Synthetic Route of 14508-49-7, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 14508-49-7 is helpful to your research.

Electric Literature of 22047-25-2, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 22047-25-2, Name is Acetylpyrazine, SMILES is C1=C(N=CC=N1)C(=O)C, belongs to Pyrazines compound. In a article, author is Xu, Su-Peng, introduce new discover of the category.

Zero/one-dimensional coordination complexes constructed from the carboxylate and multi-nitrogen chelating ligands: structural insights and photocatalytic degradation of organic dye

In the current study, two new coordination complexes with the chemical formulae of [Co(cbba)(bimb)](H2O) (1, H(2)cbba = 3-((3-carboxybenzyl)oxy)benzoic acid, bimb = 6,6 ‘-bis(1H-benzo[d]imidazol-2-yl)-2,2’-bipyridine) and {[Co(pdc)(bimb)](DMF)}(n) (2, H(2)pda = pyrazine-2,5-dicarboxylic acid) have been successfully prepared by reaction of the Co(NO3)(2)center dot 6H(2)O with the bimb ligand in the presence of different carboxylate ligands (H(2)cbba for 1 and H(2)pda for 2). The as-prepared two complexes have been determined via the elemental analysis, single crystal X-ray diffraction along with the powder X-ray diffraction. In addition, the photocatalytic activity of complex 2 toward the degradation of methyl violet (MV) in simulated polluted water was explored.

Electric Literature of 22047-25-2, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 22047-25-2.

Electric Literature of 123-32-0, Redox catalysis has been broadly utilized in electrochemical synthesis due to its kinetic advantages over direct electrolysis. The appropriate choice of redox mediator can avoid electrode passivation and overpotential. 123-32-0, Name is 2,5-Dimethylpyrazine, SMILES is C1=NC(=CN=C1C)C, belongs to Pyrazines compound. In a article, author is Lu, Huiqiang, introduce new discover of the category.

Hole transport materials based on a twisted molecular structure with a single aromatic heterocyclic core to boost the performance of conventional perovskite solar cells

Hole-transport materials (HTMs) have a critical effect on the performance of perovskite solar cells (PSCs). So far, 2,2 ‘,7,7 ‘-tetrakis[N,N-di(4-methoxyphenyl)amino]-9,9 ‘-spirobifluorene (spiro-OMeTAD) is commonly used as an HTM for highly efficient PSCs. The HTMs with a spiro framework like spiro-OMeTAD usually show high thermal stability and good film forming capacity. To date, massive efforts have been made to prepare new HTMs with a spiro core structure connecting two electron-donating moieties. However, the harsh synthetic routes and purification processes of the spiro structure are the main challenges for their large-scale applications. To solve this issue, herein, a single aromatic heterocycle pyrazine is used to connect two electron-donating groups for the construction of new HTMs (denoted as 3,6-DMPZ and 2,7-DMPZ), which could be synthesized under mild reaction conditions with high yield (over 60%). Moreover, in terms of molecular structure, the electron-withdrawing property of the pyrazine group could increase the molecular polarity, enhance intermolecular interactions, and thereby promote charge transfer, affording a high hole mobility. Experiments indicate that 2,7-DMPZ film shows a more uniform morphology, better hole transport property, and more efficient charge transfer compared to the 3,6-DMPZ film, endowing the 2,7-DMPZ-based device with an impressive power conversion efficiency of 19.61% with enhanced stability.

Electric Literature of 123-32-0, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 123-32-0 is helpful to your research.

Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Bellucci, Luca, once mentioned the application of 123-32-0, Name is 2,5-Dimethylpyrazine, molecular formula is C6H8N2, molecular weight is 108.14, MDL number is MFCD00006147, category is Pyrazines. Now introduce a scientific discovery about this category, SDS of cas: 123-32-0.

Composition-Thermometric Properties Correlations in Homodinuclear Eu3+ Luminescent Complexes

A family of homodinuclear Ln(3+) (Ln(3+) = Gd3+, Eu3+) luminescent complexes with the general formula [Ln(2)(beta-diketonato)(6)(N-oxide)(y)] has been developed to study the effect of the beta-diketonato and N-oxide ligands on their thermometric properties. The investigated complexes are [Ln(2)(tta)(6)(pyrzMO)(2)] (Ln = Eu (1.C7H8), Gd (5)), [Ln(2) (dbm)(6) (pyrzMO)(2)] (Ln = Eu (2), Gd (6)), [Ln(2)(bta)(6) (pyrzMO)(2)] (Ln = Eu (3), Gd (7)), [Ln(2)(hfac)(6)(pyrzMO)(3)] (Ln = Eu (4), Gd (8)) (pyrzMO = pyrazine N-oxide, Htta = thenoyltrifluoroacetone, Hdbm = dibenzoylmethane, Hbta = benzoyltrifluoroacetone, Hhfac = hexafluoroacetylacetone, C7H8 = toluene), and their 4,4′-bipyridine N-oxide (bipyMO) analogues. Europium complexes emit a bright red light under UV radiation at room temperature, whose intensity displays a strong temperature (T) dependence between 223 and 373 K. This remarkable variation is exploited to develop a series of luminescent thermometers by using the integrated intensity of the D-5(0) -> F-7(2) europium transition as the thermometric parameter (Delta). The effect of different beta-diketonato and N-oxide ligands is investigated with particular regard to the shape of thermometer calibration (Delta vs T) and relative thermal sensitivity curves: i.e.. the change in Delta per degree of temperature variation usually indicated as S-r (% K-1). The thermometric properties are determined by the presence of two nonradiative deactivation channels, back energy transfer (BEnT) from Eu3+ to the ligand triplet levels and ligand to metal charge transfer (LMCT). In the complexes bearing tta and dbm ligands, whose triplet energy is ca. 20000 cm(-1), both deactivation channels are active in the same temperature range, and both contribute to determine the thermometric properties. Conversely, with bta and hfac ligands the response of the europium luminescence to temperature variation is ruled by LMCT channels since the high triplet energy (>21400 cm(-1)) makes BEnT ineffective in the investigated temperature range.

Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 123-32-0, SDS of cas: 123-32-0.

Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Takabatake, Tohru, once mentioned the application of 33332-25-1, Name is Methyl 5-chloropyrazine-2-carboxylate, molecular formula is C6H5ClN2O2, molecular weight is 172.57, MDL number is MFCD01632102, category is Pyrazines. Now introduce a scientific discovery about this category, Recommanded Product: Methyl 5-chloropyrazine-2-carboxylate.

Chemical and Biochemical Reactions of Aromatic Furazan Compounds

Aromatic furazan has numerous pharmacologic and industrial applications. As part of our work on aromatic furazan chemistry and biochemistry, benzofurazan N-oxides, on irradiation using a high-pressure mercury lamp with a Pyrex filter in acetonitrile containing a little water, afforded 1H-azepine-2,7-dione. Mechanistic studies on the photoreaction using a low-pressure mercury lamp and photosensitizer suggest that photosensitized formation of 1H-azepine-2,7-dione with the aromatic hydrocarbon may be carried out by reabsorption of fluorescence. Quinoxaline 1,4-dioxide, phenazine 5,10-dioxide, and pyrido [2,3-b] pyrazine derivatives were synthesized from the corresponding aromatic or heteroaromatic furazan N-oxides by silica gel or molecular sieves under solvent-free conditions using microwave irradiation. The toxicities of some benzofurazans were examined on Escherichia coli; these may due to their reduction within the E. coli cell and their reoxidization by molecular dioxygen to form superoxide and hydrogen peroxide. The formation of 4,7-dicyanobenzofurazan anion radical in the E. coli cell suspension-4,7-dicyanobenzofurazan-glucose system in the absence of O-2 was followed by ESR spectroscopy. 4,7-Dimethylbenzofurazan was transformed by O-1(2) produced by irradiation of C-60 into 4,7-dimethylbenzofurazan 4,7-endoperoxide. The endoperoxide decomposed back to 4,7-dimethylbenzofurazan at room temperature. 4,7-Dimethylbenzofurazan was transformed by irradiation with the third harmonic of a Quanta-Ray Nd:YAG laser (355 nm) into (2Z,4Z)-2,5-dimethylhexa-2,4-dienedinitrile monoxide. Irradiation of 4,7-dimethylbenzofurazan yielded a photoproduct with a quantum yield 0.48 and chemical yield 99%.

Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 33332-25-1, Recommanded Product: Methyl 5-chloropyrazine-2-carboxylate.