Tag: M.W=100-200

Reference of 19847-12-2, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, 19847-12-2, Name is Pyrazinecarbonitrile, SMILES is N#CC1=NC=CN=C1, belongs to Pyrazines compound. In a article, author is Li, Hui, introduce new discover of the category.

Theoretical study of switching characteristics of molecular tweezers based on bis(Zn-salphen)

A series of novel tweezers based on bis(Zn-salphen) complex is theoretically studied. Density functional theory (DFT) method is used to investigate the switchable properties of terpy/bis(Zn-salphen) complex (1, terpy=2,2 ‘:6 ‘,2 ”-terpyridine) and Br-phtpy/bis(Zn-salphen) complex (2, Br-phtpy=4 ‘-bromophenyl-2,2 ‘:6 ‘,2 ”-terpyridine). In this study, the free tweezers1and2can be converted from a W open form to a U closed form upon Ru(III) coordination. The switching performances were characterized by(1)H NMR and absorption spectra. DFT calculations were carried out using a B3LYP-D3 functional and def2-SVP basis set for all atoms.H-1 NMR spectra showed that terpyridine protons had an obvious upfield shift during complexation with RuCl3. The absorption spectrum was observed in the closed tweezers with a significant red shift and a decreased oscillator strength. In addition, the tweezers were reopened by introducing molecule pyrazine in the U-shaped conformation to form a host-guest system. The recognition ability of two Zn-salphen complexes was studied by geometrical optimization and absorption spectra.

Reference of 19847-12-2, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 19847-12-2.

Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 33332-25-1, Name is Methyl 5-chloropyrazine-2-carboxylate, molecular formula is , belongs to Pyrazines compound. In a document, author is Abe, Haruka, Category: Pyrazines.

Dynamic structural reconstruction of (guanidinium(+))(2)(benzene-1,4-disulfonate(2-)) host crystal by guest adsorption

Guanidinium (G(+)) and benzene-1,4-disulfonate (BDS2-) form a rigid electrostatic cation-anion crystal lattice, which undergoes an interesting dynamic structural reconstruction through guest adsorption-desorption processes with H2O, pyrrole (Pyrr), pyrazine (Pyz), thiophene (TP), pyridine (Py), 1,4-dioxane (Diox), or aniline (Ani). The host lattice of bis(guanidinium)benzene-1,4-disulfonate, (G(+))(2)(BDS2-), which does not contain void spaces initially, changed to host-guest crystals of (G(+))(2)(BDS2-)center dot(guest)(x) upon guest adsorption (x = 1, 2, and 3). The cation-anion electrostatic N-H+MIDLINE HORIZONTAL ELLIPSIS-O3S- hydrogen bonds between the G(+) cation and BDS2- dianion formed tightly bound two-dimensional (2D) structures. These layers are connected by perpendicular BDS2- dianions, forming the guest adsorption crystalline pores. The adsorption-desorption isotherm for Diox at 298 K indicated the formation of (G(+))(2)(BDS2-)center dot(Diox)(3), which was consistent with the single-crystal X-ray structural analysis. Single crystals of (G(+))(2)(BDS2-)center dot(Py-H2O)(2) consist of two hydrogen-bonded [(G(+))(2)(BDS2-)](2) bilayers connected by the BDS2- dianions, forming crystalline pores that accommodate 2 Py guest molecules. The H2O molecules in (G(+))(2)(BDS2-)center dot(Py-H2O)(2) are lodged in the intralayer, leading to the [(G(+))(2)(BDS2-)MIDLINE HORIZONTAL ELLIPSIS(H2O)(2)MIDLINE HORIZONTAL ELLIPSIS(G(+))(2)(BDS2-)] hydrogen-bonded bilayer. The electrostatic cation-anion host lattice of (G(+))(2)(BDS2-) responded to the guest adsorption-desorption cycle by a dynamic structural reconstruction. A guest adsorption of polar Ani into (G(+))(2)(BDS2-) host changed the crystal symmetry from centric P1 to acentric P2(1) of (G(+))(2)(BDS2-)center dot(Ani)(3).

If you are hungry for even more, make sure to check my other article about 33332-25-1, Category: Pyrazines.

Synthetic Route of 89-01-0, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 89-01-0, Name is Pyrazine-2,3-dicarboxylic acid, SMILES is O=C(C1=NC=CN=C1C(O)=O)O, belongs to Pyrazines compound. In a article, author is Guo, Huanxin, introduce new discover of the category.

A Coplanar pi-Extended Quinoxaline Based Hole-Transporting Material Enabling over 21 % Efficiency for Dopant-Free Perovskite Solar Cells

Developing dopant-free hole transporting materials (HTMs) is of vital importance for addressing the notorious stability issue of perovskite solar cells (PSCs). However, efficient dopant-free HTMs are scarce. Herein, we improve the performance of dopant-free HTMs featuring with a quinoxaline core via rational pi-extension. Upon incorporating rotatable or chemically fixed thienyl substitutes on the pyrazine ring, the resulting molecular HTMs TQ3 and TQ4 show completely different molecular arrangement as well as charge transporting capabilities. Comparing with TQ3, the coplanar pi-extended quinoxaline based TQ4 endows enriched intermolecular interactions and stronger pi-pi stacking, thus achieving a higher hole mobility of 2.08×10(-4) cm(2) V-1 s(-1). It also shows matched energy levels and high thermal stability for application in PSCs. Planar n-i-p structured PSCs employing dopant-free TQ4 as HTM exhibits power conversion efficiency (PCE) over 21 % with excellent long-term stability.

Synthetic Route of 89-01-0, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 89-01-0 is helpful to your research.

Electric Literature of 19847-12-2, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 19847-12-2, Name is Pyrazinecarbonitrile, SMILES is N#CC1=NC=CN=C1, belongs to Pyrazines compound. In a article, author is Ambrozkiewicz, Weronika, introduce new discover of the category.

5-Alkylamino-N-phenylpyrazine-2-carboxamides: Design, Preparation, and Antimycobacterial Evaluation

According to the World Health Organization, tuberculosis is still in the top ten causes of death from a single infectious agent, killing more than 1.7 million people worldwide each year. The rising resistance developed by Mycobacterium tuberculosis against currently used antituberculars is an imperative to develop new compounds with potential antimycobacterial activity. As a part of our continuous research on structural derivatives of the first-line antitubercular pyrazinamide, we have designed, prepared, and assessed the in vitro whole cell growth inhibition activity of forty-two novel 5-alkylamino-N-phenylpyrazine-2-carboxamides with various length of the alkylamino chain (propylamino to octylamino) and various simple substituents on the benzene ring. Final compounds were tested against Mycobacterium tuberculosis H37Ra and four other mycobacterial strains (M. aurum, M. smegmatis, M. kansasii, M. avium) in a modified Microplate Alamar Blue Assay. We identified several candidate molecules with micromolar MIC against M. tuberculosis H37Ra and low in vitro cytotoxicity in HepG2 cell line, for example, N-(4-hydroxyphenyl)-5-(pentylamino)pyrazine-2-carboxamide (3c, MIC = 3.91 mu g/mL or 13.02 mu M, SI > 38) and 5-(heptylamino)-N-(p-tolyl)pyrazine-2-carboxamide (4e, MIC = 0.78 mu g/mL or 2.39 mu M, SI > 20). In a complementary screening, we evaluated the in vitro activity against bacterial and fungal strains of clinical importance. We observed no antibacterial activity and sporadic antifungal activity against the Candida genus.

Electric Literature of 19847-12-2, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 19847-12-2.

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 89-01-0, Name is Pyrazine-2,3-dicarboxylic acid, SMILES is O=C(C1=NC=CN=C1C(O)=O)O, in an article , author is Meena, Himani, once mentioned of 89-01-0, HPLC of Formula: C6H4N2O4.

Phomopsis tersa as Inhibitor of Quorum Sensing System and Biofilm Forming Ability of Pseudomonas aeruginosa

Endophytic fungi provide rich reservoir for novel antimicrobial compounds. An endophytic fungus, from Carica papaya plant identified as Phomopsis tersa, was investigated for attenuating the quorum sensing mediated pathogenicity of Pseudomonas aeruginosa PAO1. Crude extract of P. tersa was found to reduce the production of redox-active pigments-pyocyanin and pyoverdine in P. aeruginosa PAO1 by 92.46% and 71.55%, respectively at sub-MIC concentration of 900 mu g/mL. In addition, the crude extract was also able to inhibit the expression of virulence factors involved in biofilm formation: exopolysaccharide (72.21%) and alginate (72.50%). Secretion of cell-lytic enzymes was also found to be reduced: chitinase by 79.73% and elastase by 74.30%. 3-Isobutylhexahydropyrrolo[1,2-a]pyrazine-1,4-dione identified from GC-MS analysis, displayed favorable molecular interactions with P. aeruginosa transcriptional regulators, LasR and RhlR with good docking scores of – 6.873 kJ/mol and – 6.257 kJ/mol, respectively. The study thus reveals the potential use of P. tersa for discovering drugs against infectious pathogens.

Interested yet? Read on for other articles about 89-01-0, you can contact me at any time and look forward to more communication. HPLC of Formula: C6H4N2O4.

Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, Computed Properties of C4H3ClN214508-49-7, Name is 2-Chloropyrazine, SMILES is ClC1=CN=CC=N1, belongs to Pyrazines compound. In a article, author is Sun, Weipeng, introduce new discover of the category.

Terpolymer acceptors based on bithiophene imide for all-polymer solar cells

In order to improve light absorption and promote n-type performance, random copolymerization strategy was employed to afford a series of random terpolymer acceptors with acceptor1-acceptor2-acceptor3 (A(1)-A(2)-A(3)) type backbone. The polymers were synthesized from distannylated electron-deficient bithiophene imide monomer with various electron-deficient dibrominated co-monomers using the typical palladium-catalyzed Stille coupling condensation polymerization. Compared with their parent polymers, these A(1)-A(2)-A(3) type terpolymer acceptors, particularly the dihexylthieno[3,4-b]pyrazine based terpolymer PBTP, can exhibit good miscibility, appropriate polymer crystallinity, and improved absorption in the long-wavelength region due to the incorporation of a third strong electron-withdrawing acceptor moiety thieno[3,4-b]pyrazine. Benefitting from the noncovalent S center dot center dot center dot N interactions, PBTP possessed a planar skeleton and achieved the highest power conversion efficiency (PCE) of 7.35% in the polymer series when serving as the acceptor material in all-polymer solar cells. These results indicate that the A(1)-A(2)-A(3) type terpolymer acceptors should be promising candidates for developing high-performance all-polymer solar cells.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 14508-49-7. Computed Properties of C4H3ClN2.

Synthetic Route of 14508-49-7, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 14508-49-7, Name is 2-Chloropyrazine, SMILES is ClC1=CN=CC=N1, belongs to Pyrazines compound. In a article, author is Zaki, Remon M., introduce new discover of the category.

A convenient synthesis, reactions and biological evaluation of novel pyrazolo[3,4-b]selenolo[3,2-e]pyrazine heterocycles as potential anticancer and antimicrobial agents

A novel series of 5-amino-6-substituted-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]selenolo[3,2-e]pyrazines (3a-e) was synthesized by the reaction of the chloro pyrazolo[3,4-b]pyrazine carbonitrile1with selenium element in the presence of sodium borohydride and ethanol, followed by the reaction with alpha-halo alkylating agents to produce the selanyl-alkylated derivatives2a-e. The latter compounds underwentThorpe-Zieglercyclization upon heating with ethanolic sodium ethoxide solution to afford the target selenolopyrazolopyrazine compounds. The 5-amino-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]selenolo[3,2-e]pyrazine-6-carboxamide (3b) was used as a versatile precursor for synthesis of new heterocyclic fused to the pyrazoloselenolopyrazine moiety namely: pyrimidine and imidazopyrimidine. Assignment of the chemical structures for the newly synthesized compounds was confirmed on the bases of elemental and spectral techniques including FT-IR,H-1 NMR,C-13 NMR, and mass spectra. Furthermore, certain compounds were screened for their antimicrobial activity which revealed remarkable activities against various pathogenic strains of bacteria and fungi. Alternatively, some of these compounds exhibited promising anticancer action against some colon and breast cancer cells.

Synthetic Route of 14508-49-7, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 14508-49-7 is helpful to your research.

Reference of 123-32-0, Redox catalysis has been broadly utilized in electrochemical synthesis due to its kinetic advantages over direct electrolysis. The appropriate choice of redox mediator can avoid electrode passivation and overpotential. 123-32-0, Name is 2,5-Dimethylpyrazine, SMILES is C1=NC(=CN=C1C)C, belongs to Pyrazines compound. In a article, author is Benz, Joerg, introduce new discover of the category.

Novel beta-Glucocerebrosidase Activators That Bind to a New Pocket at a Dimer Interface and Induce Dimerization

Genetic, preclinical and clinical data link Parkinson’s disease and Gaucher’s disease and provide a rational entry point to disease modification therapy via enhancement of beta-Glucocerebrosidase (GCase) activity. We discovered a new class of pyrrolo[2,3-b]pyrazine activators effecting both Vmax and Km. They bind to human GCase and increase substrate metabolism in the lysosome in a cellular assay. We obtained the first crystal structure for an activator and identified a novel non-inhibitory binding mode at the interface of a dimer, rationalizing the observed structure-activity relationship (SAR). The compound binds GCase inducing formation of a dimeric state at both endoplasmic reticulum (ER) and lysosomal pHs, as confirmed by analytical ultracentrifugation. Importantly, the pyrrolo[2,3-b]pyrazines have central nervous system (CNS) drug-like properties. Our findings are important for future drug discovery efforts in the field of GCase activation and provide a deeper mechanistic understanding of the requirements for enzymatic activation, pointing to the relevance of dimerization.

Reference of 123-32-0, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 123-32-0 is helpful to your research.

Related Products of 89-01-0, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 89-01-0, Name is Pyrazine-2,3-dicarboxylic acid, SMILES is O=C(C1=NC=CN=C1C(O)=O)O, belongs to Pyrazines compound. In a article, author is Ulusoy, Inga S., introduce new discover of the category.

Many-photon excitation of organic molecules in a cavity-Superradiance as a measure of coherence

Coherent excitation of a molecular ensemble coupled to a common radiation mode can lead to the collective emission of radiation known as superradiance. This collective emission only occurs if there is an entanglement between the molecules in their ground and excited state and can, therefore, serve as a macroscopic measure of coherence in the ensemble. Reported here are wave packet propagations for various pyrazine models of increasing complexity and molecular ensembles thereof. We show that ensemble coherence upon photoexcitation can prevail up to relatively long time scales although the effect can diminish quickly with increasing ensemble size. Coherence can also build up over time and even reemerge after the molecules have passed through a conical intersection. The effect of the pump pulse characteristics on the collective response of the molecular ensemble is also studied. A broadband pulse imprints a large amount of initial coherence to the system, as compared to a longer pulse with a smaller spread in the frequency domain. However, the differential effects arising from a different pulse duration and coherent bandwidth become less prominent if the emission of light from the ensemble takes place after a non-adiabatic decay process.

Related Products of 89-01-0, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 89-01-0 is helpful to your research.

Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 123-32-0, Name is 2,5-Dimethylpyrazine, molecular formula is , belongs to Pyrazines compound. In a document, author is Chen, Jin-Ming, Quality Control of 2,5-Dimethylpyrazine.

A Domino Fusion of an Organic Ligand Depended on Metal-Induced and Oxygen Insertion, Unraveled by Crystallography, Mass Spectrometry, and DFT Calculations

Herein, the reaction of (1-methyl-1 H-benzo[d]imidazol-2-yl)methanamine (L1) with Co(H2O)(6)Cl-2, in CH3CN at 120 degrees C, leading to the 2,3,5,6-tetrakis(1-methyl-1 H-benzo[d]imidazol-2-yl)pyrazine (3), isolated as a dimeric cluster {[Co-2(II)(3)Cl-4].2 CH3CN} (2), is reported. When O-2 and H2O are present, (1-methyl-1 H-benzo[d]imidazole-2-carbonyl)amide (HL1 ‘) is first formed and crystallized as [Co-III(L1)(2)(L1 ‘)]Cl-2.2 H2O (4) before fusion of HL1 ‘ with L1, giving 1-methyl-N-(1-methyl-1 H-benzo[d]imidazol-2-carbonyl)-1 H-benzo[d]imidazol-2-carboxamide (HL2 ”) forming a one-dimensional (1D) chain of [Co-3(II)(L2 ”)(2)Cl-4](n) (5). The combination of crystallography and mass spectrometry (ESI-MS) of isolated crystals and the solutions taken from the reaction as a function time reveal seven intermediate steps leading to 2, but six steps for 5, for which a different sequence takes place. Control and isotope labeling experiments confirm the two carbonyl oxygen atoms in 5 originate from both air and water. The dependence on the metals, compared with FeCl3.6 H2O leading to a stable triheteroarylmethyl radical, is quite astounding, which could be attributed to the different oxidation states of the metals and coordination modes confirmed by DFT calculations. This metal and valence dependent process is a very useful way for selectively obtaining these large molecules, which are unachievable by common organic synthesis.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 123-32-0, in my other articles. Quality Control of 2,5-Dimethylpyrazine.