Tag: M.W=100-200

Electric Literature of 63744-29-6, The chemical industry reduces the impact on the environment during synthesis 63744-29-6, name is 5-Bromo-[1,2,4]triazolo[4,3-a]pyrazine, I believe this compound will play a more active role in future production and life.

Step 1: (3S,4 ?)-tert-butyl 4-(([l,2,4]triazolo[4 -a]pyrazin-5-ylamino)methyl)-3-fluoropiperidine- 1-carboxylate [0185] A mixture of 5-bromo-[l,2,4]triazolo[4,3-a]pyrazine (102 mg, 0.51 mmol), (3S,4R)-tert-butyl 4- (aminomethyl)-3-fluoropiperidine-l-carboxylate (80 mg , 0.34 mmol) and DIPEA (1.2 mL, 1.0 mmol) in ethylene glycol (2 mL) was heated to 110 C in the sealed tube for 7 hr under N2 atmosphere. The mixture was allowed to cool to rt and concentrated. The concentrate was partitioned into DCM and water. The organic phase was washed with water, brine, dried over Na2S04 and concentrated. The concentrate was purified by column chromatography over silica gel (MeOH/DCM=50/l) to afford the title compound as an off-white powder (60 mg, 50%). MS (ESI) calcd for C16H23FN602: 350.2; found: 351.3[M+H]. 1H NMR (400 MHz, CDCI3) delta 8.72 (s, 1H), 7.41 (d, J = 4.8 Hz, 1H), 7.34 (d, J = 4.8 Hz, 1H), 6.55-6.47 (m, 1H), 4.90-4.65 (m, 1H), 4.62-4.35 (m, 1H), 4.33-4.05 (m , 1H), 3.74-3.64 (m, 2H), 2.96-2.62 (m, 2H), 2.24 -2.04 (m, 1H), 1.73-1.58 (m, 1H), 1.46 (s, 9H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Bromo-[1,2,4]triazolo[4,3-a]pyrazine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; RUGEN HOLDINGS (CAYMAN) LIMITED; SHAPIRO, Gideon; (239 pag.)WO2016/100349; (2016); A2;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

912773-21-8, name is 2-Bromo-5-chloropyrazine, belongs to Pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. COA of Formula: C4H2BrClN2

A mixture of 2-bromo-5-chloro-pyrazine (800 mg, 4.14 mmol), 3-fluoro-5-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-yl)-2-[l- (trifluoromethyl)cyclobutoxy]pyridine (1642.99 mg, 4.55 mmol), CS2CO3(4042.64 mg,12.41 mmol), Pd(dppf)Cl2(60.52 mg, 0.08 mmol) in l,4-dioxane (12 mL) and H2O (4 mL) was stirred at 50 C for 8 hours. After cooling to room temperature, the reaction mixture was concentrated to remove solvent, diluted with water (20 mL), and extracted with EtOAc (20 mL x 2). The combined organic phase was washed with brine (40 mL), dried over Na2S04and concentrated to give a crude product. The crude product was purified by flash chromatography on silica gel (EtOAc in PE = 0% to 10%) to give the product as a solid, which was confirmed by LCMS Rt= 1.01 min in 1.5 min chromatography, MS ESI calcd. for C14H11CIF4N3O [M+H]+348.1, found 347.9.

The synthetic route of 912773-21-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PRAXIS PRECISION MEDICINES, INC.; GRIFFIN, Andrew, Mark; MARRON, Brian, Edward; MARTINEZ BOTELLA, Gabriel; REDDY, Kiran; WITTMANN, Marion; (0 pag.)WO2019/232209; (2019); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Electric Literature of 153800-11-4,Some common heterocyclic compound, 153800-11-4, name is 2-Ethynylpyrazine, molecular formula is C6H4N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of 227(100mg, 0.3O6mrnoI) and 10(63.7mg, 0.61 immol) in 2OmL of Et3N was added Pd(PPh3)2C12 (10.73mg, 0.OiSmrnoi) and CuT (5.82mg, 0.03 immol). The mixture was protected with N2 atmosphere, then was heated at 70C for 24 hours. TLC analysis showed complete conversion of starting material to a major product. The reaction mixture was then concentrated in vacuo. The crude product was purified by Prep-IPLC to give the target productCompound 103(18mg, yield: 1941 %).LCMS: m/z 304 (M+H)NMR (400 MHz, CDCI3): 5 8.668.65 (m, 3H), 7.67 (s, 1H), 7.60-7.57 (m, IH), 7.43.-7.40 (m, 1H), 6.55 (s, 11:1), 2.47 (s, 31:1).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Ethynylpyrazine, its application will become more common.

Reference:
Patent; HUA MEDICINE (SHANGHAI) LTD.; CHEN, Li; JIN, Xiaowei; (176 pag.)WO2017/117708; (2017); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Adding a certain compound to certain chemical reactions, such as: 4774-14-5, name is 2,6-Dichloropyrazine, belongs to Pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 4774-14-5, category: Pyrazines

General procedure: To the solution of a corresponding amine (1.8 mmol) in DMF (5 mL) was added K2CO3 (2.0 mmol). The reaction mixture was stirred at room temperature for 30 min. After the addition of 2,6-dichloropyrazine (1.3 mmol) the reaction mixture was further stirred at room temperature for 15 h. After removal of solvent under reduced pressure, the precipitates formed by a treatment of residue with DCM:methanol (95:5) mixture was filtered off. Het-Cl was obtained by the removal of solvent in vaccuo and used for next reaction without further purification.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2,6-Dichloropyrazine, other downstream synthetic routes, hurry up and to see.

Reference:
Article; More, Kunal N.; Hong, Victor S.; Lee, Ahyeon; Park, Jongsung; Kim, Shin; Lee, Jinho; Bioorganic and Medicinal Chemistry Letters; vol. 28; 14; (2018); p. 2513 – 2517;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Related Products of 122-05-4,Some common heterocyclic compound, 122-05-4, name is Pyrazine-2,5-dicarboxylic acid, molecular formula is C6H4N2O4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

270 mg (1 mmol) of FeCl3.6H2O (Alfa Aesar, 98%) and 204 mg (1 mmol) of 2,5-pyrazinedicarboxylic acid (Aldrich, 98%) are dispersed in 5 ml of DMF (Fluka, 98%) with 0.05 ml of 5M HF (SDS, 50%). The mixture is left in a 23 ml Teflon vessel inserted into a metallic PAAR type bomb for 3 days at 100 C. The solid is recovered by filtration.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Pyrazine-2,5-dicarboxylic acid, its application will become more common.

Reference:
Patent; Universite De Caen-Basse Normandie; Centre National De La Recherche Scientifique- CNRS-; US2011/172412; (2011); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Application of 74290-67-8,Some common heterocyclic compound, 74290-67-8, name is 2-Amino-5-bromo-3-methylpyrazine, molecular formula is C5H6BrN3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a suspension of 5-bromo-3-methylpyrazin-2-amine (4.63g, 24.6 mmol) in iPrOH (30 ml) was added l-bromo-2,2-dimethoxypropane (3.66 ml, 27.1 mmol), pyridinium para-toluene sulfonic acid (0.62g, 2.5 mmol) and the mixture heated to 65C in a sealed tube for 36h. The reaction was diluted with DCM, washed with saturated sodium hydrogen carbonate solution, dried (Na2S04) and concentrated. Purification by flash column chromatography on silica gel (EtOAc: Hept 1:4-1: 1) afforded the titled product as a light yellow crystalline solid (3.96 g, 71%). MS (m/e): 226.1 (M+H+, Br)

The synthetic route of 74290-67-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; GREEN, Luke; PINARD, Emmanuel; RATNI, Hasane; WILLIAMSON, Patrick; (95 pag.)WO2015/197503; (2015); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

In an article, author is Chen, Qi, once mentioned the application of 20737-42-2, HPLC of Formula: C5H4N2O3, Name is 3-Oxo-3,4-dihydropyrazine-2-carboxylic acid, molecular formula is C5H4N2O3, molecular weight is 140.0969, MDL number is MFCD00235136, category is Pyrazines. Now introduce a scientific discovery about this category.

The protective effects of liguzinediol on congestive heart failure induced by myocardial infarction and its relative mechanism

Background: Heart failure (HF) is one of the most common causes of cardiovascular diseases in the world. Currently, the drugs used to treat HF in the clinic may cause serious side effects. Liguzinediol, 2, 5-dimethyl-3, 6-dimethyl-pyrazine, is a compound synthesized after the structural modification of ligustrazine (one active ingredient ofSzechwan Lovage Rhizome). We aimed to observe the effects of liguzinediol on preventing HF and explore the related mechanisms. Methods: The ligation of left anterior descending coronary artery was operated to established the myocardial infarction (MI) model in Sprague-Dawley rats. Cardiac functions were recorded by echocardiography and hemodynamics. The changes in the Renin-Angiotensin-Aldosterone System (RAAS), inflammation, and oxidative stress were detected by radioimmunoassay and Elisa kits. Western blot and real-time PCR were applied to determine the expressions of the TGF-beta 1/Smads pathway. Results: Firstly, liguzinediol enhanced the systolic and diastolic functions of the heart in MI rats. Liguzinediol improved ventricular remodeling by reducing myocardial cell necrosis, as well as reducing collagen deposition and myocardial fibrosis. Then, liguzinediol suppressed the activation of RAAS, inhibited the synthesis of pro-inflammation factors, and reduced oxidative stress. In the end, liguzinediol also down-regulated the expressions of the TGF-beta 1/Smads pathway. Conclusions: Liguzinediol could alleviate HF caused by MI in rats, and the protective effect was associated with the regulation of the TGF-beta 1/Smads pathway.

If you are interested in 20737-42-2, you can contact me at any time and look forward to more communication. HPLC of Formula: C5H4N2O3.

Chemistry, like all the natural sciences, COA of Formula: C6H4N2O4, begins with the direct observation of nature¡ª in this case, of matter.89-01-0, Name is Pyrazine-2,3-dicarboxylic acid, SMILES is O=C(C1=NC=CN=C1C(O)=O)O, belongs to Pyrazines compound. In a document, author is Pakyapan, Bilge, introduce the new discover.

Synthesis and catalytic applications of Ru and Ir complexes containing N,O-chelating ligand

A series of monometallic complexes (Ru1-3, Ir-1(-3)) which have N,O-chelating ligand (pyrazine-2carboxylate (1), pyridine-2-carboxylate (2), quinoline carboxylate(3) and bimetallic complexes (Ru-4,Ru-5, Ir-4(,5)) bridged by pyrazine-2,3- dicarboxylate (4) and imidazole-4,5-dicarboxylate(5) were synthesized and characterized by H-1-, C-13 NMR, FT-IR, and elemental analysis. The crystal structure of Ir-2 was determined by X-ray crystallography. The complexes (Ru1-5, Ir1-5) were applied to investigate the electronic and steric effect of ligand in their catalytic activities in transfer hydrogenation and alpha(alpha)-alkylation reaction of ketones with alcohols. The activities of iridium complexes (Ir1-5) were much more efficient than ruthenium complexes (Ru1-5). The highest activity for both reactions was observed for the complex (Ir2 ) with pyridine-2-carboxylate. The Ir hydride species was monitored for both reactions. (C) 2020 Elsevier B.V. All rights reserved.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 89-01-0. COA of Formula: C6H4N2O4.

Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 123-32-0, Name is 2,5-Dimethylpyrazine, SMILES is C1=NC(=CN=C1C)C, in an article , author is Wang, Dan, once mentioned of 123-32-0, Safety of 2,5-Dimethylpyrazine.

The 3D POMOFs based two As-III-capped Keggin arsenomolybdates with four V-IV substituted: Synthesis, structures and properties

A novel 3D POMOFs based As-III-capped Keggin arsenomolybdate with four V-IV substituted, [(As2AsMO8V4O40)-As-III-M-V-V-VI-O-IV](2)[(CuCu2II)-Cu-I(pz)(4)](2)center dot 9H(2)O (1) (pz = pyrazine) was prepared by hydrothermal method and characterized by elemental analysis, IR, TG, XPS, BET, Raman, optical band gap and XRD. Compound 1 represents the first polyoxometalate metal organic frameworks (POMOFs) based [(As2AsMO8V4O40)-As-III-M-V-V-VI-O-IV](5-) polyoxoanion and {Cu-pz} complex, which forms a 3D topological network with the Schlafli symbol of {5.6.8}{5(2).6.7.8(2)}{5(2).7(2).8(2)}{6.7.8}. Compound 1 displays excellent photocatalytic activity and stability for degradation methylene blue (MB), rhodamine-B (RhB), methyl orange (MO), and Azophloxine (AP) under UV light. The photodegradation reaction kinetic and mechanism of 1 were explored. In addition, the luminescence property of 1 was also investigated.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 123-32-0, you can contact me at any time and look forward to more communication. Safety of 2,5-Dimethylpyrazine.

Application of 89-01-0, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 89-01-0, Name is Pyrazine-2,3-dicarboxylic acid, SMILES is O=C(C1=NC=CN=C1C(O)=O)O, belongs to Pyrazines compound. In a article, author is Contreras-Torres, Flavio F., introduce new discover of the category.

Dispersion-Corrected Density Functional Theory Study of the Noncovalent Complexes Formed with Imidazo[1,2-a]pyrazines Adsorbed onto Silver Clusters

Imidazo[1,2-a]pyrazines are cyclic amidine type compounds composed of alpha-amino acid residues. A full structural identification of these molecules constitutes an analytical challenge, especially when imidazo, [1, 2-a] pyrazines are obtained from physical processes (e.g., sublimation and pyrolysis of amino acids). A valuable source of molecular inforination can be obtained from absorption spectroscopies and related techniques encoinpassing the use of metallic substrates. The aim of this study is to provide new knowledge and insights into the noncovalent intermolecular interactions between imidazo[1,2-a]pyrazines and two Ag-n (n = 4 and 20) clusters using density functional theory (DFT) methods. Semiempirical DFT dispersion (DFT-D) corrections were addressed using Grimme’s dispersion (GD2) and Austin- Petersson Frisch (APF) functionals in conjunction with the 6-31+G(d,p) + LANL2DZ mixed basis set. These DFT-D methods describe strong interactions; besides, in all cases, the APF dispersion (APF-D) energies of interaction appear to be consistently overestimated. In comparison with B3LYP calculations, the mean values for the difference in the energies of interaction calculated are 2.25 (GD2) and 6.24 (APF-D) kcal mol(-1) for Ag-4(-) molecules, and 2.30 (GD2) land 8.53 (APF-D) kcal mol(-1) for Ag-20-molecules. The effect of applying GD2 and APF-D corrections to the noncovalent complexes is nuanced in the intermolecular distances calculated, mainly in the Ag center dot center dot center dot N(amidine) bonding, which appears to play the most important role for the adsorptive process. Selective enhancement and considerable red shifts for Raman vibrations suggest strong interactions, whereas a charge redistribution involving the metallic substrate and the absorbate leads to a significant rearrangement of frontier molecular orbitals mainly in the Ag-20-molecule complexes. Finally, time-dependent DFT calculations were carried out to access the orbital contributions to each of the transitions observed in the absorption spectrum. The corresponding UV-vis spectra involve transitions in the visible region at around 400 and 550 nm for the Ag-4-molecule and the Ag-20-molecule complexes, respectively.

Application of 89-01-0, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 89-01-0 is helpful to your research.