Tag: M.W=100-200

Related Products of 27825-21-4, The chemical industry reduces the impact on the environment during synthesis 27825-21-4, name is Methyl 3-chloropyrazine-2-carboxylate, I believe this compound will play a more active role in future production and life.

To asolution of the product from step 1 (100 mg, 0.58 mmol) in toluene (2 mL)was added Pd(PPh3)4 (134 mg, 0.12 mmol) and 2-(tributylstannyl)pyridine (213 mg, 0.58 mmol) at room temperature and the resulting mixture heated to 100C overnight. After cooling to RT, the mixture was filtered and 5mL of aq. KF solution was added to the filtrate. The resulting mixture was stirred for 30 mins and extracted with EtOAc (5 mL x 3). The combined organic layers were washed with brine, dried over Na2S04, filtered and concentrated in vacuo. The residue was purified by chromatography (30% EtOAc in petroleum ether) to provide the title compound as an oil. LRMS m/z (M+H) 216.1 found, 216.1 required.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 3-chloropyrazine-2-carboxylate, other downstream synthetic routes, hurry up and to see.

Related Products of 36070-80-1,Some common heterocyclic compound, 36070-80-1, name is 5-Chloropyrazine-2-carboxylic acid, molecular formula is C5H3ClN2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Oxalyl chloride (1.55 mL, 17.48 mmol), followed by DMF (2 drops), was added to a mixture of 5-chloropyrazine-2-carboxylic acid (2.31 g, 14.57 mmol) in DCM (40 mL). The reaction was stirred at RT for 2 hours after which time the volatiles were removed in vacuo. The residue was taken up DCM (40 mL) and azetidine (1.08 mL, 16.03 mmol) and triethylamine (4.46 mL, 32.06 mmol) added. The mixture was stirred at RT for 72 hours. The volatiles were removed in vacuo and ethyl acetate (100 mL) added to the residue. The organics were washed with water (100 mL), citric acid (50 mL), saturated sodium bicarbonate solution (50 mL), brine (50 mL), dried (MgSO4), filtered and the solvent removed in vacuo to give a yellow solid. The residue was chromatographed on silica, eluting with a gradient of 50 -100% ethyl acetate in iso-hexane, to give the desired compound as a yellow solid (2.38 g). 1H NMR delta (CDCl3): 2.35 – 2.42 (2H, m), 4.26 (2H, t), 4.67 (2H, t), 8.52 (IH, d), 9.09 (IH, d); m/z 198 (M+H)+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Chloropyrazine-2-carboxylic acid, its application will become more common.

These common heterocyclic compound, 939412-86-9, name is (3-Chloropyrazin-2-yl)methanamine hydrochloride, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C5H7Cl2N3

To a solution of trans-2-methyl-l -oxooctahydro- 1 H-pyrido [1, 2-c]pyrimidine-7- carboxylic acid (1.6 mmol) in DCM (20 mL) was added (3-chloropyrazin-2-yl) methanamine hydrochloride (356 mg, 2.0 mmol), EDC (477 mg, 2.5 mmol), HOBT (336 mg, 2.5 mmol) and TEA (670 mg, 6.6 mmol), and the resulting mixture was stirred at 50 C overnight. The volatiles were evaporated and the residue was purified by column chromatography on silica gel eluted with DCM/THF = 3/1 to give trans-N-((3- chloropyrazin-2-yl)methyl)-2 -methyl- 1 -oxooctahydro- 1 H- pyrido [ 1 ,2-c]pyramidine-7- carboxamide (90 mg, four steps: 17%).1H NMR (CDC13, 400 MHz) delta 1.24 – 1.34 (m, 1 H), 1.67 – 1.76 (m, 3 H), 1.92 – 2.08 (m, 3 H), 2.29 – 2.38 (m, 1 H), 2.64 (t, / = 12.0 Hz, 1 H), 2.87 (s, 3 H), 3.12 – 3.21 (m, 3 H), 4.59 – 4.69 (m, 3 H), 6.89 – 7.01 (m, 1 H), 8.24 (d, / = 4.0 Hz, 1 H), 8.37 (d, / = 4.0 Hz, 1 H).

The synthetic route of (3-Chloropyrazin-2-yl)methanamine hydrochloride has been constantly updated, and we look forward to future research findings.

Application of 912773-21-8, A common heterocyclic compound, 912773-21-8, name is 2-Bromo-5-chloropyrazine, molecular formula is C4H2BrClN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a suspension of 2-bromo-5-chloropyrazine (2.02 g, 10.44 mmol) in diethylether (30 mL)at -78 oC was added n-butyllithium (4.26 mL, 10.65 mmol) over 10 mm.The resulting mixture was stirred at -78 oC for 15 mm before propan-2-one (1.9 17 mL, 26.1 mmol) was indroduced over 2 mm. The mixture was stirred at -78 oC for 15 mm and then at rt for 30 mm. The reaction was quenched with saturated NH4C1 solution (30 mL), and the solution was extracted with ethyl acetate (4 x 40 mL). The combined extract wasdried over anhydrous Na2SO4. The desired product, 2-(5-chloropyrazin-2-yl)propan-2-ol (0.507 g, 2.94 mmol, 28.1 % yield), was isolated by ISCO (120 g silica gel, solid loading, 10-40% ethyl acetate/hexane).

The synthetic route of 912773-21-8 has been constantly updated, and we look forward to future research findings.

Electric Literature of 19847-12-2,Some common heterocyclic compound, 19847-12-2, name is Pyrazinecarbonitrile, molecular formula is C5H3N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

5-Methyl-2-pyrazin-2-yl-thiazol-4-ol: In a 250 mL round-bottomed flask, pyrazine-2-carbonitrile (10 g, 95.1 mmol), pyridine (2.26 g, 2.33 ml, 28.5 mmol) and 2-mercaptopropionic acid (10.1 g, 95.1 mmol) were combined to give a light yellow solution. The reaction mixture was heated to 100 C. and stirred for 2 h. Upon cooling, the thick yellow mixture was diluted with 100 mL ethanol and stirred for 30 min. The slurry was then filtered, and washed with diethyl ether (2*100 mL) to give 5-methyl-2-pyrazin-2-yl-thiazol-4-ol (17.86 g, 97.1%) as yellow solid which was used directly without further purification.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Pyrazinecarbonitrile, its application will become more common.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 4774-14-5, name is 2,6-Dichloropyrazine, A new synthetic method of this compound is introduced below., HPLC of Formula: C4H2Cl2N2

Step 1 (0853) To a solution of tert-butyl azetidin-3-ylcarbamate hydrochloride (LXIII) (2 g, 9.58 mmol) in dry DMF (19.2 mL) was added DIPEA (8.37 ml, 47.9 mmol). To this mixture was added 2,6-dichloropyrazine (LXIV) (1.428 g, 9.58 mmol) and the reaction was stirred at 95 C. for 3 hours. The reaction was quenched with water (20 mL) and extracted with EtOAc. The organic layer was dried over anhydrous Na2SO4, filtered and concentrated. The residue was purified by silica gel column chromatography (40 g) (100% hexanes?hexanes:EtOAc 1:1) to yield tert-butyl (1-(6-chloropyrazin-2-yl)azetidin-3-yl)carbamate (LXV) (2.2882 g, 8.04 mmol, 84% yield) as a white solid. ESIMS found for C12H17ClN4O2 m/z 285.1 (M+H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Synthetic Route of 14667-55-1, A common heterocyclic compound, 14667-55-1, name is 2,3,5-Trimethylpyrazine, molecular formula is C7H10N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

AgNO3 (34.2 mg, 0.2 mmol), tpyz (38 ml, 0.2 mmol) and H2L(313.6 mg, 0.2 mmol) were took place in CH3CN-DMF (N,Ndimethylformamide)mixed solvent (6 ml, v/v: 3/3) under stirring.Then, ammonia (14 M, 10 d) was dropped into the mixture to give aclear solution under ultrasonic treatment (160 W, 40 KHz, 30 min) atroom temperature. The resultant solution was allowed to evaporateslowly in darkness at room temperature for several days to giveirregular-yellow crystals of 1 (Yield: 32%, based on Ag). Anal. Calc.(found) for Ag2C17H23N2O4: C, 38.10 (38.16); H, 4.50 (4.33); O,11.86 (11.96); N, 5.32 (5.24) %. IR (KBr): nu(cm -1) = 3425 (s), 2977(m), 2887 (w), 2175 (w), 1653 (m), 1545 (s), 1463 (m), 1392 (s),1363 (s), 1322 (m), 1288 (m), 1207(w), 1170 (w), 1126 (w), 1085(w), 997 (w), 919 (w), 804 (m), 628 (s).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 74290-67-8, name is 2-Amino-5-bromo-3-methylpyrazine, A new synthetic method of this compound is introduced below., SDS of cas: 74290-67-8

Example 31 N-(3-((5-amino-6-methylpyrazin-2-yl)ethynyl)-2,4-difluorophenyl)-5-chloro-2-methylbenzenesulfonamide A mixture of 5-chloro-N-(3-ethynyl-2,4-difluorophenyl)-2-methylbenzenesulfonamide (100 mg), 5-bromo-3-methylpyrazin-2-amine (55 mg), dichlorobis(tricyclohexylphosphine)palladium(II) (14 mg), cesium carbonate (381 mg) and DMSO (2 mL) was stirred under microwave irradiation at 120 C. for 2 hr. After cooling to room temperature, the reaction mixture was filtered through celite, and the filtrate was diluted with water and extracted with ethyl acetate. The obtained organic layer was washed with saturated brine, dried over magnesium sulfate and concentrated to give a residue. The residue was purified by silica gel column chromatography (ethyl acetate/hexane) and further purified by HPLC (C18, mobile phase: water/acetonitrile (0.1% TFA-containing system)). Fractions containing the object product were collected, neutralized with a saturated aqueous sodium hydrogen carbonate solution, and extracted with ethyl acetate. The obtained organic layer was dried over magnesium sulfate and concentrated to give a residue. The residue was washed with ethyl acetate/IPE/hexane to give the title compound (32 mg). 1H NMR (300 MHz, DMSO-d6) delta 2.29 (3H, s), 2.57 (3H, s), 6.87 (2H, s), 7.13-7.33 (2H, m), 7.47 (1H, d, J=8.1 Hz), 7.58-7.68 (2H, m), 8.04 (1H, s), 10.56 (1H, s).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference of 109838-85-9, The chemical industry reduces the impact on the environment during synthesis 109838-85-9, name is (R)-2-Isopropyl-3,6-dimethoxy-2,5-dihydropyrazine, I believe this compound will play a more active role in future production and life.

Preparation 13: [(lS2RV3-arnino-l-(315-Muoro-bemyl)-2-hydroxy-propyl]-carbarnic acid t-butyl ester Step A: (2S,5RV2,5-dihvdro-3,6-dimethoxy-5-isopropyl-2-(3,5-dMuoro)benzylpyrazine(TR.)-2,5-dihydro-3,6-dirnethoxy-2-isopropylpyrazine (9.2 g, 50 mmol) was dissolved in THF (100 mL), to which n-BuLi (4M in THF, 15 mL) was then added at -78 °C, followed by addition of difluorobenzyl chloride (9.72 g, 60 mmol). After the reaction was complete, NH4Cl was added to the reaction mixture which was then extracted with EtOAc. The organic extract was dried over MgSO4 and concentrated under reduced pressure. The residue was purified by column chromatography (EtOAc: n-Hex = 1/1) to afford the title compound (12.4 g, 80percent).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (R)-2-Isopropyl-3,6-dimethoxy-2,5-dihydropyrazine, other downstream synthetic routes, hurry up and to see.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 4744-50-7, name is 2,3-Pyrazinecarboxylic anhydride, A new synthetic method of this compound is introduced below., name: 2,3-Pyrazinecarboxylic anhydride

12H-pyrazino[2′,3′:3,4]pyrrolo[1,2-a]perimidin-12-one (1): Naphthalene-1,8-diamine (40 mg, 0.057 mmol), furo[3,4-b]pyrazine-5,7-dione (40 mg, 34 mmol), and 10ml pyridine were added into a round bottom flask and heated to reflux. After 4h, the reaction mixture cooled down and the solvent was removed under reduced pressure. The crude residue was dispersed in 50 mL methanol with strong agitation. After 1h, the solid was collected by vacuum filtration and purified using silica-gel column chromatography with methylene chloride:methanol (50:1) to afford 1 (28 mg, 39%) as a red powder. 1H NMR (CDCl3, 400 MHz) delta 9.06 (d, 2H), 8.67 (d, 1H), 7.65-7.71 m (m, 3H), 7.54-7.57 (m, 2H); FT-IR 1732, 1654, 1402, 1375, 1131, 831, 760, 423 cm-1; Mp > 250oC; MALDI-TOF MS exact mass (M + H): 272.28; calcd. Mass: 271.27.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Zhao, Jian-Feng; Liu, Yi; Soh, Jiayun Bethia; Li, Yong-Xin; Ganguly, Rakesh; Ye, Kai-Qi; Huo, Fengwei; Huang, Ling; Tok, Alfred Iing Yoong; Loo, Joachim Say Chye; Zhang, Qichun; Tetrahedron Letters; vol. 53; 45; (2012); p. 6044 – 6047;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem