Tag: M.W=100-200

Application of 21279-62-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 21279-62-9 name is 3-Chloropyrazine-2-carboxamide, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: The starting compound (1.27 mmol) was treated with 18 aliphatic amines, alicyclic amines or saturated heterocycles containing at least one nitrogen atom (2.54 mmol). Four reactions were completed by conventional heating methods. The conditions were 110 C, toluene as a solvent and pyridine (1.27 mmol) as a base. The reaction time was set to one hour. Then the reactions were completed using the microwave reactor with focused field and conditions used for syntheses were 140 C, 30 min,120 W, methanol used as a solvent and pyridine (1.27 mmol) as a base. They were set experimentally with respect to prior experience. The progress of reaction was monitored with TLC in system hexane/ethyl acetate (1:1). Then the mixture was separated by flash column chromatograph using gradient elution. Mobile phases were hexane and ethyl acetate again.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Chloropyrazine-2-carboxamide, and friends who are interested can also refer to it.

These common heterocyclic compound, 108-50-9, name is 2,6-Dimethylpyrazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. HPLC of Formula: C6H8N2

EXAMPLE 29 2-Sulfonylmethyl-6-methylpyrazine sodium salt (2900) A mixture of 5.4 g of 2,6-dimethylpyrazine and 8.9 g of N-bromosuccinimide in 200 ml of carbon tetrachloride was heated to 75 and 6.1 g of dibenzoyl peroxide added. It was refluxed 6 hours, cooled, filtered and the filtrate concentrated. To this concentrate was added 10 g sodium sulfite/100 ml water and the mixture refluxed for 4 days. This aqueous solution was then continuously extracted overnight with chloroform, freeze-dried and the resultant solid taken up in 250 ml of methanol. It was filtered, the filtrate concentrated and chromatographed (Biogel P-2/water) to give 4.8 g of product (2900). It was recrystallized from ethanol/water, m.p. 282-5 (dec.). UV H2 O max: 208 (3.80), 276 (3.88).

The synthetic route of 2,6-Dimethylpyrazine has been constantly updated, and we look forward to future research findings.

Electric Literature of 15707-23-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 15707-23-0, name is 2-Ethyl-3-methylpyrazine belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.

In a 1000 ml three-necked flask, 30.0 g of 2-ethyl-3-methylpyrazine (content 99%), 0.82 g of ferric chloride (n/n: 50:1),0.92 g of 1,10-phenanthroline (n/n: 50:1), 14.8 g of propionic acid and 145 g of t-butanol peroxide, stirred with a magnetic stirrer,The mixture was heated to an internal temperature of 65 to 75 C, and the reaction was terminated after 24 hours, and distilled under reduced pressure to obtain 2-acetyl-3-methylpyrazine.The conversion of 2-ethyl-3-methylpyrazine was 48.75%, and the selectivity of 2-acetyl-3-methylpyrazine was 95.88%.

The synthetic route of 2-Ethyl-3-methylpyrazine has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 109838-85-9, name is (R)-2-Isopropyl-3,6-dimethoxy-2,5-dihydropyrazine, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 109838-85-9, Application In Synthesis of (R)-2-Isopropyl-3,6-dimethoxy-2,5-dihydropyrazine

Step B – Synthesis of Intermediate Compound Int-8d (i?)-2,5-Dihydro-3,6-dimethoxy-2-isopropylpyrazine (Int-8c, 25 g, 135.7 mmol) and dried THF (500 mL) were added to a dried 1 -liter flask which was cooled to -78 °C and maintained under nitrogen atmosphere. A solution of 2.5 M n-BuLi in hexane (54 mL, 135 mmol) was added slowly via a syringe. The resulting solution was allowed to stir at the cold temperature for 30 min before addition of Int-8b (90.5 g, 266.2 mmol) via a syringe. The reaction mixture was continued to stir for 4 hours and warmed to room temperature gradually over a period of 1 hour. After addition of water (100 mL) and diethyl ether (1.0 liter), the solution was washed with water (2 x 200 mL) and dried over sodium sulfate. The solution was concentrated and the residue obtained was purified using a 330 g ISCO silica column on Combi-Flash with 0-1percent ether in hexanes as an eluent to provide Int-8d as an oil (18.5 g, 35percent).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (R)-2-Isopropyl-3,6-dimethoxy-2,5-dihydropyrazine, other downstream synthetic routes, hurry up and to see.

Related Products of 33332-25-1, These common heterocyclic compound, 33332-25-1, name is Methyl 5-chloropyrazine-2-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

delta-chloro-pyrazine^-carboxylic acid methyl ester (10.02g, 58.25mmol) and hydrazine monohydrate(12.5mL, 250mmol) were dissolved in methanol (40OmL) and the reaction mixture heated to reflux for 48 hours. The reaction mixture was then filtered and the precipitate collected dried in vacuo to yield the title compound, 5.01 g (50%).1H NMR(CDCI3, 400MHz) delta: 4.09(d, 2H), 8.52(s, 1 H), 8.66(bs, 1 H), 9.14(s, 1 H). Microanalysis:C5H5CIN4O requires: C 34.80; H” 2.92; N 32.47; found C 34.89; H 2.91 , N 32.32. MS APCI+ m/z 173[MH]+

The synthetic route of 33332-25-1 has been constantly updated, and we look forward to future research findings.

Application of 313339-92-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 313339-92-3, name is 3,5-Dichloropyrazine-2-carbonitrile belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.

To a reaction vessel containing a magnetic stir bar was added 2,3-dichloro-N- [4- (4,4,5,5-tetramethyl- [1,3,2] dioxaborolan-2-yl) -phenyl] The amide (5.78 g) was added to a solution of 3,5-dichloro-pyrazine-2-carbonitrile (2.35 g), 1,1′-bis (diphenylphosphino) ferrocene-palladium (II) dichloride (Pd (dppf) 2 Cl 2) (791 mg) and cesium carbonate (13.2 g), followed by 100 ml of dioxane and 10 ml of water and the mixture was heated to 100 C. with stirring.After 3 h, the reaction mixture was cooled to room temperature and quenched with saturated aqueous sodium bicarbonate solution (100 ml) and extracted with EtOAc (3 × 200 ml). The combined aqueous phases were dried over sodium sulfate, filtered and evaporated to give the crude product as a brown oil. After purification by flash chromatography on silica gel using a mixture of EtOAc and heptane as eluent and evaporation of the solvent under reduced pressure, 2,3-dichloro-N-[4-(6-chloro-5-cyano-pyrazin-2yl)-phenyl]-benzenesulfonamide. Yield: 4.32 g (73%)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3,5-Dichloropyrazine-2-carbonitrile, other downstream synthetic routes, hurry up and to see.

Application of 313339-92-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 313339-92-3, name is 3,5-Dichloropyrazine-2-carbonitrile belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.

2,3-Dichloro-N-[4-(4,4,5,5-tetramethyl-[1 ,3,2]dioxaborolan-2-yl)-phenyl]-benzenesulfonamide (5.78 g) was added to a reaction vessel containing a magnetic stirring bar together with 3,5-dichloro-pyrazine-2-carbonitrile (2.35 g), 1,1′- bis(diphenylphosphino)ferrocene-palladium(ll) dichloride (Pd(dppf)2Cl2) (791 mg) and cesium carbonate (13.2 g), followed by 100 ml dioxane and 10 ml water, and the mixture heated to 100 C under stirring. After 3 h the reaction mixture was cooled to RT and quenched with a saturated aqueous sodium bicarbonate solution (100 ml) and extracted with EtOAc (3 x 200 ml). The combined aqueous phases were dried over sodium sulfate, filtered and evaporated to afford the crude product as a brown oil. Purification by flash chromatography on silica gel using a mixture of EtOAc and heptane as the eluent afforded 2,3-dichloro-N-[4-(6-chloro-5-cyano-pyrazin-2yl)- phenyl]-benzenesulfonamide as a light brown foam after evaporation of the solvents under reduced pressure. Yield: 4.32 g (73%). MS (ES-): m/e = 436.0 (M-H).

The synthetic route of 3,5-Dichloropyrazine-2-carbonitrile has been constantly updated, and we look forward to future research findings.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 4774-14-5 as follows. name: 2,6-Dichloropyrazine

2,6-Dichloropyrazine (55 g, 0.37 mol) and formamide (300 mL) were combined and heated to 90 C. Sodium persulfate (86.7 g, 0.36 mol) was added to the mixture at 90 C. in Ig portions at 20-30 seconds intervals. An exotherm was observed and the color of the mixture turned from yellow to dark red/brown. The mixture was stirred at 90 C. for 2 h and then cooled to room temperature. The mixture was diluted with water (500 mL) and filtered. The filtrate layers were separated. The aqueous layer was extracted with IPA:chloroform (1:3, 3*750 mL). The combined organic layers were dried over sodium sulfate and concentrated under vacuum to afford a viscous oil. The oil was purified by silica gel chromatography (0 to 100% ethyl acetate in hexanes) to provide the title product as a colorless solid (25 g, 36% yield).

According to the analysis of related databases, 4774-14-5, the application of this compound in the production field has become more and more popular.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 33332-28-4 as follows. Computed Properties of C4H4ClN3

To a stirred solution of 6-chloropyrazin-2-amine (0.500 g, 3.85 mmol, 1.0 eq.) in xylene (20.0 mL) was added 2-(tributylstannyl)pyridine reagent (1.42 g, 3.85 mmol, 1.0 eq.). The reaction mixture was deoxygenated using N2 gas and Pd(PPh3)4 (0.223 g, 0.05 eq. 0.192 mmol) was added. The reaction mixture was again purged with N2 and allowed to heat at 150° C. for 16 h in seal tube. Progress of the reaction was monitored by TLC and LCMS Reaction mixture was allowed to cool to RT and quenched by adding aq. NaOH and extracted using ethyl acetate (3*100 mL). The combined organic layers were washed with brine, dried over anhydrous Na2SO4 and concentrated under vacuum to get the solid which was purified by normal phase column chromatography to get the desired product (0.400 g, 60percent).

According to the analysis of related databases, 33332-28-4, the application of this compound in the production field has become more and more popular.

Application of 6164-79-0,Some common heterocyclic compound, 6164-79-0, name is Methyl 2-pyrazinecarboxylate, molecular formula is C6H6N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a solution of an appropriate methyl esters17(a-j) (1.0 mmol) in 50 mL of methanol was added 99 %hydrazine hydrate (4.0 mmol) and the mixture was refluxedfor 5 h up to reaction completed (TLC). After completionof reaction, it was allowed to cool and the obtained solidwas washed with methanol. The crude products wererecrystallized from ethanol.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl 2-pyrazinecarboxylate, its application will become more common.