Tag: M.W=100-200

These common heterocyclic compound, 88625-24-5, name is 5-Chloropyrazine-2-carbaldehyde, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C5H3ClN2O

To a solution of 5-chloropyrazine-2-carbaldehyde (500 mg, 3.51 mmol) in CH2Cl2 (10 mL) was added (diethylamino)difluorosulfonium tetrafluoroborate (2.0 g, 8.77 mmol) and triethylamine trihydrofluoride (0.57 mL, 3.51 mmol). The reaction mixture was stirred for 18 hours at ambient temperature. The reaction mixture was diluted with water and was extracted with CH2Cl2. The organic layer was dried over anhydrous MgSO4, filtered and concentrated under reduced pressure. Purification of the residue via column chromatography (SiO2, heptane:ethyl acetate 0~65%) gave the title (200 mg, 1.22 mmol, 35% yield). 1H NMR (500 MHz, DMSO-d6) delta ppm 9.00 – 8.93 (m, 1H), 8.86 (q, J = 1.1 Hz, 1H), 7.17 (t, J = 54.0 Hz, 1H); MS (ESI+) m/z 186 (M+Na)+.

The synthetic route of 5-Chloropyrazine-2-carbaldehyde has been constantly updated, and we look forward to future research findings.

69214-33-1, name is 8-Chloroimidazo[1,2-a]pyrazine, belongs to pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. name: 8-Chloroimidazo[1,2-a]pyrazine

Example 2 – Synthesis of A/-(3-(8-(3-fluorophenylamino)imidazori,2-a1pyrazin-3- vDphenvDacetamide (Compound 160)3-Bromo-8-chloroimidazo[ 1 ,2-a”|pyrazine[00239] Bromine (1.42 mL, 27.72 mmol) was added to a suspension of 8- chloroimidazo[l,2-a]pyrazine (2.83 g; 18.48 mmol) in glacial acetic acid (55 mL) and the resulting mixture was stirred at room temperature for 16 hours. The reaction mixture was then concentrated in vacuo and the resulting residue was taken up in DCM/methanol (9:1), subsequently washed with saturated aqueous sodium bicarbonate solution (2 x 70 mL), IM sodium thiosulfate (70 mL), brine (70 mL), dried (MgSO4) and concentrated in vacuo to give the title compound (3.397 g, 79%) as a light brown/golden solid. 1H NMR (d6-DMSO): 8.49(IH, d, J4.6), 8.04 (IH, s), 7.89-7.84 (IH, br m).[00240] The use of Br2/acetic acid could give partial bromination, along with partial chloride displacement by bromide, giving a mixture of 4 possible products A:B:C:D in a1 :2: 1 : 1 mixture. The dihalo species C and D were separated from the monohalo analogues A and B so the final compound was a mixture of two dihaloimidazopyrazines. This product composition could alter on a larger scale.X = Cl, A X = Cl, CX = Br, B X = Br, DA:B:C:D = 1 :2:1 :1

The synthetic route of 69214-33-1 has been constantly updated, and we look forward to future research findings.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 14508-49-7, name is 2-Chloropyrazine belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below. Computed Properties of C4H3ClN2

Using Procedure AU-3 (Table 5) with 2-chloropyrazine the title compound 476 was obtained (4.4 g, 46%) as a yellow solid. MS (m/z): 111.0 (M+H)

The synthetic route of 14508-49-7 has been constantly updated, and we look forward to future research findings.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 59303-10-5 as follows. Computed Properties of C5H5ClN2

Example 38(S)-5-(1 -Methanesulfonyl-1 ,2,3,6-tetrahvdro-pyridin-4-yl)-2-methyl-2-ri -(5- trifluoromethyl-pyrazin-2-yl)-piperidin-4-yl1-2,3-dihvdro-furo[2,3-clpyridineThe title compound is prepared from (S)-5-(1 -methanesulfonyl-1 ,2,3,6-tetrahydro- pyridin-4-yl)-2-methyl-2-piperidin-4-yl-2,3-dihydro-furo[2,3-c]pyridine (Intermediate 41 ; the configuration of the stereocenter is arbitrarily assigned) and 2-chloro-5- (trifluoromethyl)pyrazine in dimethylsulfoxide at 100C in the presence of potassium carbonate. LC (method 4): tR = 1 .06 min; Mass spectrum (EST): m/z = 524 [M+H]+.

According to the analysis of related databases, 59303-10-5, the application of this compound in the production field has become more and more popular.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 109838-85-9 as follows. Computed Properties of C9H16N2O2

R24 (212 g, 1151 mmol) in tetrahydrofuran (dry) (600 mL) is cooled to ?78° C. Then n-butyllithium (2.5 M in hexanes, 552 mL, 1381 mmol) is added dropwise, keeping the temperature below ?78° C. After 30 min R25 (324 g, 1209 mmol) in tertahydrofurane (dry) (120 mL) is added dropwise. The reaction mixture is stirred at ?78° C. for 1 h. The mixture is quenched with saturated NH4Cl solution and extracted three times with ethyl acetate. The organic layer is washed with brine, dried over Na2SO4 and evaporated in vacuo. The residue is purified by flash chromatography (heptane/ethyl acetate=80/20). Yield 60percent.

According to the analysis of related databases, 109838-85-9, the application of this compound in the production field has become more and more popular.

Synthetic Route of 59489-71-3, These common heterocyclic compound, 59489-71-3, name is 2-Amino-5-bromopyrazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

C. 5-(4-(Triisopropylsilyloxy)phenyl)pyrazin-2-amine. Triisopropyl(4-(4,4,5, 5-tetramethyl-l,3,2-dioxaborolan-2-yl)phenoxy)silane (1.1 g, 2.9 mmol), 5- bromopyrazin-2-amine (507 mg, 2.9 mmol), dichloro[l,l’- EPO bis(diphenylphosphino)ferrocene]palladium(II) dichloromethane adduct (64 mg, 0.087 mmol), IM sodium carbonate (8.7 mL, 8.7 mmol), and dioxane (10 mL) were heated in a Biotage Emrys Optimizer microwave reactor at 120 C for 10 min. The reaction was extracted with water and ethyl acetate. The organic layer was dried over magnesium sulfate, filtered and concentrated. The resulting residue was purified using Biotage silica gel chromatography (0-100% ethyl acetate in hexanes) to give a tan solid (0.8 g, 80 % yield). 1H NMR (400 MHz, DMSCW6) delta 8.42 (s, IH), 7.92 (s, IH), 7.80 (d, J=8.6, 2H), 6.90 (d, J=8.6, 2H), 6.45 (s, 2H), 1.26 (q, J=IA, 7.2, 3H), 1.08 (d, J=7.4, 18H); MS (ESI) m/z 344.4 – [M+l]+.

Statistics shows that 2-Amino-5-bromopyrazine is playing an increasingly important role. we look forward to future research findings about 59489-71-3.

Related Products of 54608-52-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 54608-52-5, name is 2-Hydrazinopyrazine belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.

To a solution of 2-hydrazinylpyrazine (3.00 g, 27.2 mmol) in ethanol (30 mL) was added 3-methylbutanoic anhydride (7.61 g, 40.9 mmol) at 0 , and the resulting mixture was stirred for 1 h at 0 . The reaction solution was then quenched b the addition of water (100 mL), and the resulting mixture was extracted with EtOAc (3 x 100 mL). The combined organic layers were washed with brine (100 mL), dried over anhydrous Na 2 SO4, and filtered The filtrate was concentratedunder reduced pressure to afford 3-methyl-N ‘-. (pyrazin-2-yl) butanehydrazide, which was used in the next step without further purification. MS (ESI) calc’d for (C9 H15 N4 O) [m + H] + 195; found 195

The synthetic route of 2-Hydrazinopyrazine has been constantly updated, and we look forward to future research findings.

Application of 33332-29-5, These common heterocyclic compound, 33332-29-5, name is 2-Amino-5-chloropyrazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of 5-chloropyrazin-2-amine (500 mg, 3.86 mmol) in DCM (5mL) was added NBS (686.92 mg, 3.86 mmol), and the brown mixture was stirred at 40 C for 1 hour. After cooling to r.t., the mixture was filtered through silica gel and eluted with EtOAc (20 mL x 3), and the filtrate was concentrated to give the crude product. The crude product was purified by flash chromatography on silica gel (EtOAc in PE = 20% to 40% to 50%) to give the product (600 mg) as a solid. *H NMR (400MHz, CDC13 ) _ = 7.98 (s, 1H), 5.05 (br s, 2H).

Statistics shows that 2-Amino-5-chloropyrazine is playing an increasingly important role. we look forward to future research findings about 33332-29-5.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 21279-64-1, name is 5-Chloropyrazine-2-carboxamide, A new synthetic method of this compound is introduced below., HPLC of Formula: C5H4ClN3O

General procedure: 150 mg (0.952 mmol) of 5-Cl-PZA (1) or 6-Cl-PZA (2) was dissolved in ethanol together with triethylamine (1 eq., 96 mg, 0.952 mmol). Three equivalents of corresponding alkylamine were added to the reaction mixture and refluxed in ethanol generally for 6 hours. The completion of the reaction was checked by TLC chromatography (eluent: hexane/ethyl acetate, 1:2). The crude product was absorbed on silica by solvent evaporation and purified by flash chromatography (hexane/ethyl acetate gradient elution).

The synthetic route of 21279-64-1 has been constantly updated, and we look forward to future research findings.

Synthetic Route of 939412-86-9,Some common heterocyclic compound, 939412-86-9, name is (3-Chloropyrazin-2-yl)methanamine hydrochloride, molecular formula is C5H7Cl2N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To trichloromethyl chloroformate (4.19 mmol, 0.505 ml) in ethyl acetate (5 ml) at 0 C was added dropwise 1 ,4-dioxa-8-azaspiro[4.5]decane (6.98 mmol, 0.895 ml) in ethyl acetate (5ml) and N,N- diisopropylethylamine (6.98 mmol, 1.217 ml). After one hour the mixture was concentrated, the residue was dissolved in dichloromethane (25 ml) and 2-aminomethyl-3-chloropyrazine hydrochloride (content 60%; 10.00 mmol, 3 g) and triethylamine (27.9 mmol, 3.89 ml) were added. After stirring for 16 hours at room temperature the reaction mixture was diluted with water, filtered over decalite, washed with water, filtered over a phase separation filter and concentrated in vacuo. The crude product was dissolved in dichloromethane containing 1 % triethylamine and purification by column chromatography (silica gel; dichloromethane containing 1 % triethylamine) gave N-((3-chloropyrazin-2-yl)methyl)-1 ,4-dioxa-8- azaspiro[4.5]decane-8-carboxamide (1.5 g).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route (3-Chloropyrazin-2-yl)methanamine hydrochloride, its application will become more common.