Tag: M.W=100-200

Related Products of 19847-12-2, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 19847-12-2 as follows.

5-Methyl-2-pyrazin-2-yl-thiazol-4-ol: In a 250 mL round-bottomed flask, pyrazine-2-carbonitrile (10 g, 95.1 mmol), pyridine (2.26 g, 2.33 ml, 28.5 mmol,) and 2-mercaptopropionic acid (10.1 g, 95.1 mmol) were combined to give a light yellow solution. The reaction mixture was heated to 100 C. and stirred for 2 h. Upon cooling, the thick yellow mixture was diluted with 100 mL ethanol and stirred for 30 min. The slurry was then filtered, and washed with diethyl ether (2×100 mL) to give 5-methyl-2-pyrazin-2-yl-thiazol-4-ol (17.86 g, 97.1%) as yellow solid which was used directly without further purification.

According to the analysis of related databases, 19847-12-2, the application of this compound in the production field has become more and more popular.

Reference of 4430-75-5,Some common heterocyclic compound, 4430-75-5, name is Octahydro-2H-pyrido[1,2-a]pyrazine, molecular formula is C8H16N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 12a:; A solution of acid 49 (50 mg, 0.125 mmol) in CH2C12 (2 mL) was treated with oxalyl chloride (100 muL, 1.16 mmol). After 20 min, the reaction mixture was concentrated in vacuo, diluted with CH2CI2 (1 mL) and treated with Et3N (130 muL, 1.20 mmol) followed by (+/-)-1,4-diazabicyclo[4.4.0]decane (140 mg, 1.0 mmol). After 18 h, the reaction mixture was diluted with saturated aqueous NH4CI and extracted with CH2CI2 (2x). The combined organic layers were washed with saturated aqueous NaHC03, dried over MgS04 and concentrated in vacuo. Preparative TLC (0.5:4.5:95 NH40H/MeOH/CH2CI2), afforded Example 40 (42.0 mg, 65%) as a yellow oil. Example 40: LCMS (ES): time 3.45 min, m/z 520.3 (M+H+).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Octahydro-2H-pyrido[1,2-a]pyrazine, its application will become more common.

Adding a certain compound to certain chemical reactions, such as: 870787-06-7, name is 3-(Trifluoromethyl)pyrazine-2-carboxylic acid, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 870787-06-7, Recommanded Product: 870787-06-7

Diphenylphosphoryl azide (3.47g, 12.6mmol) was added to a stirred solution of 3- trifluoromethylpyrazine-2-carboxylic acid (1 .92g, 9.7Ommol) and triethylamine (1 .28g, 12.6mmol) in tert-butanol (9.6m1, lOOmmol) and toluene (19.2m1). The resulting mixturewas heated at 90C for 4 hours and then allowed to cool. It was washed with 2M aqueous sodium bicarbonate, then dried through a phase-separation filter and concentrated under reduced pressure. The residue was purified by chromatography on silica gel using a gradient of ethyl acetate in hexane as eluent to give tert-butyl N-(3-trifluoromethylpyrazin- 2-yl)-carbamate containing 3-trifluoromethyl-2-aminopyrazine (2.Og) as a colourless oilwhich slowly crystallised to give a white solid. 1H NMR (400 MHz, CDCl3) 8.70 (s, 1H),8.40 (s, 1H), 7.20 (brs, 1H), 1.55 (s, 9H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 69214-33-1, name is 8-Chloroimidazo[1,2-a]pyrazine, A new synthetic method of this compound is introduced below., Formula: C6H4ClN3

Step 2: 3-Bromo-8-chloroimidazo[l,2-a]pyrazine[0314] A solution of 8-chloroimidazo[l,2-a]pyrazine (15g, 97.4 mmol) in DCM (300 mL) was treated with NBS (19. Ig, 108 mmol) at room temperature and stirred at this temperature for overnight. The reaction was monitored by TLC. After this time, the resulting solution was diluted with 200 mL DCM and washed with saturated solution of Na2CO3 (2×150 mL), and brine (1×150 mL). Organic layer was dried over Na2SO4, filtered and concentrated in vacuo to give the crude product that was purified by a silica gel column chromatography eluted with ethyl acetate in petroleum ether (1:2) to give 3-bromo-8-chloroimidazo[l,2-a]pyrazine (9.5g, 42%) as yellow solid. 1H NMR (400 MHz, CDCl3) delta 8.04 (IH, d, J = 4.6 Hz), 7. 84 (s, IH), 7.82 (2H, d, J = 4.6 Hz).

The synthetic route of 69214-33-1 has been constantly updated, and we look forward to future research findings.

Related Products of 36070-75-4,Some common heterocyclic compound, 36070-75-4, name is 5-Chloropyrazine-2-carbonitrile, molecular formula is C5H2ClN3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A mixture of methyl (R)-3-(3-amino-4-(isobutyl(tetrahydro-2H-pyran-4-yl)amino)phenyl) butanoate (220 mg, 0.63 mmol), 5-chloropyrazine-2-carbonitrile (177 mg, 1 .27 mmol), Pd2(dba)3 (58 mg, 0.064 mmol), Xantphos (74 mg, 0.13 mmol) and K2C03 (262 mg, 1 .9 mmol) in toluene (10 mL) was stirred at 100C under N2 atmosphere overnight. The resulting mixture was partitioned between EtOAc and H2O. The organic layer was washed with brine, dried over Na2S04, filtered and concentrated to give the crude product which was purified by flash chromatography (silica gel, 0-40% EtOAc in PE) to afford the title compound (70 mg, 25% yield). LCMS (ESI) m/z calcd for C25H33N5O3: 451 .26. Found: 452.46 (M+1)+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Chloropyrazine-2-carbonitrile, its application will become more common.

Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; DE LA ROSA, Martha Alicia; KAZMIERSKI, Wieslaw Mieczyslaw; SAMANO, Vicente; (369 pag.)WO2018/116107; (2018); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 54608-52-5 as follows. category: Pyrazines

50ml three-necked flask, add 0.2g of compound 6, 15ml of methylene chloride and 15ml of ethyl acetate, after stirring to dissolve,0.3 g of compound 4 and 3 g of T 3 P and 0.75 g of DIPEA were added at 0 C. The system was stirred at 0 C. for 30 min to carry out the reaction until the reaction junctionAfter the beam was added 50ml of dichloromethane and 30ml of water, liquid separation, the organic phase evaporated to give crude compound 7, the crude product is not purified directly down vote;

According to the analysis of related databases, 54608-52-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Guangzhou Wenhao Biological Technology Co., Ltd.; Chen Xinying; Xu Liang; Liu Wenzhong; (7 pag.)CN106831731; (2017); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Synthetic Route of 16298-03-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 16298-03-6, name is Methyl 2-aminopyrazine-3-carboxylate belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.

Example 58; Step 1; A solution of bromine (10 mL, 190 mmol) in acetic acid (10 mL) was added dropwise to a solution of 1 (20 g, 130 mmol) in glacial acetic acid (100 mL) at 45 C. The resulting mixture was stirred at 25 C. for 30 min. After completion of reaction (reaction progress was monitored by TLC), the solution was diluted with water (600 mL) and then stirred at RT for another 30 min. A yellow solid precipitated out, which was filtered, washed with water and dried to afford compound 2 as yellow solid (28.5 g, 93%). MS m/z (ES): 232 (M+H)+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 2-aminopyrazine-3-carboxylate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; de Vicente Fidalgo, Javier; Hermann, Johannes Cornelius; Lemoine, Remy; Li, Hongju; Lovey, Allen John; Sjogren, Eric Brian; Soth, Michael; US2011/59118; (2011); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 5521-55-1, name is 5-Methylpyrazine-2-carboxylic acid, A new synthetic method of this compound is introduced below., COA of Formula: C6H6N2O2

5-methylpyrazine acid (0.27 mmol, prepared as Example 2), EDCI (0.35mmol) And DMAP (0.027 mmol) were dissolved in dry methylene chloride (20 mL). The compound hederagenin alcohol (140 mg, 0.27 mmol, prepared as Example 3) was dissolved in dichloromethane (20 mL). This solution was dropped into the 5-methylpyrazine acid solution within 20 minutes, and stirred at room temperature for 12 hours. The reaction mixture was then diluted with dichloromethane (20 mL), washed with saturated aqueous NaCl solution, dried over anhydrous sodium sulfate, and purified by column chromatography to obtain a white powder, H-09. Yield: 55% (after chromatograph with DCM / MeOH, 1% -2%) as a white powder, m.p .: 192.6 C.

The synthetic route of 5521-55-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Xinhuo Zhiyao (Beijing) Technology Co., Ltd.; Fang Kang; Guo Wenbo; Wang Penglong; Cheng Gang; (26 pag.)CN110964078; (2020); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

6863-73-6, name is 3-Chloropyrazin-2-amine, belongs to pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Safety of 3-Chloropyrazin-2-amine

A mixture of bromoacetaldehyde diethyl acetal (29 ml,192.77 mmol) and 48% aqueous hydrogen bromide solution (7 ml)was stirred at reflux temperature for 1.5 h. After cooling back toroom temperature it was poured onto a suspension of sodiumhydrogen carbonate (14.50 g, 172.62 mmol) and 2-propanol(230 ml) and stirred until the gas evolution ceased. The formedprecipitate was filtered, then 2-amino-3-chloropyrazine (8) (7.51 g,58 mmol) was added to the filtrate and stirred at reflux temperaturefor 3 h. The reaction mixture was allowed to cool down toroom temperature, the resulting solid was collected by filtrationand washed with 2-propanol. The solid was partitioned betweenchloroform and 10% aqueous sodium hydrogen carbonate solution.The layers were separated and the aqueous layer was extractedwith chloroform (2). The combined organic layers were dried oversodium sulphate, filtered and concentrated under reduced pressure.The crude product was triturated with diisopropyl ether andfiltered to give the title compound (6.48 g)

The synthetic route of 6863-73-6 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Garamvoelgyi, Rita; Dobos, Judit; Sipos, Anna; Boros, Sandor; Illyes, Eszter; Baska, Ferenc; Kekesi, Laszlo; Szabadkai, Istvan; Szantai-Kis, Csaba; Keri, Gyoergy; Oerfi, Laszlo; European Journal of Medicinal Chemistry; vol. 108; (2016); p. 623 – 643;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Reference of 55557-52-3, These common heterocyclic compound, 55557-52-3, name is 3-Chloropyrazine-2-carbonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A.5 Synthesis of pyrazine-2-carboxylic acid derivativesA.5.1 Synthesis of pyrazine-2-carbonitrile derivativesA mixture of the respective boronic acid derivative (B-B(OH)2) (21.5 mmol), 3-chloro- pyrazine-2-carbonitrile (21.5 mmol), a solution of K2CO3 (59.4 mmol) in water (30 ml_), PPh3 (3. 2 mmol), Pd(OAc)2 (1.05 mmol) in dry DME was stirred at reflux under inert atmosphere for 16 h. After cooling to rt, the reaction mixture was diluted with EtOAc, filtered over celite, the filtrate was dried over MgSO4, filtered and concentrated in vacuo to yield the desired pyrazine-2-carbonitrile derivative which was used for the next step without further purification3-m-Tolyl -pyrazine-2-carbonitrile prepared by reaction with commercially available 3-m-tolyl-boronic acid LC-MS: tR = 0.88 min; [M+H+MeCN]+ = 243.63

The synthetic route of 55557-52-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ACTELION PHARMACEUTICALS LTD; AISSAOUI, Hamed; BOSS, Christoph; BROTSCHI, Christine; GABILLET, Jerome; SIEGRIST, Romain; SIFFERLEN, Thierry; WILLIAMS, Jodi T.; WO2010/38200; (2010); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem