Tag: M.W=100-200

Adding a certain compound to certain chemical reactions, such as: 356783-16-9, name is 3,6-Dichloropyrazine-2-carbonitrile, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 356783-16-9, Formula: C5HCl2N3

KF (1 g, 6 eq) and TBAB (372.3 mg, 0.4 eq) were dissolved in a mixed solvent of toluene (10 ml) and dimethylsulfoxide (5 ml)After azeotropic removal of water,Compound 6 (500 mg, 1 eq) was added,55 ‘C conditions,Stir for 3 h.TLC shows the raw material reaction is complete,After falling to room temperature,30% H2O2 (0.35 ml) was added under ice bath,Reaction at 27 C for 2 h, add water (1 ml) andNaHCO3 (0.132 g, 1.57 mmol),50 reaction 8.5h,Ice bath with 6N HCl,Adjust pH = 1.0,Ethyl acetate (4 x 5 ml)The organic layer was washed twice with saturated brine,Dried over anhydrous sodium sulfate,The organic solvent was distilled off,Recrystallization from 20 times ethanol (crude weight ratio of ethanol to 1: 5 to 30)Obtained as white solid 7 (favipiravir),The yield was 65% (from the reactants6 is calculated).mp: 175-177 C.

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Reference of 27825-21-4, A common heterocyclic compound, 27825-21-4, name is Methyl 3-chloropyrazine-2-carboxylate, molecular formula is C6H5ClN2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of the product from step 1 (100 mg, 0.58 mmol) in toluene (2 mL) was added Pd(PPh3)4 (134 mg, 0.12 mmol) and 2-(tributylstannyl)pyridine (213 mg, 0.58 mmol) at room temperature and the resulting mixture heated to 100 oC overnight. After cooling to RT, the mixture was filtered and 5 mL of aq. KF solution was added to the filtrate. The resulting mixture was stirred for 30 mins and extracted with EtOAc (5 mL x 3). The combined organic layers were washed with brine, dried over Na2SO4, filtered and concentrated in vacuo. The residue was 5 purified by chromatography (30% EtOAc in petroleum ether) to provide the title compound as a oil. LRMS m/z (M+H) 216.1 found, 216.1 required.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Some common heterocyclic compound, 33332-28-4, name is 2-Amino-6-chloropyrazine, molecular formula is C4H4ClN3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C4H4ClN3

To 2-amino-6-chloropyrazine (3.1 mmol), l-Boc-5-fluoroindole-2-boronic acid (3.1 mmol), Pd(PPh3)4, (100 mg, 0.0865 mmol) and K2CO3 (7.2 mmol) were added 7 mL MeCN and 3 mL H2O and the mixture was heated in a sealed tube at 80 0C for 1 h. The water layer was separated and the organic phase was dried over MgSO4. Filtration and removal of the solvent gave 1.05 g of the title compound.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 33332-28-4, its application will become more common.

Electric Literature of 6905-47-1,Some common heterocyclic compound, 6905-47-1, name is 2-Amino-6-methoxypyrazine, molecular formula is C5H7N3O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a mixture of MeOH (6 mL) in DMSO (12 mL) was added slowly NaH (1.2 g of 60% in oil, 30 mmol) and stirred at room temperature for 30 min. 2-amino-6-chloropyrazine (1.29 g, 10 mmol) was added to the mixture portionwise and heated at 80 C for 2 h. The reaction mixture was cooled, water was added and extracted with ethyl acetate. The organic layer was washed with brine, dried over MgSO4, filtered and concentrated. The residue was purified bycolumn chromatography to give 2-amino-6-methoxypyrazine (888 mg, 71%) as a slightly yellow solid. 1H NMR (200 MHz, CDCl3) delta 7.60 (s, 1H), 7.55 (s, 1H), 4.44 (br, 2H), 3.90 (s, 3H); 2-amino-6-methoxyprazine (186 mg, 1.45 mmol) was dissolved in MeOH. To the solution was added N-bromo-succinimide (568 mg, 3.19 mmol) and stirred at room temperature for 30 min. The reaction mixture was concentrated via vacuo, ethyl acetate was added and washed with water. The organic layer was dried over MgSO4, filtered and concentrated. The residue was purified by column chromatography to give a product 1e (242 mg, 59%). 1H NMR (200 MHz, CDCl3) delta4.91 (br, 2H), 3.96 (s, 3H);

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Amino-6-methoxypyrazine, its application will become more common.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 33332-25-1, name is Methyl 5-chloropyrazine-2-carboxylate belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below. Formula: C6H5ClN2O2

Example 95 [0308] [Formula 107]CI xj – ~ CI’ [0309] 1) In tetrahydrofuran (66 mL) was dissolved methyl 5-chloropyrazine-2-carboxylate (3.3 g), and 1M diisobutylaluminum hydride/hexane solution (38.3 mL) was added dropwise to the solution under nitrogen atmosphere at -70C or lower over 10 minutes, and the resulting mixture was further stirred for 10 minutes. At -60C or lower, 1M diisobutylaluminum hydride/hexane solution (31.3 mL) was added dropwise to the mixture over 20 minutes, and the mixture was further stirred at -70C or lower for 1 hour. The reaction mixture was poured into a saturated aqueous ammonium chloride solution, and after stirring at room temperature, filtered with Celite. The filtrate was extracted with ethyl acetate, washed with a saturated brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The obtained residue was purified by silica gel column chromatography (n-hexane: ethyl acetate=100:0 to 80:20) to obtain 5-chloropyrazine-2-carbaldehyde (970 mg). MS (m/z): 142/144 [M+H]+

The synthetic route of 33332-25-1 has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 109838-85-9, name is (R)-2-Isopropyl-3,6-dimethoxy-2,5-dihydropyrazine, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 109838-85-9, Application In Synthesis of (R)-2-Isopropyl-3,6-dimethoxy-2,5-dihydropyrazine

Step B – Preparation of Compound Int-15b Int-15bTo a solution of (2R)-(-)-2,5-dihydro-3,6-dimethoxy-2-isopropylpyrazine (0.61 g, 4.36 mmol) in THF (8 mL) was added n-BuLi (2.5 M in hexane, 1.8 mL, 4.58 mmol) at -78 °C. After allowed to stir for 0.3 hours, Compound Int-15a (2.75 g, 6.98 mmol) in 2 mL of THF was added and the mixture was allowed to stir at the temperature for 4 hours. The reaction was quenched by saturated aqueous H4C1 solution and the organic layers were extracted with EtOAc. The combined organic solution was washed with brine solution, dried (Na2S04), and concentrated in vacuo. The residue obtained was purified using ISCO 40 g column (gradient from 0percent to 2.5percent ether in hexane) to provide Compound Int-15b, 783 mg (44percent). 1H MR (CDC13) delta 4.05 (m, 1H), 3.96 (t, J= 3.4 Hz, 1H), 3.72 (s, 3H), 3.71 (s, 3H), 3.49 (dd, 7= 2,8, 0.4 Hz, 1H), 3.26 (dd, 7= 6, 9.4 Hz, 1H), 2.30 (m, 1H), 1.96 (m, 1H), 1.60 (m, 2H), 1.37-1.17 (m, 3H), 1.08 (d, 7= 6.9 Hz, 3H), 0.99-0.86 (m, 2H), 0.72 (d, 7= 6.6 Hz, 3H), 0.49 (dd, 7= 11.0, 14.4 Hz, 1H), 0.35 (dd, 7= 11.0, 14.2 Hz, 1H), 0.16 (s, 6H).

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Related Products of 54608-52-5, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 54608-52-5 as follows.

1007751 Step A: 5-amino-4-methyl-1-(pyrazin-2-yl)-1H-pyrazol-3(2H)-one: To a mixture of 2-hydrazinylpyrazine (0.551 g, 5.00 mmol) and ethyl 2-cyanopropanoate (0.669 g, 5.00 mmol) in abs. EtOH (10 mL) was added 3M NaOEt in EtOH (0.167 mL, 0.501 mmol) and the mixture was heated at reflux for 64 hours. The mixture was concentrated and the residual yellow-brown solid was treated with EtOAc (30 mL) and sonicated. The resulting tan suspension was stirred vigorously for 8 hours. The solid was collected via vacuum filtration, washed with EtOAc and dried in vacuum to afford the title compound as a light tan powder (682 mg, 71%). ?H NMR (DMSO d6) 10.3 (br s, 1H), 8.82 (s, 1H), 8.30 (d, 2H), 6.55 (s, 2H), 1.71 (s, 3H).

According to the analysis of related databases, 54608-52-5, the application of this compound in the production field has become more and more popular.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 41110-33-2, name is Methyl 5-methylpyrazine-2-carboxylate, A new synthetic method of this compound is introduced below., COA of Formula: C7H8N2O2

Synthesis Example 13-2: Synthesis of 5-bromomethyl-2-methoxy carbonyl pyrazine (Compound IV-3) 500 mg of the compound obtained in Synthesis Example 13-1 was dissolved in 10 ml of carbon tetrachloride, and then 585 mg of N-bromosuccinimide and 54 mg of azobisisobutyronitrile were added to the solution. After the solution was stirred in oil bath for 20 hours at 70C, the reaction solution was filtrated, and then the filtrate was then concentrated. The resulting residue was purified by means of silica gel column chromatography (14 g, chloroform/ethyl acetate= 2/1), and 328.7mg of the above-mentioned compound was obtained as light-yellow syrup. MS(EI,Pos.):m/z=229,231[M+1]+ 1H-NMR(500MHz,DMSO-d6): delta=4.06 (3H,s), 4.62 (2H,s), 8.83 (1H,d,J=1. 5Hz), 9.26 (1H,d,J=1.5Hz).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Some common heterocyclic compound, 36070-75-4, name is 5-Chloropyrazine-2-carbonitrile, molecular formula is C5H2ClN3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C5H2ClN3

EXAMPLE 54 5-((3 ?)-3-{[5-fluoro-6-(2-hydroxyethoxy)-2^yrazolo[1 ,5-a]pyridin-3-ylpyrimidin-4- yl]amino}piperidin-1-yl)pyrazine-2-carbonitrile A mixture of (R)-2-((5-fluoro-6-(piperidin-3-ylamino)-2-(pyrazolo[1 ,5-a]pyridin-3- yl)pyrimidin-4-yl)oxy)ethanol dihydrochloride (Example 40b, 0.050 g, 0.13 mmol), 2- chloro-5-cyanopyrazine (0.025 g, 0.18 mmol) and triethylamine (0.056 mL, 0.4 mmol) in N,N-dimethylformamide (1 .0 mL) was heated in a microwave at 120 C for 2 hours. The reaction mixture was cooled to ambient temperature and ethyl acetate (10 mL) was added. The solution was washed with water (10 mL) and brine (20 mL). The organic layer was separated, dried over anhydrous magnesium sulfate, filtered, and concentrated under reduced pressure. The residue was taken up in dichloromethane (5 mL), the suspension was filtered and dried in vacuo to give the title compound (0.012 g, 19%) as a solid. LRMS (m/z): 476 (M+1 )+. 1H-NMR delta (300 MHz, DMSO-d6): 1 .50 – 1 .98 (m, 4H), 2.00 – 2.17 (m, 1 H), 3.02 (dd, 2H), 3.68 – 3.87 (m, 2H), 4.14 (br. s., 1 H), 4.42 (d, 1 H), 4.50 (d, 2H), 4.75 (br. s., 1 H), 4.93 (d, 1 H), 6.94 – 7.10 (m, 1 H), 7.30 (dd, 2H), 8.32 (d, 1 H), 8.46 (d, 1 H), 8.58 (s, 1 H), 8.80 (d, 1 H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 36070-75-4, its application will become more common.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 21279-64-1, name is 5-Chloropyrazine-2-carboxamide, A new synthetic method of this compound is introduced below., Application In Synthesis of 5-Chloropyrazine-2-carboxamide

15 g (95.2 mmol) of 5-chloropyrazine-2-carboxamide,24.8 g (114.2 mmol) of 3-methoxy-4-hydroxybenzyl bromide,475.8 ml of DMF,33 g (238.7 mmol) of potassium carbonate were added sequentially to a 1-liter four-necked reaction flask,The reaction was carried out at 80 C for 6 hours,After the reaction is completed, the heating is stopped,Stirring was continued overnight (TLC detection, developing solvent: ethyl acetate: n-hexane = 1: 1)And then filtered to remove insoluble matter,The filtrate was transferred to a 2-liter reaction flask,To the filtrate was added 960 ml of water,Stirring under ice bath for about 3 hours crystallization, filtration, filter cake washed with 50 ml of X2 water,The filter cake was dried at 45 C,To give 24.8 g of a pale yellow solid (yield: 75.5%, purity: 97.6%).

The synthetic route of 21279-64-1 has been constantly updated, and we look forward to future research findings.