Tag: M.W=100-200

Related Products of 33332-29-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 33332-29-5, name is 2-Amino-5-chloropyrazine belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.

17 (1.1 g, 8.5 mmol) was dissolved in dichloromethane (25 mL) followed by the addition of NBS (1.52 g, 8.5 mmol) in batches over a period of 15 min at room temperature. When the reaction was completed, saturated aqueous Na2CO3 solution (10 mL) was added. After stirring for 10 min, the mixture was partitioned between dichloromethane (100 mL) and water (100 mL). The organic layer was dried over anhydrous Na2SO4, decolorized with activated charcoal (0.5 g), and concentrated to give a yellow solid (1.53 g, yield 87%). 2-Amino-3-bromo-5-chloropyrazine (18a) Yield: 87%, yellow solid, M.p.: 108-110 C. 1H NMR(400 MHz, CDCl3): delta 7.97 (s, 1H), 5.08 (s, 2H). 1H NMR(400 MHz, DMSO-d6): delta 8.10 (s, 1H), 6.99 (s, 2H). 13CNMR (125 MHz, CDCl3):delta 151.66, 140.26, 134.75, 123.27. EI-MS m/z: 207 (M+, Cl35, Br79,76), 209 (M+, Cl37,Br79 and Cl35,Br81,100), 211 (M+, Cl37, Br 81,26), 128 (M+,Cl35,-Br, 75), 130 (M+, Cl37,-Br, 25), 101 (M+, Cl35,-Br,-HCN, 30), 103 (M+, Cl37,-Br, -HCN, 10).

The synthetic route of 2-Amino-5-chloropyrazine has been constantly updated, and we look forward to future research findings.

Application of 875781-43-4, A common heterocyclic compound, 875781-43-4, name is 2-Bromo-5H-pyrrolo[2,3-b]pyrazine, molecular formula is C6H4BrN3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A 10 mL microwave vial was charged with 5-bromo-4,7-diazaindole (0.471 g, CASRN 875781-43-4), 4-pyridylboronic acid (0.58 g), lM Na2C03 (3 mL), l,l ‘-(dppf)Pd(II)Ci2 (0.097 g) and MeCN (3 mL), capped and irradiated in a microwave reactor at 150 C for 30 min. The reaction was cooled and partitioned between H20 and EtOAc. The aqueous layer was twice washed with EtOAc. The combined organic layers were washed once with brine, dried (MgS04), filtered and concentrated to afford a solid residue. The crude purified by Si02 chromatography eluting with an EtOH/EtOAc gradient (1 to 20% EtOH over 12 min) to afford 0.28g of pure 2- (pyridin-4-yl)-5H-pyrrolo[2,3-b]pyrazin (22).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

These common heterocyclic compound, 356783-16-9, name is 3,6-Dichloropyrazine-2-carbonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 3,6-Dichloropyrazine-2-carbonitrile

REFERENTIAL EXAMPLE II-15 In 50 mL of N,N-dimethylformamide was dissolved 10.0 g of 3,6-dichloro-2-pyrazinecarbonitrile. After adding 6.49 mL of thiophenol and 11.91 g of potassium carbonate successively, the mixture thus obtained was stirred at 40 C. for 3 hours. The reaction mixture was poured into a mixture of 100 mL of ethyl acetate and 100 mL of water, and pH was adjusted to 2 with 6 mol/L hydrochloric acid. The organic layer was separated, washed successively with water and saturated aqueous solution of sodium chloride, and dried on anhydrous magnesium sulfate, and then the solvent was removed under reduced pressure. The residue thus obtained was purified by silica gel column chromatography [eluent: toluene:n-hexane=1:3] to obtain 3.80 g of 6-chloro-3-(phenylsulfanyl)-2-pyrazinecarbonitrile as a light yellow-colored oily product. R (neat) cm-1: 2238 H-NMR (CDCl3) delta: 7.00-7.70(5H,m), 8.39(1H,s)

The synthetic route of 3,6-Dichloropyrazine-2-carbonitrile has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 5521-55-1, name is 5-Methylpyrazine-2-carboxylic acid, A new synthetic method of this compound is introduced below., Product Details of 5521-55-1

A mixture of 5-methyl-2-pyrazinecarboxylic acid (1) (0.01 mol) and hydrazine hydrate (0.025 mol) in ethanol (20 mL) was refluxed for 9 h on consistent stirring. After completion of the reaction (monitored by the TLC), the reaction mixture is cooled to room temperature, poured in ice-cold water (20 mL). Thus the solid separated was filtered off and the crude product was recrystallized from ethyl acetate to give pure 5-methyl-2-pyrazinecarboxylic acid hydrazide (2).

The synthetic route of 5521-55-1 has been constantly updated, and we look forward to future research findings.

Related Products of 939412-86-9, The chemical industry reduces the impact on the environment during synthesis 939412-86-9, name is (3-Chloropyrazin-2-yl)methanamine hydrochloride, I believe this compound will play a more active role in future production and life.

To a stirred suspension of (3-chloropyrazin-2-yl)methanamine hydrochloride (0092) (500 mg, 2.78mmol) in ethyl acetate (10 mL) was added acetic anhydride (315 pL, 3.33 mmol) dropwise, followed by triethylamine (1.16 mL, 8.34 mmol). The mixture was stirred at room temperature for 1 h, and the solvent was removed under reduced pressure. The obtained residue was dissolved in methylene chloride (150 mL) and washed with saturated NaHC03 (2 c 25 mL). The organic phase was evaporated under reduced pressure and was further dried under high vacuum to give the title compound as a beige solid (376 mg, 72.9% yield), which was directly used for the next reaction without further purification. MS (ESI) m/z 186.0507 [M + H]+. 1H NMR (500 MHz, Chloroform-d) d 8.5 (d, J = 2.51 Hz, 1H), 8.3 (d, J = 2.55 Hz, 1H), 4.7 – 4.7 (m, 2H), 2.1 (s, 3H)).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (3-Chloropyrazin-2-yl)methanamine hydrochloride, other downstream synthetic routes, hurry up and to see.

Related Products of 5521-55-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 5521-55-1 name is 5-Methylpyrazine-2-carboxylic acid, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a 250 ml four-necked flask was added 13.8 g of 5-methylpyrazine-2-carboxylic acid and 35.7 g of thionyl chloride, and the mixture was heated with stirringReflux reaction 2h, stop heating, vacuum distillation out of excess thionyl chloride, to be evaporated to dry, cooled to room temperature. The residue is dissolved138 g of dichloromethane, and then 20.4 g of p-aminoethylbenzenesulfonamide was added, and 30.4 g of triethylamine was slowly added with stirring,And then stirred at room temperature for 12 h. Filter, and with a small amount of dichloromethane rinse, dry, the filter cake into the water, with hydrochloric acidPH = 1, stirring for 20min, filtered and washed with water to neutral, the resulting solid at 60 ~ 70 for 12h, you can get29.5 g of a white solid product, 2- [4-aminosulfonyl-phenyl] -ethyl-5-methylpyrazine formamide, yield 92.2%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5-Methylpyrazine-2-carboxylic acid, and friends who are interested can also refer to it.

Related Products of 41110-33-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 41110-33-2 name is Methyl 5-methylpyrazine-2-carboxylate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

[0115j To a solution of methyl 5-methylpyrazine-2-carboxylate (0.5 g, 3.28 mmol) in acetic acid (5 ml) was added bromine (0.i9 ml, 3.6i mmol) at room temperature. The reaction mixture was heated at 80C for 45 mm. The reaction mixture was concentrated to remove acetic acid. The residue was basified with saturated sodium bicarbonate solution and extracted with ethyl acetate. The organic layer was dried and concentrated. The crude was purified by silica gel column chromatography using 20% ethyl acetate in hexane to afford the title compound methyl 5-(bromomethyl)pyrazine-2-carboxylate (0.3 g, 40%) as a brownish liquid. Calculated M+H: 230.97; Found M+H: 231.0.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Methyl 5-methylpyrazine-2-carboxylate, and friends who are interested can also refer to it.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 77112-52-8, name is Ethyl imidazo[1,2-a]pyrazine-2-carboxylate, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of Ethyl imidazo[1,2-a]pyrazine-2-carboxylate

Step 2: 5, 6,7, 8-Tetrahydroimidazo [1,2-a] pyrazine-2-carboxylic acid ethyl ester, Hydrochloride :; 0.46 M HCI-EtOH (169 mL) and 10% Pd-C (50% wet) (1.37 g) were added to the EtOH (546 mL) solution of imidazo [1,2-a] pyrazine-2-carboxylic acid ethyl ester (13.7 g). The mixture was hydrogenated under H2 at 40 psi at room temperature for 15 h. The reaction mixture was filtered and Pd-C was washed with EtOH. The filtrate was concentrated under reduced pressure. The residue was applied to silica gel column chromatography, then the column was eluted with CHCI3-MeOH (9/1- 2/1). The titled compound was obtained as brown crystals Yield : 10.4 g, 63%. ‘H NMR (CDCI3) 8 d 1.38 (t, 3H, J = 7.1 Hz), 3.90 (t, 2H, J = 5.7 Hz), 4.40 (q, 2H, J= 7.1 Hz), 4.59 (t, 2H, J= 5.7 Hz), 4.80 (s, 2H), 8.20 (s, 1H).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 77112-52-8.

Related Products of 19847-12-2,Some common heterocyclic compound, 19847-12-2, name is Pyrazinecarbonitrile, molecular formula is C5H3N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A solution of nitrile 3 in ethanol/H2O (0.6 M, 8:1 v/v) was passed through the column reactor R2 (100 mm × 10 mm, 5 g hydrous zirconia) heated at 100 C, with a residence time of 20 minutes, to obtain a quantitative recovery of the primary amide 2 after concentration of the reactor output (>98% yield). White solid; m.p. 191-194 C; delta H (400 MHz, d6-DMSO, 25 C) 7.84 (1H, br. s), 8.24 (1H, br. s), 8.70 (1H, dd, J = 2.5 Hz, J 1.5 Hz), 8.85 (1H, d, J = 2.5 Hz), 9.17 (1H, d, J = 1.5 Hz); delta C (100 MHz, CDCl3, 25 C) 143.46 (CH), 143.69 (CH), 145.18 (C), 147.46 (CH), 165.13 (C); FTIR (neat, nu): 3422, 3132, 1669, 1583, 1525, 1481, 1432, 1373, 1171, 1089, 1046, 1021, 870, 791 cm-1; LC-MS: retention time 0.28 min, m/z [M + H]+ = 124.19; HRMS (ESI): m/z calcd for C5H6ON3+: 124.0505; found 124.0504. Elemental analysis: calcd C = 48.78%, H = 4.09%, N = 34.13%; found C = 48.60%, H = 4.19%, N = 33.70%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Pyrazinecarbonitrile, its application will become more common.

Related Products of 14508-49-7, These common heterocyclic compound, 14508-49-7, name is 2-Chloropyrazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step A: Preparation of (4-(Pyrazin-2-yl)phenyI)methanol.A mixture of 2-chloropyrazme (0.230 ml, 2.62 mmol), 4-(hydroxymethyl)phenylboronic acid (517 mg, 3.41 mmol), tetrakis(t?phenylphosphine)palladium (0) (303 mg, 0.262 mmol) and 2 M potassium phosphate aqueous solution (2.62 ml, 5.24 mmol) in dioxane (10 mL) was heated at 80 0C overnight under nitrogen. The mixture was cooled down, poured into water and extracted with ethyl acetate. The combined organic layers were dried and concentrated. The residue was purified by preparative HPLC to give the title compound (350 mg) as an off-white solid. LCMS m/z = 187.0 [M+H]+. 1H NMR (400 MHz, CDCl3) delta 4.79 (s, 2H), 7.52 (d, J= 8.1 Hz, 2H), 8.02 (d, J = 8.1 Hz, 2H), 8.51 (d, J= 2.5 Hz, IH), 8.63 (dd, J = 2.4 and 1.6 Hz, IH), 9.03 (d, J= 1.6 Hz, IH).

Statistics shows that 2-Chloropyrazine is playing an increasingly important role. we look forward to future research findings about 14508-49-7.