Tag: M.W=100-200

Application of 4774-14-5, A common heterocyclic compound, 4774-14-5, name is 2,6-Dichloropyrazine, molecular formula is C4H2Cl2N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 1 [0665] To a solution of fert-butyl azetidin-3-ylcarbamate hydrochloride (LXIII) (2 g, 9.58 mmol) in dry DMF (19.2 mL) was added DIPEA (8.37 ml, 47.9 mmol). To this mixture was added 2,6-dichloropyrazine (LXIV) (1.428 g, 9.58 mmol) and the reaction was stirred at 95C for 3 h. The reaction was quenched with water (20 mL) and extracted with EtOAc. The organic layer was dried over anhydrous NaaSO/t, filtered and concentrated. The residue was purified by silica gel column chromatography (40 g) (100% hexanes?hexanes:EtOAc 1 : 1) to yield fert-butyl (l -(6-chloropyrazin-2-yl)azetidin-3-yl)carbamate (LXV) (2.2882 g, 8.04 mmol, 84 % yield) as a

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Synthetic Route of 109838-85-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 109838-85-9, name is (R)-2-Isopropyl-3,6-dimethoxy-2,5-dihydropyrazine, This compound has unique chemical properties. The synthetic route is as follows.

To a solution of (2R)-(-)-2,5-dihydro-3,6-dimethoxy-2-isopropylpyrazine (0.61 g, 4.36 mmol) in THF (8 mL) was added n-BuLi (2.5 M in hexane, 1.8 mL, 4.58 mmol) at -78 °C. After allowed to stir for 0.3 hours, Compound Int-15a (2.75 g, 6.98 mmol) in 2 mL of THF was added and the mixture was allowed to stir at the temperature for 4 hours. The reaction was quenched by saturated aqueous NH4CI solution and the organic layers were extracted with EtOAc. The combined organic solution was washed with brine solution, dried (Na2S04), and concentrated in vacuo. The residue obtained was purified using an ISCO 40 g column (gradient from 0percent to 2.5percent ether in hexane) to provide Compound Int-15b, 783 mg (44percent). NMR (CDC13) delta 4.05 (m, 1H), 3.96 (t, J = 3.4 Hz, 1H), 3.72 (s, 3H), 3.71 (s, 3H), 3.49 (dd, J = 2,8, 0.4 Hz, 1H), 3.26 (dd, J= 6, 9.4 Hz, 1H), 2.30 (m, 1H), 1.96 (m, 1H), 1.60 (m, 2H), 1.37 1.17 (m, 3H), 1.08 (d, J= 6.9 Hz, 3H), 0.99 0.86 (m, 2H), 0.72 (d, J= 6.6 Hz, 3H), 0.49 (dd, J= 11.0, 14.4 Hz, 1H), 0.35 (dd, J= 11.0, 14.2 Hz, 1H), 0.16 (s, 6H).

The chemical industry reduces the impact on the environment during synthesis (R)-2-Isopropyl-3,6-dimethoxy-2,5-dihydropyrazine. I believe this compound will play a more active role in future production and life.

69214-33-1, name is 8-Chloroimidazo[1,2-a]pyrazine, belongs to pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. category: Pyrazines

Example A15Mixture of 3-bromo-8-chloro-imidazo[1,2-c]pyrazine and 3,8-dibromo-imidazo[1,2-a]pyrazine N-Bromosuccinimide (2.0 g, 11.6 mmol) was added to a stirred solution of intermediate 3 (1.78 g, 11.58 mmol) in DCM (50 ml). The mixture was stirred at RT for 2 h. and then diluted with further DCM and washed with a saturated solution of sodium carbonate. The organic layer was separated, dried (Na2SO4), filtered and the solvent evaporated in vacuo to yield a 72/28 mixture of 3-bromo-8-chloro-imidazo[1,2-c]-pyrazine and 3,8-dibromo-imidazo[1,2-a]pyrazine (intermediate 15) (5.89 g, 99%) as white solid.

The synthetic route of 69214-33-1 has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 16298-03-6, name is Methyl 2-aminopyrazine-3-carboxylate, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 16298-03-6, COA of Formula: C6H7N3O2

(iii) Methyl 3-amino-6-bromopyrazine-2-carboxylate: 3-Aminopyrazine-2-carboxylic acid methyl ester (200 g, 1.3 mol, 3B ScientificCorporation) was dissolved in AcOH (1 L). The solution was warmed to 50 °C and Br2 (312 g, 1.9 mol) added dropwise. When the addition was completed, the mixture was stirred at 50 °C for additional 3 hours. The reaction mixture was poured slowly to ice-water (4 L). The precipitate was filtered, washed with water and dried under a reduced pressure to afford the subtitle compound (iii) as a red brown solid (300g).1H-NMR (400 MHz, CDC13) delta 8.28 (s, 1H), 3.97 (s, 3H);HPLC Retention Time = 1.016min.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 2-aminopyrazine-3-carboxylate, other downstream synthetic routes, hurry up and to see.

Reference of 1286754-14-0,Some common heterocyclic compound, 1286754-14-0, name is Ethyl imidazo[1,2-a]pyrazine-3-carboxylate, molecular formula is C9H9N3O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

The imidazo [1,2 – the a] pyrazine -3 – carboxylic acid ethyl ester (780 mg, 4 . 08 mmol) is dissolved under stirring 20 ml in tetrahydrofuran, then add 10% palladium carbon 400 mg, hydrogen under the protection of the 35 C stirring 12 hours, the reaction to remove the catalyst, concentrated under reduced pressure, column chromatography purification to obtain 5, 6, 7, 8 – tetrahydro imidazo [1,2 – the a] pyrazine -3 – carboxylic acid ethyl ester (600 mg, yield: 75.3%, white solid).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Ethyl imidazo[1,2-a]pyrazine-3-carboxylate, its application will become more common.

Synthetic Route of 14508-49-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 14508-49-7, name is 2-Chloropyrazine, This compound has unique chemical properties. The synthetic route is as follows.

The 2-chloropyrazine (18 ml, 200 mmol) 1a is added to the 2-(diphenylmethyleneamino)acetic acid ethyl ester(51 g, 190 mmol) with a solution of cesium carbonate (6.5 g, 20 mmol) in N,N-dimethyl formamide (250 ml), The reaction was heated to 65 C for 48 hours. The reaction is cooled down to the room temperature, the addition of water (200 ml), ethyl acetate (400 ml × 2) extraction, the combined organic phase with water (500 ml × 2) washing, drying with anhydrous sodium sulfate, filtered and concentrated, the residue by silica gel column chromatography [petroleum ether/ethyl acetate (v/v)=5/1] purification, to give the title compound 1b (48g, 69% yield) as a brown oil.

The chemical industry reduces the impact on the environment during synthesis 2-Chloropyrazine. I believe this compound will play a more active role in future production and life.

Adding a certain compound to certain chemical reactions, such as: 59489-71-3, name is 2-Amino-5-bromopyrazine, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 59489-71-3, category: Pyrazines

5-Bromopyrazin-2-amine (5 g, 28.74 mmol), (4-isopropylsulfonylphenyl)boronic acid (7.866 g, 34.49 mmol) and K3P04 (12.20 g, 57.48 mmol) were combined in MeCN (100 mL) / Water (25 mL) and Pd[P(tBu)3]2 (734.4 mg, 1.437 mmol) was added. The reaction was heated at 60 C for 1 hour. The reaction mixture was cooled to ambient temperature and diluted with EtOAc and water. The layers were separated and the aqueous layer extracted with EtOAc (x 3). The combined organic layers were dried (MgS04), filtered andconcentrated in vacuo. The residue was triturated from DCM and isolated by filtration to give the sub-title compound as an orange solid (6.43 g, 76% Yield). 1H NMR (400.0MHz, DMSO) delta 1.17 (d, 6H), 3.43 (sept, 1H), 6.86 (s, 2H), 7.87 (d, 2H), 8.00 (s,1H), 8.20 (d, 2H) and 8.67 (s, 1H) ppm; MS (ES+) 278.2

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In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 121246-96-6 as follows. Application In Synthesis of 3-Chloropyrazine-2-carbaldehyde

Add in pressure reactor3-Chloro-2-carbaldehyde pyrazine (II)(0.71 g, 5 mmol) and dioxane (20 mL),Ammonia (1.7g, 0.1mol) was added with stirring and then added4- (Pyridin-2-yl-Aminocarbonyl) benzeneboronic acid(III) (2.42 g, 10 mmol),Acetylacetonate dicarbonyl rhodium(0.26 g, 1 mmol) and water 4 mL.The reactor closed, gradually warming to 80 ~ 90 degrees,The reaction 16-18 hours, TLC detection, the reaction was completed.Concentration under reduced pressure, the residue was dissolved with methylene chloride,Saturated sodium bicarbonate and water were washed in turn, dried over anhydrous sodium sulfate.Concentrated to give a tan oil,Column chromatography with ethyl acetate and petroleum ether (1: 2 by volume) gave a white solid4- [amino (3-chloro-2-pyrazinyl)Methyl] -N- (2-pyridyl)Benzamide(IV) 1.38 g, 81.2% yield

According to the analysis of related databases, 121246-96-6, the application of this compound in the production field has become more and more popular.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 54608-52-5, name is 2-Hydrazinopyrazine belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below. COA of Formula: C4H6N4

1003301 Step A: 2-(5-methyl-4-nitroso-3-phenyl-1H-pyrazol-i-yl)pyrazine. To a solution of 2-hydrazinylpyrazine (0.485 g, 4.40 mmol) in HOAc (6 mL) was added (2- (hydroxyimino)-i-phenylbutane-i,3-dione (0.765 g, 4.00 mmol) in small portions over 2 minutes. The mixture was stirred for 5 minutes and the resulting light orange suspension was stirred at 60 C for 6 hours. EtOH (1 mL) was added and the mixture was heated at 60 C for an additional 6 hours. The resulting dark green suspension was cooled to ambient temperature and the mixture was diluted with H20 (30 mL). The green suspension was stirred for 1 hour and the solid was collected via vacuum filtration. The collected solid was washed with 1120 and dried in vacuum. The solid was suspended in EtOH (25 mL) and concentrated HC1 (500 jiL) was added. The mixture was heated at reflux for 20 hours, cooled to ambient temperature and diluted with chilled 1120 (75 mL). The mixture was treated with 1M NaOH to pH=7 and was extracted with Et20 (3X). The combined extracts were washed with saturated NaC1 and dried over MgSO4. The dried solution was filtered through packed Celite and concentrated. The residual green-yellow solid was purified on a Si02 column using step gradient elution (25% CH2C12, 50% EtOAc/hexanes) to furnish the title compound as a turquoise solid (325 mg, 3 1%). MS (apci) mlz = 266.1 (M+H).

The synthetic route of 54608-52-5 has been constantly updated, and we look forward to future research findings.

Synthetic Route of 313339-92-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 313339-92-3, name is 3,5-Dichloropyrazine-2-carbonitrile, This compound has unique chemical properties. The synthetic route is as follows.

3,5-Dichloropyrazine-2-carbonitrile (24 mg, 0.138 mmol), 6-cyclopropyl-2-[(2R,3R)-2- methylpiperidin-3-yl]-1,2-dihydroisoquinolin-1-one (36 mg, 0.118 mmol) and DIEA (0.050 mL, 0.287 mmol) were dissolved in EtOH (2.5 mL) and stirred at 40 C for 100 minutes. The reaction was quenched with aqueous NH4Cl. DCM was added and the mixture was filtered through a phase separator. The organic layer was concentrated under high vacuum and the residue was purified by silica flash chromatography with 0% to 40% of ethyl acetate in cyclohexane to give 3-chloro-5-[(2R,3R)-3-(6-cyclopropyl-1-oxo-1,2-dihydroisoquinolin-2-yl)- 2-methylpiperidin-1-yl]pyrazine-2-carbonitrile (39 mg, 79% yield) as a white solid. MS found for C23H22ClN5O as (M+H)+ 420.1.

The chemical industry reduces the impact on the environment during synthesis 3,5-Dichloropyrazine-2-carbonitrile. I believe this compound will play a more active role in future production and life.