Tag: M.W=100-200

Synthetic Route of 50866-30-3, These common heterocyclic compound, 50866-30-3, name is 5-Methylpyrazine-2-carbaldehyde, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of the BOC-protected intermediate from Example 2 (32 mg, 0.07 mmol) in 1/1 dichloromethane/ methanol (1 mL) was added a solution of 5-methylpyrazine-2-carbaldehyde (11 mg, 0.09 mmol) in 1/1 dichloromethane/methanol (0.3 mL), followed by acetic acid (20 muL, 0.35 mmol) and the mixture was stirred at 50 C. for 15 minutes. MP-cyanoborohydride resin (327 mg, 0.07 mmol) was added and the mixture was shaken at 50 C. overnight, filtered and concentrated. To the residue was added 4M hydrogen chloride in dioxane (2 mL) and the mixture was shaken at 50 C. for 2 hours. The mixture was concentrated, dissolved in 1:1 dimethylsulfoxide/methanol and purified by preparative HPLC (Phenomenex Luna C8(2) 5 mum 100 AXIA column) eluting with a gradient of 5-100% acetonitrile/0.1% trifluoroacetic acid in water to afford the title compound as the trifluoroacetate salt. 1H NMR (400 MHz, pyridine-d5) delta 12.04 (s, 1H) 8.74 (s, 1H) 8.69 (s, 1H) 8.49-8.51 (m, 1H) 8.46 (s, 1H) 7.18 (d, J=7.32 Hz, 1H) 6.91-6.96 (m, 2H) 4.53 (s, 2H) 3.91-4.03 (m, J=8.55 Hz, 1H) 3.63-3.71 (m, J=8.70, 8.70 Hz, 2H) 3.61 (s, 1H) 3.53-3.60 (m, 1H) 3.47 (t, J=8.39 Hz, 2H) 3.07-3.16 (m, 1H) 2.92 (t, J=8.54 Hz, 2H) 2.44 (s, 3H) 2.19-2.27 (m, J=2.44 Hz, 1H) 1.87-2.11 (m, J=28.08 Hz, 2H) 1.76-1.86 (m, J=14.34 Hz, 1H). MS (ESI) m/z 463 (M+H)+.

The synthetic route of 50866-30-3 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 6164-79-0, name is Methyl 2-pyrazinecarboxylate, A new synthetic method of this compound is introduced below., Safety of Methyl 2-pyrazinecarboxylate

LiAlH4 (4g, 100 mMol) was slowly added to a solution of pyrazinecarboxylic acid methyl ester (12. 8g, 100 mMol) in tetrahydrofuran (400 mL) at-70° C. The mixture was stirred at this temperature for 40 min, followed by neutralisation with 20 mL of glacial acetic acid. The solvent was evaporated in vacuo and the residue was partitioned between 30 mL of 2N HCL and dichloromethane. A large amount of brown solid precipitated which was filtered off. The dichloromethane layer was passed through a pad of silica, the solvent was evaporated to give the pyrazine 2-carboxaldehyde (1.4g) as a yellow oil.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Related Products of 121246-96-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 121246-96-6 name is 3-Chloropyrazine-2-carbaldehyde, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Preparation 1; 4-Methyi-3,4,5,6-tetrahydro-2H-[1,2’lbip(at)rrazinyl-3′-carbaldehyde; n-BuLi (56 mmol, 22.4 mL, 2.5 M in hexanes) was added to tetrahydrofuran (300 mL) cooled to-78 C followed by the addition of 2,2-6,6-tetramethylpiperidine (52 mmol, 8.71 mL). The solution was removed from the cooling bath and stirred for 30 minutes and then cooled back to -78C. 2-chloropyrazine (40 mmol, 3.65 mL) was added dropwise, and the solution turned a reddish-brown color. After stirring 30 minutes, methylformate (60 mmol, 3.7 mL) was added and the reaction mixture was stirred for 2.25 hrs at -78C. Acetic acid (8 mL) was added and the mixture was warmed to 0C, was washed 3 times with 1: 1 brine-water, dried over sodium sulfate, and then concentrated in vacuo. The residue was dissolved in 1,4- dioxane (250 mL) and 1-methylpiperazine (60 mmol, 6.6mL) and potassium carbonate solution (8.28g in 60 mL of water) were added and the mixture was heated at 100C for 1.5 hours. After cooling to room temperature, the mixture was filtered through a Celite pad which was then washed with chloroform. The filtrate was concentrated in vacuo and purified by silica gel chromatography (100: 1:1 chloroform-methanol-ammonium hydroxide) to yield 3.3 g (40% yield for two steps) of 4-methyl-3,4,5,6-tetrahydro-2H-[1,2′]bipyrazinyl-3′-carbaldehyde; ¹3C NMR (100 MHz, CDC13) d 191.7,154.3, 145.3,134.5, 133.2, 55.1, 48.7, 46.3; MS (AP/CI) 207.2 (M+H)+.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Chloropyrazine-2-carbaldehyde, and friends who are interested can also refer to it.

Related Products of 13924-95-3, The chemical industry reduces the impact on the environment during synthesis 13924-95-3, name is Methyl 5-hydroxypyrazine-2-carboxylate, I believe this compound will play a more active role in future production and life.

2-hydroxy-5-carbomethoxy-pyrazine (15.4 g) was dissolved in phosphorus oxychloride (100 ml) and several drops of dimethylformamide were added, followed by stirring with heating at 140C for 3 hours. After the reaction solution was poured into ice water and extracted with chloroform, the organic layer was washed with an aqueous saturated sodium hydrogen carbonate solution and saturated brine, dried and then concentrated. The resulting crystal was collected by filtration and washed with ether to obtain 2-chloro-5-carbomethoxy-pyrazine (14.0 g).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 5-hydroxypyrazine-2-carboxylate, other downstream synthetic routes, hurry up and to see.

4858-85-9, name is 2,3-Dichloropyrazine, belongs to pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Quality Control of 2,3-Dichloropyrazine

Step 1: 2-chloro-3-hydrazinylpyrazi [0196] To a stirred solution of 2,3-dichloropyrazine (10.0 g, 67.6 mmol) in ethanol (95%, 120 ml) was added 85% hydrazine hydrate (25.6 mL, 338 mmol) dropwise at room temperature. The mixture was stirred for 4 hours and cooled to ice-water bath temperature. The resulting precipitate was isolated by filtration and washed with cold ethanol (95%) to give the title compound as a light yellow powder (6.5 g, 67%) which was used in the next step without further purification.

The synthetic route of 4858-85-9 has been constantly updated, and we look forward to future research findings.

Related Products of 1060814-53-0, A common heterocyclic compound, 1060814-53-0, name is (5-Chloropyrazin-2-yl)methanamine, molecular formula is C5H6ClN3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 254 4-N-[(5-chloropyrazin-2-yl)methyl]-6-(2,3-dimethylphenyl)pyrimidine-2,4-diamine. 4-Chloro-6-(2,3-dimethylphenyl)pyrimidin-2-amine (12 mg, 0,050 mmol), (5- chloropyrazin-2-yl)methanamine (14 mg, 0, 10 mmol), Et3N (0,040 mL, 0,30 mmol) and 1-butanol (0,20 mL) were stirred at 100C for 20 hours. MeOH (1 mL) was added and the mixture was purified by preparative HPLC to give the desired product. LCMS [M+H]+ 341.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Electric Literature of 109838-85-9, These common heterocyclic compound, 109838-85-9, name is (R)-2-Isopropyl-3,6-dimethoxy-2,5-dihydropyrazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a stirred solution containing 0.62 mL (650 mg, 3.53 mmol) of Schoellkopf’s reagent in 10 mL of anhydrous THF at -78 °C was added 0.45 mL (308 mg, 4.82 mmol) of 2.5 M BuLi. The reaction mixture was stirred at -78 °C for 30 min under argon and then a solution containing 1.03 g (3.21 mmol) of 3-(chloromethyl)-1-tosyl-1H-pyrrolo[2,3-b]pyridine (4) in 10 mL of anhydrous THF was added. The reaction mixture was stirred for 1 h under argon at -78 °C, then diluted with 50 mL of satd aq NH4Cl and extracted with two 50-mL portions of EtOAc. The combined organic phase was dried (MgSO4) and concentrated under diminished pressure. The residue was purified by chromatography on a silica gel column (10 * 2 cm). Elution with 2:1 hexanes/ethyl acetate gave 3-(((2S,5R)-5-isopropyl-3,6-dimethoxy-2,5-dihydropyrazin-2-yl)methyl)-1-tosyl-1H-pyrrolo[2,3-b]pyridine (5) as a yellow oil: yield 783 mg (52percent); silica gel TLC Rf 0.15 (4:1 hexanes/ethyl acetate); 1H NMR (CDCl3, 400 MHz) delta 0.51(d, 3H, J = 6.8 Hz), 0.78 (d, 3H, J = 8 Hz), 1.99-2.03 (m, 1H), 2.22 (s, 3H), 3.07-3.12 (m, 3H), 3.57 (s, 3H), 3.60 (s, 3H), 4.22-4.25 (m, 1H), 7.02-7.05 (m, 1H), 7.13 (d, 1H, J = 8 Hz), 7.36 (s, 1H), 7.74 (dd, 1H, J = 8.0 and 1.6 Hz), 7.87 (d, 2H, J = 8.4 Hz) and 8.29 (dd, 1H, J = 4.8 and 1.6 Hz); 13C NMR (CDCl3, 400 MHz) delta 16.4, 18.8, 21.5, 29.1, 31.3, 52.1, 52.3, 55.5, 60.4, 114.9, 118.3, 123.7, 124.6, 127.5, 128.2, 129.5, 135.5, 144.6, 144.8, 147.1, 161.8 and 164.0; mass spectrum (APCI), m/z 469.1921 (M+H)+ (C24H29N4O4S requires m/z 469.1909).

The synthetic route of 109838-85-9 has been constantly updated, and we look forward to future research findings.

Related Products of 14508-49-7, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 14508-49-7 as follows.

In air, a vial was charged with complex Ih (6.8 mg, 0.01 mmol), potassium carbonate (207 mg, 1.50 mmol), the boronic acid (0.6 mmol) and the organohalide (0.5 mmol). The vial was sealed with a septum and purged with argon (3×). Dioxane (2.0 mL) was added and the contents were stirred at 60 C. for the specified period of time. The reaction was then diluted with diethyl ether (2 mL) and transferred to a round bottom flask. The reaction vial was rinsed with additional diethyl ether (2 mL) and combined with the previous dilution. Each reaction was performed in duplicate and the contents were combined, concentrated onto silica gel and purified by flash chromatography.

According to the analysis of related databases, 14508-49-7, the application of this compound in the production field has become more and more popular.

Application of 19847-12-2,Some common heterocyclic compound, 19847-12-2, name is Pyrazinecarbonitrile, molecular formula is C5H3N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of pyrazine-2-carbonitrile (1.0 g, 9.52 mmol) in methanol (20 mL) was addedNaOCH3 (0.10 g, 1.90 mmol). The resulting mixture was heated with stirring at rt for 12 hrs. Tothe reaction mixture was added NH4C1 (0.51 g, 9.52 mmol). After being heated under reflux for 3 hrs, the resulting reaction mixture was concentrated in vacuo. The residue was suspended in ethanol (30 mL). The suspension was heated under reflux for 1 hr, then cooled to rt and filtered. The filtrate was concentrated in vacuo to give pyrazine-2-carboxamidine hydrochloride (1.2 g),which was used in the next step without further purification.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Pyrazinecarbonitrile, its application will become more common.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 108-50-9 as follows. Formula: C6H8N2

EXAMPLE 107 alpha,alpha’-Dichloro-2,6-dimethylpyrazine A stirred mixture of 2,6-dimethylpyrazine (55 mmol), N-chlorosuccinimide (110 mmol) and benzoylperoxide (1.0 mmol) in carbon tetrachloride (150 mL) is heated to reflux under nitrogen for 30 hours. Additional N-chlorosuccinimide (140 mmol) and benzoylperoxide (2.3 mmol) are added at 6 hours. The cooled reaction mixture is filtered and the filtrate washed with sodium carbonate (saturated aqueous solution) and dried. Evaporation of the solvent gives the title compound.

According to the analysis of related databases, 108-50-9, the application of this compound in the production field has become more and more popular.