Tag: M.W=100-200

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1220330-11-9, name is 5-Ethoxypyrazine-2-carboxylic acid, A new synthetic method of this compound is introduced below., Recommanded Product: 1220330-11-9

5-Ethoxypyrazine-2-carboxylic acid (53.9 mg, 320 muiotaetaomicron) was suspended in dichloromethane (5 mL), the suspension was cooled to 0-5C (ice bath) and oxalyl chloride (56.9 mg, 39.3 mu, 448 muiotaetaomicron) as well as dimethylformamide (0.308 M in toluene, 51.9 mu, 16 muiotaetaomicron) were added. The mixture was stirred for 1.5 h at room temperature. Then, it was concentrated in vacuo (40C, 5 mbar) and dried azeotropically by two cycles of addition of toluene (3 mL) followed by concentration in vacuo to afford 5-ethoxypyrazine-2-carbonyl chloride as yellow oil (59.7 mg, quant.). After that, tert-butyl ((3aS,4R,8R)-4-(5-amino-2-fluorophenyl)-4,7,7-trimethyl-8-oxido- 3,3a,4,7-tetrahydro-2H-isothiazolo[l,5-a] [l,4]thiazin-6-yl)carbamate (Int- 16ABp, 80 mg, 188 muiotaetaomicron) was dissolved in dichloromethane (5 mL), the solution cooled to 10C and N,N- diisopropylethylamine (36.5 mg, 49.4 mu, 283 muiotaetaomicron) was added, followed by a solution of 5- ethoxypyrazine-2-carbonyl chloride (vide supra, 47.7 mg, 256 muiotaetaomicron) in dichloromethane (4 mL). The reaction mixture was stirred for 15 min at 10C. Then, methanol (2 mL) was added, the mixture was stirred for 5 min at room temperature and concentrated in vacuo. The crude was purified by column chromatography (silica gel, 24 g, eluting with 2 M ammonia in methanol / dichloromethane, gradient 1 :99 to 3:97) to yield, after drying in vacuo (40C, 5 mbar), the title compound as a white solid (92 mg, 85% yield). HPLC (method LCMS_fglm) tR = 1.37 min. MS (ES+) m/z 575.4 [M+H] .

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Synthetic Route of 77168-85-5, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 77168-85-5, name is Methyl 5-chloro-6-methylpyrazine-2-carboxylate, This compound has unique chemical properties. The synthetic route is as follows.

Step 1: methyl 5-(5-fluoro-2-methoxypyridin-4-yl)-6-methylpyrazine-2-carboxylate To a nitrogen-purged solution of methyl 5-chloro-6-methylpyrazine-2-carboxylate (15 g, 80 mmol), (5-fluoro-2-methoxypyridin-4-yl)boronic acid (16.49 g, 96 mmol), Pd (dppf) Cl2 dichloromethane adduct (1.2 g,1.469 mmol) and Pd(dppf)C12 (4.6 g, 6.29 mmol) in THF (199 ml) and water (40.8 ml) was addedpotassium phosphate tribasic (51.2 g, 241 mmol) under a nitrogen atmosphere. A reflux condenserwas attached and the mixture was vigorously refluxed with a 100 °C oil bath with stirring. After 105mm, the reaction was cooled to rt and partitioned between EtOAc (200 mL) and water (200 mL).The layers were separated and the aqueous layer was extracted with ethyl acetate (150 mL). Theorganic layers were combined, filtered through C eliteTM, washed with brine, dried over anhydrousMg504, filtered and evaporated to afford a crude residue. The resulting residue was purified via column chromatography on silica gel (ISCO RediSep Gold 330g silica gel column, gradient elution with 0percent to 50percent EtOAc in hexanes) to give the title compound.

The chemical industry reduces the impact on the environment during synthesis Methyl 5-chloro-6-methylpyrazine-2-carboxylate. I believe this compound will play a more active role in future production and life.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 73627-18-6 as follows. Product Details of 73627-18-6

Example 1 (6-chloro-pyrazolo[1,5-a]pyrimidin-2-yl)-(1-methyl-3,4-dihydro-1H-pyrrolo[ 1,2-a]pyrazin-2-yl)-methanone A solution of 6-chloro-pyrazolo[1,5-a]pyrimidine-2-carboxylic acid (181 mg, 0.92 mmol, 1.0 equiv), 1-methyl-1,2,3,4-tetrahydro-pyrrolo[1,2-a]pyrazine (150 mg, 1.10 mmol, 1.2 equiv), EDC (176 mg, 0.92 mmol, 1.0 equiv) and HOAt (125 mg, 0.92 mmol, 1.0 equiv) in DMF (5 mL) was heated at 50C for 4 h. The mixture was allowed to cool to room temperature and poured into water and extracted with ethyl acetate. The combined organic layers were washed three times with brine, dried over Na2SO4 and concentrated. The residue was subjected to flash column chromatography (40% ethyl acetate in heptane) to yield 265 mg (91 %) of the title compound in good to moderate yield. LC/MS: m/z = 317 (MH+)

According to the analysis of related databases, 73627-18-6, the application of this compound in the production field has become more and more popular.

Reference of 38557-71-0, These common heterocyclic compound, 38557-71-0, name is 2-Chloro-6-methylpyrazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a suspension of 2-chloro-6-methylpyrazine (24 g, 186.7 mmol) in anhydrous MeOH (240 mL) was added NaOMe (12.1 g, 224 mmol). The mixture was stirred at 60-70C for 16hours. The mixture was cooled and filtered. The filtrate was concentrated in vacuo to give 2- methoxy-6-methylpyrazine (22 g, 95% yield). 1H NMR (CDCI3400 MHz): 7.98 (s, 1H), 7.94(s, 1H), 3.91 (s, 3H), 3.40 (s, 3H). LC-MS: tR = 1.47 mm (method 14), mlz= 124.8 [M + H].

Statistics shows that 2-Chloro-6-methylpyrazine is playing an increasingly important role. we look forward to future research findings about 38557-71-0.

Electric Literature of 43029-20-5, These common heterocyclic compound, 43029-20-5, name is 3-Amino-6-methylpyrazin-2(1H)-one, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

EXAMPLE H3 3-Amino-1,6-dimethylpyrazin-2-one (Compound 14.12) 8.87 g of dimethyl sulfate are added dropwise to a mixture of 8.13 g of 3-amino-6-methylpyrazin-2-one and 72 ml of 1N sodium hydroxide solution at room temperature. After the mixture has been stirred at 20-25 C. for 15 hours, the precipitate is filtered off, the filtrate is concentrated to one quarter of the volume and the concentrate is extracted with ethyl acetate. 1.7 g of 3-amino-1,6-dimethylpyrazin-2-one with a melting point of 217-219 C. are obtained by washing with saturated sodium chloride solution, drying with sodium sulfate and concentrating the organic phase.

The synthetic route of 43029-20-5 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 70838-55-0, name is 2-Chloropyrido[2,3-b]pyrazine, A new synthetic method of this compound is introduced below., category: Pyrazines

EXAMPLE 6 STR36 A mixture of 2-chloro-pyrazino[2,3-b]pyridine (3.35g), isopropanol (20 mL) and concentrated ammonium hydroxide (50 mL) was heated at 115 C. for 17 h in a sealed tube. The tube was cooled and the product was collected and recrystallized from ethanol to afford 2-amino-pyrazino[2,3-b]pyridine as a yellow solid.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Related Products of 5910-89-4, The chemical industry reduces the impact on the environment during synthesis 5910-89-4, name is 2,3-Dimethylpyrazine, I believe this compound will play a more active role in future production and life.

A mixture of 2,3-dimethylpyrazine (2Og, 18.5mmol), selenium dioxide (41.06g, 37mmol) and diatomeous earth (2Og) in EtOAc (500ml) was stirred and heated at 7O0C for 2 hours. The mixture was allowed to cool and the insoluble matter was removed by filtration EPO through diatomeous earth. The filtrate was washed with saturated aqueous sodium hydrogen carbonate solution and then saturated aqueous sodium chloride solution, dried (MgSO4) and the solvent removed by evaporation. The residue was suspended in water (100ml) and hydroxylamine (45ml of a 50% aqueous solution) was added. The mixture was stirred at ambient temperature for 18 hours and the mixture then extracted with EtOAc. The extracts were combined, washed with saturated aqueous sodium chloride solution, dried (MgSO4) and the solvent removed by evaporation. The residue was triturated with isohexane to give 3- methylpyrazine-2-carboxaldehyde oxime (9.65g, 38%); NMR Spectrum 2.67 (s, 3H), 8.23 (s, IH), 8.45-8.49 (m, 2H), 11.87 (s, IH).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2,3-Dimethylpyrazine, other downstream synthetic routes, hurry up and to see.

Electric Literature of 127406-08-0,Some common heterocyclic compound, 127406-08-0, name is 4-(Pyrazin-2-yl)benzaldehyde, molecular formula is C11H8N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

The compound from step A (6.2 g, 33.5 mmole), (1,3-dioxolan-2-yl-methyl)triphenylphosphonium bromide (22.6 g, 52.7 mmole), tris[2-(2-methoxyethoxy)ethyl]amine (11.2 ml, 34.9 mmole), sat. aq. K2CO3 (150 mls), and CH2Cl2 (150 ml) were heated at reflux for 17 hours. The mixture was cooled and the aqueous layer was washed with CH2Cl2 (2×). The combined organic layers were washed with NaHCO3, brine, dried (MgSO4), and concentrated.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-(Pyrazin-2-yl)benzaldehyde, its application will become more common.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 5521-61-9, name is 6-Methylpyrazine-2-carboxylic acid, A new synthetic method of this compound is introduced below., category: Pyrazines

General procedure: Under argon, a stirred solution of appropriate carboxylic acid (0.37 mmol, 1.0 eq.) and Et3N (0.48 mmol, 1.3 eq.) in dry THF (7 mL) was cooled to -10 °C. Ethyl chloroformate (0.55 mmol, 1.5 eq.) was dropwise added and the resulting mixture was stirred for 2 h. Afterward, a solution of sodium azide (0.63 mmol, 1.7 eq.) in water (2 mL) was added in one portion. After 1 h at -10 °C, the reaction was found to be complete (TLC) and was quenched into iced water (5 mL). The mixture was extracted with EtOAc (3 * 10 mL) and the combined organic layers were successively dried over MgSO4, filtered and evaporated under reduced pressure. The crude acyl azide was placed in dry toluene (20 mL) and the mixture heated at reflux for 1 h to give the corresponding crude isocyanate. The latter was dissolved in dry dioxane (7 mL) prior to adding the amine 4 (0.37 mmol, 1.0 eq.). The solution was heated at reflux for 24 h. The reaction mixture was cooled to room temperature and the volatiles were removed to dryness in vacuum at 40 °C. The dark residue was purified by silica gel chromatography column (CH2Cl2/MeOH 99/1) to afford the desired valmerins.

The synthetic route of 5521-61-9 has been constantly updated, and we look forward to future research findings.

Synthetic Route of 50866-30-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 50866-30-3 as follows.

To a solution of N,Nbis(4-methoxybenzyl)ethanesulfonamide (Example 361.0, 73.13 g, 0.209 mol, 1.2 equiv.) in anhydrous THF (600 mL) at -78C was added n-butyllithium (83.71 mL, 0.21 mol, 2.5 M solution in hexanes, 1.2 equiv.) via additional funnel slowly, and the resulting mixture was stirred for 10 mm. A solution of 5 -methylpyrazine-2-carbaldehyde (Example 376.1, 21.3 g, 0.17 mol, 1.0 equiv.) in anhydrous THF (150 mL) was then added, and the mixture was stirred at the same temperature for 45 mm and then allowed to warm to RT for 2 h. The reaction mixture was quenched by addition of aqueous ammonium chloride (200 mL) and extracted with EtOAc (2 x 2 L). The combined organic layers were washed with brine (2 x 500 mL). After drying over anhydrous Na2SO4, the filtrate was concentrated in vacuo to afford the initial product as an oil. The oil was purified by flash column chromatography (silica gel, 230-400 mesh) to afford the two isomers. The faster moving isomer (32 g as white solid) was obtained from the column with a gradient of 10 % to 30 % EtOAc in petroleum ether. 1H NMR (400 MHz, DMSO-d6) oe 8.61 (d, J 1.5 Hz, 1H), 8.51 (d, J= 1.5 Hz, 1H), 7.22-7.11 (m, 4H), 6.90-6.80 (m, 4H), 6.10 (d, J 5.9 Hz, 1H), 5.29 (dd, J= 5.9, 2.2 Hz, 1H), 4.36-4.16 (m, 4H), 3.73 (app s, 6H), 3.70-3.66 (m, 1H) 2.50 (merged with solvent peak, 3H) and 1.10 (d, J = 7.0 Hz, 3H). LCMS (ESI positive ion) m/z: 472.4 (M+H)t

According to the analysis of related databases, 50866-30-3, the application of this compound in the production field has become more and more popular.