Tag: M.W=100-200

Adding a certain compound to certain chemical reactions, such as: 19848-54-5, name is 2-Hydrazinyl-3-methylpyrazine, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 19848-54-5, Formula: C5H8N4

Step B. lV1-(3-Methylpyrazin-2-yl)-222-trifluoroacetohydrazide; To 1.6 g (12.9 mmol) of the product from Step A at 0 C was added slowly and with vigorous stirring 16 mL of trifluoroacetic anhydride that had been cooled to 0 C. The resultant mixture was stirred at ambient temperature for 1 h, concentrated in vacuo, and made basic by treatment with methanolic ammonia. The residue was purified by column chromatography (silica gel, 5% methanol/0.5% ammonium hydroxide/dichloromethane) to give 2.83 g (100%) of the title compound. MS 221 (M+1).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Hydrazinyl-3-methylpyrazine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; MERCK & CO., INC.; WO2003/82817; (2003); A2;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Related Products of 5910-89-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 5910-89-4, name is 2,3-Dimethylpyrazine belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.

EXAMPLE III 2-(3-Hexyl-2-hydroxy-4-phenyl-3-buten-1-yl)-3-methylpyrazine STR11 To a solution of lithium diisopropylamide (1.5 Molar, 73.3 mL, 0.11 mole) in 150 mL of tetrahydrofuran at -78 C. is added slowly to a solution of 2,3-dimethylpyrazine (10.8 g, 0.1 mole) in 100 mL of tetrahydrofuran. The mixture is allowed to warm to room temperature and then cooled to -78 C. A solution of alpha-hexylcinnamaldehyde (23.7 g, 0.11 mole) in 100 mL of tetrahydrofuran is added dropwise over 15 minutes. The reaction product mixture is then worked up according to the procedures of Example I to provide the title compound.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2,3-Dimethylpyrazine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Philip Morris Incorporated; Philip Morris Products Inc.; US5218118; (1993); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Some common heterocyclic compound, 213019-67-1, name is 3-(Trifluoromethyl)pyrazin-2-amine, molecular formula is C5H4F3N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of 3-(Trifluoromethyl)pyrazin-2-amine

N-lodosuccinimide (3.4g, 15mmol) was added to a stirred suspension of 2-amino-3- trifluoromethylpyrazine (1 .63g, 10mmol) and trifluoroacetic acid (340mg, 3mmol) in acetonitrile (20ml) at room temperature. After stirring at room temperature for another 18 hours, the mixture was filtered. The filtrate was diluted with ethyl acetate and washed with a saturated aqueous solution of sodium thiosulfate. The organic layer was dried over sodium sulfate and concentrated under reduced pressure. The residue was purified by column chromatography on silica gel using petroleum ether/ethyl acetate = 5:1 as eluent to give 2-amino-3-trifluoromethyl-5-iodopyrazine (1.27g, 44%) as a yellow solid. (0278) 1H NMR (300Mz, DMSO-d6): delta 8.48 (s, 1 H), 7.06 (br s, 2H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 213019-67-1, its application will become more common.

Reference:
Patent; SYNGENTA PARTICIPATIONS AG; WAILES, Jeffrey, Steven; CARTER, Neil, Brian; CLOUGH, John, Martin; WILLIAMS, John; (57 pag.)WO2019/57723; (2019); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

These common heterocyclic compound, 40155-47-3, name is 3-Methoxypyrazine-2-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C6H6N2O3

[0423] A solution of 3-amino-4-(4-(2,4-difluorophenoxy)piperidin-l-yl)benzonitrile (50 mg, 0.152 mmol), 3~niethoxypyrazme-2-carboxyiie acid (46.8 mg, 0.304 mmol), HATU (115 mg, 0.304 mmol) and DIPEA (106 mu,, 0.607 mmol) in DMF (759 muEpsilon) was stirred on a hot plate at 80C overnight. The reaction mixture was filtered through a Millipore filter, diluted with DMF and MeOH, and purified by HPLC (Shimadzu) eluting with a gradient of ACN in water (basic mode) to give the title compound as a light brown solid (68.7 mg, 97%). .H NMR (400 MHz, CDCb) delta ppm 2.07 – 2.18 (m, 2 H), 2.19 – 2.28 (m, 2 H), 2.91 (ddd, J=l 1.68, 8.02, 3.28 Hz, 2 H), 3.26 (ddd,./ 1 1.62. 7.58, 3.54 Hz, 2 H), 4.18 (s, 3 H), 4.37 – 4.45 (m, 1H), 6.78 ¡¤¡¤ 6.86 (m, 1H), 6.90 (ddd,.7=11, 12, 8.34, 3.03 Hz, 1H), 7.03 (td,.7=9.09, 5,56 Hz, 1H), 7.23 (d,.7=8,34 Hz, 1H), 7.41 (dd, J=8.34, 2.02 Hz, 1H), 8.26 (d, J=2.27 Hz, 1H), 8.41 (d, J=2.53 Hz, 1H), 8.93 (d,./ 1.77 Hz, 1H), 10.62 (s, 1H); ESI-MS m/z [M+H}+ 466.2.

The synthetic route of 3-Methoxypyrazine-2-carboxylic acid has been constantly updated, and we look forward to future research findings.

Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; GREEN, Jason; HOPKINS, Maria; JONES, Benjamin; KIRYANOV, Andre A.; KUEHLER, Jon; MONENSCHEIN, Holger; MURPHY, Sean; NIXEY, Thomas; SUN, Huikai; (300 pag.)WO2018/183145; (2018); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Application of 89-01-0, The chemical industry reduces the impact on the environment during synthesis 89-01-0, name is Pyrazine-2,3-dicarboxylic acid, I believe this compound will play a more active role in future production and life.

Pyrazine-2,3-dicarboxylic acid (4.0 g, 23.8 mmol) was dissolved in acetic anhydride (30 mL).The reaction mixture was refluxed for one hour, and subsequently cooled down to 0 C in ice bath.The obtained crystals of pyrazine-2,3-dicarboxylic anhydride were filtered off (yield 70%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Pyrazine-2,3-dicarboxylic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Semelkova, Lucia; Jano?cova, Petra; Fernandes, Carlos; Bouz, Ghada; Jand?Ourek, Ond?ej; Kone?na, Klara; Paterova, Pavla; Navratilova, Lucie; Kune?, Ji?i; Dole?al, Martin; Zitko, Jan; Molecules; vol. 22; 9; (2017);,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 13924-99-7, name is 6-Oxo-1,6-dihydropyrazine-2-carboxylic acid, A new synthetic method of this compound is introduced below., HPLC of Formula: C5H4N2O3

Example 68. Formula II: R1 =CH3; R2 =R3 =H; R4 =OCH3 To 0.42 g (0.003 mol) of 6-hydroxy-pyrazinoic acid suspended in 10 mL of anhydrous methanol was added 4 mL of (0.030 mol) of chlorotrimethylsilane. The resultant mixture was allowed to stir for 48 hours at room temperature during which time the suspension became a solution. It is expected that this procedure may be used to convert 6-hydroxypyrazinoic acid to any 6-alkoxypyrazinoic ester by the use of the appropriate alcohol and, when the alcohol is not a liquid, the use of an inert solvent such as THF. The solvent and excess chlorotrimethylsilane were removed in vacuo by rotary evaporation. The crude product was purified by column chromatography on silica gel with a hexane-ethyl acetate gradient to yield 0.11 g (22%) of methyl 6-methoxypyrazinecarboxylate.

The synthetic route of 13924-99-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; The Research Foundation of State University of NY; US5643912; (1997); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Adding a certain compound to certain chemical reactions, such as: 33332-30-8, name is 2-Chloro-6-methoxypyrazine, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 33332-30-8, Recommanded Product: 2-Chloro-6-methoxypyrazine

To a solution of 0.49 g (0.0034 mol) of 2-chloro-6-methoxy-pyrazine (Example P7) in 9 mi of dichloromethane there are added, under an argon gas atmosphere, first, within a period of 45 minutes and at 20C, 0.19 g (0.002 mol) of hydrogen peroxide-urea adduct and then, dropwise, 0.3 ml (0.0021 mol) of trifluoroacetic anhydride in dichloromethane. Then there are again added, within a period of 45 minutes and at 20C, 0. 19 g (0.002 mol) of hydrogen peroxide-urea adduct and 0.3 ml (0.0021 mol) of trifluoroacetic anhydride in dichloro- methane, and the reaction mixture is stirred further at 20C for 30 minutes. The reaction is stopped by adding water, and the aqueous phase obtained is extracted with chloroform. The combined organic phases are washed with 5 % sodium hydrogen carbonate solution and saturated sodium chloride solution and dried over sodium sulfate. The desired title compound, having a melting point of 121-123C, is obtained in a yield of 0.53 g (98 % of theory). The compound can be used directly for the next reaction step. ‘H NMR (300 MHz, CDC13) : 7.802 ppm (d (J=1.2 Hz), 1 H) ; 7.691 ppm (d (J=1.2 Hz), 1 H) ; 4.012 ppm (s, 3H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Chloro-6-methoxypyrazine, other downstream synthetic routes, hurry up and to see.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 84996-40-7, name is 2-Amino-3-(methylamino)pyrazine, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C5H8N4

To a mixture of 26 (3.99 g, 32.1 mmol) in THF (200 mL) was added carbonyldiimidazole (CDI; 10.4 g, 64.1 mmol), and the mixture was stirred at 70 C for 5 h. The reaction mixture was allowed to cool to room temperature and concentrated in vacuo. The residue was purified by flash column chromatography (silica gel, 0-5% MeOH in CHCl3). The residue was washed with EtOAc/n-hexane. To the residue in MeCN (100 mL) were added ethyl acrylate (7.00 mL, 64.4 mmol) and DBU (2.40 mL, 16.4 mmol), and the mixture was stirred at 50 C for 12 h under argon atmosphere. The mixture was concentrated in vacuo. The residue was purified by flash column chromatography (silica gel, 0-5% MeOH in CHCl3) to give 27 (6.11 g, 76%) as a colorless solid. 1H NMR (DMSO-d6) delta 1.10 (t, 3H, J = 7.1 Hz), 2.81 (t, 2H, J = 7.1 Hz), 3.34 (s, 3H), 4.00 (q, 2H, J = 7.1 Hz), 4.11 (t, 2H, J = 7.1 Hz), 7.95 (d, 1H, J = 3.3 Hz), 7.96 (d, 1H, J = 3.3 Hz); MS (ESI) m/z 251 [M+H]+.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 84996-40-7.

These common heterocyclic compound, 40155-47-3, name is 3-Methoxypyrazine-2-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 40155-47-3

4-(31) N-(3-((4aS,5S,7aS)-2-amino-5-(fluoromethyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-7a-yl)-4,5-difluorophenyl)-5-methoxypyrazine-2-carboxamide (also called 4-(17)) Methoxypyrazine-2-carboxylic acid (159 mg), PyBOP (898 mg), and diisopropylethylamine (754 mul) were added to a mixture of tert-butyl ((4aS,5S,7aS)-7a-(5-amino-2,3-difluorophenyl)-5-(fluoromethyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-2-yl)carbamate, obtained in Preparation Example 4-(30), (359 mg) in DCM (14 ml) at RT. The mixture was stirred for 3 h at the same temperature. The resultant mixture was purified directly by silica gel column chromatography (gradient from 15% to 70% EtOAc in heptane).

The synthetic route of 3-Methoxypyrazine-2-carboxylic acid has been constantly updated, and we look forward to future research findings.

Reference of 40155-47-3,Some common heterocyclic compound, 40155-47-3, name is 3-Methoxypyrazine-2-carboxylic acid, molecular formula is C6H6N2O3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of amine salt E1.1 (0.868g, 3.39 mmol) and carboxylic acid 1a (0.475g, 3.08 mmol) in DCE (50 mL) at room temperature was sequentially added bromotripyrrolidinophosphonium hexafluorophosphate (1.80 g, 3.85 mmol), and DIEA (1.59g, 112.33 mmol). The reaction was then stirred at room temperature for 72 hours. Then CH2CI2 (100 mL) and water (100 mL) were added to the reaction, layers separated, and the organic phase washed with water (2 x 100 mL), dried over Na2S04, and concentrated in vacuoto afford a residue. The residue was purified by column chromatography using silica gel, eluting with 100% EtOAc, to afford the desired compound as an off white solid (0.690g, 69% yield). LC-MS: mass calc’d. for C17H15CI2N5O2 [M+H]+ 356.1 , found 356.0; tR= 0.688 min.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Methoxypyrazine-2-carboxylic acid, its application will become more common.