Tag: M.W=100-200

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Research Support, N.I.H., Extramural, Research Support, U.S. Gov’t, P.H.S., Organic Letters called A Two-Stage Iterative Process for the Synthesis of Poly-oxazoles, Author is Atkins, Jeffery M.; Vedejs, Edwin, which mentions a compound: 118994-89-1, SMILESS is O=C(C1=CN=CO1)OCC, Molecular C6H7NO3, Related Products of 118994-89-1.

Methodol. has been developed to prepare bis-oxazoles via a two-stage iterative process. The sequence begins with C(2)-chlorination of a lithiated oxazole using hexachloroethane. Generation of the C(2)-C(4′) bond by SNAr substitution with TosMIC anion, followed by conversion to the heterocycle in a one-pot reaction with glyoxylic acid monohydrate, affords the desired bis-oxazole in good yield and purity. The two-stage process allows for efficient synthesis of a tris-oxazole and the iterative preparation of a tetra-oxazole.

As far as I know, this compound(118994-89-1)Related Products of 118994-89-1 can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.

Reference:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Quality Control of 2-Amino-4,5-dihydrothiazole-4-carboxylic acid. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 2-Amino-4,5-dihydrothiazole-4-carboxylic acid, is researched, Molecular C4H6N2O2S, CAS is 2150-55-2, about Cloning, expression, and identification of genes involved in the conversion of DL-2-amino-Δ2-thiazoline-4-carboxylic acid to L-cysteine via S-carbamyl-L-cysteine pathway in Pseudomonas sp. TS1138. Author is Yu, Yangsheng; Liu, Zhong; Liu, Chunqin; Li, Yang; Jin, Yongjie; Yang, Wenbo; Bai, Gang.

Two novel genes (tsB, tsC) involved in the conversion of DL-2-amino-Δ2-thiazoline-4-carboxylic acid (DL-ATC) to L-cysteine through S-carbamyl-L-cysteine (L-SCC) pathway were cloned from the genomic DNA library of Pseudomonas sp. TS1138. The recombinant proteins of these two genes were expressed in Escherichia coli BL21, and their enzymic activity assays were performed in vitro. It was found that the tsB gene encoded an L-ATC hydrolase, which catalyzed the conversion of L-ATC to L-SCC, while the tsC gene encoded an L-SCC amidohydrolase, which showed the catalytic ability to convert L-SCC to L-cysteine. These results suggest that tsB and tsC play important roles in the L-SCC pathway and L-cysteine biosynthesis in Pseudomonas sp. TS1138, and that they have potential applications in the industrial production of L-cysteine.

In addition to the literature in the link below, there is a lot of literature about this compound(2-Amino-4,5-dihydrothiazole-4-carboxylic acid)Quality Control of 2-Amino-4,5-dihydrothiazole-4-carboxylic acid, illustrating the importance and wide applicability of this compound(2150-55-2).

Reference:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Tomasik, Piotr researched the compound: 5-Amino-2-fluoropyridine( cas:1827-27-6 ).Related Products of 1827-27-6.They published the article 《3-Phenylazopyridines》 about this compound( cas:1827-27-6 ) in Roczniki Chemii. Keywords: phenyl azo pyridines; azo pyridines phenyl; pyridines azo phenyl; nitrosobenzene amino pyridines; amino pyridines nitrosobenzene; nitro pyridines reduction amines. We’ll tell you more about this compound (cas:1827-27-6).

Hydrogenation of 2-substituted I (X = NO2), under CO2, in MeOH with Pd/C gave I (X = NH2) (II) (method A). II were also prepared by reduction of I (X = NO2) with Fe dust in aqueous AcOH (method B). The II prepared were (R, method of preparation, and % yield given): Me, A, 95; SMe, A, 85; F, B, 70; Cl, B, 73.5; Br, B, 81; iodo, B, 86; MeO, A/B, 90.1/80.5; and AcNH, A/B, 90/70. A mixture of PhNO and II (R = MeO) kept 20 min in 50% aqueous NaOH gave III (R = OMe) (method A). In method B the above reaction was carried out at room temperature in AcOH. Similarly prepared were 7 other III analogs.

In addition to the literature in the link below, there is a lot of literature about this compound(5-Amino-2-fluoropyridine)Related Products of 1827-27-6, illustrating the importance and wide applicability of this compound(1827-27-6).

Reference:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 3-Chloropicolinamide( cas:114080-95-4 ) is researched.SDS of cas: 114080-95-4.Dunn, A. D. published the article 《The addition of hydroxylamine to derivatives of halopyridine carboxylic acids》 about this compound( cas:114080-95-4 ) in Zeitschrift fuer Chemie. Keywords: halopyridinecarboxylate hydroxylamine addition; pyridinecarboxylate halo hydroxylamine addition; halopyridinenitrile hydroxylamine cyclization; isoxazolopyridine. Let’s learn more about this compound (cas:114080-95-4).

Cyanopyridines I (R = Cl, R1 = cyano, R2 = H; R = cyano, R1 = Cl, R2 = H; R = H, R1 = cyano, R2 = Cl) reacted with a MeOH solution of NH2OH and MeONa to give isoxazolopyridines. Thus, I (R = Cl, R1 = cyano, R2 = H) gave isoxazolopyridine II. However, I (R = H, R1 = Cl, R2 = cyano) reacted with the same reagent to give I (R, R1, same, R2 = CONH2), and I (R = H, R1 = Br, R2 = cyano) gave I [R, R1, same, R2 = C(:NOH)NH2]. No bicyclic products were formed . Esters I (R = Cl, R1 = CO2Me, R2 = H) reacted with the same reagent to give the hydroxamic acids I (R, R2, same, R1 = CONHOH). Similarly esters I (R = CO2Me, R1 = Br, R2 = H; R= H, R1 = Br, R2 = CO2Me) also gave the corresponding hydroxamic acids.

In addition to the literature in the link below, there is a lot of literature about this compound(3-Chloropicolinamide)SDS of cas: 114080-95-4, illustrating the importance and wide applicability of this compound(114080-95-4).

Reference:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 2150-55-2, is researched, Molecular C4H6N2O2S, about Fed-batch fermentation kinetics of L-cysteine producing Pseudomonas strain TS1138, the main research direction is cysteine Pseudomonas.Category: pyrazines.

L-cysteine was produced by means of microbial transformation of DL-2-amino-Δ2-thiazoline-4-carboxylic acid (DL-ATC) in the presence of L-cysteine synthesizing enzyme from Pseudomonas sp. TS1138. Based on the exptl. data of fed-batch fermentation in 5 L fermentation reactor, the kinetic model of cell growth, enzyme production and substrate consumption were constructed. Three kinetic models were in good agreement with the exptl. results through proper anal. by software MATALAB. The kinetic models appeared to provide a reasonable description for each parameter in the fermentation

In addition to the literature in the link below, there is a lot of literature about this compound(2-Amino-4,5-dihydrothiazole-4-carboxylic acid)Category: pyrazines, illustrating the importance and wide applicability of this compound(2150-55-2).

Reference:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Huai, Lihua; Chen, Ning researched the compound: 2-Amino-4,5-dihydrothiazole-4-carboxylic acid( cas:2150-55-2 ).Name: 2-Amino-4,5-dihydrothiazole-4-carboxylic acid.They published the article 《Effect of dissolved oxygen on production of L-cysteine synthetase by Pseudomonas sp. TS1138》 about this compound( cas:2150-55-2 ) in Shipin Kexue (Beijing, China). Keywords: dissolved oxygen cysteine synthetase Pseudomonas fermentation. We’ll tell you more about this compound (cas:2150-55-2).

Pseudomonas sp. TS1138 has potential to produce L-cysteine synthetase through asym. hydrolysis of DL-2-amino-Δ2-thiazoline-4-carboxylic acid (DL-ATC). The effect of dissolved oxygen level on the production of L-cysteine synthetase was investigated in shake flasks or 7 L bioreactor. The results indicated that the cell growth and the production of L-cysteine synthetase were inhibited at low dissolved oxygen level. Although cell growth was improved at the high dissolved oxygen level, the inhibition against production of L-cysteine synthetase was still observed in shake flasks. In 7 L bioreactor, dissolved oxygen concentration controlled at more than 30% was helpful for improving the cell growth and the production of L-cysteine synthetase through regulating agitation rate and air flow rate during the middle and late stage.

In addition to the literature in the link below, there is a lot of literature about this compound(2-Amino-4,5-dihydrothiazole-4-carboxylic acid)Name: 2-Amino-4,5-dihydrothiazole-4-carboxylic acid, illustrating the importance and wide applicability of this compound(2150-55-2).

Reference:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Seizures and selective CA-1 hippocampal lesions induced by an excitotoxic cyanide metabolite, 2-iminothiazolidine-4-carboxylic acid, published in 1995, which mentions a compound: 2150-55-2, Name is 2-Amino-4,5-dihydrothiazole-4-carboxylic acid, Molecular C4H6N2O2S, HPLC of Formula: 2150-55-2.

Excitatory amino acid (EAA)-like and excitotoxic properties of the secondary metabolite of cyanide, 2-iminothiazolidine-4-carboxylic acid (2-ICA), were evaluated because of its possible role in cyanide-induced neurotoxicity. Intracerebroventricular (i.c.v.) injections of 2-ICA in mice produced wild-running seizures that were qual. and quant. similar to seizures observed with glutamate. 2-ICA, kainate, and proline seizures were prevented by both the NMDA and non-NMDA antagonists, MK-801 and CNQX, resp. In contrast, NMDA-induced seizures were prevented by MK-801, but not CNQX. When infused i.c.v. in rats over a 7-day period, 2-ICA produced extensive and selective loss of CA-1 pyramidal neurons of the hippocampus. In hippocampal slices preloaded with D-[3H]aspartate, 2-ICA superfusion did not evoke release nor significantly augment potassium-stimulated release of the radiolabeled transmitter. These findings indicate 2-ICA has excitotoxic properties and its role in cyanide neurotoxicity deserves further study.

In addition to the literature in the link below, there is a lot of literature about this compound(2-Amino-4,5-dihydrothiazole-4-carboxylic acid)HPLC of Formula: 2150-55-2, illustrating the importance and wide applicability of this compound(2150-55-2).

Reference:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Munoz, Juan de M.; Alcazar, Jesus; de la Hoz, Antonio; Diaz-Ortiz, Angel published an article about the compound: Ethyl oxazole-5-carboxylate( cas:118994-89-1,SMILESS:O=C(C1=CN=CO1)OCC ).Recommanded Product: Ethyl oxazole-5-carboxylate. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:118994-89-1) through the article.

The reduction of esters to aldehydes is an important transformation in organic chem. and several reducing agents have been described. However, the use of this reaction in medicinal and natural product chem. is limited due to the instability of the intermediates and the high reactivity of the reaction products. In the current article, the general and selective reduction of esters with lithium diisobutyl-tert-butoxyaluminum hydride (LDBBA) in flow is reported. This reagent allows esters to be reduced in the presence of different functional groups, including those considered to be of similar or higher reactivity.

In addition to the literature in the link below, there is a lot of literature about this compound(Ethyl oxazole-5-carboxylate)Recommanded Product: Ethyl oxazole-5-carboxylate, illustrating the importance and wide applicability of this compound(118994-89-1).

Reference:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Youn, Sung Hun; Park, Hae Woong; Choe, Deokyeong; Shin, Chul Soo researched the compound: 2-Amino-4,5-dihydrothiazole-4-carboxylic acid( cas:2150-55-2 ).Reference of 2-Amino-4,5-dihydrothiazole-4-carboxylic acid.They published the article 《Preparation of eutectic substrate mixtures for enzymatic conversion of ATC to L-cysteine at high concentration levels》 about this compound( cas:2150-55-2 ) in Bioprocess and Biosystems Engineering. Keywords: enzymic conversion eutectic mixture cysteine production. We’ll tell you more about this compound (cas:2150-55-2).

High concentration eutectic substrate solutions for the enzymic production of L-cysteine were prepared Eutectic melting of binary mixtures consisting of D,L-2-amino-Δ2-thiazoline-4-carboxylic acid (ATC) as a substrate and malonic acid occurred at 39 °C with an ATC mole fraction of 0.5. Formation of eutectic mixtures was confirmed using SEM, SEM-EDS, and XPS surface analyses. Sorbitol, MnSO4, and NaOH were used as supplements for the enzymic reactions. Strategies for sequential addition of five compounds, including a binary ATC mixture and supplements, during preparation of eutectic substrate solutions were established. Eutectic substrate solutions were stable for 24 h. After 6 h of enzymic reactions, a 550 mM L-cysteine yield was obtained from a 670 mM eutectic ATC solution

In addition to the literature in the link below, there is a lot of literature about this compound(2-Amino-4,5-dihydrothiazole-4-carboxylic acid)Reference of 2-Amino-4,5-dihydrothiazole-4-carboxylic acid, illustrating the importance and wide applicability of this compound(2150-55-2).

Reference:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Electric Literature of C6H7NO3. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: Ethyl oxazole-5-carboxylate, is researched, Molecular C6H7NO3, CAS is 118994-89-1, about Construction of 2-(2-Arylphenyl)azoles via Cobalt-Catalyzed C-H/C-H Cross-Coupling Reactions and Evaluation of Their Antifungal Activity. Author is Wang, Xinmou; Chen, Yuming; Song, Hongjian; Liu, Yuxiu; Wang, Qingmin.

Although compounds with a 2-(2-arylphenyl) benzoxazole motif are biol. important, there are only a few methods for synthesizing them. Herein, authors report an efficient method for synthesis of such compounds by means of cobalt-catalyzed C-H/C-H cross-coupling reactions. This method has a broad substrate scope and good tolerance for sensitive functional groups. In addition, authors demonstrate that introducing a heteroarene moiety to biphenyl compounds enhanced their antifungal activity.

In addition to the literature in the link below, there is a lot of literature about this compound(Ethyl oxazole-5-carboxylate)Electric Literature of C6H7NO3, illustrating the importance and wide applicability of this compound(118994-89-1).

Reference:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem