Tag: M.W=100-150

I found the field of Chemistry very interesting. Saw the article Palladium-Catalyzed Regioselective C-H Iodination of Unactivated Alkenes published in 2019. Category: Pyrazines, Reprint Addresses Carreira, EM (corresponding author), Swiss Fed Inst Technol, HCI, Vladimir Prelog Weg 3, CH-8093 Zurich, Switzerland.. The CAS is 98-97-5. Through research, I have a further understanding and discovery of Pyrazine-2-carboxylic acid

A palladium-catalyzed C-H iodination of unactivated alkenes is reported. A picolinamide directing group enables the regioselective functionalization of a wide array of olefins to furnish iodination products as single stereoisomers. Mechanistic investigations suggest the reversible formation of a six-membered alkenyl palladacycle intermediate through a turnover-limiting C-H activation.

About Pyrazine-2-carboxylic acid, If you have any questions, you can contact Schreib, BS; Carreira, EM or concate me.. Category: Pyrazines

Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Recently I am researching about BASIC SIDE-CHAINS; C-H CARBONYLATION; OXIDATIVE CARBONYLATION; DESIGN; C(SP(2))-H; INHIBITORS; BONDS; OPTIMIZATION; CYCLIZATION; ACTIVATION, Saw an article supported by the Zhejiang Natural Science Fund for Young Scholars [LQ18B020008]; Zhejiang Sci-Tech UniversityZhejiang University of Science & Technology [17062078-Y]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21772177]. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Ying, J; Fu, LY; Zhong, GQ; Wu, XF. The CAS is 98-97-5. Through research, I have a further understanding and discovery of Pyrazine-2-carboxylic acid. COA of Formula: C5H4N2O2

A cobalt-catalyzed C-H carbonylation of naphthylamides for the synthesis of benzo[cd]indol-2(1H)-one scaffolds has been developed. The reaction employs a traceless directing group and uses benzene-1,3,5-triyltriormate as the CO source, affording various free (NH)-benzo[cd]indol-2(1H)-ones in moderate to high yields (up to 88%). Using this protocol, the total synthesis of BET bromodomain inhibitors A and B was accomplished as well.

COA of Formula: C5H4N2O2. About Pyrazine-2-carboxylic acid, If you have any questions, you can contact Ying, J; Fu, LY; Zhong, GQ; Wu, XF or concate me.

Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Quality Control of Pyrazine-2-carboxylic acid. In 2020 CHEM BIOL DRUG DES published article about CYSTEINE PROTEASE; TRYPANOSOMA-CRUZI; DRUG DISCOVERY; INTEGRATION; ISOFORMS; LIGANDS; IMPROVE in [de Albuquerque, Sergio; Duque, Carla; da Silva, Joao Santana] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Sao Paulo, Brazil; [Cianni, Lorenzo; de Vita, Daniela; Leitao, Andrei; Montanari, Carlos A.; Ribeiro, Jean F. R.] Univ Sao Paulo, Inst Quim Sao Carlos, Grp Quim Med, Ave Trabalhador Sancarlense 400, BR-13566590 Sao Carlos, SP, Brazil; [Gomes, Ana S. M.; Gomes, Paula; Teixeira, Catia] Univ Porto, Dept Quim & Bioquim, LAQV REQUIMTE, Fac Ciencias, Porto, Portugal; [Laughton, Charles] Univ Nottingham, Sch Pharm, Nottingham, England; [Laughton, Charles] Univ Nottingham, Ctr Biomol Sci, Nottingham, England; [Montanari, Raphael] Univ Sao Paulo, Ctr Robot Sao Carlos, EESC ICMC, Sao Paulo, Brazil; [Ribeiro, Jean F. R.] Univ Fed Goias, Inst Trop Pathol & Publ Hlth, Goiania, Go, Brazil in 2020, Cited 59. The Name is Pyrazine-2-carboxylic acid. Through research, I have a further understanding and discovery of 98-97-5.

Cruzain is an established target for the identification of novel trypanocidal agents, but how good are in vitro/in vivo correlations? This work describes the development of a random forests model for the prediction of the bioavailability of cruzain inhibitors that areTrypanosoma cruzikillers. Some common properties that characterize drug-likeness are poorly represented in many established cruzain inhibitors. This correlates with the evidence that many high-affinity cruzain inhibitors are not trypanocidal agents againstT. cruzi. On the other hand,T. cruzikillers that present typical drug-like characteristics are likely to show better trypanocidal action than those without such features. The random forests model was not outperformed by other machine learning methods (such as artificial neural networks and support vector machines), and it was validated with the synthesis of two new trypanocidal agents. Specifically, we report a new lead compound,Neq0565, which was tested onT. cruziTulahuen (beta-galactosidase) with a pEC(50)of 4.9. It is inactive in the host cell line showing a selectivity index (SI = EC50cyto/EC50T. cruzi) higher than 50.

About Pyrazine-2-carboxylic acid, If you have any questions, you can contact de Albuquerque, S; Cianni, L; de Vita, D; Duque, C; Gomes, ASM; Gomes, P; Laughton, C; Leitao, A; Montanari, CA; Montanari, R; Ribeiro, JFR; da Silva, JS; Teixeira, C or concate me.. Quality Control of Pyrazine-2-carboxylic acid

Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Pang, HY; Wang, N; Chai, JL; Wang, XY; Zhang, YH; Bi, Z; Wu, WB; He, G in [Pang, Haiying; Wang, Ning; Chai, Jinlong; Wang, Xiaoyun; Zhang, Yuehua; Bi, Zhiang; He, Gu] Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Sichuan, Peoples R China; [Pang, Haiying; Wang, Ning; Chai, Jinlong; Wang, Xiaoyun; Zhang, Yuehua; Bi, Zhiang; He, Gu] Sichuan Univ, West China Hosp, Canc Ctr, Chengdu 610041, Sichuan, Peoples R China; [Pang, Haiying; Wang, Ning; Chai, Jinlong; Wang, Xiaoyun; Zhang, Yuehua; Bi, Zhiang; He, Gu] Collaborat Innovat Ctr, Chengdu 610041, Sichuan, Peoples R China; [Wu, Wenbin] Chongzhou Peoples Hosp, Dept Neurol, Chengdu 611230, Peoples R China published Discovery of novel TNNI3K inhibitor suppresses pyroptosis and apoptosis in murine myocardial infarction injury in 2020, Cited 49. SDS of cas: 98-97-5. The Name is Pyrazine-2-carboxylic acid. Through research, I have a further understanding and discovery of 98-97-5.

Myocardial infarction (MI) injury is a highly lethal syndrome that has, until recently, suffered from a lack of clinically efficient targeted therapeutics. The cardiac troponin I interacting kinase (TNNI3K) exacerbates ischemia-reperfusion (IR) injury via oxidative stress, thereby promoting cardiomyocyte death. In this current study, we designed and synthesized 35 novel TNNI3K inhibitors with a pyrido[4,5]thieno [2,3-d] pyrimidine scaffold. In vitro results indicated that some of the inhibitors exhibited sub-micromolar TNNI3K inhibitory capacity and good kinase selectivity, as well as cytoprotective activity, in an oxygen-glucose deprivation (OGD) injury cardiomyocyte model. Furthermore, investigation of the mechanism of the representative derivative compound 6o suggested it suppresses pyroptosis and apoptosis in cardiomyocytes by interfering with p38MAPK activation, which was further confirmed in a murine myocardial infarction injury model. In vivo results indicate that compound 6o can markedly reduce myocardial infarction size and alleviate cardiac tissue damage in rats. In brief, our results provide the basis for further development of novel TNNI3K inhibitors for targeted MI therapy. (C) 2020 Elsevier Masson SAS. All rights reserved.

About Pyrazine-2-carboxylic acid, If you have any questions, you can contact Pang, HY; Wang, N; Chai, JL; Wang, XY; Zhang, YH; Bi, Z; Wu, WB; He, G or concate me.. SDS of cas: 98-97-5

Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

In 2021 CHEMOSPHERE published article about MONOCARBOXYLATE-N-OXIDES; PYRIDINE MONOCARBOXYLATES; COMPLEXES; PYRAZINES; THORIUM; NPO2+; PLUTONIUM; CHEMISTRY; EU(III); SPECTRA in [Dumpala, Rama Mohana Rao; Srivastava, Ashutosh; Rawat, Neetika] Bhabha Atom Res Ctr, Radiochem Div, Mumbai 400085, Maharashtra, India in 2021, Cited 53. The Name is Pyrazine-2-carboxylic acid. Through research, I have a further understanding and discovery of 98-97-5. Application In Synthesis of Pyrazine-2-carboxylic acid

Pyrazines are omnipresent in nature and have their occurrence in plants, microbes, food supplies, marine arenas. The present studies aimed at aquatic speciation of the neptunyl ion (NpO2+) with two pyrazine compounds namely pyrazine monocarboxylic acid (PMC) and pyrazine dicarboxylic acid (PDC). Absorption spectrophotometry was used to probe the stability, speciation and spectral properties for the complexation process. NpOO2+ forms a more stable complex with PMC than PDC for 1:1 (ML), while for 1:2 (ML2) the opposite trend is observed. The extent of shift in lambda(max), which is also an indicator for the strength of complexation, reflected similar trends for the complexation process. Isothermal titration calorimetry was employed to determine the enthalpies of complex formation, which is found to be endothermic. The complexation process is entropy driven. Linear free energy correlations were established to retrieve the coordination modes of the complexes. The variation in peak potentials (the cyclic voltammograms) with change in pH and metal to ligand ratio were explored to understand redox speciation, electron transfer kinetics and Eh-pH characteristics for the interaction of NpOO2+ with pyrazine carboxylate ligands. Density functional theory calculations were employed to optimize the geometries and to calculate the bond distances and partial charges on key atoms of the optimized geometries. The theoretical calculations helped to reveal the contributions from two different configurations of the same geometry towards the optical absorption. The bond distances and partial charges estimated theoretically helped to understand the aqueous interactions at the molecular level. (C) 2021 Elsevier Ltd. All rights reserved.

Application In Synthesis of Pyrazine-2-carboxylic acid. About Pyrazine-2-carboxylic acid, If you have any questions, you can contact Dumpala, RMR; Srivastava, A; Rawat, N or concate me.

Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

COA of Formula: C5H4N2O2. In 2019 ANN I SUPER SANITA published article about SUSCEPTIBILITY in [Mustazzolu, Alessandro] Ist Super Sanita, Serv Comunicaz Sci, Rome, Italy; [Piersimoni, Claudio] AOU Osped Riuniti Ancona, Lab Patol Clin, Lab Unico Reg Diagnost Micobatteri, Ancona, Italy; [Iacobino, Angelo; Giannoni, Federico; Fattorini, Lanfranco] Ist Super Sanita, Dipartimento Malattie Infett, Viale Regina Elena 299, I-00161 Rome, Italy; [Chirullo, Barbara] Ist Super Sanita, Dipartimento Sicurezza Alimentare Nutr & Sanita P, Rome, Italy in 2019, Cited 22. The Name is Pyrazine-2-carboxylic acid. Through research, I have a further understanding and discovery of 98-97-5.

Pyrazinamide (PZA) is a first-line key drug used in combination with other agents for the treatment of tuberculosis (TB). Phenotypic and molecular assays for testing susceptibility of Mycobacterium tuberculosis (Mtb) to PZA have been developed, with the assay in liquid medium at acidic pH in the Bactec MGIT 960 (M960) system being routinely used in the mycobacteriology laboratories. However, false resistance to PZA by this method was reported to occur by several investigators, mostly due to high Mtb inoculum, which may impair drug activity by increasing the pH of the medium. In this study, a revision of the literature on the issue of false resistance in the M960 PZA assay was performed. In the reports examined, all improvements of the M960 test proposed to decrease false resistant results were based on the use of reduced inoculum densities of Mtb cells, to be easily translated into laboratory practice.

About Pyrazine-2-carboxylic acid, If you have any questions, you can contact Mustazzolu, A; Piersimoni, C; Iacobino, A; Giannoni, F; Chirullo, B; Fattorini, L or concate me.. COA of Formula: C5H4N2O2

Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Recently I am researching about PHARMACEUTICAL COCRYSTALS; SALTS; DESIGN; POLYMORPHISM; INVESTIGATE; SOLUBILITY; STABILITY; BEHAVIOR; COFORMER; LIQUID, Saw an article supported by the FAPESP foundation (Brazil)Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2013/09022-7, 2017/14936-9, 2018/12463-9, 2018/24378-6]; CNPq foundation (Brazil)Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPQ) [141829/2017-6]; CAPES foundation (Brazil)Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES) [001]; CPID/CDMF foundation (Brazil). Published in SPRINGER in DORDRECHT ,Authors: de Almeida, AC; Ferreira, PO; Torquetti, C; Ekawa, B; Carvalho, ACS; dos Santos, EC; Caires, F. The CAS is 98-97-5. Through research, I have a further understanding and discovery of Pyrazine-2-carboxylic acid. Recommanded Product: 98-97-5

Novel cocrystals of ciprofloxacin with pyrazinoic acid and p-aminobenzoic acid in the 1:1 stoichiometric ratio were obtained by the mechanochemical method, under conditions of liquid-assisted grinding (LAG/ethanol) and neat grinding. They were characterized by powder X-ray diffractometry, infrared spectroscopy, simultaneous thermogravimetry, differential thermal analysis, differential scanning calorimetry (DSC) and DSC-Microscopy system. The results confirmed the successful synthesis of the cocrystals and indicated the functional groups responsible for the formation of the new supramolecular synthons. In addition, from the thermal analysis, it was possible to evaluate the thermal stability, composition, crystallization processes during heating, polymorphic transitions and construct the binary phase diagrams.

About Pyrazine-2-carboxylic acid, If you have any questions, you can contact de Almeida, AC; Ferreira, PO; Torquetti, C; Ekawa, B; Carvalho, ACS; dos Santos, EC; Caires, F or concate me.. Recommanded Product: 98-97-5

Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

I found the field of Pharmacology & Pharmacy; Chemistry very interesting. Saw the article Synthesis of novel of 2, 5-disubstituted 1, 3, 4-oxadiazole derivatives and their in vitro anti-inflammatory, anti-oxidant evaluation, and molecular docking study published in 2020. Computed Properties of C5H4N2O2, Reprint Addresses Ghanwat, AA (corresponding author), Solapur Univ, Sch Chem Sci, Chem Res Lab, Solapur 413255, India.. The CAS is 98-97-5. Through research, I have a further understanding and discovery of Pyrazine-2-carboxylic acid

A series of novel 2, 5-disubstituted 1, 3, 4-Oxadiazole derivatives as a potential anti-inflammatory, and antioxidant agent were synthesized via cyclisation. Hydrazide molecule treated with substituted acids in the presence of phosphorus oxychloride (POCl3) as an efficient reagent as well as solvent by conventional method with shorter reaction time and excellent yield. The newly synthesized 1, 3, 4-oxadiazole derivatives exhibited excellent to good anti-inflammatory and anti-oxidant activities compaired to the standard drugs. Molecular docking study on the crucial anti-inflammatory target-cyclooxygenase-2 (COX-2) revealed the ability of the scaffold to correctly recognize the active site and achieve significant bonded and non-bonded interactions with key residues therein. This study could identify potential compounds which can be pertinent starting points for structure-based drug design to obtain newer anti-inflammatory agents.

Computed Properties of C5H4N2O2. About Pyrazine-2-carboxylic acid, If you have any questions, you can contact Kashid, BB; Salunkhe, PH; Dongare, BB; More, KR; Khedkar, VM; Ghanwat, AA or concate me.

Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

An article A structural and thermodynamic study of the complexes of U(vi) with azinecarboxylates WOS:000454920800018 published article about AQUEOUS-SOLUTION; EQUILIBRIUM-CONSTANTS; CARBOXYLIC-ACIDS; URANIUM(VI); CRYSTAL; ION; CHEMISTRY; LIGAND in [Lv, Lina; Chen, Baihua; Liu, Jun; Yang, Yanqiu] China Acad Engn Phys, Inst Nucl Phys & Chem, Mianyang 621900, Sichuan, Peoples R China; [Chen, Jing; Xu, Chao] Tsinghua Univ, Inst Nucl & New Energy Technol, Beijing 100084, Peoples R China in 2019, Cited 42. The Name is Pyrazine-2-carboxylic acid. Through research, I have a further understanding and discovery of 98-97-5. Computed Properties of C5H4N2O2

Complexation of U(vi) with pyridazine-3-carboxylate (PDZ) and pyrazine-2-carboxylate (PAZ) was studied by spectrophotometry, potentiometry and microcalorimetry in 1.0 mol dm(-3) NaClO4. Three complexes, [UO2L](+), UO2L2(aq) and [UO2L3](-), were identified and their stability constants (log) and the corresponding formation enthalpies were determined. The thermodynamic parameters indicate that the formation of the three complexes is endothermic and driven exclusively by entropy. H-1 and C-13-NMR data provide insight into the coordination modes of the complexes which corroborate with the thermodynamic data. Ligands chelate to U(vi) via (2)(N,O) coordination mode in complexes [UO2L](+) and UO2L2(aq). The crystal structures of four U(vi) complexes, [(UO2)(PAZ)(2)(H2O)]H2O(i), [(UO2)(PDZ)(2)(H2O)](ii), [(UO2)(PDZ)(3)Na2ClO4]2H(2)O(iii), and [(UO2)(2)(PDZ)(4)(H2O)(2)]2H(2)O(iv), were determined by single-crystal X-ray diffraction and compared with the U(vi) complex with picolinate (PA) (CH6N3)[UO2(PA)(3)] in the literature. The structure data suggest that the carboxylates coordinate with uranium in O?C-O-U mode. The strengths of the U-O-C-C-N chelate cycles in the U(vi)/L complexes decrease with the trend of PA > PDZ > PAZ, which is in great agreement with the trend of thermodynamic parameters in aqueous solutions. It is interesting that in compound II two PDZ molecules coordinate with U(vi) in cis-planar positions via (2)(N,O) mode, but in other metal complexes of the three ligands having the same (2)(N,O) coordination mode the two ligand molecules are all in trans-arrangement. In the dimeric complex IV, one ligand coordinate with U(vi) in (2)(N,O) mode, while the other does it in (2)-L-(2)(O:O) mode respectively.

About Pyrazine-2-carboxylic acid, If you have any questions, you can contact Lv, LN; Chen, BH; Liu, J; Chen, J; Xu, C; Yang, YQ or concate me.. Computed Properties of C5H4N2O2

Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

In 2021 J MOL STRUCT published article about FLUORESCENT DETECTION; CHEMOSENSOR; PROBE; COPPER; PRECONCENTRATION; FE3+; SITE in [Tomer, Nisha; Goel, Apurva; Malhotra, Rajesh] Guru Jambheshwar Univ Sci & Technol, Dept Chem, Hisar 125001, Haryana, India; [Ghule, Vikas D.] Natl Inst Technol, Dept Chem, Kurukshetra 136119, Haryana, India in 2021, Cited 45. The Name is Pyrazine-2-carboxylic acid. Through research, I have a further understanding and discovery of 98-97-5. Safety of Pyrazine-2-carboxylic acid

A new chromone based Schiff base ligand L was synthesized by the condensation of 3-formyl chromone and pyrazine-2-carbohydrazide as a colorimetric probe to detect Cu (II) ions selectively. An instant visual colour change from colourless to yellow was obtained on addition of Cu2+ ions to the probe L solution, while other metal ions found ineffective. The ligand L was characterized by H-1 NMR, FTIR and HRMS spectral techniques. UV-Visible spectroscopic technique was used to study the sensing ability of probe L for copper ions above other metal ions. The Job’s plot obtained from absorption studies and HRMS data confirmed that the Cu2+ ions bind with ligand L in 1:1 stoichiometric ratio. DFT computations were also supported the binding framework between L and Cu (II) ions. The LOD value and the association constant were obtained 3.9 x 10(-7) M and 2.3 x 10(5) M-1 respectively, via Benesi-Hildebrand equation. Selectivity of L towards Cu2+ ions was also studied and it was found that the probe L worked specifically for copper ions without any considerable influence of other intruding metal ions. In addition, in real water samples, the ligand L was fully implemented for identification and quantification of Cu2+ ions. (C) 2020 Elsevier B.V. All rights reserved.

About Pyrazine-2-carboxylic acid, If you have any questions, you can contact Tomer, N; Goel, A; Ghule, VD; Malhotra, R or concate me.. Safety of Pyrazine-2-carboxylic acid

Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem