Tag: M.W=0-100

Application of 4949-13-7, These common heterocyclic compound, 4949-13-7, name is 2-Fluoropyrazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 5: N-((4S,6S)-4-(2-fluoro-5-(pyrazin-2-yloxy)phenyl)-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-yl)benzamide (8e) To a microwave vial were added N-((4S,6S)-4-(2-fluoro-5-hydroxyphenyl)-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-yl)benzamide (95 mg, 0.229 mmol), 2-fluoro-pyrazine (24.74 mg, 0.252 mmol), cesium carbonate (90 mg, 0.275 mmol) in DMSO (459 muL). The vial was heated in microwave instrument at 100 C. for 30 min. After cooling to room temperature, water was added to the reaction mixture and precipitate was observed. After stirring for 10 min, the precipitate was collected by filtration, washed with water and hexane, dried in vacuum oven at 60 C. for 1 h to provide N-((4S,6S)-4-(2-fluoro-5-(pyrazin-2-yloxy)phenyl)-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-yl)benzamide (85 mg, 0.173 mmol, 75% yield) as off-white solid. MS m/z=493 [M]+. Calculated for C23H17F5N4O3: 492.4.

Statistics shows that 2-Fluoropyrazine is playing an increasingly important role. we look forward to future research findings about 4949-13-7.

Reference:
Patent; MINATTI, Ana Elena; LOW, Jonathan D.; ALLEN, Jennifer R.; CHEN, Jian; CHEN, Ning; CHENG, Yuan; JUDD, Ted; LIU, Qingyian; LOPEZ, Patricia; QIAN, Wenyuan; RUMFELT, Shannon; RZASA, Robert M.; TAMAYO, Nuria A.; XUE, Qiufen; YANG, Bryant; ZHONG, Wenge; US2014/249104; (2014); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Reference of 109-08-0,Some common heterocyclic compound, 109-08-0, name is 2-Methylpyrazine, molecular formula is C5H6N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

2-methylpyrazine 0.478 (5 mmol) with 0.17 g of tetrabutylammonium bisulfate (0.5 mmol)5 ml of an aqueous solution of sodium hydroxide per liter was added,Heating to reflux, adding 5 mmol of p-dimethylaminobenzaldehyde,Reflux reaction. After completion of the reaction, the mixture was cooled to room temperature,The crude product was obtained by filtration and recrystallized from ethanol to give the product,Yield 56%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Methylpyrazine, its application will become more common.

Reference:
Patent; University of Science and Technology of China; Zhang Guoqing; Chen Biao; Xu Cheng; Wang Hao; Du Jiajun; Bi Guoqiang; Luo Yi; (111 pag.)CN107118586; (2017); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

These common heterocyclic compound, 5049-61-6, name is Pyrazin-2-amine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of Pyrazin-2-amine

To a mixture of 2-amino pyrazine (50 g, 0.5 mol) in chloroform (1000 ml) cooled to 0C was added pyridine (100 ml, 1.21 mol) and bromine (54 ml, 1.05 mmol) dropwise. The mixture was stirred at rt for 16h, then water was added. The organic phase was extracted, dried (MgS04), filtered and evaporated to obtain I- 01 , 48 g (Y: 36 %) of a yellow solid which was dried in vacuo.

The synthetic route of Pyrazin-2-amine has been constantly updated, and we look forward to future research findings.

Reference:
Patent; CENTRO NACIONAL DE INVESTIGACIONES ONC&Oacgr;LOGICAS (CNIO); PASTOR FERNANDEZ, Joaquin; MARTINEZ GONZALEZ, Sonia; ALVAREZ ESCOBAR, Rosa Maria; RODRIGUEZ ARISTEGUI, Sonsoles; GONZALES CANTALAPIEDRA, Esther; HERNANDEZ HIGUERAS, Ana Isabel; VARELA BUSTO, Carmen; WO2011/36461; (2011); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Reference of 109-08-0, A common heterocyclic compound, 109-08-0, name is 2-Methylpyrazine, molecular formula is C5H6N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step C – Synthesis of mt 7-3 To a solution of 2-methylpyrazine (272 mg, 2.9 mmol) and HIVIPA (520 mg, 2.9 mmol) in THF (2.5 mL) was added LDA (1.6 mL, 3 mmol) at -78¡ãC dropwise. The mixture was allowed to stir at -78¡ãC for 30 minutes before a solution of mt 7-2 (600 mg, 2.45 mmol) in 2 mL of THF was added. The mixture was allowed to warm to room temperature for 3 hours before itwas quenched with 10 mL of saturated NH4C1 solution. The resulting mixture was extractedwith EtOAc (3 x 10 mL) and the combined organic washings were dried over sodlum sulfate,filtered and in vacuo. The resulting residue was purified using column chromatography (25percentEtOAc/ petroleum ether) to provide mt 7-3 (100 mg, 12percent). MS (ES): m/z (M+H) 339.

The synthetic route of 109-08-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MERCK SHARP & DOHME CORP.; COBURN, Craig A.; MALETIC, Milana; SOLL, Richard; LI, Chunsing; LUO, Yunfu; QI, Zhiqi; WO2014/178; (2014); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Application of 109-08-0, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 109-08-0 as follows.

[00401] Intermediate 26: Synthesis of l-phenyl-2-(pyrazin-2-yl)ethanone[00402] To a mixture of diisopropyl-amine (1.29 g, 12.7 mmol) in anhydrous THF (10 mL) was added w-BuLi (2.5 M/L in hexane, 4.7 mL, 11.7 mmol) at -78C, after being stirred for 30 minutes, a solution of 2-methylpyrazine (1 g, 10.6 mmol) in THF (5 mL) was added, and the mixture was stirred at -78C for 30 minutes, a solution of methyl benzoate (1.4 g, 10.6 mmol) in THF (5 mL) was added, and the mixture was stirred at this temperature for 3 hours. When TLC indicated that the starting material was consumed, the reaction mixture was diluted with EtOAc, and the mixture was washed with water and brine, and concentrated. The residue was purified by column chromatography (PE:EtOAc=30: l) to give Intermediate 26 (700 mg, yield 33.3%).

According to the analysis of related databases, 109-08-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; N30 PHARMACEUTICALS, LLC; SUN, Xicheng; QIU, Jian; WO2011/38204; (2011); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 5049-61-6 as follows. Computed Properties of C4H5N3

5.1. 5-Bromo-2-pyrazinamine 28.2 g of N-bromosuccinimide (0.158 mol) are added portionwise, at 0 C., to a solution of 2-amino-pyrazine (15.0 g, 0.158 mol) in 900 ml of dichloromethane. After 3 hours, the reaction mixture is filtered through a sinter funnel, washed with saturated sodium carbonate (2*400 ml), water (400 ml) and brine (200 ml), dried over sodium sulphate, filtered and concentrated under reduced pressure. The residue obtained is purified on a column of silica eluted under pressure with a cyclohexane/ethyl acetate gradient (9/1) to (1/1). 18.0 g of 5-bromo-2-pyrazinamine are obtained in the form of a yellowish powder. Yield (%)=66; m.p. ( C.)=144

According to the analysis of related databases, 5049-61-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Altenburger, Jean-Michel; Cremer, Gerard; Lassalle, Gilbert; Matrougui, Mostafa; US2003/207920; (2003); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Electric Literature of 5049-61-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 5049-61-6, name is Pyrazin-2-amine belongs to Pyrazines compound, it is a common compound, a new synthetic route is introduced below.

To a solution of the compound 2-aminopyrazine (3.8 g, 40.00 mmol) in dimethyl sulfoxide (30 mL) and water (2 mL) was added N-bromosuccinimide (17.80 g, 0.10) in an ice bath. Mol). After stirring at room temperature for 4 hours, the reaction was poured into ice water (250 mL). Extract with ethyl acetate (50 mL¡Á4). Combine the organic phases, filter, and wash the filtrate with 5% sodium carbonate solution (200 mL) and saturated aqueous sodium chloride solution (50 mL), dry over anhydrous sodium sulfate, and concentrate. The residue is subjected to silica gel column chromatography. Purification by chromatography (petroleum ether/ethyl acetate=5:1) gave compound 56-b (4.10 g, 41%).

The synthetic route of Pyrazin-2-amine has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SHANGHAI KAIHUI TECHNOLOGY DEVELOPMENT CO;LTD; XU, ZUSHENG; Kaihui Science And Technology Development (Shanghai) Co., Ltd.; Xu Zusheng; (100 pag.)CN103304571; (2018); B;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 109-08-0, name is 2-Methylpyrazine, A new synthetic method of this compound is introduced below., SDS of cas: 109-08-0

Example 10 Synthesis of (1-CYANOCYCLOPROPYL)-3-PYRAZIN-2-YLMETHANESULFONYL-2 (R)- (2, 2, 2-TRIFLUORO-1 (S)- 4-fluorophenylethylamino) propionamide AND N-(1-CYANOCYCLOPROPYL)-3-PYRAZIN-2-YLMETHANE- SULFONYL-2 (R)- (2, 2, 2-TRIFLUORO-L (R)-4-FLUOROPHENYLETHYLAMINO) propionamide STEP 1 A mixture of 2-methylpyrazine (7.0 g, 74.4 mmol), N-CHLOROSUCCINAMIDE (12.6 g, 94.4 MMOL), and benzoyl peroxide (0.1 g, 0.41 mmol) in carbon tetrachloride (200 mL) was heated to reflux for 16 h. The resulting dark heterogeneous solution was filtered, the filtrate concentrated, and the residue purified by flash chromatography (EtOAC/hexanes) to give 2-chloromethyl- pyrazine.

The synthetic route of 109-08-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; AXYS PHARMACEUTICALS, INC.; WO2005/28429; (2005); A2;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Adding a certain compound to certain chemical reactions, such as: 2423-65-6, name is Pyrazine 1-oxide, belongs to Pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2423-65-6, Application In Synthesis of Pyrazine 1-oxide

10219] Procedure:10220] Pd(OAc)2 (39.0 mg, 0.17 mmoles), [P(t-13u)3H] HF4 (151 mg, 0.52 mmoles), Pyrazine-i-oxide (1.0 g, 10.4 mmoles), and K2C03 (959 mg, 6.9 mmoles) were added to a dried flask. The flask was fitted with a reflux condenser capped with a septum, evacuated, and purged with nitrogen (.-5 times). A degassed solution of 2-bromopyridine (548 mg, 3.5 mmoles) in dry dioxane (17 mE) was added via syringe, and the reaction was stirred at 1100 C. for 18 hours. The reaction mixture was cooled and filtered through Celite, and the filtrate was concentrated under reduced pressure. The crude product was then purified by chromatography on silica (30% acetone in hexanes) to afford the title compound (312 mg, 52%) as a pale yellow solid. ?H NMR (400 MHz, CDC13) oe 9.35 (s, 1H), 8.75-8.72 (m, 2H), 8.38 (d, J=4.0 Hz, 1H), 8.15 (dd, J=0.4, 4.0 Hz, 1H), 7.81 (ddd, J=i.6, 2.0, 8.0 Hz, 1H), 7.25 (ddd, J=0.8, 4.8, 8.0 Hz, 1H); ?3C NMR (100 MHz, CDC13) oe 149.9, 149.7, 147.3,145.8, 142.2, 136.5, 134.5, 125.4, 124.8; HRMS (ESI) mlz174.0662 [calc?d for C9H8N30 (M+H) 174.0662].

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Pyrazine 1-oxide, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; WISCONSIN ALUMNI RESEARCH FOUNDATION; RAINES, Ronald T.; Vasta, James; (50 pag.)US2016/280701; (2016); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Reference of 109-08-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 109-08-0, name is 2-Methylpyrazine belongs to Pyrazines compound, it is a common compound, a new synthetic route is introduced below.

Reaction of AgNO3 (33.8 mg, 0.2 mmol), methylpyrazine (mpyz)(19 mg, 0.2 mmol) and isophthalic acid (H2ipa) (33.3 mg, 0.2 mmol) took place in methanol-DMF (DMF = N,N-dimethylformamide) solvents (6 ml, v/v = 1:1) under ultrasonic treatment (160 W, 40 KHz,30 min) at 50 ¡ãC. Addition of ammonia (25percent, 0.5 mL) was found to be an efficient way to eliminate the white precipitate. The resultant solution was allowed slowly and quietly to evaporate at room temperature. The pale pink and prismatic crystals of compound 1 are obtained after several days in the darkness. The crystals were isolated by filtration and washed by deionized water and enthanol and dried in the air. Yield: ca. 80percent based on Ag. Elemental analysis: Anal. Calc. for Ag2C13H10N2O4: C, 32.94; H,2.13; N, 5.91. Found: C, 32.04; H, 2.24; N 6.09percent. Selected IR peaks(cm1): 3355 (s), 3068 (m), 2370 (w), 1606 (s), 1556 (s), 1477(m), 1429 (s), 1379 (s), 1263 (w), 1157 (w), 1062 (m), 1027 (m),943 (w), 906 (w), 821(w), 723 (s), 711 (s), 655 (m), 507 (w), 445(w), 406 (m).

The synthetic route of 2-Methylpyrazine has been constantly updated, and we look forward to future research findings.

Reference:
Article; Wang, Dan-Feng; Wang, Zhan-Hui; Zhang, Ting; Dai, Si-Min; Huang, Rong-Bin; Zheng, Lan-Sun; Inorganica Chimica Acta; vol. 415; (2014); p. 61 – 68;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem