Tag: M.W=0-100

Related Products of 5049-61-6, These common heterocyclic compound, 5049-61-6, name is Pyrazin-2-amine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 1: Synthesis of 5-bromopyrazin-2-amine To a stirred solution of pyrazin-2-amine (3 g, 31.545 mmol) in anhydrous DCM (30 mL) was added NBS (5.6 g, 31.54 mmol) under nitrogen and stirred at 0 C. for 1 h. Progress of reaction was monitored by TLC. After reaction completion DCM was added and washed with water. The organic layer was dried over sodium sulphate and concentrated under reduced pressure. Crude was purified by silica gel (100-200 mesh) column chromatography using 70% DCM/hexane to 10% ethyl acetate in hexane as eluent to yield 5-bromopyrazin-2-amine (3.4 g, 62.9%) as white solid. MS: 175.1 [M++1]

The synthetic route of 5049-61-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Mankind Pharma Ltd.; Patil, Rakesh Ishwar; Verma, Jeevan; Shah, Dharmesh; Ali, Sazid; Bapuram, Srinivasa Reddy; Rai, Santosh Kumar; Kumar, Anil; (146 pag.)US2017/291910; (2017); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Electric Literature of 109-08-0, The chemical industry reduces the impact on the environment during synthesis 109-08-0, name is 2-Methylpyrazine, I believe this compound will play a more active role in future production and life.

A solution of lithium diisopropylamine [prepared from a solution of butyl lithium in hexanes (100 mL, 2.5M) and diispropylamine (25.3 g) at -35¡ã C.] was treated with a solution of 2-methylpyrazine (23.5 g) in dry tetrahydrofuran (300 mL) at -20¡ã C. The mixture was stirred at -20¡ã C. for 1 hour then cooled to -78¡ã C. and treated with a solution of allyl bromide (30.8 g) in dry tetrahydrofuran (300 mL). This mixture was warned to room temperature and stirred at this temperature for 2 hours then left overnight and then treated with saturated ammonium chloride solution (50 mL) followed by water (200 mL). The mixture was then extracted twice with ether (200 mL). The combined extracts were dried over magnesium sulfate then evaporated. The residue was distilled to give the title compound (22 g) as a colorless oil, b.p. 70¡ã C./1 mm Hg.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Methylpyrazine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Cox, Paul J.; Majid, Tahir N.; Lai, Justine Y.Q.; Morley, Andrew D.; Amendola, Shelley; Deprets, Stephanie D.; Edlin, Christopher; US2004/9983; (2004); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Related Products of 109-08-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 109-08-0, name is 2-Methylpyrazine belongs to Pyrazines compound, it is a common compound, a new synthetic route is introduced below.

Under an argon gas flow, diisopropylamine (7.70 g) was dissolved in tetrahydrofuran (50 ml), followed by stirring at -78C. A solution of 1.52 M n-butyl lithium in hexane (50 ml) was slowly added dropwise. After the dropwise addition, the mixture was slowly returned to room temperature over 30 minutes and cooled to -78C again to prepare lithium diisopropylamide. To this was added 2-methylpyrazine (4.29 g), the solution was stirred at 0C for 30 minutes and benzonitrile (4.7 g) was slowly added dropwise so that the inner temperature does not exceed 15C. After stirring at 0C for 90 minutes, lithium diisopropylamide was added dropwise, followed by stirring at 40C for 3 hours. The reaction solution was mixed with ice water, extracted with chloroform, washed with saturated brine, dried and then concentrated. The residue was purified by silica gel column chromatography (chloroform:n-hexane = 20:1) to obtain the objective product (2.2 g).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Methylpyrazine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Nippon Shinyaku Co., Ltd.; EP1452525; (2004); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

These common heterocyclic compound, 109-08-0, name is 2-Methylpyrazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 109-08-0

EXAMPLE 13 4-(2-Pyrazinyl)-1-butene (1300) To a mixture of 15.6 g of sodium amide in 400 ml of ammonia was added dropwise 37.6 g of 2-methylpyrazine. The mixture was stirred for 2 hours and then 24.2 g of allyl bromide in 50 ml of ether was slowly added. This was stirred for 2 hours, 25 g of ammonium chloride added and the ammonia replaced by 500 ml of ether. 250 ml of water was added, the organic layer separated and the aqueous layer extracted twice with ether. The combined organic layers were then concentrated at reduced pressure. The residue was fractionated by distillation to give 20.5 g of product (1300), b.p. 96¡ã-7¡ã (25 mm). UV 2percent EtOH max: 268 (3.82), 273 (3.82). From the above distillation was also obtained 5.4 g of a second product, characterized as the bisalkylated compound, 4-(2-pyrazinyl)-1,6-beptadiene (1301), b.p. 122¡ã-3¡ã (24 mm). UV 10percent EtOH max: 269 (3.83), 273 (3.83).

The synthetic route of 2-Methylpyrazine has been constantly updated, and we look forward to future research findings.

Reference:
Patent; The Coca-Cola Company; US4638005; (1987); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 109-08-0, name is 2-Methylpyrazine, This compound has unique chemical properties. The synthetic route is as follows., Product Details of 109-08-0

A 2.5 M hexanes solution of n-BuLi (18.0 mL, 45 mmol) was added to a -78 0C THF solution (60 mL) of t-BuOK (5.1 g, 45 mmol) and diisopropylamine (6.3 mL, 45 mmol). After 5 min at -78 0C the yellow mixture was warmed to -40 0C. Neat methylpyrazine (2.7 mL, 30 mmol) was added and the mixture rapidly turned dark red. After 30 min at – 40 0C the mixture was cooled to -78 0C and neat allyl bromide (7.6 mL, 90 mmol) was added. After 30 min at -78 0C water was added and the mixture was partially concentrated to remove volatile organics. The resulting mixture was extracted with dichloromethane and the combined organics were dried (Na2SO4), concentrated, and purified via column chromatography to give 2.2 g of 2-but-3-enyl-pyrazine.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 109-08-0.

Reference:
Patent; JANSSEN PHARMACEUTICA NV; BARBAY, J., Kent; LEONARD, Kristi; CHAKRAVARTY, Devraj; SHOOK, Brian, Christopher; WANG, Aihua; WO2010/45015; (2010); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Reference of 2423-65-6, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2423-65-6, name is Pyrazine 1-oxide, This compound has unique chemical properties. The synthetic route is as follows.

Preparation 28 2-Amino-6-cyanopyrazine This intermediate was prepared via a stepwise procedure. A mixture of 21 g. of pyrazine-2-carboxamide, 85 ml. of glacial acetic acid, and 75 ml. of 30 percent hydrogen peroxide was heated at about 55 C. for about 35 hours. The reaction product mixture was cooled and filtered. The solid which was collected was extracted with n-butanol and the extracts discarded. The solid which was insoluble in n-butanol was recrystallized from hot water to yield a white solid having a melting point of about 302-305 C. The solid was identified by elemental analyses as pyrazine-2-carboxamide 4-oxide. To a mixture of 4 g. of the pyrazine oxide (prepared above) in 40 ml. of dimethylformamide cooled in an ice bath, there was quickly added 12 ml. of phosphorus oxychloride. The reaction mixture was poured into water and the aqueous mixture extracted with ethyl acetate, and the extracts saved. Additional water was added to the aqueous layer and the aqueous mixture extracted with hexane-ether. The ethyl acetate and hexane-ether extracts were combined and concentrated in vacuo to leave a residue. The residue was identified by elemental analyses and IR spectrum as 2-chloro-6-cyanopyrazine, and was used without further purification in the next step. A mixture of 1 g. of the above chlorocyanopyrazine and 25 ml. of dimethyl sulfoxide was prepared and anhydrous ammonia was bubbled thereinto. The reaction mixture was stirred overnight and then poured into water. The aqueous mixture was extracted with ethyl acetate, and the extracts dried. The drying agent was filtered off and the solvent removed in vacuo to leave a solid which was identified by its IR spectrum as 2-amino-6-cyanopyrazine. It was used as is without further purification in the preparation of final products of the invention.

The chemical industry reduces the impact on the environment during synthesis Pyrazine 1-oxide. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Eli Lilly and Company; US4293552; (1981); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 109-08-0, name is 2-Methylpyrazine, This compound has unique chemical properties. The synthetic route is as follows., Product Details of 109-08-0

General procedure: 2-aminophenyl ketones 1 (0.3 mmol), methylazaarenes 2 (0.6 mmol), NH4OAc (0.6 mmol), CuCl2 (20 mol %), TFA (50 mol %), DMF (2.0 mL) were added to a 25mL Schlenk tube under O2 atmosphere with magnetic stirrer bar. The reaction mixture was stirred at 120 _C (oil bath temperature) for 24 h. After the reaction was finished (monitored by TLC), the mixture was cooled to room temperature, quenched with solution of NaHCO3 (10 mL) and extracted with EtOAc (3 _ 10 mL). The combined organic layers were dried over anhydrous MgSO4 and the solvent was removed under vacuum. The crude product was purified by column chromatography (EtOAc/hexanes) on silica gel.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 109-08-0.

Reference:
Article; Liang, En; Wu, Yinrong; Chen, Jiewen; Xiong, Wei; Zhao, Jinwu; Yao, Xingang; Tang, Xiaodong; Tetrahedron; vol. 75; 52; (2019);,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Some common heterocyclic compound, 5049-61-6, name is Pyrazin-2-amine, molecular formula is C4H5N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 5049-61-6

To a solution of pyrazin-2-amine(A70, 2.0 g, 2.10 mmol) and ethyl 3- bromo-2-oxopropanoate(A15, 3.0 mL, 2.30 mmol) in ethanol(15.0 mL) was added Cone., HC1(1.0 mL) at 0 C and stirred for 12 h at 95 C. The reaction mixture was concentrated under reduced pressure followed by addition of water(10 mL), the mixture was then extracted with DCM and the organic layer was washed with saturated NaHC03 solution and brine, dried over sodium sulphate, filtered and concentrated under reduced pressure. The obtained crude was purified by combi-flash purifier with 3% methanol in dichloromethane as eluent to afford the desired product A71 as yellow solid(0.4 g, 10 %). 1H NMR (DMSO-d6, 400 MHz) d 1.31(t, / = 7.2 Hz, 3H), 4.33(q, / = 7.2 Hz, 2H), 7.96(d, J = 4.4 Hz, 1H), 8.57(d, J = 4.0 Hz, 1H), 8.66(s, 1H), 9.15(s, 1H); MS(ESI) m/z = 192.1(M+H)+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5049-61-6, its application will become more common.

Reference:
Patent; JUBILANT BIOSYS LIMITED; VADIVELU, Saravanan; RAJAGOPAL, Sridharan; BURRI, Raghunadha Reddy; GARAPATY, Shivani; SIVANANDHAN, Dhanalakshmi; THAKUR, Manish Kumar; NATARAJAN, Tamizharasan; SWAMY, Indu N; NAGARAJU, Nagendra; KANAGARAJ, Subramaniam; MOHD, Zainuddin; SARKAR, Sayantani; SAMANTA, Swapan Kumar; ., Hariprakash; (284 pag.)WO2019/102494; (2019); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Synthetic Route of 109-08-0, A common heterocyclic compound, 109-08-0, name is 2-Methylpyrazine, molecular formula is C5H6N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A solution of 2.0 g methylpyrazine and 1.8g trichloro isocyanuric acid in 30 ml chloroform was refluxed for 18 hours. The resulting solids were filtered off and the solvent evaporated. The residue was dissolved in 7 ml DMF, 160 mg (0.62 mmol) of triazinone (see example 38) and 1 ml DBU were added and stirred for 18 hours. The crude product was purified after20 evaporation of the solvent, using flash chromatography (50 g silica gel, ethyl acetate:chloroform 85/15). The product fractions were combined and the solvent removed under vacuum. The product was crystallized from chloroform: ethyl acetate to give 130 mg of a white solid with the following properties: MP: 229-2310C; 1H NMR (300 MHz, CDCl3) delta 8.79 (IH, s) 8.71 (IH, s), 8.51 (2H, s), 7.85 (IH, s), 5.78 (2H, s), 5.61 (IH, t, J = 6.0 Hz),-25 3.97-3.88 (IH, m), 3.74-3.66 (IH, m) and 2.60-1.95 ppm (4H, m).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; CORTEX PHARMACEUTICALS, INC.; WO2008/85505; (2008); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 6270-63-9, name is Pyrazin-2(1H)-one, A new synthetic method of this compound is introduced below., name: Pyrazin-2(1H)-one

Weigh the pyrazin-2(1H)-one (481 mg, 5 mmol) in a 50 mL single-mouth bottle. Add anhydrous N,N-dimethylformamide (6 mL), Sodium hydride (240 mg, 6 mmol, 60%) was added and the mixture was stirred at room temperature. Weighed after 20 minutes Ethyl 2-bromoacetate (1.0 g, 10.0 mmol, Dissolved in 4 mL of anhydrous N,N-dimethylformamide) and added dropwise to the reaction flask. After the addition was completed, the reaction was stirred at room temperature overnight. Stop the reaction, The reaction was quenched by dropwise addition of water (2 mL). Add water (30mL), Extracted with ethyl acetate (30 mL ¡Á 3), Combine the organic phase to concentrate, The residue was purified by column chromatography ( petroleum ether / ethyl acetate (v / v) = 1 / 1) The title compound was obtained as a pale yellow liquid (360 mg, 40%).

The synthetic route of 6270-63-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Xu Tengfei; Jin Chuanfei; Zhong Wenhe; Xue Yaping; (45 pag.)CN109761892; (2019); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem