Tag: M.W=0-100

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 109-08-0, name is 2-Methylpyrazine belongs to Pyrazines compound, it is a common compound, a new synthetic route is introduced below. Quality Control of 2-Methylpyrazine

Butyllithium (1.6 M in hexane solution, 10 ml, 16 mmol) was added dropwise to a solution of diisopropylamine (2.25 ml, 16 mmol) in anhydrous THF (50 ml) at -20¡ãC under a nitrogen atmosphere. The mixture was stirred at -20¡ãC for 30 minutes and after cooling at -70¡ãC a solution of 2-methyl-pyrazine (1.47 ml, 16 mmol) in THF (10 ml) was added dropwise. After 15 minutes, a solution of 3-bromo-propionic acid ethyl ester (2.54 ml, 19.2 mmol) in THF (10 ml) was added and the mixture maintained at -70¡ãC for 2 hours and then stirred at room temperature overnight. The reaction was then quenched with a saturated solution of NH4Cl and extracted with ethyl acetate, the organic phase was dried (Na2SO4) and evaporated. The residue was purified by flash chromatography (hexane/ ethyl acetate from 9/1 to 1/1 respectively) to give the title compound (1 g, 33percent yield). UPLC/MS: 195.1 (MH+).

The synthetic route of 109-08-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Neurotune AG; EP2098526; (2009); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Some common heterocyclic compound, 109-08-0, name is 2-Methylpyrazine, molecular formula is C5H6N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C5H6N2

Step C??Synthesis of mt 7-3 10347] To a solution of 2-methylpyrazine (272 mg, 2.9 mmol) and HMPA (520 mg, 2.9 mmol) in THF (2.5 mE) was added EDA (1.6 mE, 3 mmol) at ?78¡ã C. dropwise. The mixture was allowed to stir at ?78¡ã C. for 30 minutes before a solution of mt 7-2 (600 mg, 2.45 mmol) in 2 mE of THF was added. The mixture was allowed to warm to room temperature for 3 hours before it was quenched with 10 mE of saturated NH4C1 solution. The resulting mixture was extracted with EtOAc (3×10 mE) and the combined organic washings were dried over sodium sulfate, filtered and in vacuo. The resulting residue was purified using column chromatography (25percent EtOAc/petroleum ether) to provide mt 7-3 (100 mg, 12percent). MS (ESI): mlz (M+H) 339.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 109-08-0, its application will become more common.

Reference:
Patent; Coburn, Craig A.; Maletic, Milana; Soll, Richard; Li, Chunsing; Luo, Yunfu; Qi, Zhiqi; US2014/5103; (2014); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 6270-63-9, name is Pyrazin-2(1H)-one belongs to Pyrazines compound, it is a common compound, a new synthetic route is introduced below. Safety of Pyrazin-2(1H)-one

To Pyrazin-2(1H)-one (0.333 g, 3.47 mmol) was added 5 N sodium hydroxide solution (2.1 ml) followed by chloroacetic acid (0.524 g, 5.54 mmol). The reaction mixture was heated at 100C for 2 h. After cooling to ambient temperature, 2 N hydrochloric acid (3.5 ml) was added and the reaction mixture was directly purified by reverse phase etaPLC (TMC Pro-Pac C18; 0-40% 0.1% trifluoroacetic acid in acetonitrile/ 0.1% trifluoroacetic acid in water gradient). The pure fractions were lyophilized overnight to yield the title compound as a yellow solid. LC/MS 155.2 (M+l)+.

The synthetic route of 6270-63-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MERCK & CO., INC.; WO2009/123870; (2009); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Electric Literature of 5049-61-6,Some common heterocyclic compound, 5049-61-6, name is Pyrazin-2-amine, molecular formula is C4H5N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Initial attempt showed that the reaction gave a lot of black polymers after a few min., with the main product being 3,5-dichloro-2-amino pyrazine. Only small amount of 5- chloro-2-aminopyrazine was isolated (eq 7). This reaction could not be scaled up because it was not reproducible.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Pyrazin-2-amine, its application will become more common.

Reference:
Patent; THE GOVERNMENT OF THE UNITED STATES, as represented by the secretary of HEALTH AND HUMAN SERVICES; WO2007/124345; (2007); A2;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Chemistry, like all the natural sciences, begins with the direct observation of nature¡ª in this case, of matter.290-37-9, Name is Pyrazine, SMILES is C1=NC=CN=C1, belongs to Pyrazines compound. In a document, author is Kergreis, Angelique, introduce the new discover, Safety of Pyrazine.

Influence of Ligand and Nuclearity on the Cytotoxicity of Cyclometallated C boolean AND N boolean AND C Platinum(II) Complexes

A series of cyclometallated mono- and di-nuclear platinum(II) complexes and the parent organic ligand, 2,6-diphenylpyridine1((HCNCH)-N-boolean AND-C-boolean AND), have been synthesized and characterized. This library of compounds includes [((CNC)-N-boolean AND-C-boolean AND)Pt-II(L)] (L=dimethylsulfoxide (DMSO)2and triphenylphosphine (PPh3)3) and [(((CNC)-N-boolean AND-C-boolean AND)Pt-II)(2)(L’)] (whereL’=N-heterocycles (pyrazine (pyr)4, 4,4′-bipyridine (4,4′-bipy)5or diphosphine (1,4-bis(diphenylphosphino)butane (dppb)6). Their cytotoxicity was assessed against four cancerous cell lines and one normal cell line, with results highlighting significantly increased antiproliferative activity for the dinuclear complexes (4-6), when compared to the mononucleated species (2and3). Complex 6is the most promising candidate, displaying very high selectivity towards cancerous cells, with selectivity index (SI) values >29.5 (A2780) and >11.2 (A2780cisR), and outperforming cisplatin by >4-fold and >18-fold, respectively.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 290-37-9 is helpful to your research. Safety of Pyrazine.

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 290-37-9, Name is Pyrazine, formurla is C4H4N2. In a document, author is Zhou, Xiaomin, introducing its new discovery. Category: Pyrazines.

Urine Metabolome Profiling Reveals Imprints of Food Heating Processes after Dietary Intervention with Differently Cooked Potatoes

Heat treatment is a widely used method for food processing, and the compounds formed by heat processes may serve as biomarkers of heated food intake in nutrition studies. Therefore, we aimed to characterize the differential metabolic signatures resulting from intake of different potato products and identify potential intake biomarkers. In a randomized, controlled, crossover meal study, healthy volunteers consumed boiled rice, boiled potatoes, and two deep-fried potato products, potato chips and French fries. The urine metabolome was acquired by LC-MS-based untargeted metabolomics. Twenty-two selected metabolites were found for deep-fried potatoes, two for potato intake in general, and one for boiled rice. Fourteen of the 22 selected metabolites were tentatively identified as furan-, pyrrole- and pyrazine-derived compounds indicative of Maillard reactions. With further validation, these candidate biomarkers will be important tools to investigate the influence of heated foods on human health.

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Let¡¯s face it, organic chemistry can seem difficult to learn. Especially from a beginner¡¯s point of view. Like 290-37-9, Name is Pyrazine. In a document, author is Dai, Xin-Peng, introducing its new discovery. Formula: C4H4N2.

A Highly Porous Co-MOF for Cyanosilylation Reaction and Inhibition on P. gingivalis Growth and rgp and kgp Expression for Periodontal Treatment

A novel porous three-dimensional Co(II) organic framework of metal, [{Co-2(TCPP)(H2O)}center dot DMF](n)(1), (where H4TCPP = 2,3,5,6-tetrakis(4-carboxyphenyl)pyrazine) was synthesized under the solvent thermal condition, consisting of a H4TCPP ligand which is rigid and tetratopic. Intriguingly, the centers of Co(II) coordinated water molecules can be dislodged via activating1under 120 degrees C, resulting in a pores skeleton arranged by Lewis acidic Co(II) ions which are unsaturated. Activated1has great activity of catalysis for without solvent cyanosilylation of acetaldehydes under mild conditions. To develop the candidates for the periodontal diseases therapy, the inhibitory effect of the compound on the growth curves ofPorphyromonas gingivaliswas evaluated. Next, the RT-PCR detection ofrgpandkgpwas conducted to explore the effect of compound on the key gene expression.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 290-37-9 help many people in the next few years. Formula: C4H4N2.

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 290-37-9, Name is Pyrazine, SMILES is C1=NC=CN=C1, belongs to Pyrazines compound. In a document, author is Rogovoy, Maxim I., introduce the new discover, COA of Formula: C4H4N2.

Efficient one-pot synthesis of diphenyl(pyrazin-2-yl)phosphine and its Ag-I, Au-I and Pt-II complexes

A convenient one-pot synthesis of diphenyl(pyrazin-2-yl)-phosphine has been developed based on reaction of Ph3P with metallic lithium followed by treatment of the Ph2PLi formed with 2-chloropyrazine. The Ag-I, Au-I and Pt-II chloride complexes derived from this phosphine have been synthesized and structurally characterized.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 290-37-9 is helpful to your research. COA of Formula: C4H4N2.

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, Recommanded Product: Pyrazine, 290-37-9, Name is Pyrazine, SMILES is C1=NC=CN=C1, belongs to Pyrazines compound. In a document, author is Usman, Muhammad, introduce the new discover.

Characterization and biogas production potentials of aqueous phase produced from hydrothermal carbonization of biomass – Major components and their binary mixtures

Hydrothermal carbonization aqueous phase (HTC-AP) can be used for methane production by anaerobic digestion (AD). However, it generally had low conversion efficiency due to the formation of complex dissolved organic matters, which depends upon the components of biomass. The present study investigated the characteristics, methane potentials, and recalcitrant chemicals of HTC-AP produced from different combinations of model compounds carbohydrate (alpha-cellulose, C) and protein (bovine serum albumin, BSA) with mass ratios of 1:0, 0.75:0.25, 0.5:0.5, 0.75:0.25 and 0:1. The methane yields of samples 1:0 (pure C) and 0:1 (pure BSA) were 192 mL/g COD and 187 mL/g COD, respectively, while it was decreased to 105.5 CH4 mL/g COD for sample 0.75:0.25 (C/BSA), indicating more recalcitrant organics were produced with the combination of C and BSA. It was found that the mean MW (209157) of sample 0.75:0.25 was much higher than the other samples (< 7000 Da). While the highest percentage (51%) of hard bio-degradable hydrophobic DOC, humics, and building blocks organics were also observed in this sample by LC-OCD-OND analysis. Furthermore, a high value of SUVA index 2.56 was noted, indicating the presence of a large number of aromatic compounds. In addition, fluorescent compounds mainly relating to humic-like substances were also detected by 3D-EEM. GC-MS analysis showed higher concentrations of pyrazine and its derivatives were present in sample 0.75:0.25, which indicated the occurrence of a serious Maillard reaction. The continuous experiment further verified the lower biodegradability of sample 0.75:0.25 with a methane yield of 108 mL/g COD. It also showed that only 18.9% of the fluorescent components were degraded and 13 recalcitrant chemicals were identified to be hard bio-degradable organics in AD process. A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 290-37-9. Recommanded Product: Pyrazine.

In an article, author is Gugin, Nikita Y., once mentioned the application of 290-37-9, SDS of cas: 290-37-9, Name is Pyrazine, molecular formula is C4H4N2, molecular weight is 80.09, MDL number is MFCD00006122, category is Pyrazines. Now introduce a scientific discovery about this category.

Structural variety of aluminium and gallium coordination polymers based on bis-pyridylethylene: from molecular complexes to ionic networks

A systematic structural study of the complexes formed by aluminium and gallium trihalides with 1,2-bis(4-pyridyl)ethylene (bpe) was performed. Quantum chemical computations revealed that the energy differences between the ionic and the molecular complexes expected in the MX3-bpe (M = Al, Ga; X = Cl, Br) system are very small. These computational findings indicate that this system is a rich source of compounds with diverse structural motifs. Indeed, eleven complexes, namely, [M2Cl4(bpe)(5)](2+)[M2Cl4-(bpe)(6)](2+)[MCl4](4)(-)*3bpe (M[double bond, length as m-dash]Al (1), M[double bond, length as m-dash]Ga (2)), [Al3Br8(bpe)(3)](+)[AlBr4](-) (3), [Al2Br4(bpe)(5)](2+)[AlBr4](2)(-)*bpe (4), [Ga2Br4(bpe)(7)](2+)[GaBr4](2)(-)*bpe (5), [GaCl3(bpe)](infinity) (6), [(MX3)(2)(bpe)] (MX3 = AlCl3 (7), AlBr3 (8), GaCl3 (9), GaBr3 (10a, 10b), and [(GaBr3)(2)(bpe)]*bpe (11) were synthesized in a solvent-free melt reaction of group 13 metal halides and bpe. The diversity of the complexes obtained shows the marked effect of different reagent ratios as well as Lewis acid on the product structures. Ionic coordination polymers (CPs) 1 and 2 exhibit isostructural unusual mixed one-dimensional-two-dimensional (1D-2D) networks. Interaction of bpe with excess AlBr3 yielded ionic 1D CP 3 while the same reaction in excess bpe produced ionic 2D CP 4. Reaction of GaBr3 and bpe in equimolar ratio yielded binuclear ionic complex 5 in a mixture with an adduct solvate 11. The only molecular CP 6 with 1D structure was isolated when the reaction between GaCl3 and bpe was carried out in both 1 : 1 and 1 : 2 stoichiometric ratios. In the case of the 2 : 1 ratio, irrespective of the Lewis acid, [(MX3)(2)(bpe)] adducts 7-10a and 10b were obtained. Remarkably, complex 10 crystallizes in two polymorphic modifications, 10a and 10b. The solid-state structures of complexes 1, 3-5, and 7-11 were determined for the first time.

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