Tag: M.W=0-100

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 109-08-0, name is 2-Methylpyrazine, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C5H6N2

(1) Under the protection of nitrogen,A 2-methyl pyrazine in a molar ratio of 1: 0.05: 1.2,Dibenzoyl peroxide and N-chlorosuccinimide were added to the solvent anhydrous carbon tetrachloride, A-chloromethylpyrazine by refluxing;

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 109-08-0.

Application of 6270-63-9, A common heterocyclic compound, 6270-63-9, name is Pyrazin-2(1H)-one, molecular formula is C4H4N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A solution of compound pyrazin-2(1H)-one (11.0 g, 114 mmol), Mg(Ot-Bu)2 (39.0 g, 229 mmol) and t-BuOK (13.5 g, 120 mmol) in THF (220 mL) was stirred at 25 C. for 20 min under N2. And then compound (R)-2-bromo-4-methylpentanoic acid (33.5 g, 172 mmol) was added drop-wise into the mixture. The reaction was stirred at 25 C. for 20 hrs. HCl (3.0 M, 153 mL) was added dropwise to the mixture. The organic phase was washed with brine (100 mL), and concentrated. The mixture was purified by SFC (Instrument: Thar SFC80 preparative SFC; Column: Chiralpak AD-H 250*30 mm i.d. 5u; Mobile phase: A for CO2 and B for IPA (0.1% NH3H2O); Gradient: B %=35%; Flow rate: 75 g/min; Wavelength: 220 nm; Column temperature: 40 C.; System back pressure: 100 bar; Cycle time:13 min; Injection amount: 105 mg per injection) to give (S)-4-methyl-2-(2-oxopyrazin-1(2H)-yl)pentanoic acid (15.0 g, 61.7% Yield, 99.0% purity) as a yellow solid. 1H NMR (400 MHz, DMSO-d6) delta 7.96 (d, J=5.6 Hz, 1H), 7.58 (d, J=4.8 Hz, 1H), 7.30 (d, J=4.4 Hz, 1H), 5.14-5.21 (m, 1H), 1.84-1.92 (m, 2H), 1.17-1.26 (m, 1H), 0.82-0.84 (m, 6H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 5049-61-6, name is Pyrazin-2-amine, A new synthetic method of this compound is introduced below., category: Pyrazines

A I L three-necked round bottom flask was charged with pyrazin-2-amine (20 g, 0.21 mol), DMSO (600 mL) and water (15 mL). To the above was added in portions N-Bromosuccinimide (77.9 g, 0.44 mol) while keeping the inner temperature below 5 C. The resulting mixture was stirred at 20 C overnight. The solvent was evaporated and the residue was purified by flash columnchromatography on silica gel with a 1 :10 EtOAc/petroleum ether, to afford 18 g (34%) of the product as a yellows solid. *H NMR (300 MHz, CDC13) delta: 8.02 (s, 1H), 4.72 (br, 2H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Application of 109-08-0, A common heterocyclic compound, 109-08-0, name is 2-Methylpyrazine, molecular formula is C5H6N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

In the glove box,Mn(CO)5Br (0.005 mmol),[(E)-2-(2-(1-(2-pyridyl)ethylidene)-indenyl)pyridine] (0.006 mmol),Add 1.0 mL of toluene,After stirring for two hours,Add 2-methylpyrazine 1a (2mmol),Benzyl alcohol 2a (1mmol),After the reaction at 135 C for 48 hours, the reaction was stopped.Evaporate the solvent,Column chromatography ethyl acetate / petroleum ether (1:10),Trans-disubstituted olefin derivative 3a.The product is a white solid.The yield was 81%.

The synthetic route of 109-08-0 has been constantly updated, and we look forward to future research findings.

Application of 5049-61-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 5049-61-6 name is Pyrazin-2-amine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Description 64: 5-bromo-2-pyrazinamine (D64); In a 2 L, ice-bath cooled (NaCl) round-bottomed flask, 2-pyrazinamine (30 g, 315 mmol) was dissolved in DCM (850 ml) NBS (59.0 g, 331 mmol) was added and the reaction mixture was left stirring at 0 0C for 1 hour. The mixture was let to warm-up to room temperature and was left stirring for 1 hour. Solvent was evaporated and the crude was purified by Silica Pad eluting with DCM 100% to DCM/MeOH 90:10. The recovered product was triturated with cyclohexane. The resulting pale yellow solid was filtered through a gouch funnel and dried under vacuum to give the title compound D64 (23.6 g). Mother liquors were concentrated under vacuum to give a second batch of title compound D64 (4.8 g). Impure fractions coming from the silica pad were purified by Silica Chromatography (Biotage SP – column size 34Og) using DCM 100% to DCM/MeOH 90 : 10 as eluent. It was recovered a third batch of title compound D64 (7.2 g). UPLC (Acid Final QC): rt = 0.54 minutes, peak observed: 174 (M) C4H4BrN3 requires 174. 1H NMR (400 MHz, DMSO-J6) delta ppm 6.64 (br. s., 2 H) 7.70 (d, 1 H) 8.04 (d, 1 H)

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Pyrazin-2-amine, and friends who are interested can also refer to it.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 5049-61-6, name is Pyrazin-2-amine, A new synthetic method of this compound is introduced below., COA of Formula: C4H5N3

NBS (45 g, 253 mmol) was added in portions to a suspention of 2- aminopyrazine (25 g, 263 mmol) in dichloromethane (500 ml) over a period of 2h. The mixture was filtered and evaporated. The residue was suspended in dichloromethane (60 ml) and stirred for 10 minutes before hexane (60 ml) was added. The mixture was stirred vigorously for 15 minutes and filtrated. The yellow powder was washed with CH2CI2/ hexane 1 : 1 (3x). The solid was dis- solved in diethylether and washed with water (3x), dried (mgso4) and evaporated, yield: 15.0 g (33%). Light yellow solid. HPLC 95% Rt=I .04 (system A. 10- 97% MeCN over 3 minutes). HPLC 95% Rt=O.78 (system B. 10-97% MeCN over 3 minutes). MS (elecronspray; [M+H}+ 174.4. IH NMR (400 MHz, CHLORO- FORM-D) delta ppm 4.60 (s, 2 H) 7.76 (d, J= I .51 Hz, 1 H) 8.08 (d, J= I .51 Hz, 1 H).

The synthetic route of 5049-61-6 has been constantly updated, and we look forward to future research findings.

Related Products of 4949-13-7, A common heterocyclic compound, 4949-13-7, name is 2-Fluoropyrazine, molecular formula is C4H3FN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of sodium sulfite (3.86 g, 30.6 mmol) in water (20 mL) was added 2-fluoropyrazine (2 g, 20.4 mmol). It was stirred at 150C under pressure tube overnight. After removal of solvent, the solid was dried to give crude product sodium pyrazine-2-sulfonate as a white solid (6 g) which was used directly for next step without further purification.

The synthetic route of 4949-13-7 has been constantly updated, and we look forward to future research findings.

Synthetic Route of 109-08-0,Some common heterocyclic compound, 109-08-0, name is 2-Methylpyrazine, molecular formula is C5H6N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A solution of 1.4.1 (3.0 g, 32 mmol) in CHC13( 100 mL) was heated to reflux and solid Trichloro isocyanuric acid (3.11 g, 13.4 mmol) was added in 4 portions in 1 hour and the reaction was refluxed overnight. The reaction mixture was filtered through celite and washed with IN NaOH, dried and concentrated. The crude 1.4.2 (3.0g) was taken to the next step without purification.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Methylpyrazine, its application will become more common.

Electric Literature of 4949-13-7,Some common heterocyclic compound, 4949-13-7, name is 2-Fluoropyrazine, molecular formula is C4H3FN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

n-Butyllithium (2.5M in hexanes, 1.05 mL, 2.58 mmol) was added to a solution of 2,2,6,6-tetramethylpiperidine (462 muL, 2.73 mmol) in THF (10 mL) at -78 C. The reaction mixture was stirred at 0 C. for 20 min. A solution of 2-fluoropyrazine (224 mg, 2.28 mmol) in THF was added at -78 C. After stirring at -78 C. for 5 min, ZnCl2 (0.5 M in THF, 11 mL, 5.32 mmol) was then added. The reaction mixture was stirred at -78 C. for 30 min and then at 0 C. for 1 h. A solution of the bromide (500 mg, 1.52 mmol) and Pd(PPh3)4 (352 mg, 0.304 mmol) in THF (20 mL) was then added. The reaction mixture was stirred at rt for 3 days. A sat. aq. solution of EDTA was added. After stirring at rt for 15 min, a sat. aq. solution of NaHCO3 was added. The reaction mixture was extracted with DCM. The combined organics were separated, dried (MgSO4), filtered and concentrated. The crude residue was purified by SiO2 chromatography eluting with 20:80 EtOAc/hexane to afford 200 mg (38%) of pyrazine as a yellow oil. MS m/z (ES): 346 (M+H)+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Fluoropyrazine, its application will become more common.

Electric Literature of 5049-61-6, These common heterocyclic compound, 5049-61-6, name is Pyrazin-2-amine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

2-Amino-5-bromopyrazine (15).; To a cooled solution of 2-aminopyrazine 11 (2.00 g, 21.00 mmol) in dichloromethane (50 mL) N-bromosuccinimide (NBS) (3.73 g, 21.00 mmol) was added in portion. The mixture was stirred at 0 0C for 2h and washed with Na2CO3 s.s. and water, the organic layer was dried over Na2SO4, filtered and the solvent removed under reduced pressure to get 2.80 g of the title compound 15 (77% yield) as an orange solid without further purification (mp 105-110 0C). 1H-NMR (CDCl3): 4.61 (br s, 2H), 7.75 (s, IH), 8.07 (s, IH). MS (GC-MS): m/z 174 .

Statistics shows that Pyrazin-2-amine is playing an increasingly important role. we look forward to future research findings about 5049-61-6.