Tag: M.W=0-100

Adding a certain compound to certain chemical reactions, such as: 109-08-0, name is 2-Methylpyrazine, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 109-08-0, Product Details of 109-08-0

EXAMPLE 27 2-(hept-6-enyl)pyrazine (Compound ID 57) Methylpyrazine (940 mg, 912 10 mmol) was added to sodium amide (490 mg, 12.5 mmol) in 10 ml liquid NH3 at -65° C. and the red mixture was stirred for 30 min. A solution of 1-bromohex-5-ene (7.5 mmol) in dry ether was added dropwise and the mixture was stirred for another hour. The reaction was quenched by addition of ammonium chloride (626 mg, 11.7 mmol) and NH3 was evaporated by heating at ether reflux. The ether was removed and the residue extracted several times with ether. The combined ether phases were washed with water, dried over sodium sulfate, evaporated under vacuum and purified by FC (hexane/ethyl acetate 1/1). 2-(hept-6-enyl)pyrazine was isolated as a GC-pure oil (1.03 g, 78percent). Rf 0.52 (hexane/ethyl acetate 1/1). 1H-NMR (400 MHz, CDCl3): 8.48 (s, 1H); 8.45 (s, 1H); 8.39 (s, 1H); 5.78 (m, 1H); 5.00-4.94 (m, 2H); 2.81 (t, J=7 Hz, 2H); 2.04 (m, 2H); 1.75 (m, 2H); 1.41 (m, 4H). 13C-NMR (CDCl3): 158.29; 144.96; 144.34; 142.46; 139.22; 114.82; 35.81; 33.99; 29.65; 29.12; 29.03. GC-MS: 16.23 min, m/z 176.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Methylpyrazine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Givaudan SA; US2010/113460; (2010); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Application of 290-37-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 290-37-9, name is Pyrazine belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.

General Procedure 1:; Diazine Oxidation;The appropriate diazine (1 equiv.) and mCPBA (1 equiv.) were dissolved in DCM (0.2 M). The reaction was allowed to stir for 16 hours. PPh3 (0.5 equiv.) was then added to reduce any unreacted peracid and the mixture was stirred for an additional 4 h. The volatiles were evaporated under reduce pressure and the residue was purified via silica gel column chromatography.; Pyrazine N-oxide (80) Synthesised according to general procedure 1. Purification via silica gel column chromatography using 100% EtOAc then a mixture of 20% MeOH/EtOAc gave a white solid (88%). 1H NMR (300 MHz, CDCl3, 293K, TMS): delta 8.50 (2H, d, J=3.9 Hz), 8.14 (2 H, d, J=4.8 Hz).13C NMR (75 MHz, CDCl3, 293K, TMS): 147.8, 134.0.HRMS calculated for C4H4N2O1 (M+) 96.0324; Found: 96.0295.Melting point C.: 103.2-104.5IR (vmax/cm-1): 3120, 3088, 1595, 861, 847, 838.Rf (20% MeOH/EtOAc): 0.3

The synthetic route of Pyrazine has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 5049-61-6, name is Pyrazin-2-amine, A new synthetic method of this compound is introduced below., Quality Control of Pyrazin-2-amine

Under absence of light and at 0 C., N-bromosuccinimide (7.84 g, 44.05 mmol) was added to a solution of 2-aminopyrazine (4.19 g, 44.06 mmol) in dry dichloromethane (250 ml). The mixture was stirred for 20 h at 4 C. and then washed with four 40 ml portions of a saturated sodium carbonate solution in water. The organic layer was dried (MgSO4) and evaporated under reduced pressure, affording the title compound as 5.90 g of a light brown solid. Column chromatography, using silica and a dichloromethane/ethyl acetate (3/1) mixture as the eluent, yielded pure 2-bromo-5-aminopyrazine as 5.00 g (65%) of a light yellow solid. 1H-NMR (CDCl3, 400 Mhz): 8.09 (s, 1H, H-6), 7.77 (s, 1H, H-3), 4.65 (bs, 2H, NH) ppm. 13C-NMR (CDCl3, 100 Mhz): 153.5 (C-2), 144.3 (C-6), 131.9 (C-3), 126.8 (C-5) ppm.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Synthetic Route of 5049-61-6,Some common heterocyclic compound, 5049-61-6, name is Pyrazin-2-amine, molecular formula is C4H5N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

[0094] Pyrazin-2-amine (VIII) (1.91 g, 20.08 mmol) was dissolved in dimethylsulfoxide (DMSO) (40 mL) and distilled water (1 mL). To the resulting solution was slowly added dropwise N-Bromosuccinimide (NBS) (8.20 g, 46.07 mmol) at 0 C and the solution was stirred at room temperature for 16 hrs. Ice was added to the solution and the solution was stirred to give a yellow solid which was filtered to give the title compound (3.40 mg, 67 %). 1H NMR (400 MHz, CDCl3) delta 8.04 (s, 1H), 5.05 (br, 2H).

The synthetic route of 5049-61-6 has been constantly updated, and we look forward to future research findings.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5049-61-6, name is Pyrazin-2-amine, This compound has unique chemical properties. The synthetic route is as follows., Product Details of 5049-61-6

To a solution of 2-amino pyrazine (20 g, 210 mmol) in dimethoxy ethane (400 ml) was added ethyl bromopyruvate (32.8 ml) at 25 C. and the resulting reaction mixture was allowed to stir at the same temperature for 4 hrs. It was then cooled to 0 C. and stirred for 30 minutes. The separated solid was filtered and washed with ether. Solid residue was taken in ethanol (1000 ml) and refluxed for 4 hrs. Solvent was removed completely, residue taken in chloroform (1000 ml), saturated sodium bicarbonate solution (700 ml) was added to it and the mixture was allowed to stir for 45 minutes. The mixture was filtered through celite bed, washed several times with chloroform and filtrate was dried over sodium sulfate. Evaporation of the organic layer under reduced pressure gave the crude mass, which was purified by crystallization using ether-methanol mixture. Yield: 20%

According to the analysis of related databases, 5049-61-6, the application of this compound in the production field has become more and more popular.

Related Products of 109-08-0, A common heterocyclic compound, 109-08-0, name is 2-Methylpyrazine, molecular formula is C5H6N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

In a 500 mL reactor, 94.1 g (1 mol) of 2-methylpyrazine was added.0.2 g (0.0016 mol) of ferrous chloride, and 225 g (1.99 mol) of hydrogen peroxide having a mass concentration of 30percent was added dropwise at 30 ° C.After the completion of the dropwise addition for 4 hours, the temperature was raised to 50 ° C, and 40 g (2.35 mol) of ammonia gas was introduced. After the completion of the ammonia gas, the temperature was maintained for 7 hours.After cooling to 10 ° C, the crude product was filtered.The crude product was recrystallized from 3 times by weight of water to give 117 g of the desired pyrazinamide in a yield of 95percent.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference of 2423-65-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2423-65-6, name is Pyrazine 1-oxide belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.

General Procedure 2:; Palladium-Catalyzed Direct Arylation with Aryl Chlorides and Bromides.; To a dried flask was added the diazine N-oxide (1.0 to 3.0 equiv.), K2CO3 (2.0 equiv.), Pd(OAc)2 (5 mol %) and HP(t-Bu)3BF4 (15 mol %). If the arylhalide is a solid, it is added at this point (1.0 equiv.). The flask and its contents were then purged under nitrogen for 10 minutes. If the aryl halide is a liquid, it is added via syringe after purging, followed by the addition of degassed dioxane (to produce a reaction concentration of 0.3 M relative to the halide). The reaction mixture was then heated at 110 C. until the reaction was complete, after which the volatiles were removed under reduced pressure and the residue was purified via silica gel column chromatography.; 2-(Naphthalen-1-yl)pyrazine N-oxide (Table 4, entries 2, 13 and 14) Synthesised according to general procedure 2 employing the corresponding aryl bromide and chloride. Purification via silica gel column chromatography using 100% DCM then a mixture of 10% Acetone/DCM gave a brown oil, 89% from the bromide and 60% from the chloride. 1H NMR (300 MHz, CDCl3, 293K, TMS): delta 8.61 (1H, s), 8.48 (1H, d, J=3.9 Hz), 8.26 (1H, d, J=4.2 Hz), 8.00 (1H, d, J=7.8 Hz), 7.93-7.87 (1H, m), 7.59-7.37 (5H, m). 13C NMR (75 MHz, CDCl3, 293K, TMS): 150.1, 147.1, 145.7, 134.8, 133.9, 131.5, 131.3, 129.2, 128.9, 127.6, 127.0, 125.7, 125.3. HRMS calculated for C14H10N2O1 (M+) 222.0793; Found: 222.0775. IR (vmax/cm-1): 3057, 3010, 2923, 2853, 1578, 1301, 873, 801, 776.

The synthetic route of Pyrazine 1-oxide has been constantly updated, and we look forward to future research findings.

Synthetic Route of 5049-61-6, A common heterocyclic compound, 5049-61-6, name is Pyrazin-2-amine, molecular formula is C4H5N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A 250ml round bottom flask was charged with 2-aminopyrazine (1Og, O.lmol), N-chlorosuccinimide (14g, O.lmol) and dichloromethane (100ml) under nitrogen. The reaction mixture was refluxed for 5h, then allowed to cool to room temperature. The reaction mixture was filtered though a 1 cm thick celite pad, which was then thoroughly washed with dichloromethane. The EPO organic was concentrated in vacuo and the compound was purified by flash chromatography, using as eluent pentane/EtOAc 0% to 50%, to give the title compound (3g, 22%). IHNMR (CDCl3) 4.5-4.8 (2H, brs), 7.8 (IH, s), 8.0 (IH, s).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference of 5049-61-6, A common heterocyclic compound, 5049-61-6, name is Pyrazin-2-amine, molecular formula is C4H5N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Method b:; 2-Amino-pyrazine (0.10 g, 1.05 mmol) and NCS (80 mg, 0.60 mmol) were added in a microwave tube with 1.5 mL of the anhydrous CHCl3 and sealed. The tube was placed in the microwave cavity and heated at 70C for 10 min. (70C10M60W300Psi). After the workup, the crude (0.15 g) was purified by FCC (Hexane/DCM/ AcOEt = 1 :1 :1) to afford 35 mg (yield 45%) of the product as yellow solid. 1H NMR (270 MHz; d6-DMSO), delta 7.99 (IH, s, H-6), 7.67 (IH, s, H-3), 6.65 (2H, bs, NH2). m/z (EI-MS): 129 (M+), 99, 94 ([M-Cl]+).; When the distilled chloroform used for the reaction was pre-treated over basic Al2O3, the black polymers formed in the reaction decreased dramatically. When NCS was added slowly into the refluxing 2-aminopyrazine, the product was isolated at 26%. Moreover, when microwave irradiation was used at 70C for 10 min., the yield reached 45% (Figure 4)

The synthetic route of 5049-61-6 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 5049-61-6, name is Pyrazin-2-amine, A new synthetic method of this compound is introduced below., Computed Properties of C4H5N3

[0077] Method A- oxylate [0078] To a stirred solution of 2-aminopyrazine (1.0 g, 10.5 mmol) in dimethoxyethane, ethyl bromopyruvate (2.36 g, 13.0 mmol) was added at room temperature and stirred for 2.5 hours. The reaction mixture was cooled to 0C and stirred for 30 min to afford a pale brown precipitate. The precipitate was filtered and washed with ethyl acetate to give a pale brown solid. The precipitate was suspended in 50 mL ethyl alcohol and heated at reflux temperature to turn to a clear solution. After refluxing for 2 hours, the reaction mixture was concentrated under reduced pressure and then mixed with CH2CI2 and saturated aqueous NaHCC>3 solution. The mixture was filtered through a pad of Celite, and the separated organic layer was dried by Na2S04 and filtered. The residue was applied to silica gel column chromatography, and the column was eluted with (CH2Cl2:MeOH = 99:1 to 97:3), and the collected fractions were concentrated under reduced pressure. The title compound was obtained as pale yellow crystals (0.546 g, 27%). *H NMR (400 MHz, CDC13) delta 9.21 (s, 1H), 8.26 (s, 1H), 8.09 (dd, 7 = 4.7, 1.6 Hz, 1H), 7.96 (d, 7 = 4.7 Hz, 1H), 4.49 (q, 7 = 7.1 Hz, 2H), 1.45 (t, 7 = 7.1 Hz, 3H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.