Tag: M.W=0-100

Application of 4949-13-7,Some common heterocyclic compound, 4949-13-7, name is 2-Fluoropyrazine, molecular formula is C4H3FN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Preparation of intermediate DM A suspension of intermediate G (0.238 g, 1.01 mmol), 2-fluoropyrazine (0.123 mL, 1.52 mmol) and potassium carbonate (420 mg, 3.04 mmol) in DMSO (6.2 mL) was heated at 120 C using a single mode microwave (Biotage initiator60) with a power 25 output ranging from 0 to 400 W for 1 h [fixed hold time]. The reaction mixture was evaporated in Genevac and purified by preparative LC (irregular SiOH, 15-40 muiotaeta, 40 g, Merck, dry loading (silica), mobile phase gradient from DCM/MeOH from 100/0 to 90/10) to give 0.194 g of intermediate DM as a yellow solid (69%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Fluoropyrazine, its application will become more common.

Reference:
Patent; JANSSEN SCIENCES IRELAND UC; GUILLEMONT, Jerome, Emile, Georges; MOTTE, Magali, Madeleine, Simone; RABOISSON, Pierre, Jean-Marie, Bernard; TAHRI, Abdellah; (194 pag.)WO2017/1660; (2017); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Synthetic Route of 5049-61-6, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5049-61-6, name is Pyrazin-2-amine, This compound has unique chemical properties. The synthetic route is as follows.

3,5-Dibromopyrazin-2-amine Pyrazin-2-amine (2.0g, 21 mmol) was dissolved in dichloromethane (50 mL)and the resulting solution was stirred at room temperature. N-bromosuccinimide(9.4g, 53mmol) was added. After completion, the mixture was concentrated underreduced pressure to give brown solid crude which was subsequently purified bychromatography (applied in hexane; eluted 10% EtOAc/hexane) to give the title compound as a pale yellowsolid (3.6g 14 mmol, 68%). Mpt: 106-108 oC; Rf = 0.80 (1:1 EtOAc/hexane);IR (numax/cm-1, thin film): 3447, 3280, 3154, 1621, 1549,1506, 1450; 1H NMR (600 MHz, CDCl3): deltaH = 5.04(brs, 2H, NH2), 8.04(s, 1H, 6-H); 13C NMR(150 MHz, CDCl3): deltaC = 123.8 (C-5), 124.0 (C-3),143.3 (C-6), 152.0 (C-2); HRMS m/z (CI+): found251.87731 [M+H]+, C4H4Br2N3requires 251.87720.

The chemical industry reduces the impact on the environment during synthesis Pyrazin-2-amine. I believe this compound will play a more active role in future production and life.

Reference:
Article; Sayer, James R.; Walldn, Karin; Pesnot, Thomas; Campbell, Frederick; Gane, Paul J.; Simone, Michela; Koss, Hans; Buelens, Floris; Boyle, Timothy P.; Selwood, David L.; Waksman, Gabriel; Tabor, Alethea B.; Bioorganic and Medicinal Chemistry; vol. 22; 22; (2014); p. 6459 – 6470;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Synthetic Route of 109-08-0, The chemical industry reduces the impact on the environment during synthesis 109-08-0, name is 2-Methylpyrazine, I believe this compound will play a more active role in future production and life.

a) t-butyl 3-(2-pyrazinyl)propionate A solution of diisopropylamine (4.0 mL, 28.5 mmol) in THF (20 mL) was treated with 2.5M n-butyllithium (11.42 mL, 28.5 mmol) at -78° C. The mixture was warmed to RT for 0.5 h, cooled to -78° C., and 2-methylpyrazine (2.0 mL, 21.9 mmol) was added. The reaction mixture was warmed to RT, stirred for 1 h, cooled to -78° C., and butyl bromoacetate (4.25 mL, 26.3 mmol) was added. The reaction mixture was warmed to RT, stirred for 18 h and quenched with water (1 mL). The mixture was concentrated and the residue was purified by flash chromatography (silica gel, 60percent ethyl acetate/hexane) to give the title compound (3.06 g, 67percent) as a light yellow oil. MS(ES) m/e 209 [M+H]+; 1H NMR (250 MHz) delta8.37-8.57 (m, 3H), 3.10 (t, 2H), 2.74 (t, 2H), 1.43 (s, 9H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Methylpyrazine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; SmithKline Beecham Corporation; US6403578; (2002); B1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 5049-61-6, name is Pyrazin-2-amine, A new synthetic method of this compound is introduced below., category: Pyrazines

2-Aminopyrazine (100 mg, 1.1 mmol) and bromoacetaldehyde dimethylacetal (253 mg, 1.6 mmol) were dissolved in ethanol (4.5 ml), hydrobromic acid (48%, 0.5 ml) added and the mixture was heated under reflux for 18 h. The solution was allowed to cool to room temperature then pre-adsorbed directly onto silica. Purification by silica gel chromatography eluding with dichloromethane and 1% conc. ammonia on a gradient of methanol (1-4%) gave imidazo[1,2-alpha]pyrazine (90 mg, 72%) as a white crystalline solid: deltaH (360 MHz, CDCl3) 6.70 (1H, s), 7.82 (1H, s), 7.88 (1H, d, J 4), 8.29 (1H, d, J 4), 9.12 (1H, s).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Goodacre, Simon Charles; Hallett, David James; Street, Leslie Joseph; US2004/19057; (2004); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 290-37-9, name is Pyrazine, A new synthetic method of this compound is introduced below., COA of Formula: C4H4N2

A 250 ml round bottom flask was first placed in an ice-water bath followed by the addition of 0.01 mmol of pyrazine,0.05 mol acetaldehyde (dissolved in 15 ml of water), 15 ml of glacial acetic acid and 3 ml of concentrated sulfuric acid, stirring to completely dissolve pyrazine,And then continue to stir for 10 min, slowly dropping 0.02mmol of t-butyl hydroperoxide solution, after dripping and then continue to stir for 20 min, and finally slowly dropping the concentration of 0.02mol / L ferrous sulfate solution 1ml,After the completion of the dropwise stirring for 2 h, the mixture was filtered and washed with a large amount of water to obtain 2,5-dicarboxylic acid pyrazine.

The synthetic route of 290-37-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Zhengzhou University of Light Industry; LI, XILI; ZHOU, LIMING; LI, CAIFENG; GAO, LIJUN; FANG, SHAOMING; (15 pag.)CN103896972; (2016); B;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Application of 109-08-0, A common heterocyclic compound, 109-08-0, name is 2-Methylpyrazine, molecular formula is C5H6N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

2-methylpyrazine (2 mmol), benzyl alcohol (4 mmol, 2 equiv.), CsOH (50 mol%), 2.0 mL of toluene were sequentially added to a 100 mL reaction tube.The mixture was directly heated under air to 120 C for 24 h. The product was purified by column chromatography to give an isolated yield of 60%.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Wenzhou University; Xu Qing; Li Shuangyan; Chen Jianhui; Yuan Xueqin; Zhang Zhengping; (13 pag.)CN104529889; (2018); B;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Electric Literature of 5049-61-6, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5049-61-6, name is Pyrazin-2-amine, This compound has unique chemical properties. The synthetic route is as follows.

Step 1 imidazo[1,2-c]pyrazine Pyrazin-2-amine 4a (5 g, 52 mmol) was dissolved in a 40% 2-chloroacetaldehyde solution (15 mL, 78 mmol), followed by addition of sodium bicarbonate (6.60 g, 78 mmol). After stirring for 48 hours at 100 C., the reaction mixture was cooled to room temperature, added with 100 mL of a saturated potassium carbonate solution, and extracted with dichloromethane (100 mL*3). The organic phase was combined, dried over anhydrous sodium sulfate and filtered. The filtrate was concentrated under reduced pressure to obtain imidazo[1,2-a]pyrazine 4b (3 g, yield 50.0%) as a brown solid. MS m/z (ESI): 120.1 [M+1]

The chemical industry reduces the impact on the environment during synthesis Pyrazin-2-amine. I believe this compound will play a more active role in future production and life.

Reference:
Patent; JIANGSU HANSOH PHARMACEUTICAL CO., LTD.; Tang, Peng Cho; Li, Xin; Li, Xiangqin; Chen, Yang; Wang, Bin; Zhu, Zhe; US2013/131068; (2013); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Related Products of 109-08-0, A common heterocyclic compound, 109-08-0, name is 2-Methylpyrazine, molecular formula is C5H6N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

2-methylpyrazine (2 mmol), 4-methylbenzyl alcohol (4 mmol, 2 equiv.), CsOH (50 molpercent), 2.0 mL of toluene were sequentially added to a 100 mL reaction tube.The mixture was directly heated under air to 120 ° C for 24 h. The product was purified by column chromatography to give a yield of 76percent.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Wenzhou University; Xu Qing; Li Shuangyan; Chen Jianhui; Yuan Xueqin; Zhang Zhengping; (13 pag.)CN104529889; (2018); B;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Reference of 5049-61-6,Some common heterocyclic compound, 5049-61-6, name is Pyrazin-2-amine, molecular formula is C4H5N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of 2-aminopyrazine (1.0 g, 10.5 mmol) in dioxane (25 mL) was added ethyl 3-bromo-2-ketopropionate (2.0 g, 10.5 mmol). The reaction was stirred at 50 C for 16 h. The mixture was filtered and the solid was washed with two portions of ethyl acetate. The solid was heated in 35 ML of isopropanol at reflux temperature for 4 h. The reaction mixture was concentrated and partitioned between ethyl acetate and saturated aqueous sodium bicarbonate. The aqueous phase was extracted with three portions of ethyl acetate. The combined organics were washed with brine, dried over magnesium sulfate, and concentrated. Purification by chromatography (Biotage system, silica gel, ethyl acetate then 10% methanol/ethyl acetate) gave the title compound as a solid.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Pyrazin-2-amine, its application will become more common.

Reference:
Patent; MERCK & CO., INC.; WO2004/58266; (2004); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Synthetic Route of 5049-61-6,Some common heterocyclic compound, 5049-61-6, name is Pyrazin-2-amine, molecular formula is C4H5N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Aminopyrazine (95g, 1 mol) in chloroform (2.5 L) was cooled to between O0C and -5C. N-bromosuccimide (375 g, 2.1 mol) was then added over a 6 hour period, during which time the temperature was kept below O0C. The reaction mixture was stored in a freezer overnight and then stirred vigorously and quenched with water (1 L). The mixture was filtered through glass wool and the phases separated. The organic phase was washed with 10% K2CO3 (aq, 1 L), dried over MgSO4, and concentrated in vacuo. The residue was triturated with hexane and ethyl acetate. The yellow/brown solid was filtered and dried under high vacuum in a desiccator overnight to give the title compound (119 g). 1H (270MHz, CDCI3) 4.99 (2H, bs), 8.09(1H, s); LC-MS (AP+): 254:256 (1:1 isotopes, M+H+).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Pyrazin-2-amine, its application will become more common.

Reference:
Patent; CANCER RESEARCH TECHNOLOGY LIMITED; WO2008/74997; (2008); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem