Tag: 200-300

Carboxylic N,N-diphenylcarbamic anhydrides. New acylating agents was written by Shepard, Kenneth L.;Halczenko, Wasyl. And the article was included in Journal of Heterocyclic Chemistry in 1979.Name: Methyl 3,5-diamino-6-chloropyrazine-2-carboxylate This article mentions the following:

Title anhydrides I and RCO₂CONPh₂ (R = Ph, 2-furyl, p-HOC₆H₄, o-, p-H₂NC₆H₄) were prepared by treating carboxylate salts with 1-(N,N-diphenylcarbamoyl)pyridinium chloride in aqueous or ethanolic solution These anhydrides are stable, crystalline derivatives and are very reactive in acylation reactions. These products are more reactive than cyanomethyl esters or the so-called Woodward’s esters, acyloxyacrylamides. In the experiment, the researchers used many compounds, for example, Methyl 3,5-diamino-6-chloropyrazine-2-carboxylate (cas: 1458-01-1Name: Methyl 3,5-diamino-6-chloropyrazine-2-carboxylate).

Methyl 3,5-diamino-6-chloropyrazine-2-carboxylate (cas: 1458-01-1) belongs to pyrazine derivatives. Pyrazine is a symmetrical molecule with point group D2h. Pyrazine is less basic than pyridine, pyridazine and pyrimidine. A large number of pyrazine derivatives are known for their antitumor, antibiotic, anticonvulsant, antituberculosis, and diuretic activities.Name: Methyl 3,5-diamino-6-chloropyrazine-2-carboxylate

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Biochemical identification of two types of phenamil binding sites associated with amiloride-sensitive sodium channels was written by Barbry, Pascal;Chassande, Olivier;Duval, Daniele;Rousseau, Bernard;Frelin, Christian;Lazdunski, Michel. And the article was included in Biochemistry in 1989.Safety of Methyl 3,5-diamino-6-chloropyrazine-2-carboxylate This article mentions the following:

The biochem. basis for the existence of distinct forms of the epithelium Na⁺ channel that differ in their sensitivity to amiloride was analyzed by using phenamil, the most potent inhibitor known so far for the epithelium Na⁺ channel. [³H]Phenamil of high radioactive specific activity (30 Ci/mmol) was prepared and used to titrate [³H]phenamil-binding sites in pig kidney membranes. Kinetic experiments, equilibrium binding studies, and competition experiments indicated the presence in crude membrane preparations of 12 classes of independent binding sites. The 1st binding site was characterized by a high affinity for phenamil (dissociation constant 1 (K_d1) = 0.4 nM) and for amiloride (K_d1 = 0.1 μM). The 2nd binding site recognized phenamil and amiloride with lower affinities (K_d2(phenamil) = 28 nM, K_d2(amiloride) = 4 μM). The ratio of the resp. amounts of low- and high-affinity binding sites was 14 in different membrane preparations (range: 6-22). The 2 types of binding sites for [³H]phenamil copurified and were still observed after purification of the epithelium Na⁺ channel to homogeneity. Thus, â‰? types of pharmacol. distinguishable Na⁺ channels exist in the kidney. They correspond either to 2 isoforms of the apical Na⁺ channel or to 1 single type of channel under 2 different states of covalent regulation. In the experiment, the researchers used many compounds, for example, Methyl 3,5-diamino-6-chloropyrazine-2-carboxylate (cas: 1458-01-1Safety of Methyl 3,5-diamino-6-chloropyrazine-2-carboxylate).

Methyl 3,5-diamino-6-chloropyrazine-2-carboxylate (cas: 1458-01-1) belongs to pyrazine derivatives. Pyrazinesare six-membered aromatic heterocyclic organic compounds with two nitrogen atoms at 1,4-positions. Pyrazine is a weaker base (pKb = 13.4) than pyridine (pKb = 8.8), pyrimidine (pKb = 12.7). Pyrazines are chemical compounds (technically called “methoxypyrazinesâ€? found in grape skin and stems that are responsible for many “greenâ€?flavors in wine. Levels of pyrazines are dependent on viticultural practices, climate, and grape variety.Safety of Methyl 3,5-diamino-6-chloropyrazine-2-carboxylate

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Dramatically enhanced fluorescence of heteroaromatic chromophores upon insertion as spacers into oligo(triacetylene)s was written by Edelmann, Michael J.;Raimundo, Jean-Manuel;Utesch, Nils F.;Diederich, Francois. And the article was included in Helvetica Chimica Acta in 2002.SDS of cas: 148231-12-3 This article mentions the following:

In continuation of a previous study on the modulation of π-electron conjugation of oligo(triacetylene)s by insertion of central hetero-spacer fragments between two (E)-hex-3-ene-1,5-diyne ((E)-1,2-diethynylethene, DEE) moieties, trimeric hybrid oligomers (I; A = spacer, R = SiEt₃, SiMe₃) were prepared Spacers used were both electron-deficient (quinoxaline-based heterocycles, pyridazine) and electron-rich (2,2′-bithiophene, 9,9-dioctyl-9H-fluorene)chromophores. With a dipyridophenazine spacer, transition metal complexes were synthesized as potential precursors for nanoscale scaffolding based on both covalent acetylenic coupling and supramol. assembly. The UV/visible spectra revealed that the majority of spacers provided heterotrimers featuring extended π-electron delocalization. The new hybrid chromophores show a dramatically enhanced fluorescence compared with the DEE dimer and homo-trimer. This increase in emission intensity appears as a general feature of these systems: even if the spacer mol. is nonfluorescent, the corresponding hetero-trimer may show a strong emission. The redox properties of the new hybrid chromophores were determined by cyclic voltammetry (CV) and rotating disk voltammetry (RDV). In each case, the first 1-electron reduction step in the hetero-trimers appeared anodically shifted compared with DEE dimer and homo-trimer. With larger spacer chromophore extending into two dimensions, the anodic shift (by 240-490 mV) seems to originate from inductive effects of the two strongly electron-accepting DEE substituents rather than from extended π-electron conjugation along the oligomeric backbone, as had previously been observed for DEE substituted porphyrins. In the experiment, the researchers used many compounds, for example, 5,8-Dibromoquinoxaline (cas: 148231-12-3SDS of cas: 148231-12-3).

5,8-Dibromoquinoxaline (cas: 148231-12-3) belongs to pyrazine derivatives. Pyrazine has the elements of symmetry for the point group D2h. It has three mutually perpendicular two-fold axes. It also has three mutually perpendicular planes of symmetry. As a result, pyrazine also has a centre of symmetry. Pyrazines undergo nearly all of the same reactions as pyrimidines, from nucleophilic substitution (SNAr) to palladium-catalyzed cross coupling reactions.SDS of cas: 148231-12-3

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

In Silico Design of 2D and 3D Covalent Organic Frameworks for Methane Storage Applications was written by Mercado, Rocio;Fu, Rueih-Sheng;Yakutovich, Aliaksandr V.;Talirz, Leopold;Haranczyk, Maciej;Smit, Berend. And the article was included in Chemistry of Materials in 2018.Recommanded Product: 5,8-Dibromoquinoxaline This article mentions the following:

We present a database of 69,840 largely novel covalent organic frameworks assembled in silico from 666 distinct organic linkers and 4 established synthetic routes. Due to their light weights and high internal surface areas, the frameworks are promising materials for CH₄ storage applications. To assess their CH₄ storage performance, we used grand-canonical Monte Carlo simulations to calculate their deliverable capacities. We demonstrate that the best structure, composed of C-C bonded triazine linkers in the tbd topol., has a predicted 65-bar deliverable capacity of 216 v STP/v, better than the best CH₄ storage materials published to date. Using our approach, we also discovered other high-performing materials with 300 structures with calculated deliverable capacities >190 v STP/v and 10% of these outperforming 200 v STP/v. To encourage screening studies of these materials for other applications, all structures and their properties were made available on the Materials Cloud. In the experiment, the researchers used many compounds, for example, 5,8-Dibromoquinoxaline (cas: 148231-12-3Recommanded Product: 5,8-Dibromoquinoxaline).

5,8-Dibromoquinoxaline (cas: 148231-12-3) belongs to pyrazine derivatives. Pyrazines are part of several biologically active polycyclic compounds; examples are quinoxalines, phenazines; and the bio-luminescent natural products pteridines, flavins, and their derivatives. Pyrazine heterocycles and their benzo derivatives possess many interesting properties, including chemical reactivity profiles, and have diverse applications in total synthesis, medicine, chemical biology, materials, dyes, and imaging.Recommanded Product: 5,8-Dibromoquinoxaline

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Purity of intermediate ammoniate and its influence on quality of amiloride was written by Zhang, Shengqiang;Chen, Jianming;Yu, Wenxian;Jiang, Xinru. And the article was included in Zhongguo Yaoke Daxue Xuebao in 1995.Safety of Methyl 3,5-diamino-6-chloropyrazine-2-carboxylate This article mentions the following:

The purity of 3,5-diamino-6-chlor-2-methoxycarboxyl-pyrazine (ammoniate) was examine by HPLC. The chromatog. determination results of crude ammoniate were conformed by melting data. Ammoniate of high purity processed high m.p., the amiloride prepared with ammoniate of high purity had good quality. In the experiment, the researchers used many compounds, for example, Methyl 3,5-diamino-6-chloropyrazine-2-carboxylate (cas: 1458-01-1Safety of Methyl 3,5-diamino-6-chloropyrazine-2-carboxylate).

Methyl 3,5-diamino-6-chloropyrazine-2-carboxylate (cas: 1458-01-1) belongs to pyrazine derivatives. Pyrazine heterocycles and their benzo derivatives possess many interesting properties, including chemical reactivity profiles, and have diverse applications in total synthesis, medicine, chemical biology, materials, dyes, and imaging. Substituted pyrazines have been found as subunits of multiple synthetically constructed therapeutic agents, as well as several natural products.Safety of Methyl 3,5-diamino-6-chloropyrazine-2-carboxylate

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

The effect of molecular structure on the properties of quinoxaline-based molecules for OLED applications was written by Ledwon, Przemyslaw;Motyka, Radoslaw;Ivaniuk, Khrystyna;Pidluzhna, Anna;Martyniuk, Natalia;Stakhira, Pavlo;Baryshnikov, Glib;Minaev, Boris F.;Agren, Hans. And the article was included in Dyes and Pigments in 2020.SDS of cas: 148231-12-3 This article mentions the following:

Different donor-acceptor-donor (D-A-D) and donor-π-bridge-acceptor-π-bridge-donor (D-π-A-π-D) systems based on a quinoxaline acceptor are compared. A significant difference in electrochem. and photophys. properties was found depending on mol. structure. A luminescence shift from 539 up to 671 nm was observed upon extension of conjugation length. The studied compounds were tested in fluorescent organic light emitting diodes (OLEDs) demonstrating an external quantum efficiency up to 4.5% for a deep red nondoped device and 7% when doped into an exciplex host device. A quantum-chem. interpretation of the electroluminescence spectra for the fabricated OLEDs was carried out including modeling of excimers and exciplexes. In the experiment, the researchers used many compounds, for example, 5,8-Dibromoquinoxaline (cas: 148231-12-3SDS of cas: 148231-12-3).

5,8-Dibromoquinoxaline (cas: 148231-12-3) belongs to pyrazine derivatives. Pyrazines are part of several biologically active polycyclic compounds; examples are quinoxalines, phenazines; and the bio-luminescent natural products pteridines, flavins, and their derivatives. Pyrazines undergo nearly all of the same reactions as pyrimidines, from nucleophilic substitution (SNAr) to palladium-catalyzed cross coupling reactions.SDS of cas: 148231-12-3

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Side chain engineering of quinoxaline-based small molecular nonfullerene acceptors for high-performance poly(3-hexylthiophene)-based organic solar cells was written by Xiao, Bo;Zhang, Qianqian;Li, Gongqiang;Du, Mengzhen;Geng, Yanfang;Sun, Xiangnan;Tang, Ailing;Liu, Yingliang;Guo, Qiang;Zhou, Erjun. And the article was included in Science China: Chemistry in 2020.Related Products of 148231-12-3 This article mentions the following:

Poly(3-hexylthiophene) (P3HT) is one of the most used semiconducting polymers for organic photovoltaics because it has potential for commercialization due to its easy synthesis and stability. Although the rapid development of the small mol. non-fullerene acceptors (NFAs) have largely improved the power conversion efficiency (PCE) of organic solar cells (OSCs) based on other complicated p-type polymers, the PCE of P3HT-based OSCs is still low. In addition, the design principle and structure-properties correlation for the NFAs matching well with P3HT are still unclear and need to be investigated in depth. Here we designed a series of NFAs comprised of acceptor (A) and donor (D) units with an A₂-A₁-D-A₁-A₂ configuration. These NFAs are abbreviated as Qx3, Qx3b and Qx3c, where indaceno[1,2-b:5,6-b’]dithiophene (IDT), quinoxaline (Qx) and 2-(1,1-dicyanomethylene)rhodanine serve as the middle D, bridged A₁ and the end group A₂, resp. By subtracting the Ph side groups appended on both IDT and Qx skeletons, the absorption spectra, energy levels and crystallinity could be regularly modulated. When paired with P3HT, three NFAs show totally different photovoltaic performance with PCEs of 3.37% (Qx3), 6.37% (Qx3b) and 0.03% (Qx3c), resp. From Qx3 to Qx3b, the removing of Ph side chain in the middle IDT unit results in the increase of crystallinity and electron mobility. However, after subtracting all the grafted Ph side groups on both IDT and Qx units, the final mol. Qx3c exhibits the lowest PCE of only 0.03%, which is mainly attributed to the serious phase-separation of the blend film. These results demonstrate that optimizing the substituted position of Ph side groups for A₂-A₁-D-A₁-A₂ type NFAs is vital to regulate the optoelectronic property of mol. and morphol. property of active layer for high performance P3HT-based OSCs. In the experiment, the researchers used many compounds, for example, 5,8-Dibromoquinoxaline (cas: 148231-12-3Related Products of 148231-12-3).

5,8-Dibromoquinoxaline (cas: 148231-12-3) belongs to pyrazine derivatives. Pyrazine heterocycles and their benzo derivatives possess many interesting properties, including chemical reactivity profiles, and have diverse applications in total synthesis, medicine, chemical biology, materials, dyes, and imaging. A number of pyrazine-based derivatives were used as dyes or fluorescent probes.Related Products of 148231-12-3

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Molecular pharmacology of the amiloride analog 3-amino-6-chloro-5-[(4-chloro-benzyl)amino]-N-[[(2,4-dimethylbenzyl)-amino]iminomethyl]-pyrazinecarboxamide (CB-DMB) as a pan inhibitor of the Na⁺-Ca²⁺ exchanger isoforms NCX1, NCX2, and NCX3 in stably transfected cells was written by Secondo, Agnese;Pannaccione, Anna;Molinaro, Pasquale;Ambrosino, Paolo;Lippiello, Pellegrino;Esposito, Alba;Cantile, Maria;Khatri, Priti R.;Melisi, Daniela;Di Renzo, Gianfranco;Annunziato, Lucio. And the article was included in Journal of Pharmacology and Experimental Therapeutics in 2009.Reference of 1458-01-1 This article mentions the following:

With the help of single-cell microfluorimetry, ⁴⁵Ca²⁺ radiotracer fluxes, and patch-clamp in whole-cell configuration, the authors examined the effect of the amiloride derivative 3-amino-6-chloro-5-[(4-chloro-benzyl)amino]-N-[[(2,4-dimethylbenzyl) amino]-iminomethyl]-pyrazinecarboxamide (CB-DMB) on the activity of the three isoforms of the Na⁺/Ca²⁺ exchanger (NCX) and on several other membrane currents including voltage- and pH-sensitive ones. This amiloride analog suppressed the bidirectional activity of all NCX isoforms in a concentration-dependent manner. The IC₅₀ values of CB-DMB were in the nanomolar range for the outward and the inward components of the bidirectional NCX1, NCX2, and NCX3 activity. Deletion mutagenesis showed that CB-DMB inhibited NCX activity mainly at level of the f-loop but not through the interaction with Gly 833 located at the level of the α₂ repeat. CB-DMB suppressed in the micromolar range the other plasma membrane currents encoded by voltage-dependent Ca²⁺ channels, tetrodotoxin-sensitive Na⁺ channels, and pH-sensitive ASIC1a. Collectively, the data of the present study showed that CB-DMB, when used in the nanomolar range, is one of the most potent compounds that can block the activity of the three NCX isoforms when they work both in the forward and in the reverse modes of operation without interfering with other ionic channels. In the experiment, the researchers used many compounds, for example, Methyl 3,5-diamino-6-chloropyrazine-2-carboxylate (cas: 1458-01-1Reference of 1458-01-1).

Methyl 3,5-diamino-6-chloropyrazine-2-carboxylate (cas: 1458-01-1) belongs to pyrazine derivatives. Pyrazine heterocycles and their benzo derivatives possess many interesting properties, including chemical reactivity profiles, and have diverse applications in total synthesis, medicine, chemical biology, materials, dyes, and imaging. Pyrazine heterocycles and their benzo derivatives possess many interesting properties, including chemical reactivity profiles, and have diverse applications in total synthesis, medicine, chemical biology, materials, dyes, and imaging.Reference of 1458-01-1

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Enhanced performance of quasi-solid-state dye-sensitized solar cells by tuning the building blocks in D-(π)-A’-π-A featured organic dyes was written by Lan, Tian;Lu, Xuefeng;Zhang, Lu;Chen, Yijing;Zhou, Gang;Wang, Zhong-Sheng. And the article was included in Journal of Materials Chemistry A: Materials for Energy and Sustainability in 2015.Product Details of 148231-12-3 This article mentions the following:

D-(π)-A’-π-A featured organic dyes with different numbers of 3,4-ethylenedioxythiophene (EDOT) bridges and different anchoring groups, i.e., cyanoacrylic acid or rhodanine-3-acetic acid, have been designed and synthesized for application in quasi-solid-state dye-sensitized solar cells (DSSCs). The absorption, electrochem. and photovoltaic properties are systematically studied. Upon the incorporation of an auxiliary EDOT unit into sensitizers FNE60 and FNE61 with D-A’-π-A configuration, sensitizers FNE62 and FNE63 with D-π-A’-π-A configuration exhibit much broader absorption spectra, which is beneficial to the light-harvesting capability and photocurrent generation. When the cyanoacrylic acid group in sensitizers FNE60 and FNE62 is replaced by a much stronger electron-withdrawing group, rhodanine-3-acetic acid, strengthened intramol. charge transfer interactions are realized, which results in the significantly bathochromically shifted maximum absorption wavelengths for sensitizers FNE61 and FNE63. However, the methylene group in the rhodanine-3-acetic acid unit interrupts the LUMO delocalization on the anchoring group in sensitizers FNE61 and FNE63, as revealed by theor. calculation, which may result in less effective electron injection from the LUMO to the conduction band of the TiO₂ semiconductor. Consequently, the quasi-solid-state DSSC based on FNE62 exhibits a highest power conversion efficiency of 8.2%, which illustrates good long-term stability after continuous light soaking for 1000 h. In the experiment, the researchers used many compounds, for example, 5,8-Dibromoquinoxaline (cas: 148231-12-3Product Details of 148231-12-3).

5,8-Dibromoquinoxaline (cas: 148231-12-3) belongs to pyrazine derivatives. Pyrazine is an N-heterocyclic moiety, and it can be easily prepared from ethylenediamine and 1,2-diketone, α-hydroxyketone, α-methyl ketone. Pyrazines are chemical compounds (technically called “methoxypyrazinesâ€? found in grape skin and stems that are responsible for many “greenâ€?flavors in wine. Levels of pyrazines are dependent on viticultural practices, climate, and grape variety.Product Details of 148231-12-3

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

The accessibility of nitrogen sites makes a difference in selective CO₂ adsorption of a family of isostructural metal-organic frameworks was written by Song, Chengling;Hu, Jiayi;Ling, Yajing;Feng, YunLong;Krishna, Rajamani;Chen, De-li;He, Yabing. And the article was included in Journal of Materials Chemistry A: Materials for Energy and Sustainability in 2015.Electric Literature of C8H4Br2N2 This article mentions the following:

By using three rigid diisophthalate organic linkers incorporating different numbers and orientations of Lewis basic nitrogen atoms into the spacers between two terminal isophthalate moieties, namely, 5,5′-(quinoline-5,8-diyl)-diisophthalate, 5,5′-(isoquinoline-5,8-diyl)-diisophthalate, and 5,5′-(quinoxaline-5,8-diyl)-diisophthalate, a family of isostructural copper-based metal-organic frameworks, ZJNU-43, ZJNU-44, and ZJNU-45, were successfully solvothermally synthesized and structurally characterized by single-crystal X-ray diffraction. The three MOFs, after activation, exhibited almost the same porosities but distinctly different CO₂ adsorption properties. At room temperature and 1 atm, the adsorption capacities for CO₂ reached 103, 116, and 107 cm³ (STP) g^-1 for ZJNU-43a, ZJNU-44a, and ZJNU-45a, resp. Furthermore, Ideal Adsorbed Solution Theory (IAST) and simulated breakthrough analyses indicated that ZJNU-44a bearing much more easily accessible nitrogen sites is the best among the three MOFs for the separation of the following two binary gas mixtures at 296 K, i.e., 50/50 CO₂/CH₄ and 15/85 CO₂/N₂ gas mixtures, indicating that the accessibility of nitrogen sites plays a much more crucial role, which is further confirmed by comprehensive quantum chem. calculations This work demonstrates that the CO₂ adsorption properties of MOFs depend not only on the number of Lewis basic nitrogen sites but also more importantly on their accessibility. In the experiment, the researchers used many compounds, for example, 5,8-Dibromoquinoxaline (cas: 148231-12-3Electric Literature of C8H4Br2N2).

5,8-Dibromoquinoxaline (cas: 148231-12-3) belongs to pyrazine derivatives. Pyrazine is an N-heterocyclic moiety, and it can be easily prepared from ethylenediamine and 1,2-diketone, α-hydroxyketone, α-methyl ketone. A number of pyrazine-based derivatives were used as dyes or fluorescent probes.Electric Literature of C8H4Br2N2

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem