Tag: 200-300

Synthesis, characterization and properties of aryl-fused bis-BN dihydropyrenes was written by Zhang, Jinyun;Liu, Fude;Sun, Zhe;Li, Chenglong;Zhang, Qian;Zhang, Chen;Liu, Zhiqiang;Liu, Xuguang. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2018.HPLC of Formula: 148231-12-3 This article mentions the following:

Aryl-fused bis-BN dihydropyrenes such as I were prepared from 5,8-dibromoquinoxaline (prepared in four steps from o-phenylenediamine), arylboronic acids, and PhBCl₂ using an amino-directed borylation reaction as the key step.. The UV/visible and fluorescence spectra, oxidation potentials, and optical bandgaps for four of the aryl-fused bis-BN dihydropyrenes were determined; their NICS aromaticities and the structures and energies of their HOMO and LUMO were calculated The aryl-fused bis-BN dihydropyrenes showed blue emission, and their phys. properties could be finely tuned through varying the fused aryl rings. The complexation of fluoride ion by the bis-BN dihydropyrenes was determined; the fluoride ion response depended strongly on the fused aryl rings. The structures of I and of two other aryl-fused bis-BN dihydropyrenes were determined by X-ray crystallog. In the experiment, the researchers used many compounds, for example, 5,8-Dibromoquinoxaline (cas: 148231-12-3HPLC of Formula: 148231-12-3).

5,8-Dibromoquinoxaline (cas: 148231-12-3) belongs to pyrazine derivatives. Pyrazine derivatives have antitumor, antibiotic, anticonvulsant, antituberculous and diuretic effects as well as kinase, enzymatic and potent tubulin and FtsZ polymerization inhibitory activities. A number of pyrazine-based derivatives were used as dyes or fluorescent probes.HPLC of Formula: 148231-12-3

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Design, Synthesis, and Structure-Activity Relationships of Novel 2-Substituted Pyrazinoylguanidine Epithelial Sodium Channel Blockers: Drugs for Cystic Fibrosis and Chronic Bronchitis was written by Hirsh, Andrew J.;Molino, Bruce F.;Zhang, Jianzhong;Astakhova, Nadezhda;Geiss, William B.;Sargent, Bruce J.;Swenson, Brian D.;Usyatinsky, Alexander;Wyle, Michael J.;Boucher, Richard C.;Smith, Rick T.;Zamurs, Andra;Johnson, M. Ross. And the article was included in Journal of Medicinal Chemistry in 2006.Application In Synthesis of Methyl 3,5-diamino-6-chloropyrazine-2-carboxylate This article mentions the following:

Amiloride, the prototypical epithelial sodium channel (ENaC) blocker, has been administered with limited success as aerosol therapy for improving pulmonary function in patients with the genetic disorder cystic fibrosis. This study was conducted to synthesize and identify more potent, less reversible ENaC blockers, targeted for aerosol therapy and possessing minimal systemic renal activity. A series of novel 2-substituted acylguanidine analogs of amiloride were synthesized and evaluated for potency and reversibility on bronchial ENaC. All compounds tested were more potent and less reversible at blocking sodium-dependent short-circuit current than amiloride. Compounds I [R = NH(CH₂)₄C₆H₄O(CH₂)₂OH-4, NH(CH₂)₄C₆H₄O(CH₂)₃OH-4, NH(CH₂)₄C₆H₄OCH₂CH(OH)CH₂OH-4 (both R and S isomers)] showed the greatest potency on ENaC with IC₅₀ values below 10 nM. A regioselective difference in potency was found, whereas no stereospecific difference in potency on ENaC was displayed. Lead compound I [R = NH(CH₂)₄C₆H₄OCH₂CH(OH)CH₂OH-4 (racemic)] was 102-fold more potent and 5-fold less reversible than amiloride and displayed the lowest IC₅₀ value ever reported for an ENaC blocker. In the experiment, the researchers used many compounds, for example, Methyl 3,5-diamino-6-chloropyrazine-2-carboxylate (cas: 1458-01-1Application In Synthesis of Methyl 3,5-diamino-6-chloropyrazine-2-carboxylate).

Methyl 3,5-diamino-6-chloropyrazine-2-carboxylate (cas: 1458-01-1) belongs to pyrazine derivatives. Pyrazine is a symmetrical molecule with point group D2h. Pyrazine is less basic than pyridine, pyridazine and pyrimidine. A large number of pyrazine derivatives are known for their antitumor, antibiotic, anticonvulsant, antituberculosis, and diuretic activities.Application In Synthesis of Methyl 3,5-diamino-6-chloropyrazine-2-carboxylate

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Preparation of poly(quinoxaline-5,8-diyl) derivatives by using zero-valent nickel complexes. Electrical and optical properties and light-emitting diodes was written by Kanbara, T.;Inoue, T.;Sugiyama, K.;Yamamoto, T.. And the article was included in Synthetic Metals in 1995.Application In Synthesis of 5,8-Dibromoquinoxaline This article mentions the following:

Dehalogenation polycondensation of 5,8-dibromoquinoxaline derivatives affords π-conjugated poly(quinoxaline-5,8-diyl) derivatives having high electron-accepting properties, and the polymers are easily converted into elec. conducting materials on chem. and electrochem. reductions The polymers having aromatic substituents show strong fluorescence and are useful materials to make light-emitting diodes. In the experiment, the researchers used many compounds, for example, 5,8-Dibromoquinoxaline (cas: 148231-12-3Application In Synthesis of 5,8-Dibromoquinoxaline).

5,8-Dibromoquinoxaline (cas: 148231-12-3) belongs to pyrazine derivatives. Pyrazine heterocycles and their benzo derivatives possess many interesting properties, including chemical reactivity profiles, and have diverse applications in total synthesis, medicine, chemical biology, materials, dyes, and imaging. Pyrazines are chemical compounds (technically called “methoxypyrazines”) found in grape skin and stems that are responsible for many “green” flavors in wine. Levels of pyrazines are dependent on viticultural practices, climate, and grape variety.Application In Synthesis of 5,8-Dibromoquinoxaline

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Linear Conjugated Polymers for Solar-Driven Hydrogen Peroxide Production: The Importance of Catalyst Stability was written by Liu, Lunjie;Gao, Mei-Yan;Yang, Haofan;Wang, Xiaoyan;Li, Xiaobo;Cooper, Andrew I.. And the article was included in Journal of the American Chemical Society in 2021.Computed Properties of C8H4Br2N2 This article mentions the following:

Hydrogen peroxide (H₂O₂) is one of the most important industrial oxidants. In principle, photocatalytic H₂O₂ synthesis from oxygen and H₂O using sunlight could provide a cleaner alternative route to the current anthraquinone process. Recently, conjugated organic materials have been studied as photocatalysts for solar fuels synthesis because they offer synthetic tunability over a large chem. space. Here, we used high-throughput experiments to discover a linear conjugated polymer, poly(3-4-ethynylphenyl)ethynyl)pyridine (DE7), which exhibits efficient photocatalytic H₂O₂ production from H₂O and O₂ under visible light illumination for periods of up to 10 h or so. The apparent quantum yield was 8.7% at 420 nm. Mechanistic investigations showed that the H₂O₂ was produced via the photoinduced stepwise reduction of O₂. At longer photolysis times, however, this catalyst decomposed, suggesting a need to focus the photostability of organic photocatalysts, as well as the initial catalytic production rates. In the experiment, the researchers used many compounds, for example, 5,8-Dibromoquinoxaline (cas: 148231-12-3Computed Properties of C8H4Br2N2).

5,8-Dibromoquinoxaline (cas: 148231-12-3) belongs to pyrazine derivatives. Pyrazines are volatile compounds that are used in the cosmetic, food, flavor, and fragrance industries. Pyrazine heterocycles and their benzo derivatives possess many interesting properties, including chemical reactivity profiles, and have diverse applications in total synthesis, medicine, chemical biology, materials, dyes, and imaging.Computed Properties of C8H4Br2N2

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Molecular engineering of quinoxaline-based organic sensitizers for highly efficient and stable dye-sensitized solar cells was written by Lu, Xuefeng;Feng, Quanyou;Lan, Tian;Zhou, Gang;Wang, Zhong-Sheng. And the article was included in Chemistry of Materials in 2012.Product Details of 148231-12-3 This article mentions the following:

A series of quinoxaline based metal-free organic sensitizers has been designed and synthesized for dye-sensitized solar cells (DSSCs). The absorption, electrochem., and photovoltaic properties for all sensitizers have been systematically investigated. It is found that the incorporation of quinoxaline unit instead of thienopyrazine unit results in a neg. shift of the LUMO levels for FNE44, FNE45, FNE46, and FNE47, in comparison to FNE32, which induces a remarkable enhancement of the electron injection driving force from the excited organic sensitizers to the TiO₂ semiconductor. Moreover, when the alkyl substituents are removed from the spacer part in FNE44 to the donor part in FNE45 and FNE46, a more conjugated system and a bathochromically shifted maximum absorption band can be realized, which consequently results in an increased light harvesting efficiency and photogenerated current. In addition, the length of the alkyl substituents on the donor part has a certain influence on the DSSC performance. Combining the three contributions, FNE46-based DSSC with liquid electrolyte displays the highest power conversion efficiency (η) of 8.27%. Most importantly, a η of 7.14% has been achieved for FNE46 based quasi-solid-state DSSC and remained at 100% of the initial value after continuous light soaking for 1000 h, which indicates that FNE46 is appropriate for promising com. application. Our findings will facilitate the understanding of the crucial importance of mol. engineering and pave a new path to design novel metal-free organic dyes for highly efficient and stable DSSCs. In the experiment, the researchers used many compounds, for example, 5,8-Dibromoquinoxaline (cas: 148231-12-3Product Details of 148231-12-3).

5,8-Dibromoquinoxaline (cas: 148231-12-3) belongs to pyrazine derivatives. Pyrazine derivatives have antitumor, antibiotic, anticonvulsant, antituberculous and diuretic effects as well as kinase, enzymatic and potent tubulin and FtsZ polymerization inhibitory activities. Pyrazine and a variety of alkylpyrazines are flavor and aroma compounds found in baked and roasted goods. Tetramethylpyrazine (also known as ligustrazine) is reported to scavenge superoxide anion and decrease nitric oxide production in human Granulocytes.Product Details of 148231-12-3

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Bromination of quinoxaline and derivatives: Effective synthesis of some new brominated quinoxalines was written by Ucar, Sefa;Essiz, Selcuk;Dastan, Arif. And the article was included in Tetrahedron in 2017.HPLC of Formula: 148231-12-3 This article mentions the following:

The synthesis of brominated quinoxaline derivatives starting from several kinds of quinoxaline by different bromination strategies was studied. First the synthesis of some brominated quinoxalines was accomplished along with the development of an alternative and effective synthesis of some known compounds A new, clean, and effective synthetic method for selective reduction of quinoxaline to 1,2,3,4-tetrahydroquinoxaline was also developed. In the experiment, the researchers used many compounds, for example, 5,8-Dibromoquinoxaline (cas: 148231-12-3HPLC of Formula: 148231-12-3).

5,8-Dibromoquinoxaline (cas: 148231-12-3) belongs to pyrazine derivatives. Pyrazines are volatile compounds that are used in the cosmetic, food, flavor, and fragrance industries. A large number of pyrazine derivatives are known for their antitumor, antibiotic, anticonvulsant, antituberculosis, and diuretic activities.HPLC of Formula: 148231-12-3

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Preparation and Biofunctionalization of Multicolor Conjugated Polymer Nanoparticles for Imaging and Detection of Tumor Cells was written by Feng, Liheng;Liu, Libing;Lv, Fengting;Bazan, Guillermo C.;Wang, Shu. And the article was included in Advanced Materials (Weinheim, Germany) in 2014.Formula: C8H4Br2N2 This article mentions the following:

Multicolor conjugated polymer nanoparticles (CPNs) are designed and biofunctionalized with antibody for targeted cell imaging and cell detection. In comparison to single-antibody recognition mode to tumor cells, enhanced specificity for targeted imaging and detection of tumor cells is achieved by binding two antibody functionalized CPNs to one tumor cell. This strategy provides a new platform for designing CPNs useful for targeted imaging, cells detection and other biol. applications. In the experiment, the researchers used many compounds, for example, 5,8-Dibromoquinoxaline (cas: 148231-12-3Formula: C8H4Br2N2).

5,8-Dibromoquinoxaline (cas: 148231-12-3) belongs to pyrazine derivatives. Pyrazine heterocycles and their benzo derivatives possess many interesting properties, including chemical reactivity profiles, and have diverse applications in total synthesis, medicine, chemical biology, materials, dyes, and imaging. Pyrazine-based skeletons were incorporated into agents targeting a range of ailments. Many derivatives were synthesized and evaluated as potential cancer treatments.Formula: C8H4Br2N2

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Efficient quasi-solid-state dye-sensitized solar cells based on organic sensitizers containing fluorinated quinoxaline moiety was written by Jia, Xiaowei;Zhang, Weiyi;Lu, Xuefeng;Wang, Zhong-Sheng;Zhou, Gang. And the article was included in Journal of Materials Chemistry A: Materials for Energy and Sustainability in 2014.Recommanded Product: 5,8-Dibromoquinoxaline This article mentions the following:

Two novel organic sensitizers (FNE55 and FNE56) containing a 6,7-difluoroquinoxaline moiety were designed and synthesized for quasi-solid-state dye-sensitized solar cells (DSSCs). For comparison, an organic dye, FNE54, without fluorine has also been synthesized. The effects of the introduction of fluorine on the absorption, electrochem., and photovoltaic properties have been systematically investigated. Upon the incorporation of fluorine in the quinoxaline unit, the electron-withdrawing ability is strengthened, which results in the enhanced push-pull interactions and thus narrows the energy band gap. The absorption maximum wavelength in toluene solution bathochromically shifts from 504 nm for FNE54 to 511 nm for FNE55, and further to 525 nm for FNE56. However, although the lowest unoccupied MOs (LUMOs) are lowered down after the introduction of fluorines, the driving force for the photo-excited electrons from their excited states to the semiconductor conduction band is still sufficient. Consequently, the quasi-solid-state DSSC based on FNE56 exhibits a highest power conversion efficiency of 8.2%, which is 37% higher than that for FNE54 based quasi-solid-state DSSCs. In the experiment, the researchers used many compounds, for example, 5,8-Dibromoquinoxaline (cas: 148231-12-3Recommanded Product: 5,8-Dibromoquinoxaline).

5,8-Dibromoquinoxaline (cas: 148231-12-3) belongs to pyrazine derivatives. Pyrazinesare six-membered aromatic heterocyclic organic compounds with two nitrogen atoms at 1,4-positions. Pyrazine is a weaker base (pKb = 13.4) than pyridine (pKb = 8.8), pyrimidine (pKb = 12.7). Pyrazines are chemical compounds (technically called “methoxypyrazines”) found in grape skin and stems that are responsible for many “green” flavors in wine. Levels of pyrazines are dependent on viticultural practices, climate, and grape variety.Recommanded Product: 5,8-Dibromoquinoxaline

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Controlling epithelial sodium channels with light using photoswitchable amilorides was written by Schoenberger, Matthias;Althaus, Mike;Fronius, Martin;Clauss, Wolfgang;Trauner, Dirk. And the article was included in Nature Chemistry in 2014.Formula: C6H7ClN4O2 This article mentions the following:

Amiloride is a widely used diuretic that blocks epithelial sodium channels (ENaCs). These heterotrimeric transmembrane proteins, assembled from β, γ and α or δ subunits, effectively control water transport across epithelia and sodium influx into non-epithelial cells. The functional role of δβγENaC in various organs, including the human brain, is still poorly understood and no pharmacol. tools are available for the functional differentiation between α- and δ-containing ENaCs. Here we report several photoswitchable versions of amiloride. One compound, termed PA1, enables the optical control of ENaC channels, in particular the δβγ isoform, by switching between blue and green light, or by turning on and off blue light. PA1 was used to modify functionally δβγENaC in amphibian and mammalian cells. We also show that PA1 can be used to differentiate between δβγENaC and αβγENaC in a model for the human lung epithelium. In the experiment, the researchers used many compounds, for example, Methyl 3,5-diamino-6-chloropyrazine-2-carboxylate (cas: 1458-01-1Formula: C6H7ClN4O2).

Methyl 3,5-diamino-6-chloropyrazine-2-carboxylate (cas: 1458-01-1) belongs to pyrazine derivatives. Pyrazine has the elements of symmetry for the point group D2h. It has three mutually perpendicular two-fold axes. It also has three mutually perpendicular planes of symmetry. As a result, pyrazine also has a centre of symmetry. Pyrazine-based skeletons were incorporated into agents targeting a range of ailments. Many derivatives were synthesized and evaluated as potential cancer treatments.Formula: C6H7ClN4O2

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Reductive sulfur extrusion reaction of 2,1,3-benzothiadiazole compounds: a new methodology using NaBH₄/CoCl₂·6H₂O_(cat) as the reducing system was written by Da Silveira Neto, Brenno A.;Lopes, Aline S.;Wuest, Martina;Costa, Valentim E. U.;Ebeling, Guenter;Dupont, Jairton. And the article was included in Tetrahedron Letters in 2005.HPLC of Formula: 148231-12-3 This article mentions the following:

A new simple and efficient methodol. for reductive sulfur extrusion from 2,1,3-benzothiadiazoles was developed using NaBH₄ in the presence of catalytic amounts of CoCl₂.6H₂O (1 mol%). This method is an efficient alternative for the generation of various 1,4-disubstituted 2,3-diaminobenzenes from 4,7-disubstituted 2,1,3-benzothiadiazoles. The diamines can be easily converted into 4,7-disubstituted quinoxalines by simple reaction with glyoxal-sodium bisulfite. In the experiment, the researchers used many compounds, for example, 5,8-Dibromoquinoxaline (cas: 148231-12-3HPLC of Formula: 148231-12-3).

5,8-Dibromoquinoxaline (cas: 148231-12-3) belongs to pyrazine derivatives. Pyrazines are part of several biologically active polycyclic compounds; examples are quinoxalines, phenazines; and the bio-luminescent natural products pteridines, flavins, and their derivatives. Pyrazines undergo nearly all of the same reactions as pyrimidines, from nucleophilic substitution (SNAr) to palladium-catalyzed cross coupling reactions.HPLC of Formula: 148231-12-3

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem